Viewing affirmative mentions of regulation of Cd8a (M. musculus) in T cells

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Witkowski and Micklem (1985)Lyt-2T lymphocytesIn old animals most, and in the older individuals almost all, T lymphocytes were found to be depolarized; both Lyt-2+ and Lyt-2- subsets were affected.
Zhang et al. (1998)CD8T cellsTo delineate the mechanisms underlying regulation of CD8 during these developmental transitions, we have examined expression of a series of mouse CD8 alpha gene constructs in developing T cells of conventional and CD8 alpha "knock-out" transgenic mice.
Fung-Leung et al. (1994)CD8 alphaT cellsOur result also reveals the role of CD8 beta in regulating CD8 alpha expression on thymic derived T cells.
Winkel et al. (1997)CD8T cellThe nature of the signals regulating CD8 T cell proliferative responses to CD8alpha+ or CD8alpha- dendritic cells.
Shrikant et al. (2010)CD8T cellTo determine the tumor efficacy of various effector types and/or memory CD8 T cells, it is imperative to better understand intrinsic and extrinsic factors that regulate CD8(+) T cell differentiation and use this information to generate and test distinct functional cell types in tumor models.
Kemball et al. (2005)CD8T cellInterestingly, epitope-specific CD8(+) T cells differed in CD62L-selectin expression profiles when primed in acute or persistent phases of infection, indicating that the context of priming affects CD8(+) T cell heterogeneity.
Zhang et al. (2001)CD8alphaT lymphocytesControl of CD8alpha transcription during development of alpha/beta T cell receptor (TCR) T lymphocytes is mediated by at least two distinct stage-specific cis-acting transcriptional mechanisms (i.e., enhancers).
Hostert et al. (1998)CD8alphaT cellsDeletion of two of the intergenic cluster CIII DNaseI-HSS in homozygous mutant mice affects expression of CD8alphaalpha homodimers on intraepithelial T cells (IEL), particularly on the gammadeltaTCR+ subset.
Marten et al. (2001)CD8T-cellThe loss of cytolytic activity, but retention of IFN-gamma secretion during viral clearance suggests stringent regulation of CD8+ T-cell effector function, possibly as a means to minimize CNS damage.
Landry et al. (1993)CD8T cellThese results provide the first evidence for the role of a T cell-restricted factor in the regulation of either CD8 or CD4 genes.
Kaldjian et al. (1988)CD8T cellSince activation of protein kinase C (PKC) is known to cause rapid down-regulation of various receptors, including the T cell receptor complex (TcR complex), we treated cells with phorbol 12-myristate 13-acetate (PMA), a PKC activator, to determine whether cell-surface expression of CD4 and CD8 would be similarly affected by this intracellular mediator.
Clambey et al. (2008)CD8T cellCD8 memory T cells are tightly regulated in young, healthy individuals but are often perturbed in aged animals by the appearance of large CD8 T cell clones.
Zhang et al. (1998)CD8 alphaT cellDistinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8 alpha at double- and single-positive stages of thymic development.
Gomes-Pereira et al. (2004)CD8T cellIn the liver, these pre-activated cells become effector T lymphocytes, however, a strong regulation of CD8+ T cell effector function was observed, probably preventing hepatic tissue damage.
van Oers et al. (1993)CD8T cellsTo examine the effects of CD8 expression on intracellular signaling responses in the CD4-CD8- cells, the H-Y TCR transgenic mice were mated with transgenic mice that constitutively expressed the CD8 alpha molecule on all T cells.
Banan et al. (1997)CD8aT cellThe present study demonstrates that a DNA element, called L2a, which has been implicated in the transcriptional regulation of the mouse CD8a gene encoding an important T cell coreceptor, is a MAR.
French et al. (2009)CD8T cellUsing an adoptive transfer model to study lymphopenia-induced homeostatic expansion, we show that CD8(+) and NK1.1(+) gammadelta T cell subsets are differentially regulated.
Kemball et al. (2007)CD8T cellsIn summary, these studies show that CD4(+) T cells differentially affect CD8(+) T cell responses over the course of a persistent virus infection.
Whitmire et al. (2000)CD8T cellsSo while there is long-term memory in both the CD8 and CD4 compartments, the rules regulating the activation of CD8 and CD4 T cells and the overall magnitude of the responses are different.
Capone et al. (2003)CD8T cellCollectively, our data reveal an unexpected difference in the regulation of CD8(+) T cell homeostasis by beta2m-associated ligands in the intestine as compared to peripheral lymphoid organs.
Chang et al. (2001)CD8T cellThe significance of these results for the regulation of the CD8(+) T cell response to RSV is discussed.
Apte et al. (2008)CD8T cellThe CD8 co-receptor can modulate CD8(+) T cell function through its contributions to T cell receptor (TCR) binding and signaling.
Bender et al. (1992)CD8T lymphocytesTo investigate the role of CD8+ T lymphocytes in recovery from influenza pneumonia, we used transgenic mice either homozygous (-/-) or heterozygous (+/-) for beta 2-microglobulin (beta 2-M) gene disruption.
Harty and Badovinac (2008)CD8T-cellTechnical advances that allow direct ex vivo identification and characterization of antigen-specific CD8+ T cells at various stages of the response to infection or vaccination in mouse models have fuelled efforts to characterize the factors that control memory CD8+ T-cell generation.
Raveney and Morgan (2007)CD8T cellDynamic control of self-specific CD8+ T cell responses via a combination of signals mediated by dendritic cells.
Tanchot and Rocha (1995)CD8T cellThe peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8+ T cell pools.
Chen et al. (2004)CD8T cellsThe effects of donor T cells, or their CD8+ subset, on engraftment and tolerance induction in fetal transplantation were evaluated using an F1-into-parent mouse-model that does not permit a graft-versus-host effect.
Mody et al. (1994)CD8T cellsTo determine whether CD8 T cells enhance or inhibit host defence during an infection with a highly virulent strain of C. neoformans, we examined the effect of in vivo CD8 cell depletion on survival and on the number of organisms in mice infected by either the intratracheal or intravenous routes.
Niederkorn et al. (2006)CD8T lymphocytesDifferential roles of CD8+ and CD8- T lymphocytes in corneal allograft rejection in 'high-risk' hosts.
Obar et al. (2008)CD8T cellThus, initial endogenous precursor frequencies were surprisingly diverse and not only regulated initial immune response characteristics but also controlled memory CD8+ T cell lineage decisions.
McDole et al. (2006)CD8T-cellsThe role of CD8+ T-cells in lesion formation and axonal dysfunction in multiple sclerosis.
Zimring et al. (2005)CD8T lymphocyteRegulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway.
Moser et al. (2002)CD8T cellCD94-NKG2A receptors regulate antiviral CD8(+) T cell responses.
Fung-Leung et al. (1993)CD8 alphaT cellA T cell-specific transgene encoding CD8 alpha truncated at the cytoplasmic domain ("tailless CD8 alpha"), was introduced into CD8 alpha-deficient mice.
Huang et al. (2010)CD8T cellThere is also evidence for loci with specific effects: the single largest QTL effect on CD4+ versus CD8+ T cell subsets scarcely contributes to KI67 counts.
Huang et al. (2010)CD8T cellsAll QTLs that control the proportions of CD4+ and CD8+ T cells also have an impact on neurogenesis, with the glaring exception of the strongest of them, the H2-Ea locus [17], whose homolog has also been identified in human GWAS studies of CD4+/CD8+ ratio determinism [18].
Sawada et al. (1993)CD8T lymphocytesInterestingly, CD8 expression was hardly suppressed in CD4-CD8+ peripheral T lymphocytes, suggesting that the mechanisms of suppression of CD8 is developmentally regulated.
Badovinac et al. (2003)CD8T cellThus, perforin was essential for resistance to secondary LCMV infection, and, in the absence of perforin, vaccination resulted in lethal disease mediated by dysregulated CD8(+) T cell expansion and cytokine production.
Salem and Hossain (2000)CD8T cellLack of effects of CD8(+) T cell depletion on the viral load and NK cytolytic activity is also observed in CD8(+) knockout mice.
Boulanger et al. (2010)CD8T cellThis alteration of the CD8(+) T cell hierarchy was a consequence of tapasin editing and not a consequence of the alteration of the T cell repertoire in tapasin-deficient mice, because bone marrow chimeric mice (wild-type recipients reconstituted with tapasin knockout bone marrow) showed the same hierarchy as the tapasin knockout mice.
Erlebacher et al. (2007)CD8T cellsUsing a system to visualize both CD4+ and CD8+ T cell responses during pregnancy in mice, we find that maternal T cells become aware of the fetal allograft exclusively through "indirect" antigen presentation, meaning that T cell engagement requires the uptake and processing of fetal/placental antigen by maternal APCs.
Kambayashi et al. (2000)CD8T cellsThese results demonstrate that a significant proportion of CD8(+) T cells acquire NK1.1 and other NK cell-associated molecules, and suggests that these receptors may possibly regulate CD8(+) T cell effector functions during viral infection.
Bosselut et al. (2000)CD8T cellsRole of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus.
Villacres and Bergmann (1999)CD8T cellThis report investigates these disparate roles of IL-4 in CD8+ T lymphocyte regulation by comparing T cell responses specific for a single HIV-IIIIB gp120-derived epitope in BALB/c mice deficient in IL-4 to those in wild-type controls.
Cano et al. (2000)CD8T cellsEmploying the same experimental model, we examined herein the role of CD8(+) T cells in the course of paracoccidioidomycosis.
Wofsy (1988)Lyt-2T cellsThe role of Lyt-2+ T cells in the regulation of autoimmunity in murine lupus.
Hoeveler and Malissen (1993)CD8T cellTo determine the relative importance of these residues for CD8 function, a mouse T cell hybridoma expressing a T cell receptor specific for the class I major histocompatibility product H-2Kb was transfected with a set of CD8 alpha chain genes encoding polypeptides in which the cytoplasmic cysteine or serine residues were substituted with alanine.
Le Borgne et al. (2006)CD8T cellDendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.
Kronin et al. (1997)CD8T cellThis applied to both the CD4 and the CD8 T cell responses.
Johnson et al. (2010)CD8T cellsHerein, we review evidence supporting a role for CD8(+) T lymphocytes in both MS and EAE and also highlight several novel murine systems designed for investigating the role(s) of CD8(+) T cells in autoimmune demyelination.
Krieg et al. (2007)CD8T lymphocyteB and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation.
Kotturi et al. (2007)CD8T-cellCD8(+) T-cell responses control lymphocytic choriomeningitis virus (LCMV) infection in H-2(b) mice.
Garside et al. (1996)CD8T-lymphocyteThis increased cell death affects both CD4+ and CD8+ T-lymphocyte subsets, and morphological and flow cytometric analyses suggest that it occurs via apoptosis.
Mosley et al. (1998)CD8T cellIdiosyncratic alterations of TCR size distributions affecting both CD4 and CD8 T cell subsets in aging mice.
Mueller and Ahmed (2009)CD8T cellTo address these issues, we examined the influence of antigen presentation by different cell types on CD8(+) T cell responses during persistent infection of mice with lymphocytic choriomeningitis virus (LCMV) clone 13.
Martin et al. (2008)CD8T cellFurthermore, loss of p110gamma did not affect CD8 T cell proliferation and effector cell differentiation in vitro in response to anti-CD3 stimulation or in vivo in response to vaccinia virus (VV) challenge.
Newell et al. (1989)CD8T-lymphocyteEffects of CD4+ and CD8+ T-lymphocyte depletion on the induction and expression of herpes simplex stromal keratitis.
Hardy et al. (2001)CD8T-cellFactors controlling levels of CD8+ T-cell lymphocytosis associated with murine gamma-herpesvirus infection.
Mbawuike et al. (2007)CD8T cellsControl CD8+ T cells stimulated with vaccinia-gp120 did not kill influenza virus-infected target cells in vitro and did not mediate clearance of virus in vivo.
Beaumier and Rothman (2009)CD8T cellsFurthermore, adoptive transfer of memory CD4+ T cells altered the response of memory CD8+ T cells to secondary infection.
Schmolz et al. (2001)CD8T-lymphocyteIn all groups, changes in CD4 + and CD8 + T-lymphocyte subpopulations of the peripheral blood were observed, but no clear relationship to the treatment results was seen.
Bettini et al. (2009)CD8T cellsXIncreasing evidence supports a role for CD8+ T cells in multiple sclerosis.
Zhong and Reinherz (2005)CD8T cellThese results demonstrate that the role of CD8alphaalpha in the generation of antiviral CD8 T cell memory is complex, presumably because various viral stimuli differentially regulate CD8alphaalpha expression.
Steitz et al. (2005)CD8T cellsPeripheral CD8+ T cell tolerance against melanocytic self-antigens in the skin is regulated in two steps by CD4+ T cells and local inflammation: implications for the pathophysiology of vitiligo.
Wicker et al. (1994)CD8T-cellsThese results demonstrate an essential role for CD8+ T-cells in the initiation of the autoimmune response to beta-cells in the NOD mouse.
Shah et al. (2009)CD8T cellsHerein, we studied the role of CD154/CD40 costimulation in the regulation of allospecific CD8(+) T cells, as airway rejection has been reported to be CD154-dependent.
Wallace et al. (1993)CD8T-cellRecent data also demonstrate that the requirement for CD4 and CD8 in negative selection of T cells is not absolute and may be regulated by T-cell receptor affinity for the deleting ligand, an interpretation consistent with the affinity model of thymic selection.
Pulle et al. (2006)CD8T cellsWe show that IL-15, a cytokine involved in regulation of CD8+ memory T cell survival, induces the expression of 4-1BB on CD8+CD44(high) memory phenotype T cells, but not on CD4+ T cells.
Schaller et al. (2005)CD8T lymphocytesAltogether, these studies highlight a role for CD8(+) T lymphocytes in the development of allergen-induced airway responses.
Grujic et al. (2008)CD8T cellIn summary, the present report points to a novel, previously unrecognized role for serglycin proteoglycan in regulating the kinetics of antiviral CD8(+) T cell responses.
Zajac et al. (1998)CD8T cellWe examined the regulation of virus-specific CD8 T cell responses during chronic lymphocytic choriomeningitis virus (LCMV) infection of mice.
He et al. (2008)CD8T cellsThe results showed that a significantly higher expression of CD94-NKG2A heterodimer on CD8+T cells was induced following OVA inoculation into the anterior chamber, and that AC-injection of antigen and immunization have a synergistic effect on the increase of CD8+CD94+T cells.
He et al. (2008)CD8T cellsCD8+CD94+T cells were characterized by minimal expression of perforin, granzyme B and Foxp3.
Badovinac et al. (2004)CD8T cellCD8+ T cell contraction is controlled by early inflammation.
Scott et al. (2004)CD8T lymphocytesRole of CD8+ and CD4+ T lymphocytes in jejunal mucosal injury during murine giardiasis.
Zhou et al. (2008)CD8T cellsTNF-alpha produced by Ag-specific CD8+ T cells appears primarily responsible for this immunopathology, and we have examined the negative regulation of CD8+ TNF production by CD94/NKG2A engagement with its receptor, Qa-1b.
Snyder et al. (2009)CD8T cellCD4+ T cell help has an epitope-dependent impact on CD8+ T cell memory inflation during murine cytomegalovirus infection.
Vuckovi? et al. (2006)CD8T lymphocytesThe current study was based on in vivo T-cell subsets depletion to evaluate the role of CD4+ and CD8+ T lymphocytes in disseminated C. jejuni infection in C57BL/6 mice.
Yoshida et al. (2004)CD8T cellCD8 T cell of donor splenocyte mixed with bone marrow cells is more effective than CD4 T cell for induction of donor-specific tolerance in sublethally irradiated mice.
Lang et al. (2008)CD8T cellAge-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication.
Schepers et al. (2005)CD8T cellFurthermore, we discuss our current understanding of the formation of antigen-specific T cell responses, with particular attention to the similarities and differences in CD4+ and CD8+ T cell responses, the functional heterogeneity within responder T cell pools and the regulation of CD8+ T cell responses by dendritic cells and CD4+ helper T cells.
Kelly et al. (2003)CD8T cellThese findings identify Stat5 proteins as critical signaling mediators used by cytokines to regulate CD8+ T cell homeostasis.
Snyder et al. (2010)CD8T cellThese results support the interpretation that cross-presentation is responsible for most CD8+ T cell priming in MCMV infection.
Snyder et al. (2010)CD8T cellThus, in order to characterize the CD8+ T cell response to K181 (wild-type) and ?
Snyder et al. (2010)CD8T cellTo investigate the CD8+ T cell response when priming was limited to cross-presentation, we infected class I MHC-deficient (KbDb-/-) MEFs in vitro with either wild-type K181 or ?
Snyder et al. (2010)CD8T cellgL infected fibroblasts should only mount a CD8+ T cell response if endogenous cells can capture and cross-present viral antigen in class I MHC.
Lukens et al. (2009)CD8T cellWhen we carried out a corresponding comparison of the impact of IV versus SubQ inoculation on the subsequent CD8+ T cell response in the liver using rAd expressing ?
Lukens et al. (2009)CD8T cellAs Fig. 1D demonstrates, the decreased dose of virus inoculum administered by the IV route only served to reduce the overall magnitude of CD8+ T cell response detected in the liver by either tetramer staining or IFN-?
Lukens et al. (2009)CD8T cellFunctionally exhausted CD8+ T cell populations and CD8+ T cell death in the liver impair viral clearance during persistent infections including HCV and HBV [33].
Lukens et al. (2009)CD8T cellHowever, naďve T cell activation by antigen within the liver or the encounter of previously activated CD8+ T cells with antigen displayed in the liver results in the dysregulation of CD8+ T cell effector function.
Salát et al. (2002)CD8T lymphocytesRole of CD4+ and CD8+ T lymphocytes in the protection of mice against Encephalitozoon intestinalis infection.
Sullivan et al. (2003)CD8T cellAntigen-driven effector CD8 T cell function regulated by T-bet.
Gray et al. (2004)CD8T cellModulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection.
Sumaria et al. (2009)CD8T cellsAlthough the role of NK and CD8(+) T cells is defined, the molecular mechanisms they utilize to limit acute infection are poorly understood.