Viewing negative mentions of regulation of Cd8a (M. musculus) in T cells

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Anderson and Coleclough (1993)CD8T cellsWhereas PMA causes the disappearance of almost all CD4 from the surface of mouse CD4+8+ thymocytes, it induces only a partial (approximately 60%) and transient (10 to 12 h) loss of CD4 from the surface of mouse peripheral T cells, with no effect on CD8 expression.
Lee et al. (2009)CD8T cellAlthough CD4 and CD8 coreceptors are not directly involved in the interaction between CD1d and the T cell receptors (TCRs) of iNKT cells, a conspicuous lack of CD8(+) iNKT cells in mice raised the question of whether CD8(+) iNKT cells are excluded due to negative selection during their thymic development, or if there is no lineage commitment for the development of murine CD8(+) iNKT cells.
Schmidt-Ullrich and Eichmann (1990)Lyt-2T cellsHowever, results on T cells unrelated to C196 suggests that the site whose methylation appears to be critical in C196 is not responsible for Lyt-2 transcription in all T cells.
Hensley et al. (2009)CD8T-cellMNV infection had no effect on CD8(+) T-cell or antibody responses to secondary viruses or to secondary virus-induced morbidity or mortality.
van den Berg et al. (2010)CD8T cellsNormal CD8(+) T cell tolerance was observed in MHC class II deficient mice, indicating that CD4(+) T cells are not required for both oral and nasal CD8(+) T cell tolerance induction.
Shi et al. (2007)CD8T cellWe found that deficiency of IL-10, IL-12, IFN-gamma, CD28, CD40, CD80, CD40L, and 41BBL in recipients did not affect CD8(+) T cell survival after adoptive transfer.
Dawicki and Watts (2004)CD8T cellAlthough 4-1BB is expressed early in the primary response, there was no effect of 4-1BBL deficiency on initial CD8 T cell expansion and only a minor effect on initial CD4 T cell expansion.
Furtado et al. (2006)CD8T cellsUnlike the classical models of experimental autoimmune encephalomyelitis, depletion of CD4+ and CD8+ T cells did not affect disease induction.
Varga et al. (2001)CD8T cellThese data indicate that the CD4(+) and CD8(+) memory T cell pools are regulated independently and that the loss in CD8(+) T cell memory following heterologous virus infections is not a consequence of a parallel loss in the memory CD4(+) T cell population.
Lang et al. (2007)CD8T cellThe primary specific CD8+ T cell responses remained unaffected by peptide tolerisation.
Frimpong-Boateng et al. (2010)CD8T cellWe found that depletion of Tregs had no effect on CD8+ T cell immune responses, a result that ruled out iNKT cells as key players in Treg-mediated plasmid DNA CD8+ T cell immune suppression (Fig. 2C).
Tan et al. (1999)CD8T cellThis result contrasts with our earlier work with CD40L-deficient (CD40L-/-) mice, in which the CD8 T cell response was unaffected and the CD4 T cell response was markedly impaired.
Strehl et al. (2006)CD8T cellsRecently, the function of I-proteasomes in antimicrobial responses was challenged by showing that the lack of I-proteasomes has no effect on induction and function of lymphocytic choriomeningitis virus-specific CD8(+) T cells.
Maile et al. (2005)CD8T cellIn this study, we suggest that CD8 levels on T cells are not static, but can change and, as a result, modulate CD8(+) T cell responses.
Mitchell and Lawrence (2003)CD8T cellUnexpectedly, we discovered that exposure to TCDD did not alter CD8(+) T cell function in the transgenic mice.
Moretto et al. (2000)CD8T-cellLack of CD4(+) T cells does not affect induction of CD8(+) T-cell immunity against Encephalitozoon cuniculi infection.
Stiles et al. (2006)CD8T cellAdministration of anti-CXCR3 antibody reduced CD4+ T cell infiltration (pCD8+ T cell trafficking was not affected.
Le Saout et al. (2010)CD8T cellsSurprisingly, we found that the self-reactivity mediated by the cooperation of memory-like CD8+ and CD4+ T cells was not abrogated by CD40L blockade.
McComb et al. (2010)CD8T cellIn agreement with this, it has previously been shown that the application of a caspase inhibitor has no effect on contraction of CD8+ T cell response [46].
Zhai et al. (2007)CD8T cellOnly transient CD4 help was required, as short-term CD4 blockade at the time of first skin graft challenge only delayed alloreactive CD8 activation, without affecting the CD8 T cell memory response to a second skin graft.
Zwacka et al. (1997)CD8T cellKinetic analysis of T cell infiltration in the livers of BALB/c mice demonstrated a fivefold increase in the number of hepatic CD4(+) T-lymphocytes within the first hour of reperfusion with no significant change in the number of CD8(+) T-lymphocytes.
Yamasaki et al. (1988)Lyt-2T-cellH-2Kk and H-2Dd induction by DMSO was equal to pretreatment of YAC-1 cells with 50-100 and 10-20 U/ml interferon (IFN)-gamma, respectively, but the T-cell differentiation antigens Lyt-1, Lyt-2, Thy-1, and L3T4 remained unaffected.
Tang et al. (2008)CD8T lymphocyteThe analysis of T lymphocyte subsets showed that the percentage of CD3, CD4 and CD4/CD8 ratio decreased significantly in model group when compared with the normal ones (P < 0.01), while no change was observed in CD8.
Nair et al. (2007)CD8T cellAlso, while CD8(+) T cell activation and function in the brain were not affected by stress, the number of CD8(+) T cells in the superficial cervical lymph nodes (SCLN) was decreased in stressed mice via GR-mediated mechanisms.
Palma et al. (2010)CD8T cellAgonistic anti-4-1BB mAb treatment had only a little influence on CD4+ or CD8+ T cell proliferation in P-mice (Fig. 4 and Table 1).
Hatta et al. (2010)CD8T cellWhy is the CD8 T cell response unable to effectively control a lethal H5N1 infection?
Nagai et al. (2004)CD8T-cellOn the other hand, CD8(+) T-cell depletion did not affect the tumor growth in the early phase but allowed B16/IL-12 to grow in rather a late phase and resulted in almost the same degree of tumor growth as in mice without administration of anti-CD25 mAb.
Gorbachev and Fairchild (2010)CD8T-cellIn contrast, CD4(+)CD25(+) T cells did not regulate hapten-specific CD8(+) T-cell priming and CHS responses initiated by Fas-defective (lpr) DC.
Bhadra et al. (2010)CD8T cellshad no clear effect on adoptively transferred CD8+ T cells [18].
Bhadra et al. (2010)CD8T cellThis suggests that absence of IL-15 or IL-7 alone does not affect CD8+ T cell activation during acute Toxoplasmosis.
Bhadra et al. (2010)CD8T cellIn the present study we demonstrate that depletion of IL-7 alone did not impede the induction of primary CD8+ T cell response in the WT animals.
Chang and Norman (1992)CD8T-cellsHowever, the ability of T-cells from ethanol diet-fed mice to produce IL2 and to express IL2 R or CD4+/CD8+ subset markers was not affected.
Kang and Allen (2005)CD8T cellAdditionally, little is known about whether initial priming in the presence of IL-10 can have long-lasting effects and influence subsequent CD8(+) T cell responses that occur in the absence of the cytokine.
Basler and Groettrup (2007)CD8T cellIn contrast to Reits' proposal, TPPII inhibition and TPPII overexpression experiments revealed that five out of six LCMV-derived CD8(+) T cell epitopes were not affected by inhibition of TPPII, while one epitope (GP276) was slightly reduced upon TPPII overexpression.
Keir et al. (2007)CD8T cellsLoss of PD-1 affected CD8(+) cells intrinsically, and did not significantly alter the responses of wild-type OT-I T cells adoptively transferred into the same RIP-ova(high) recipient mouse.
Eralp et al. (2004)CD8T-cellThe present data revealed that DOX could induce an antigen-specific CD8+ T-cell response when given 1 day before the vaccine; however, if given 1 week after the vaccine, no CD8+ T-cell response was observed (data not shown).
Fortner et al. (1998)CD8T lymphocytesUsing an anti-CD2 antibody, CD2 was down-modulated in vivo on mouse T lymphocytes without affecting the levels of surface CD3, TCR alphabeta, CD4 or CD8.
Nakagawa et al. (2001)CD8T cellsDepletion of CD8(+) T cells did not affect the alpha-GalCer-induced antitumor cytotoxicity of liver MNCs but reduced the effect of alpha-GalCer on the survival of B6 mice.
Flatz et al. (2010)CD8T cellAlso, depletion of only CD4+ or CD8+ T cells or genetic deficiency for MHC-I (affecting the CD8+ but not the CD4+ T cell compartment) afforded at least partial protection.
Khan et al. (1994)CD8T cellsDepletion of host CD4+ T cells with mAb had no effect on CD8(+)-mediated adoptive protection, whereas treatment with anti-IFN-gamma completely abrogated this protection.
Kooij et al. (2009)CD8T cellNotably, fixation of BMDCs showed no effect of P-gp inhibition on CD4+ and CD8+ T cell proliferation (Figure 5g,h) or on Th1 cytokine secretion (Figure 5i–l).
Orr et al. (2005)CD8T cellsThat depletion of CD8 T cells in mice infected with 27US11 or 27m152 did not affect CNS viral titers indicates that the effect of MHC class I inhibition is also manifest primarily at this site.
Guo et al. (2000)CD8T cellsIn tier II, we found that exposure to glycidol decreased the number and percentage of B cells and the absolute number of CD4+ T cells in the spleen while the number of total T cells, CD8+ T cells and CD4+CD8+ T cells was not affected.
Feng et al. (2004)CD8T cellexpression in the T cell lineage did not grossly affect the percentage of CD4/CD8 double positive, double negative, or single positive population despite high viral transduction efficiency (greater than 84% cells were GFP+) (data not shown).
Marussig et al. (1997)CD8T cellsIn vivo, depletion of CD4+ or CD8+ T cells did not affect protection.
Wernimont et al. (2010)CD8T cellsT cells from Capn4F/F:CD4-CRE mice developed normally, and we observed no change in the CD4 and CD8 distribution in thymic populations of 6 week old Capn4F/F:CD4-CRE mice compared to control mice (Figure 1C).
Espinoza et al. (2010)CD8T cellCD8+ T cell levels remained unchanged in the acute phase and showed a significant increase in the chronic phase of Ninoa infection, in agreement with their timing for expansion and contraction phases in T. cruzi infection [40].
Hunt et al. (1999)CD8T cellResting T cells treated with sub-lethal levels of BPD-MA and light did not exhibit changes in surface levels of CD3, CD4, CD8, CD28, CD45 or T cell receptor (TCR) beta-chain structures.
Huang et al. (2010)CD8T cellsThese data strongly imply that endothelial Tim-3 expression in lymphoma might affect CD4+ but not CD8+ T cells or CD1a+ dendritic cells in vivo.
Schmidt et al. (2010)CD8T cellThus, following the induction of CD8 T cell responses via Pb-RAS-vaccination of BALB/c mice, the persistence of attenuated parasites in the liver does not regulate the stability or protective capacity of the RAS-induced memory CD8 T cell populations.
Valkenburg et al. (2010)CD8T cellInterestingly, a similar P3 substitution in the influenza virus DbPA224 epitope had no affect on DbPA224+CD8+ T cell recognition and recruited a diverse array of TCR clones comparable to the spectrum found for the wt response [21].
Cottingham et al. (2008)CD8T cellDeletion of C12L, A44L, A46R or B7R did not significantly affect CD8(+) T cell immunogenicity in BALB/c mice, but deletion of B15R enhanced specific CD8(+) T cell responses to one of two endogenous viral epitopes (from the E2 and F2 proteins), in accordance with published work (Staib et al., 2005, J.
Bruckner et al. (2006)CD8T cellsIn vivo depletion of CD4(+) T cells in P. carinii/TBI mice abrogated pulmonary dysfunction and reduced TNF-alpha levels in BALF, whereas depletion of CD8(+) T cells did not affect lung compliance or TNF-alpha.
Machado et al. (2008)CD8T cellsMoreover, direct testing of the effect of proteasome inhibition on CD8+ T cell during LCMV infection showed that such treatment did not affect expansion of CD8+ T cells specific for LCMV-derived peptides (Fig.
Randall et al. (2008)CD8T cellsSpecific blockade of LIGHT-LTbetaR, but not LIGHT-herpesvirus entry mediator interactions, abrogated the accumulation of parasites and the recruitment of pathogenic CD8(+) T cells and monocytes to the brain during infection without affecting early activation of CD4(+) T cells, CD8(+) T cells, or NK cells.
Johanns et al. (2010)CD8T cellsBy contrast, the percent CD8+ T cells remained essentially unchanged throughout these same time points.
Schmidt et al. (2010)CD8T cellWe were unable to detect CS-specific CD8 T cell responses in RAS-vaccinated B6 mice (data not shown), which could account for reduced protection.
Loh et al. (2005)CD8T cellHowever, v-Bcl-2 transgenic mice displayed no abnormalities in CD4 and CD8 T cell development in the thymus (Figures 1D and S1), nor were there any alterations in thymic architecture (unpublished data).
Sawyer et al. (1995)CD8T cellsPreexposure to bacteria induced a significant increase in the percentage of splenic T cells without altering the CD4/CD8 ratio.