Viewing affirmative mentions of regulation of Cd4 (M. musculus) in T cells

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Poitrasson-Rivière et al. (2008)CD4T cellIn vivo studies have shown that regulatory CD4(+) T cells regulate conventional CD4(+) T cell responses to self- and environmental Ags.
Sleckman et al. (1989)L3T4T cellsThese results suggest that the inability to modulate L3T4 from the surface of murine peripheral T cells is due to features of the cell and not the molecule.
Watanabe et al. (2005)CD4T cellsCD4+CD25+ T cells regulate colonic localization of CD4 T cells reactive to a microbial antigen.
Alard et al. (2006)CD4T-cellDeficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice.
Weigle (1989)CD4T-cellThe T-cell compartment, notably the CD4 subset, which includes helper cells, is most affected by thymic involution.
Myrick et al. (2002)CD4T cellsCorrelation analysis of the CD4:CD8 ratio in thymic precursors vs peripheral T cells in F2 and backcross mice found that thymic precursor ratios are inherited independently from those in the periphery, indicating that the CD4:CD8 ratios in these populations are affected by distinct genetic mechanisms.
Anderson and Coleclough (1993)CD4T cellsRegulation of CD4 and CD8 expression on mouse T cells.
Hori et al. (2002)CD4T cellWe tested the ability of this CD25(+)CD4(+) population to regulate CD4(+) T cell-mediated inflammatory response to PC.
McHugh et al. (2002)CD4T cellImportantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset.
McKinstry et al. (2010)CD4T-cellRegulation of CD4+ T-cell contraction during pathogen challenge.
Sparks-Thissen et al. (2005)CD4T cellCD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNgamma.
Brabletz et al. (1999)CD4T cellCD4 expression during the various stages of T cell differentiation is controlled at the transcriptional level by a complex array of regulatory elements in the CD4 gene locus, consisting of at least three enhancers, one promoter and one silencer.
Brabletz et al. (1999)CD4T cellsThe conversion of the CD4 proximal enhancer into a potential silencer element by the transcriptional repressor ZEB offers an additional concept of CD4 gene regulation in T cells.
Sawada et al. (1994)CD4T lymphocyteA lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development.
Du et al. (2009)CD4T cellsInterestingly, this allograft acceptance was transferable and maintained at least partly by the immune regulation of CD4(+)CD25(+) T cells.
Fehr et al. (2005)CD4T cellRapid peripheral deletion of donor-specific CD8 T cells precludes an ongoing requirement for CD4 T cell-mediated regulation.
Peters et al. (2009)CD4T cellsWe address here the role of CD4 T cell cooperation in the activation of CD4 T cells.
Huber et al. (1999)CD4T-cellHormonal regulation of CD4(+) T-cell responses in coxsackievirus B3-induced myocarditis in mice.
Bajénoff et al. (2002)CD4T cellsThe mechanisms that regulate CD4(+) T cells responses in vivo are still poorly understood.
Feito et al. (1997)CD4T lymphocytesThe effect of CD4 expression on the activation threshold of mouse T lymphocytes has been analysed.
Berzins et al. (1998)CD4T cellsThis export ratio is similar to that of T cells in the mature thymic compartment, but soon after entry into the periphery, the ratio falls, indicating separate thymic and peripheral regulation of the CD4/CD8 ratio.
Mukherjee et al. (2003)CD4T cellsAlthough, non-self antigenic OVA (323-339) peptide immunization and in vitro culture with OVA (323-339) peptide does result in up regulation of CD4+CD25+ T cells, these cells did not prevent transfer of diabetes.
Bhagwat et al. (2006)CD4T cellsIn contrast, CD8(+) T cells contributed to neither lung injury nor organism clearance when CD4(+) cells were present, but instead served to modulate CD4 function.
Mayack and Berg (2006)CD4T cellThis report addresses the role of gamma-chain cytokine signals in regulating CD4(+) T cell differentiation following activation.
Nakamura et al. (1996)CD4T cellsThese results indicate that in T cells, oxidants inhibit protein kinase C-mediated CD4 down-regulation due to perturbing a signaling process other than the above two steps, implying that oxidative stress may tune the functions of CD4+ T cells and their susceptibility to HIV-1 through the control of CD4 expression.
Havenar-Daughton et al. (2006)CD4T cellsThe action of type I IFN (IFN-I) on APCs is well studied, but their direct effect on CD4 T cells is unclear.
Sarafova and Siu (2000)CD4T-cellThe control of CD4 expression is linked to the signaling events that mediate T-cell development and is directly dependent on the CD4 promoter.
Gocinski et al. (1993)CD4T cellcis-dominant regulation of CD4 and CD8 gene expression in rat/mouse T cell heterohybridomas.
Wu et al. (2002)CD4T cellTumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice.
Lo et al. (1995)CD4T cellRegulation of CD4 T cell reactivity to self and non-self.
Mosley et al. (1998)CD4T cellIdiosyncratic alterations of TCR size distributions affecting both CD4 and CD8 T cell subsets in aging mice.
Kodama et al. (2003)CD4T cellRole of interleukin-12 in the regulation of CD4+ T cell apoptosis in a mouse model of asthma.
McCausland et al. (2007)CD4T cellIt is unknown what signaling molecules are involved in regulation of SAP-dependent CD4 T cell help functions.
Jordan et al. (2000)CD4T cellAnergy and suppression regulate CD4(+) T cell responses to a self peptide.
Burgert et al. (1989)CD4T cellBoth, the CD4+ as well as the CD8+ T cell subsets are affected.
Dugas et al. (2010)CD4T cellsTogether, these findings constitute an in vivo demonstration that CD47 is involved in diabetes susceptibility and controls the homeostatic regulation of CD4(-)CD8(-) T cells.
Farrer et al. (2008)CD4T cellIn order to identify the direct target of Pb in the immune system and the potential mechanism of Pb-induced immunotoxicity, myeloid suppressor cells (MSCs) were evaluated for their ability to modulate CD4(+) T cell proliferation after Pb exposure.
Boll and Reimann (1996)CD4T cellTCR alpha beta and TCR gamma delta, CD4+ and CD8 alpha+ T cell subsets were affected.
Landry et al. (1993)CD4T cellThese results provide the first evidence for the role of a T cell-restricted factor in the regulation of either CD8 or CD4 genes.
Valzasina et al. (2006)CD4T-lymphocyteThe CD25- and CD25+ CD4 T-lymphocyte compartments are tightly regulated.
van den Berg et al. (2010)CD4T cellDifferent mechanisms regulate CD4(+) T cell independent induction of oral and nasal tolerance of CD8(+) T cells.
Sawada and Littman (1993)CD4T-lymphocyteA T-lymphocyte-specific enhancer located 13 kb upstream of the murine CD4 gene was recently shown to be required for the developmentally regulated expression of CD4.
Niedbala et al. (1999)CD4T cellsNO appears to affect CD4(+) T cells directly and not at the antigen-presenting cells.
Talmadge et al. (2007)CD4T cellIn summary, our results suggest that celecoxib chemoprevention of autochthonous intestinal tumors can regulate IMSCs and CD4(+) T cell numbers.
Crist et al. (2003)CD4T cellCD28 costimulation, an important second signal for antigen-mediated T cell activation, is known to enhance expression of several genes important for the regulation of CD4+ T cell effector function including interleukin-2 and CD154.
Kashiwada et al. (2006)CD4T cellDownstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development.
Ford et al. (2008)CD4T cellWe addressed the possibility that variations in CD4(+) T cell precursor frequency following transplantation might affect CD4(+) T cell proliferation, effector function, and provision of help for donor-reactive B cell and CD8(+) T cell responses.
Zamoyska (2003)CD4T-cellT-cell differentiation: chromatin remodelling in CD4/CD8 regulation.
Rizzello et al. (2006)CD4T lymphocytesModulation of CD4(+)CD28null T lymphocytes by tumor necrosis factor-alpha blockade in patients with unstable angina.
Chambers et al. (1992)CD4T cellEctopic expression of exogenous IL-4 in hematopoietic cells had dramatic effects on T cell development resulting in changes in CD4:CD8 ratios.
Velupillai and Harn (1994)CD4T-cellOligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets.
Wilkinson et al. (1991)CD4T-lymphocyteA model system for T-lymphocyte differentiation: regulation of CD4 and CD8 gene expression in SL12.4 T-lymphoma cell clones.
You-Ten and Lapp (1996)CD4T cellIn this report, we investigated whether the marked reduction of CD4+8+ and CD4+ thymocyte populations would affect host CD4+ and CD8+ T cell populations in the spleens and lymph nodes (LN) of mice undergoing GVHD.
Sumiwi et al. (2010)CD4T cellsThe role of CD4+ T cells in the induction of contact hypersensitivity to mercury in a murine model.
Foster et al. (2002)CD4T-lymphocytesWe used an improved mouse model of chronic asthma to investigate the role of CD4(+) T-lymphocytes in airway remodeling and hyper-reactivity.
Foster et al. (2002)CD4T-lymphocytesCD4(+) T-lymphocytes regulate airway remodeling and hyper-reactivity in a mouse model of chronic asthma.
Thoman (1997)CD4T cellEffects of the aged microenvironment on CD4+ T cell maturation.
Rocha et al. (1989)CD4T lymphocytesThis indicates that peripheral T lymphocytes are tightly regulated by homeostatic mechanisms that control pool sizes and CD4/CD8 ratios, in a manner independent of the cell input into the peripheral compartment.
Bushell et al. (1995)CD4T cellTransplantation tolerance induced by antigen pretreatment and depleting anti-CD4 antibody depends on CD4+ T cell regulation during the induction phase of the response.
van der Heyde et al. (1993)CD4T cellRole of CD4+ T cells in the expansion of the CD4-, CD8- gamma delta T cell subset in the spleens of mice during blood-stage malaria.
Nishioka et al. (2006)CD4T cellsOur in vitro analyses revealed that CD4+CD25+ T cells, the well-characterized naturally occurring regulatory/suppressive CD4 T cells, in aged mice are functionally comparable to those in young mice (i.e., anergic and suppressive), although slightly increased in number.
Zajac et al. (1996)CD4T-cellThus a role for CD4+ T-cell-mediated cytotoxicity in virus-induced immunopathology has now been demonstrated.
Kobayashi et al. (1996)CD4T cellEffects of lycopene, a carotenoid, on intrathymic T cell differentiation and peripheral CD4/CD8 ratio in a high mammary tumor strain of SHN retired mice.
Anis et al. (2007)CD4T-cellModulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.
Scanga et al. (2000)CD4T cellA major risk factor for reactivation of latent tuberculosis is HIV infection, suggesting a role for the CD4(+) T cell subset in maintaining the latent persistent infection.
Serre et al. (2009)CD4T cellsBy 3 days IL-4-producing effector CD4 T cells developed in the draining node and a proportion of the responding cells had migrated to B-cell follicles, while yet others had left the draining node.
Blazar et al. (1998)CD4T cellInterleukin-10 dose-dependent regulation of CD4+ and CD8+ T cell-mediated graft-versus-host disease.
Palma et al. (2010)CD4T cellsOn the contrary, the anti-4-1BB mAb in vivo treatment significantly reduced the frequency of proliferating CD4+CD45.2+T cells (Fig. 7 D) as well as the percentage of IFN-?
Winslow et al. (2003)CD4T cellTo address this question we examined the CD4 T cell response to a peptide from ESAT-6 during tuberculosis infection in the mouse.
Suto et al. (2002)CD4T-cellCD4(+)CD25(+) T-cell development is regulated by at least 2 distinct mechanisms.
Dondji et al. (2010)CD4T cellsThese data demonstrate an effector role for CD4(+) T cells in hookworm immunity and disease pathogenesis.
Wang et al. (1987)L3T4T cellDown modulation of L3T4 molecules on thymocytes did not interfere with their capacity to respond to concanavalin A or activation signals delivered via their T cell receptors.
Schubert et al. (2004)CD4T cellsTherefore, CD4+ T cells are important for both the induction of the disease and the effector phase.
Patel et al. (2004)CD4T cellCD4 T cell differentiation is a complex process affected by many transcription factors interacting in a tightly regulated manner.
Skoberne et al. (2002)CD4T cellTo analyze the influence of these immunoevasive mechanisms on the antilisterial CD4 T cell response, the expansion of L. monocytogenes-specific CD4 and CD8 T cells was monitored in infected mice.
Leitenberg et al. (1998)CD4T cellCD4 regulation of TCR signaling and T cell differentiation following stimulation with peptides of different affinities for the TCR.
Ishikawa et al. (2009)CD4T cellsInduction of autoimmunity in a bleomycin-induced murine model of experimental systemic sclerosis: an important role for CD4+ T cells.
Whitmire et al. (2000)CD4T cellsSo while there is long-term memory in both the CD8 and CD4 compartments, the rules regulating the activation of CD8 and CD4 T cells and the overall magnitude of the responses are different.
Robinson and Gorham (2007)CD4T cellsThese results indicate that CD4+ T cells in TGF-beta1(-/-) mice are activated by and respond to self-Ags present in the periphery, and define a key role for TGF-beta1 in the peripheral regulation of Ag-specific CD4+ T cell responses.
Janeway et al. (1987)L3T4T cellThe role of the murine L3T4 molecule in T cell activation: differential effects of anti-L3T4 on activation by monoclonal anti-receptor antibodies.
Almeida et al. (2002)CD4T cellHomeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers.
Kaldjian et al. (1988)CD4T cellSince activation of protein kinase C (PKC) is known to cause rapid down-regulation of various receptors, including the T cell receptor complex (TcR complex), we treated cells with phorbol 12-myristate 13-acetate (PMA), a PKC activator, to determine whether cell-surface expression of CD4 and CD8 would be similarly affected by this intracellular mediator.
Hadeiba and Locksley (2003)CD4T cellTo study the effects of chronic Ag deposition in the airway mucosa on CD4(+) T cell priming and subsequent airway disease, transgenic mice were generated that expressed OVA under the control of the surfactant protein C promoter.
Rajan et al. (1994)CD4T-lymphocytesIn the present study, we have examined the role of CD4+ T-lymphocytes in resistance to filarial infection using two experimental systems.
Wang et al. (2008)CD4T cellsA novel role for CD4+ T cells in the control of cachexia.
Garside et al. (1996)CD4T-lymphocyteThis increased cell death affects both CD4+ and CD8+ T-lymphocyte subsets, and morphological and flow cytometric analyses suggest that it occurs via apoptosis.
Arens et al. (2008)CD4T cellsCD4 T lymphocytes regulate the adaptive immune response to most viruses, both by providing help to CD8 T cells and B cells as well as through direct antiviral activity.
Schnizlein-Bick et al. (2003)CD4T lymphocyteEffects of CD4 and CD8 T lymphocyte depletion on the course of histoplasmosis following pulmonary challenge.
Ko et al. (2004)CD4T cellPresent study implies that SCRT can correct Th2 dominant condition directly affecting to the CD4+ T cell without significantly depressing general T cell activities.
Scott et al. (2004)CD4T lymphocytesRole of CD8+ and CD4+ T lymphocytes in jejunal mucosal injury during murine giardiasis.
Majlessi et al. (1993)CD4T cellRole of CD4+ and CD8+ cell subsets during amplification of natural T cell activity against IgG2ab in Igha mice and during induction of IgG2ab allotype suppression in Igha/b mice.
Schuhbauer et al. (1996)CD4T cellsThe response of CD4+ T cells taken from DO11.10 alpha beta TCR-transgenic mice to their specific antigen, ovalbumin, was examined in an adoptive transfer system.
Newell et al. (1989)CD4T-lymphocyteEffects of CD4+ and CD8+ T-lymphocyte depletion on the induction and expression of herpes simplex stromal keratitis.
Kurts et al. (1997)CD4T cellIn this report, we investigate the influence of CD4+ T cell help on this process.
Young et al. (2009)CD4T cellsUnexpectedly, the ratio of CD4(+):CD8(+) T cells was tightly controlled in the islets throughout diabetogenesis.
El Azami El Idrissi et al. (1998)CD4T lymphocytesThe effect of LCMV on CD4+ T lymphocytes was analyzed in C3HeB/FeJ mice after infection with the Docile strain of this virus.