Viewing negative mentions of regulation of Cd4 (M. musculus) in T cells

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Varga et al. (2001)CD4T cellThese data indicate that the CD4(+) and CD8(+) memory T cell pools are regulated independently and that the loss in CD8(+) T cell memory following heterologous virus infections is not a consequence of a parallel loss in the memory CD4(+) T cell population.
Rivas et al. (1988)CD4T cellsSimilar treatment of PHA-activated CD4+ T cells with anti-CD3/Ti antibodies also induced CD4 modulation; however, the same antibodies failed to affect CD4 expression on fresh resting T cells.
Magnusson et al. (2008)CD4T cellsThis mechanism of T-cell tolerance did not affect CD4 T cells, which produced antigen-specific lethal autoimmunity.
Magnusson et al. (2008)CD4T cellsFurthermore, we show that conventional CD4 T cells are not affected by this mechanism of tolerance, and their targeting of EGCs produces lethal intestinal autoimmunity.
Sleckman et al. (1989)L3T4T cellsL3T4, the murine CD4 equivalent, is not modulated from the surface of mature, peripheral T cells in response to PMA.
Hurez et al. (2002)CD4T cellThus, adenoviral transduction did not significantly affect primary CD4 T cell proliferation.
Sparks-Thissen et al. (2005)CD4T cellTogether, data presented here demonstrate that both CD4 T cell-mediated helper-independent control of gammaHV68 replication and inhibition of the establishment of gammaHV68 latency require IFNgamma.
Yoon et al. (1996)CD4T cellRepeated in vivo topical treatment of SSIN mice with TPA caused significant decreases in splenic T cell contents, but affected neither the splenic CD4+/CD8+ T cell ratio nor the development of a CTL response upon allogeneic tumor challenge.
Ohtake et al. (2005)CD4T-cellSST, wogonin-7-O-glucuronoside (a major SST ingredient), and wogonin (an intestinal metabolite of wogonin-7-O-glucuronoside) increased CD4/CD8 ratio via a decrease of CD8+ T-cell counts with no effect on CD4+ T-cell counts.
Kuvibidila et al. (1990)L3T4T cellsHowever, it did not affect the ratio of L3T4+ to Lyt-2+ T cells.
Yamasaki et al. (1988)L3T4T-cellH-2Kk and H-2Dd induction by DMSO was equal to pretreatment of YAC-1 cells with 50-100 and 10-20 U/ml interferon (IFN)-gamma, respectively, but the T-cell differentiation antigens Lyt-1, Lyt-2, Thy-1, and L3T4 remained unaffected.
Sawyer et al. (1995)CD4T cellsPreexposure to bacteria induced a significant increase in the percentage of splenic T cells without altering the CD4/CD8 ratio.
Furtado et al. (2006)CD4T cellsUnlike the classical models of experimental autoimmune encephalomyelitis, depletion of CD4+ and CD8+ T cells did not affect disease induction.
Cordero et al. (2007)CD4T cellsIn CD4 depleted animals CD26 expression was not altered on the CD45RB- subset but the density of CD26 was marginally increased on the remaining CD45RB+ CD4 T cells.
Kolbus et al. (2010)CD4T cellsremained elevated in CD8+CD28+ T cells (Figure 6F), while no changes in the population of CD4+CD25+FoxP3+ (8.6 2.1% vs. 7.2 1.6% of CD4+ cells, n.s.), CD4+CD28+ IFN-?
Kemball et al. (2009)CD4T cellWhy, though, are CD4+ T cell responses not stronger?
Kawamura et al. (2003)CD4T cellBy contrast, addition of antiretroviral drugs did not affect CD4(+) T cell proliferation.
Halim et al. (2000)CD4T cellUsing a test recombinant, we showed that prior exposure to the parental CB4-P virus did not affect the ability of the recombinant to induce a CD4(+) T cell response against the foreign sequence.
Simon et al. (2007)CD4T cellsTransfer of CD4+CD25 T cells had no effect on tumour development (Fig. 3A).
Lang et al. (2007)CD4T cellWe demonstrate that in vivo treatment with LCMV-derived MHC-II peptides induced non-responsiveness of specific CD4+ T cells without affecting CD4+ T cell reactivity towards other antigens.
Palma et al. (2010)CD4T cellAgonistic anti-4-1BB mAb treatment had only a little influence on CD4+ or CD8+ T cell proliferation in P-mice (Fig. 4 and Table 1).
Gurung et al. (2009)CD4T cellIn conclusion, these results suggest that antigen-specific CD4+ T cell responses to LM are affected little by chronic ethanol consumption; however, antigen-specific CD8+ T cell responses are reduced significantly, as are in vivo and in vitro proliferation.
Tschoetschel et al. (1997)CD4T cellECM proteins used in various concentrations had no effect on IL-2 production or proliferation of highly purified CD4+ T cell populations.
Combe et al. (2005)CD4T-cellHowever, recently CD4(+) T-cell-independent CD8 responses during several microbial infections including those with Toxoplasma gondii have been described, although the mechanism is not understood.
Lu et al. (2008)CD4T cellSeveral experiments were performed to ensure that treatment with this antibody did not affect CD4+ T cell number or function.
Lei et al. (2008)CD4+T cellsThis result suggests that a penetrating ocular injury at an early stage after an AC injection of OVA does not alter the expression of CD4+CD25+Foxp3+T cells and thereby does not result in the induction of ACAID.
Zhong et al. (2003)CD4T cellsConversely, over-expression of B-cell lymphoma-2 (Bcl-2), which is known to protect T cells from apoptosis signalled through the TNF receptor or due to the withdrawal of cytokines, totally protected CD8+ T cells from infected mice but had no effect on CD4+.
Orgun et al. (2008)CD4T cellsDespite this change in CD4 T cell response, neither the kinetics of the CD4 and CD8 T cell responses, the quality of the CD8 T cell response, nor the ability of CD8 T cells to mediate protection were affected.
Harrison et al. (2006)CD4T cellWhen included in the boost, but not the prime of a poxvirus prime-boost strategy, 4-1BBL significantly enhanced the anti-HIV T cell response generated to this vaccination in BALB/c mice, as detected by ex vivo IFNgamma ELISPOT responses, intracellular cytokine staining to HIV Gag antigens, and enumeration of Gag-reactive CD8 T cells. 4-1BBL however, is not capable of modulating the CD4 T cell response, nor the antibody response to this vaccination strategy.
Chang and Norman (1992)CD4T-cellsHowever, the ability of T-cells from ethanol diet-fed mice to produce IL2 and to express IL2 R or CD4+/CD8+ subset markers was not affected.
Ungar et al. (1991)CD4T lymphocytesIndependent roles for IFN-gamma and CD4+ T lymphocytes in protective immunity.
Gao et al. (2010)CD4T cellIt is noteworthy that, although eventually five HCV patients were identified with the proper HLA-DP4 haplotype, they did not commonly exhibit the CD4+ T cell response against the defined peptides.
Marussig et al. (1997)CD4T cellsIn vivo, depletion of CD4+ or CD8+ T cells did not affect protection.
Sedgmen et al. (2006)CD4T cellCD4+ T cell responses were also unaffected by LIGHT deficiency.
Bhler et al. (2004)CD4T-lymphocyteHowever, we observed that lower doses of FTY (0.25-2 mg, n = 11) did not affect peripheral CD4(+)CCR5(+) T-lymphocyte counts, while the highest FTY dose of 3.5 mg (n = 2) exerted a rapid reduction of CD4(+)CCR5(+) cells.
Austin et al. (2006)CD4T lymphocytesWe further show that the efficacy of IFN-alpha1 transgene treatment is independent of CD4+ T lymphocytes.
Huang et al. (2010)CD4T cellsThese data strongly imply that endothelial Tim-3 expression in lymphoma might affect CD4+ but not CD8+ T cells or CD1a+ dendritic cells in vivo.
Foryst-Ludwig et al. (2010)CD4T-lymphocyteIn our study we did not investigate CD4+ T-lymphocyte subsets; however, as previously described in other studies using the HFD model, pro-inflammatory TH1 cells are the predominant subset during weight gain.
Lee et al. (2009)CD4T cellAlthough CD4 and CD8 coreceptors are not directly involved in the interaction between CD1d and the T cell receptors (TCRs) of iNKT cells, a conspicuous lack of CD8(+) iNKT cells in mice raised the question of whether CD8(+) iNKT cells are excluded due to negative selection during their thymic development, or if there is no lineage commitment for the development of murine CD8(+) iNKT cells.
Yang and HayGlass (1993)CD4T cellThe data demonstrate the IL-2 independence of CD4 T cell-derived IL-4 synthesis by allergen-primed cells, distinguishing IL-2-dependent from IL-2-independent stages of IL-4 responses.
Kooij et al. (2009)CD4T cellNotably, fixation of BMDCs showed no effect of P-gp inhibition on CD4+ and CD8+ T cell proliferation (Figure 5g,h) or on Th1 cytokine secretion (Figure 5il).
Yung et al. (2003)CD4T-cellFlow analyses confirmed that upregulation of CD49d did not affect CD18, CD28, CD4, CD62L or T-cell receptor expression.
Fortner et al. (1998)CD4T lymphocytesUsing an anti-CD2 antibody, CD2 was down-modulated in vivo on mouse T lymphocytes without affecting the levels of surface CD3, TCR alphabeta, CD4 or CD8.
Feng et al. (2004)CD4T cellexpression in the T cell lineage did not grossly affect the percentage of CD4/CD8 double positive, double negative, or single positive population despite high viral transduction efficiency (greater than 84% cells were GFP+) (data not shown).
Flatz et al. (2010)CD4T cellAlso, depletion of only CD4+ or CD8+ T cells or genetic deficiency for MHC-I (affecting the CD8+ but not the CD4+ T cell compartment) afforded at least partial protection.
Noben-Trauth et al. (1997)CD4T cellAn interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.
Yamada et al. (2005)CD4T cellCD70 blockade had little effect on CD4(+) T cell function but prevented CD8(+) T cell-mediated rejection, inhibited the proliferation and activation of effector CD8(+) T cells, and diminished the expansion of effector and memory CD8(+) T cells in vivo.
Seaman et al. (2004)CD4T-cellInterestingly, this delayed administration of plasmid IL-12 had no significant effect on antigen-specific CD4(+)-T-cell and antibody responses.
SEDEGAH et al. (2007)CD4T cellsDepletion of CD4+ T cells had no effect on protection (Table 5), but depletion of both CD4+ and CD8+ T cells had a modest effect on protective efficacy (Table 5).
Renaudet et al. (2010)CD4T cellUnlike the CD8+ T cell responses, PADRE-specific CD4+ T cell proliferative responses were not affected by the position of the lipid moiety (not shown).
Shepherd et al. (2000)CD4T cellAlthough TCDD exposure had little effect on the expansion or activation of the adoptively transferred, OVA-specific CD4(+) T cells, these cells disappeared from the spleen more rapidly in TCDD-treated mice and produced significantly decreased levels of the T cell-derived cytokines IL-2 and IL-10.
King et al. (2003)CD4T-cellMeHg had no significant effect on the percentages of CD4(+), CD8(+), or non-T-cell subpopulations in the spleen.
Pang et al. (2009)CD4T cellsFurthermore, ectopic expression of CD80 by beta cells accelerated the onset of insulitis mediated by beta-cell-specific CD8(+) T cells, but had no effect on CD4(+) T-cell-mediated diabetes, suggesting an antigenic interaction between beta cells and naive CD8(+) T cells.
de Gor de Herve et al. (2010)CD4T cellsNo significant change in the FoxP3+ CD4 T cells subset following in vivo CD25 blockade
McMurray et al. (1998)CD4T cellSuppression of autoimmunity was achieved without obvious side effects or altered CD4:CD8 T cell ratios.
Castagna et al. (2010)CD4T-cellAge, gender, baseline CD4(+)/CD8(+) T-cell ratio and a history of AIDS-defining events had no independent effect on CD4(+) T-cell recovery.
Crawford et al. (1998)CD4T cellWhile binding of the multimeric MHC/peptide complex is proportional to T cell receptor affinity and expression level, there is little influence of T cell CD4.
Massanella et al. (2010)CD4T-cellsIncreasing PEG-IFN-alpha2a/RBV doses mainly affect CD4+ T-cells but failed to modify clinical outcome.
Bae et al. (2010)CD4T cellCR had no mitogenic effects on un-stimulated CD4(+) T cells, however, it increased the CD4(+) T cell population.
Lee et al. (2004)CD4T-cellThe results demonstrated that ginsenoside Rg1 had no mitogenic effects on unstimulated CD4(+) T cells, but augmented CD4(+) T-cell proliferation upon activation with anti-CD3/anti-CD28 antibodies in a dose-dependent manner.
Nateghi Rostami et al. (2010)CD4T cellIn both CD4+ and CD8+ T cell cultures, the changes in the gene expression of IL-5, IL-10 and IL-13 were not significantly different between HCL volunteers and healthy controls.
Hunt et al. (1999)CD4T cellResting T cells treated with sub-lethal levels of BPD-MA and light did not exhibit changes in surface levels of CD3, CD4, CD8, CD28, CD45 or T cell receptor (TCR) beta-chain structures.
Brod et al. (1990)CD4T cellThese results show that IL-4 can upregulate CD8 expression on CD4+ T cell clones while not effecting CD4 expression on CD8+ T cell clones.
Loh et al. (2005)CD4T cellHowever, v-Bcl-2 transgenic mice displayed no abnormalities in CD4 and CD8 T cell development in the thymus (Figures 1D and S1), nor were there any alterations in thymic architecture (unpublished data).
White et al. (2010)CD4T-cellSitagliptin treatment of patients with type 2 diabetes does not affect CD4+ T-cell activation.
Dorfman and Germain (2002)CD4T lymphocytesOverall, our analysis of the available data suggests that most or all mature CD4(+) (and perhaps also many CD8(+)) T lymphocytes do not depend on self-recognition for their viability in the periphery.
Davignon et al. (2010)CD4posT-cellWe observed that the CD4pos T-cell response toward CMV Ags was not altered by anti-TNF antagonists, whether soluble receptor or antibodies.
Millington et al. (2006)antigen-specific CD4T-cellDespite severely impaired T-cell migration and effector function, early stimulation of antigen-specific CD4+ T cells is not affected by malaria infection, as T cells stimulated in vitro and in vivo upregulate CD69, suggesting that, despite suppression of DC function, there is sufficient antigen presentation to induce initial T-cell activation.
Lu et al. (2008)CD4T cellsThe accumulation of CD4(+) T cells and CD8(+) T cells in granulomas may not depend on hLptn.
Lowrey et al. (2002)CD4T cellsThe addition of the biologically active amino-terminal Shh peptide had no effect on resting CD4(+) T cells, but significantly enhanced proliferation of anti-CD3/28 Ab-activated CD4(+) T cells.
Ciupe et al. (2009)CD4T cellIn humans, transplantation of thymic tissue at varying doses into complete DiGeorge anomaly subjects showed no significant effect on the nave CD4 or CD8 T cell numbers [27].
Janic et al. (2008)CD4T cellThe results showed 1) FePro labeling had no effect on the changes in morphology and expression of cell surface proteins associated with TPA induced differentiation; 2) FePro labeled cells responded to LPS with slightly higher levels of NFkappaB pathway activation, as shown by immunobloting; TNF-alpha secretion and cell surface expression levels of CD54 and CD83 activation markers, under these conditions, were still comparable to the levels observed in non-labeled cells; 3) FePro labeling exhibited differential, chemokine dependent, effect on THP-1 chemotaxis with a decrease in cell directional migration to MCP-1; 4) FePro labeling did not affect the ability of THP-1 cells to down-regulate T cell expression of CD4 and CD8 and to induce T cell proliferation.
Alfano et al. (1999)CD4T cellsB-oligomer also blocked cocapping of CCR5 and CD4 induced by R5 HIV-1 in primary T cells, but did not affect cocapping of CXCR4 and CD4 after inoculation of the cultures with X4 HIV-1.
Moretto et al. (2010)CD4T cellSplenic dendritic cells pulsed with rEhPTP1 are able to induce E. cuniculi specific CD8(+) T cell response with no effect on the CD4(+) T cell subset.