Viewing affirmative mentions of positive regulation of Il2 (M. musculus) in T cells

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McGuire and Rothenberg (1987)IL2 geneT-cellTo study the regulation of the murine IL2 gene in T-cell populations of differing stages of maturation, we have used a calcium ionophore in conjunction with the phorbol ester, TPA, to stimulate IL2 gene transcription while bypassing the requirement for triggering through a mature cell surface receptor.
McGuire and Rothenberg (1987)IL2 RNAT-cellWe have combined in situ hybridization with RNA probe protection analyses to quantitate accumulated cytoplasmic IL2 RNA and to identify the cells capable of inducing the IL2 gene in mature, immature and precursor T-cell populations.
Fujiwara and Yokoyama (1994)IL-2T cellsIt can be assumed that activated L3T4- T cells interact with antigen-specific L3T4+ T cells and lead to enhanced IL-2 production.
Gillis and Watson (1981)Interleukin-2T cellsInterleukin-2 induction of hapten-specific cytolytic T cells in nude mice.
Gismondo et al. (1998)IL-2T-cellIn glutamine-fed animals, we observed a marked increase in IL-2 concentrations after 10 days of treatment in comparison with control group and a modest but significant increase in intestinal T-cell counts.
DosReis et al. (1986)IL-2T-cellClAdo inhibited both IL-2 secretion and induction of IL-2 responsiveness up to control levels in the same dose range it inhibited T-cell mitogenesis.
Nagarkatti et al. (1994)interleukin 2T cellsConstitutive activation of the interleukin 2 gene in the induction of spontaneous in vitro transformation and tumorigenicity of T cells.
Hardy et al. (1990)IL-2T-cellDominant mice had elevated T-cell proliferation and IL-2 production when compared to the other treatment groups.
Bubeník et al. (1984)interleukin 2T-cellPhorbol myristate acetate-stimulated production of interleukin 2 by T-cell lymphoma and constitutive production by derived hybridomas.
Bubeník et al. (1984)IL-2T-cellTo isolate a stable tumor cell line source of IL-2 (TCGF), 19 murine T-cell lines and their derivatives were screened for both constitutive and mitogen-stimulated IL-2 production.
Horowitz et al. (1986)IL-2T-cellIn the cloned T-cell line producing the inhibitory substance, this increase in IL-2 receptors is driven by the monokine interleukin-1.
Motta et al. (1986)Il-2T-cellThe low level of Il-2 produced by LPS-sensitized spleen cells is sufficient for lectin-induced T-cell proliferation.
Kidao et al. (1993)interleukin-2T lymphocytesRRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells.
Kidao et al. (1993)IL-2T cellSupernatants from 0.1 microgram/mL vitamin E succinate-supplemented chicken splenic T cell cultures exhibited 42-72% enhanced IL-2 production over vehicle controls when tested in a chicken T cell blast bioassay.
Kidao et al. (1993)IL-2T lymphocytesSupplementation of chicken splenic T lymphocyte cultures with butylated hydroxyanisole (BHT) and butylated hydroxytoluene (BHA) also induced elevated levels of IL-2, suggesting a role for antioxidants in IL-2 production by avian splenic T lymphocytes.
Karasuyama et al. (1989)IL-2T cellsWe thus provide evidence that the aberrant activation of the IL-2 autocrine circuit can lead T cells to malignant transformation.
Fischbach and Talal (1985)interleukin-2T cellAbility of isoprinosine to restore interleukin-2 production and T cell proliferation in autoimmune mice.
Sjöö et al. (2006)interleukin-2T cellsTreatment with treosulfan induced only interleukin-2 production in spleen cells for a short time and had no significant effect on synthesis of tumor necrosis factor-alpha and/or interferon-gamma as compared with that observed in splenic T cells isolated from mice treated with either busulfan or cyclophosphamide.
Ashwell et al. (1986)interleukin 2T lymphocytesThe interleukin 2 (IL 2) receptor on T lymphocytes can be upregulated by a variety of stimuli including antigen, lectin, and IL 2 itself.
Ashwell et al. (1986)IL 2T cellIn this report, the direct binding of radiolabeled IL 2 and a quantitative bioassay of T cell responsiveness to IL 2 were used to determine the biological significance of upregulation of the murine IL 2 receptor.
Lillehoj et al. (1984)IL 2T cellThe same concentration (0.25 microgram/ml) of CsA that produced optimal inhibition of the T cell proliferative response to concanavalin A (Con A) was also very effective at inhibiting IL 2 production and the induction of IL 2 responsiveness, as well as the expression of the IL 2 and transferrin receptors when measured 72 hr after mitogen activation.
Lillehoj et al. (1984)IL 2T cellsThese results suggest that inhibition of the maturation of receptor expression is secondary to an early effect of CsA in blocking the induction of IL 2 responsiveness or to an arrest in the sequence of events required for maturation of T cells that bear high densities of these receptors.
Ertesvag et al. (2009)IL-2T cellsWe have previously reported that all-trans retinoic acid (atRA) enhances the secretion of IL-2 from human peripheral blood T cells in vitro, followed by increased proliferation and inhibition of spontaneous cell death.
Kobayashi et al. (1989)interleukin 2T cellCharacterization of the antigen-reactive T cell line mediating in vivo delayed type hypersensitivity established by antigen-induced interleukin 2.
Kobayashi et al. (1989)interleukin 2T cellThe murine antigen-reactive T cell line has been established by antigen-induced interleukin 2 (IL-2) derived from immunized syngeneic mice.
Kobayashi et al. (1989)IL-2T cellsThese results suggest that the interaction of antigen-induced IL-2 and IL-2 dependent antigen-reactive T cells may play a significant role in the induction/expression of in vivo delayed type hypersensitivity to specific antigen, because antigen-induced IL-2 is probably only a relevant IL-2 in the immunized mice.
Toyota et al. (1986)interleukin 2T cellsIt is the most potent immunomodulator in activating both macrophages and killer T cells and in increasing interleukin 2 production.
Daynes et al. (1990)IL 2T cellWe determined that (a) lymphocytes from DHEA- or DHEAS-treated mice consistently produced much greater levels of IL 2 than normals in response to stimulation, (b) direct lymphocyte exposure to DHEA at low doses (10(-10)-10(-7) M) caused an enhanced capacity to secrete IL 2 following activation, (c) IL 2 production by activated cloned T cell lines could be augmented by DHEA treatment, and (d) GCS-induced depressions in IL 2 synthesis by T cells or T cell clones could be overcome in vitro and in vivo by exposure to the effects of DHEA.
Rojo et al. (1986)IL-2T lymphocytesIn addition, mitogenic responses of T lymphocytes, but not IL-2 production, were also increased in immunosuppressed mice after treatment with the immunomodulator.
Mills et al. (1989)interleukin 2T-cellPhorbol esters, potent activators of PKC, augment secretion of the T-cell growth factor, interleukin 2 (IL2).
Mills et al. (1989)IL2T-lymphocyteWe have determined whether IL2 secretion can be induced in the murine cell T-lymphocyte line LBRM 331A5, where PKC is inhibited by staurosporine or sphingosine or in cells where PKC is depleted by prolonged incubation with high concentrations of phorbol esters.
Nóbrega et al. (1986)IL-2T cellA marked synergism between A23187 and PMA was noted in induction of T cell enlargement, IL-2 release, and induction of IL-2 responsiveness.
Nóbrega et al. (1986)IL-2T cellThe results indicate that T cell mitogenesis by A23187/PMA is IL-2-dependent, and suggest a critical role for protein kinase C in IL-2 release and induction of IL-2 responsiveness.
Suzuki et al. (1996)interleukin-2T lymphocytesHormones and lupus: defective dehydroepiandrosterone activity induces impaired interleukin-2 activity of T lymphocytes in patients with systemic lupus erythematosus.
Adachi and Rothenberg (2005)IL2T-cellsMeanwhile, the great majority of naïve T-cells retain the potential to activate IL2 expression even after long periods when the gene is transcriptionally silent.
Rosenberg et al. (1984)IL 2T cellsThe results indicate that cultivation in vitro leads to constitutive production of IL 2 and the capacity to respond to growth factors, thereby facilitating the continuous proliferation of T cells bearing the dull Lyt-1+2- phenotype in vitro in the absence of exogenous antigen or mitogen.
Jan and Kaminski (2001)IL-2T cellsSuboptimal activation of T cells in the presence of cannabinol produced an enhancement of IL-2 secretion, which was paralleled by an increase in nuclear phospho-extracellular-regulated kinase (ERK) 1/2.
Jan and Kaminski (2001)IL-2T cellsIn contrast, T cells activated with stimuli that were optimized to induce maximal IL-2 secretion elicited a marked suppression in the production of this cytokine when cultured in the presence of cannabinol.
Martins et al. (2008)IL-2T cellsEnforced expression of Fos in T cells caused elevated IL-2 production (28); however, deletion of Fos alone is insufficient to decrease IL-2 production (29), and the effects of Fos in regulating proliferation can only be observed when both FosB and Fos are missing (for review see [30]).
Benedetto et al. (1988)IL-2T lymphocytesThe results show an increase in IL-2 production by T lymphocytes in the spleen.
Rejas et al. (1988)IL-2T lymphocyteAn enhancement of T lymphocyte proliferation in CY-treated animals and an increase of IL-2 production in both normal and immunosuppressed mice was observed.
Serfling et al. (1989)interleukin 2T lymphocytesUbiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.
Serfling et al. (1989)Il-2 geneT cellThese data indicate the involvement of the TCEd and its recognition factor(s) in the cell type specific induction of the Il-2 gene during T cell activation.
Young et al. (1993)IL-2T-cellAt this low dose, serotonin stimulated splenic T-cell proliferation in response to IL-2, and enhanced both proliferation and IL-2 production in response to a suboptimal concentration of Con A.
Ishihara et al. (2010)IL-2T-cellThis may facilitate more rapid IL-2 production once T-cell activation ensues.
Jiang et al. (1993)interleukin-2T-cellA mechanism of retinoid potentiation of murine T-cell responses: early upregulation of interleukin-2 receptors.
Via (1991)IL-2T cellsIn both forms of GVHD, increased spontaneous proliferation and IL-2 production were dependent on the presence of donor CD4+ T cells.
Schmidberger et al. (1988)interleukin 2T cellsPrimary activation of murine CD8 T cells via cross-linking of T3 cell surface structures: two signals regulate induction of interleukin 2 responsiveness.
Chang et al. (1982)IL 2T cellFurther cell mixture studies revealed a decrease in IL 2 production by young T cells in presence of old adherent cells, which did not approach that of the old T cell-old adherent cell mixture, and an increase in IL 2 production by old T cells in the presence of young adherent cells, which did not approach that of the young T cell-young adherent cell mixture.
Lechler et al. (1985)IL 2T cellIn striking contrast, anti-LFA-1 antibody, which totally blocked B lymphoma-induced responses, had no effect on L cell antigen presentation, measured as interleukin 2 (IL 2) release by T hybridomas, proliferation, IL 2 release, or IL 2 receptor upregulation by a T cell clone.
Gillis et al. (1980)IL-2T cellTo isolate a stable tumor cell line source of Interleukin 2 (IL-2 formerly referred to as T cell growth factor), over 40 murine leukemia and lymphoma cells as well as 9 clonal helper and killer IL-2-driven T cell lines were screened for both constitutive and mitogen-stimulated IL-2 production.
Tarleton (1988)IL-2T cellsAlthough Con A can provide either of the signals necessary for IL-2 production, calcium flux or protein kinase C activation, to T cells from normal mice, Con A in combination with either calcium ionophore or phorbol ester failed to activate T cells from infected mice to produce IL-2.
Erard et al. (1985)IL-2T lymphocytesMinimal requirements for the induction of interleukin 2 (IL-2) responsiveness in purified subsets of murine T lymphocytes have been investigated.
Rayter et al. (1992)IL-2T cellFurthermore, using a dominant negative mutant of ras, Ha-rasN17, we show that endogenous ras function is essential for induction of IL-2 expression in response to protein kinase C or T cell receptor stimulation.
McKean et al. (1985)IL 2T cellThe same B lymphoma cells are capable of stimulating IL 2 release and proliferative responses from other T cell clones.
McKean et al. (1985)IL 2T cellThe absence of comparable IL 1-induced stimulation of IL 2 secretion suggests that IL 1 primarily enhances antigen specific T cell proliferation through mechanisms other than acting as a co-stimulant for IL 2 release.
Adachi and Rothenberg (2005)IL-2T-cellsT-cells retain cell-type-specific programming for IL-2 inducibility through many rounds of division without being stimulated to transcribe the locus.
Adachi and Rothenberg (2005)IL2T-cellsThese results identify a discrete new domain of IL2 regulatory sequence marked by dimethylated histone H3/K4 in expression-permissive T-cells even when they are not transcribing IL2, setting boundaries for histone H3 and H4 acetylation when the IL2 gene is transcriptionally activated.
Rose and Reddy (1992)IL-2T cellInterestingly, v-myb oncogene brings about growth-factor independence in IL-2-dependent T cell lines with concomitant induction of IL-2 mRNA and downregulation of IL-2 receptor synthesis.
Wong and Pamer (2004)IL-2T cellsWe find that increased periods of Ag stimulation result in enhanced CD25 up-regulation and greater IL-2 production by CD8 T cells.
Wong and Pamer (2004)IL-2T cellsAlthough IL-2 production by stimulated CD8 T cells appears to be essential for in vitro proliferation, upon transfer into recipient mice, IL-2-deficient CD8 T cells undergo extensive proliferation in vivo after transient stimulation.
McGuire et al. (1988)interleukin 2T cellsInfluence of activating stimulus on functional phenotype: interleukin 2 mRNA accumulation differentially induced by ionophore and receptor ligands in subsets of murine T cells.
Lian et al. (2007)IL-2T cellsIn addition, T cells from lymph nodes of mice vaccinated with pIL-18 or pAPOPTIN + pIL-18 secreted high levels of the Th1 cytokine IL-2 and IFN-gamma, indicating that the regression of tumor cells is related to a Th1-type dominant immune response.
Liou et al. (1999)IL-2T cellsIn addition, the induction of IL-2R alpha chain is impaired in the c-Rel(-/-) T cells.
Rakasz et al. (1997)IL-2T cellsHowever, vaginal gamma delta T cells are responsive to TCR-mediated signals since injection of normal mice with pan-anti-TCR antibody or stimulating anti-gamma delta TCR antibody resulted in an increase in cell number and increased expression of transferrin and IL-2 receptors.
Lacey et al. (1987)IL 2T cellAlthough the steroid does not affect the quantity of bioassayable T cell growth factors as assessed by HT-2 cell proliferation, the expression of immunoreactive IL 2 receptors by lectin-activated D10 cells exposed to 1,25(OH)2D3 is enhanced.
Kim et al. (1986)IL 2T cellsIt was found that 8B2 T cells cultured with PGM and ionomycin, but not with PGM and PMA, were activated for IL 2 production.
Stingl et al. (1987)interleukin 2T cellsInduction of interleukin 2 receptiveness and proliferation in resting peripheral T cells by monoclonal anti-CD3 (T3) antibodies does not require the presence of macrophages.
Smith (2004)IL2 geneT cellsFrom the discussion thus far, it must be apparent that the strength of the signals delivered to T cells ultimately determines the outcome, i.e. either anergy, or activation of the IL2 gene, and if activation occurs, the duration that it persists.
Zhou et al. (2005)IL-2T cellsThese data suggest that the cellular immune response to acute neurotropic JHMV infection requires a distinct CD4(+) T cell component, but is independent of a requirement for IL-2 for induction, activation, recruitment, and/or maintenance of CD8(+) T cells within the CNS during acute infection.
Overwijk et al. (2000)IL-2T cellsStimulation with specific antigen can enhance the ability of T cells to respond to IL-2 by triggering the rapid upregulation of the high-affinity IL-2 receptor.
Liang et al. (1998)IL-2T cellsAltogether, these results suggest that an extremely low level of IL-2 production in lpr DN T cells was due to both the increased instability of mRNA and the reduced activation of IL-2 gene promoter, the latter defect could be attributed to the inactivation of AP-1 and NF-AT as well as the poor activation of the upstream MAP kinase and JNK.
Pandey et al. (2003)IL-2T cellsThe higher amount of IL-2 in the supernatant of the con A stimulated T cells, cultured in the presence of the immunomodulator, indicated accumulation of IL-2 due to its reduced utilisation.
Demanet et al. (1992)IL2T cellThe dual specificity of the hybrid-hybridoma produced monoclonal antibodies (MAbs) could be demonstrated by flow cytometry, the induction of T cell proliferation, the induction of IL2 secretion by polyclonal T cells, and redirected lysis of the relevant target cells.
Sadlack et al. (1994)IL-2T cellsParadoxically, proliferation of T cells was increased in both IL-2 and IL-4-deficient homozygous mice.
Ocha?ek and Porwit-Bóbr (1985)TCGFT cellsThe ability of spleen T cells from mice inoculated with influenza virus to transfer delayed hypersensitivity increases after 5 days culture in the presence of TCGF and influenza virus or its hemagglutinin.
Choi et al. (2009)IL-2T cellsIncreased IL-2 production in T cells by xanthohumol through enhanced NF-AT and AP-1 activity.
Choi et al. (2009)IL-2T cellsTreatment with XN significantly increased IL-2 production in mouse EL-4 T cells activated with phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io) in a dose-dependent manner.
Broome et al. (1995)IL-2T cellsFor a few days after concanavalin A (Con A) plus IL-2 activation, the overall level of Bcl-2 in T cells remains unchanged, but it becomes more heterogeneous.
Sosman et al. (1993)IL-2T cellsCONCLUSION: The doses of OKT3 administered on this schedule failed to enhance significantly the number of circulating CD3+, CD25+ T cells and did not appear to increase the antitumor activity of IL-2 alone, which underscores the need for other approaches to enhance the efficacy of IL-2 therapy.
Makoul et al. (1985)IL 2T cellPhysiologic concentrations of PGE2 inhibited the induction of IL 2 secretion by the T cell hybridomas tested, when they were activated either by TA3 cells or by mitogenic signals.
Sando et al. (1982)T-cell growth factorT-cellThese data support identification of the phorbol ester-binding component in the responding cells as the receptor mediating T-cell growth factor production.
Redelman and Hudig (1984)TCGF receptorT-cellK-76 COONa did not appreciably decrease the production of T-cell growth factor (TCGF), but it did inhibit the induction of TCGF receptor expression by both functional criteria, i.e., induction of responsiveness to TCGF, and by morphological criteria, i.e., the expression of the Tac antigen.
Ochi et al. (1994)IL-2T cellsEvidence for an enhancement of IL-2 expression in splenic T cells stimulated via TCR/CD3 complex.
Ochi et al. (1994)IL-2T cellsIL-2 gene expression and IL-2 production by H2-c-fos T cells stimulated with immobilized anti-CD3 Abs were enhanced and prolonged as compared with those by control T cells.
Shi et al. (2007)IL-2T cellsNF90 regulates inducible IL-2 gene expression in T cells.