Viewing negative mentions of positive regulation of Ifng (M. musculus) in T cells

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Wheeler et al. (2006)IFN-gammaT cellsThere was greater expression of IL-12/23p40 by antigen-presenting cells in these mice, and in vitro, TNFR1-/- antigen-presenting cells induced greater secretion of IFN-gamma but not interleukin (IL)-17 when cultured with primed T cells than did WT antigen presenting cells.
Peng et al. (2000)IFN-gammaT cellExtrapulmonary tumors (MCA-205 s.c. and intracranial) that required adjunct sublethal irradiation for treatment efficacy also displayed no requirement for host or T cell expression of IFN-gamma.
Ren et al. (2008)IFN-gammaT cellUnexpectedly, DC(ap) supported T cell activation to a similar extent as normal DC in vitro, leading to proliferation and IL-2 production, except that DC(ap) did not support T cell production of IFN-gamma.
Chuang et al. (2007)IFN-gammaT cellsIn addition, these heat-killed Lactobacillus strains also stimulated high-level secretion of IL-12 p70 in DCs and switched T cells to T helper (Th) 1 immune responses, as evidenced by the elevated secretion of IFN-gamma but not IL-5, IL-13, and TGF-beta.
Zhou et al. (2006)IFN-gammaT cellsDepletion of CD4+ T cells did not affect the increased serum IFN-gamma levels induced by anti-CD40 and IL-2 treatment and, importantly, did not affect the antifungal effect of combination therapy.
Vesosky et al. (2006)IFN-gammaT cellsAge dependent increase in early resistance of mice to Mycobacterium tuberculosis is associated with an increase in CD8 T cells that are capable of antigen independent IFN-gamma production.
Karpuzoglu-Sahin et al. (2005)IFN-gammaT cellsThis increase in IFN-gamma in 17-beta estradiol-treated mice was not due to an increase in the relative percentages of T cells, since they were comparable to relative percentages of T cells from oil-treated control mice.
Yimin et al. (2001)IFN-gammaT cellsIt is suggested that the role of T cells in granuloma formation is not dependent on their IFN-gamma production.
Fujii et al. (2003)IFN-gammaT cellsDCs from mice given ovalbumin plus adjuvant, but not the non-DCs, stimulated ovalbumin-specific proliferative responses and importantly, induced antigen-specific, IFN-gamma producing, CD4+ and CD8+ T cells upon transfer into naive animals.
Xiong et al. (1996)IFN-gammaT cellsIn the present study, CD4+ T cells from Listeria monocytogenes-immune mice produced IFN-gamma upon stimulation with specific antigen and NO was generated in culture.
Sharp et al. (2008)IFNgammaT-cellsSplenic T-cells isolated from P2x7 null mice produced greater IFNgamma and IL-17 (from 3 to 12 fold greater levels) than wildtype cells, however cytokine production from P2x7 derived cells was not increased by a selective P2x7 agonist as was cytokine production from wildtype cells.
Gieni et al. (1996)IFN-gammaT cellsIn addition, differences in the quantity of IL-12 produced by DBA/2 and BALB/c antigen-presenting cells (APC) was not dependent on differential production of IFN-gamma by T cells, since APC from DBA/2 mice still produced much greater quantities of IL-12 than did BALB/c APC when each was cultured with the same H-2d-restricted Th2 clones, in the complete absence of IFN-gamma, or when each was cultured with primed (BALB/c x DBA/2)F1 T cells.
Furukawa et al. (2004)IFN-gammaT cellsTransfer of IFN-gamma-/- T cells induced neither GAD nor host macrophage IFN-gamma expression.
George (1996)IFN-gammaT-cellParenteral immunization does not generate an IFN-gamma T-cell response in PP, and parenteral challenge of orally immunized mice does not elicit a secondary response in PP.
Engwerda et al. (1996)IFN-gammaT cellsT cells from aged mice, when compared with young controls, showed increased IFN-gamma production, no difference in IL-4 production, and decreased IL-2 production.
Franco et al. (1997)IFN-gammaT cellsHence, CD8+ T cells have an antirotaviral effect that is not mediated by perforin and appears to be independent of fas and the release of IFN-gamma.
Butrapet et al. (2002)interferon gammaT-cellIn addition, there was no significant increase in the levels of interferon gamma and soluble interleukin 2 receptor in the sera of the challenged monkeys, which suggests a reduction in immunopathogenesis caused by T-cell activation.
Mancini et al. (1998)IFN-gammaT cellsThis effect was mediated by a cytokine-dependent mechanism common to both T cell subpopulations; this mechanism did not require cell lysis, but did involve the production of IFN-gamma by the activated T cells.
Roman et al. (2010)IFN-gammaT cellsUsing T cells from IFN-gamma receptor-deficient mice and promoter reporter studies in transiently transfected Jurkat T cells, we found that the enhancing effects of hypoxia on IFN-gamma expression were not due to effects on IFN-gamma consumption or proximal promoter activity.
Pien et al. (2002)IFN-gammaT cellsProduction of IFN-gamma was MHC class I/CD8 dependent, but did not require IL-12, NK cells, TCR-gammadelta T cells, MHC class II, or CD4 T cells.
Gazzinelli et al. (1993)interferon gammaT-cellInterleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.
Heo et al. (2007)IFNgammaT cellsHowever, Pb did significantly lower the amount of IFNgamma protein in supernatants and cell lysates of antigen-activated T cells in comparison to stimulated controls, suggesting that the lower amounts of IFNgamma released into culture supernatants were not due to a blockage of secretion that gave rise to a cytoplasmic accumulation of IFNgamma.
Mitchell and Lawrence (2003)IFNgammaT cellsMoreover, ex vivo restimulation of lymph node cells with influenza virus nucleoprotein (NP366-374) peptide and exogenous interleukin-2 (IL-2) only partially restored the proliferation of influenza virus-specific CD8+ T cells from TCDD-exposed mice and failed to stimulate interferon-gamma (IFNgamma) production by these cells.
Yang and Hayglass (1993)IFN-gammaT cellsT cells from mice immunized with allergen in complete Freund's adjuvant (CFA) generate strong IL-2 and IFN-gamma production, but virtually no IL-4, while unimmunized mice do not respond detectably to allergen in vitro (< 1 U).
Murray and Young (1999)IFN-gammaT cellsContrary to expectations, however, IL-10(-/-) mice did not have increased levels of IFN-gamma, either from T cells or in the plasma, suggesting that other mechanisms are responsible for the increased resistance.
Tvinnereim and Harty (2000)IFN-gammaT cellsThese results demonstrate that the regulatory functions of IFN-gamma are not required for priming of CD8(+) T cells by cross-presentation of a model exogenous antigen or in response to a nonsecreted L. monocytogenes antigen.
Murray et al. (1987)IFN-gammaT cellIn contrast, T cell-deficient nude BALB/c mice exerted no control over L. donovani, their spleen cells failed to generate antigen-induced IFN-gamma, and at 4 weeks, their livers were devoid of any tissue reaction.
Ando et al. (2000)IFN-gammaT cellsThe pretreatment of APC with IL-12 did not restore the impaired IFN-gamma production by T cells from UVB-irradiated mice.
Ando et al. (2000)IFN-gammaT cellsInstead, we observed that anti-CD3 mAb-induced IFN-gamma production by T cells from UVB-irradiated mice was not augmented in the presence of anti-CD28 mAb, whereas IL-4 production was enhanced by the addition of anti-CD28 mAb.
Flórido et al. (2005)IFN-gammaT cellsAlthough T-cell loss was IFN-gamma dependent, expression of the IFN-gamma receptor on T cells was not required for depletion.
Rizzitelli et al. (2005)IFN-gammaT cellIn contrast, similar activation of CD8- DC produced a more modest increase in capacity to stimulate CD4 T cell proliferation and no increase in capacity to stimulate IFN-gamma production.
Hartikka et al. (2009)IFN-gammaT-cellsLower doses of Vaxfectin (30 microg) did not enhance antibody responses, but increased the number of IFN-gamma secreting T-cells by up to 18-fold.
Seymour et al. (1998)IFN-gammaT cellsThis T cell unresponsiveness was shown not to require CD8+ or TCR-gamma/delta+ T cells or IFN-gamma.
Nguyen et al. (2003)IFN-gammaT-cellTogether, our data suggest that the virulent strain RH induces in BALB/c mice a type 1 cytokine pattern with T-cell-independent overproduction of IL12 and IFN-gamma that may be involved in the pathogenesis of this micro-organism.
Flórido et al. (2009)gamma interferonT lymphocytesWhen compared with control littermates, transgenic mice exhibited an increase in the resistance to infection which was independent of B or T lymphocytes and did not require the production of gamma interferon.
Mun et al. (2003)IFN-gammaT cellsAfter intraperitoneal infection with the Fukaya strain of T. gondii, unirradiated IFN-gamma knock-out (GKO) mice transferred with wild type (WT) CD8+ effector T cells from infected mice failed to induce the production of IFN-gamma and died, whereas irradiated (IR) GKO mice transferred with WT CD8+ T cells induced IFN-y production and survived more than 6 months.
Rutkowski et al. (2009)IFN gammaCTLOur results indicate that SYNTGRFPPL-specific effector CTL preferentially utilize perforin-mediated cytolysis to provide protection against LP-BM5-induced pathogenesis, whereas CTL production of IFN gamma is not required.
Myers et al. (2005)IFN-gammaT cellsThe mechanism of suppression required IFN-gamma, but IFN-gamma alone was not sufficient to suppress the responding CD4 T cells.
Cocks et al. (1995)IFN-gammaT-cellParticularly, the production of interferon-gamma (IFN-gamma) is strongly upregulated, even in T helper type 2 (Th2) CD4+ T-cell clones, whereas no induction of interleukin (IL)-4 or IL-5 production was observed in Th1 clones.
Heckford et al. (1986)IFN-gammaT cellStimulation of T cell clones with recombinant IL 2 resulted in proliferation and sustained expression of the c-myc cellular proto-oncogene, but did not induce the expression of mRNA for the lymphokines IFN-gamma and IL 2.
Koarada et al. (2001)IFN-gammaT cellsThe increased IFN-gamma production was not due to an increase in the amount of IFN-gamma produced per cell but to an increase in the number of NOD CD4(+) T cells entering the IFN-gamma-producing pathway.
Nohara et al. (2009)IFN-gammaT cellsConstitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-gamma production in mice but does not suppress T(h)2-cytokine production or antibody production.
Smith and Hayday (2000)IFN-gammaT-cellStrikingly, the requirements for a highly effective alpha beta-T-cell-driven memory response are less stringent, requiring neither IFN-gamma nor IL-6 nor class I MHC.
Rogers et al. (1992)interferon gammaT cellsUsing monoclonal antibodies that neutralize the biologic activities of interleukin 1 alpha and interleukin 1 beta, we document that interleukin 1 participates neither directly in the induction of interferon gamma from isolated SCID natural killer cells nor in the antigen-specific activation of CD4+ T cells derived from Listeria-immune C.B-17 mice.
Chilton and Mitchell (2006)IFN-gammaT cellsThese studies showed that Bcl-3 is required for secondary gamma interferon (IFN-gamma) production by CD8 T cells but not for adjuvant-induced survival effects.
Kim et al. (1997)IFN-gammaT cellThe Ag specificity of this response was dependent upon covalent linkage of Ag and IL-12, since immunization of mice with OVA alone induced little or no IFN-gamma, while immunization with OVA and free rIL-12 enhanced T cell production of IFN-gamma, but the IFN-gamma production was not OVA specific.
Fattorini et al. (2002)IFN-gammaT cells-exposed mice had few mycobacteria in the tissues (>100 c.f.u.) and showed an expansion of CD4(+) T cells associated with overproduction of IL-12 and IFN-gamma, but not IL-4 and IgG antibodies.
Takahashi et al. (1995)IFN-gammaT cellsRT-PCR analysis revealed that CD4+ T cells from the SEB-sensitive mice expressed significant levels of IFN-gamma, IL-2, IL-4 and IL-10 mRNA, while those from the tolerant mice exhibited significant levels of IFN-gamma but not IL-2 or IL-4 mRNA.
Gorczynski et al. (2000)IFN-gammaT cellsDC incubated with ODN-1 to MD-1 did not stimulate IL-2 or IFN-gamma production, but generated cells able to suppress, in a second culture of fresh DC plus allogeneic T cells, production of IL-2 and IFN-gamma.
Smythies et al. (2000)IFN-gammaT cellsSplenic T cells from the same infected WT mice produced high levels of IFN-gamma, no detectable IL-4, and low amounts of IL-10 following in vitro H. pylori urease stimulation, reflecting a systemic Th1 response.
Rizzitelli et al. (2005)IFN-gammaT cellsIn contrast to CD8- DC, the quiescent CD8+ DC did not induce IFN-gamma production from CD4 T cells.
Ofosu-Appiah et al. (1996)IFN-gammaT cellWhen cultured with either heparan sulfate or Concanavalin A, the T cell clones produced high levels of IL-4 and IL-5 with no detectable IL-2 or IFN-gamma.
Crenier et al. (2002)interferon-gammaT cellsIslet xenograft rejection in absence of CD8+ T cells does not require either interferon-gamma or interleukin-5.
Ascon et al. (2006)IFN-gammaT cellsIncreased TNF-alpha and IFN-gamma production of kidney infiltration CD3+ T cells in IRI mice but not sham-operated mice was found.
Yoo et al. (2002)IFN-gammaT cellIn this study, we demonstrated that IL-12 activates phosphatidylinositol 3-kinase (PI3K)/Akt pathway in murine CD4(+) T cells, and that this signaling pathway is required for IL-12-induced T cell proliferation and antiapoptotic function, but not for IFN-gamma induction.
Choi et al. (2007)interferon-gammaT cellMsp2 variation in Anaplasma phagocytophilum in vivo does not stimulate T cell immune responses or interferon-gamma production.
Kane et al. (2001)interferon gammaT cellsRetrovirus-mediated expression of activated Akt in primary T cells from CD28-deficient mice is capable of selectively restoring production of IL-2 and interferon gamma, but not IL-4 or IL-5.
Nakamura et al. (1993)IFN-gammaT-cellHowever, the factor failed to stimulate IFN-gamma production when staphylococcal enterotoxin A, a superantigenic T-cell mitogen, was employed.
Zhu et al. (2007)IFN-gammaT cellsCD137-mediated proliferation of memory T cells is directly through CD137 on T cells and does not require IL-15 and IFN-gamma.
Marinaro et al. (1995)IFN-gamma mRNAT cellsBoth Peyer's patches and splenic CD4+ T cells expressed markedly increased levels of IL-4-specific message, but did not result in changes in IFN-gamma mRNA expression.
Westwood et al. (2004)IFN-gammaT cellsSurprisingly, during the priming phase, CD4+ T cells, but not CD8+ T cells, were also required to generate this secondary T cell immunity; however, T cell priming was independent of Th1 cytokines, such as IFN-gamma and IL-12.
Sarawar et al. (2001)IFN-gammaT cellsCD8(+) T cells were essential for this effect, whereas virus-specific serum antibody was undetectable and IFN-gamma production was unchanged.
Joachim et al. (2006)interferon-gammaT cellsIn contrast, the influence of stress did not increase the percentages of interferon-gamma-positive CD3+ cells, meanwhile the application of SP increased the percentages of T cells positive for this cytokine.
Yu et al. (2003)IFN-gammaT cellSolid-phase EFNB2 along with suboptimal anti-CD3 strongly stimulated T cell proliferation, with concomitant augmentation of IFN-gamma but not IL-2 or IL-4 secretion.
Cao et al. (1993)IFN-gammaT cellFive of these T cell clones produced both IL-2 and IFN-gamma but not IL-4 after stimulation with either phorbol 12-myristate 13-acetate (PMA) or concanavalin A (Con A).
Chu et al. (1997)IFN-gammaT cellsWe find that in the absence of added IL-12, B lymphomas expressing the alternate costimulatory ligand 4-1BBL can support the production of IL-2 and IL-4 but little detectable IFN-gamma by allogeneic CD28+ and CD28- T cells.
Thomas et al. (2001)IFN-gammaT cellThis process appears to be independent of CD8 T cell-derived IFN-gamma, as both Tc2 (IFN-gamma-) and Tc1 (IFN-gamma+) CD8 T cells inhibited IgE.
Rudd et al. (2007)IFN-gammaT cellsAlthough MyD88(-/-) BMDCs infected with RSV did up-regulate costimulatory molecules, they did not up-regulate class II as efficiently and stimulated less IFN-gamma from CD4(+) T cells in vitro compared with wild-type BMDCs.
Claesson et al. (1999)IFN-gammaT cellsIn SCID mice transplanted with IL-12-unresponsive STAT-4-/- CD4+ T cells, the colonic lamina propria, mesenteric lymph node, and splenic CD4+ T cells produced very little IFN-gamma but abundant levels of TNF-alpha.
Gilbertson et al. (2004)IFN-gammaT cellsThe transferred CD8+ T cells proliferated in vivo, although this was not essential for IFN-gamma production.
Agranovich et al. (1999)IFN-gammaT cellsThese effects on T cells were maximal for CD28 and B7.2 at 40 to 48 h and were not dependent on interleukin-12 (IL-12) or IFN-gamma.
Bhonde et al. (2008)IFN-gammaT cellIn vitro and in vivo assays of proinflammatory cytokine production revealed that P2281 diminishes induced IFN-gamma production but not TNF-alpha production, indicating preferential inhibitory effects of P2281 on T cell function.
Lim et al. (1998)pIFN-gammaT cellsIntramuscular injection of BALB/c mice with the pOVA/IFN-gamma DNA increased both the production of OVA-specific IFN-gamma by CD4+ T cells and the ratio of anti-OVA immunoglobulin G (IgG) 2a to IgG1 isotypes, while the injection with the pOVA alone, or with the mixture of the pOVA and pIFN-gamma, caused no or little increase.
Way et al. (2007)IFN-gammaT cellsIL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infection.
Lang et al. (2003)IFN-gammaT cellsWe found that LACK-reactive T cells from mice inoculated with a high dose of parasites first produced IFN-gamma and later on IL-4; the level of IFN-gamma produced early by these cells was dependent upon the stage of the promastigotes inoculated, the highest level being reached with cells recovered from mice inoculated with the least infectious parasites, LP; sequential production of IFN-gamma and then of IL-4 also characterized L. major antigen-reactive CD4 T cells, suggesting that the early production of IFN-gamma does not impede the subsequent rise of IL-4 and finally the expansion of the parasites; after low-dose inoculation of MP, cutaneous lesions developed with kinetics similar to that of lesions induced after inoculation of 10(6) LP, but in this case CD4 T lymphocytes did not release IFN-gamma or IL-4 in the presence of LACK and neither cytokine was produced in response to L. major antigens before the onset of lesion signs.
Artis et al. (2003)IFN-gammaT cellsCritically, the frequency of proliferating KO CD4(+) T cells secreting IFN-gamma matched that of wild-type cells, suggesting that NF-kappaB1 was not required for efficient transcription of the IFN-gamma gene.
Daugelat et al. (1994)gamma interferonT cellsProliferation of antigen-specific T cells correlated with the production of high concentrations of gamma interferon, whereas IL-4 and IL-10 production in response to listerial protein fractions could not be detected.
Byun et al. (2010)IFN-gammaT lymphocytesGISF (50 and 150 kGy) augmented immune responsiveness via activation of NK cells, T lymphocytes proliferation, NO production, and cytokine level, such as IL-6, IL-2, IL-12, IFN-gamma, TNF-alpha, as compared with NISF, which strongly suggested that GISF significantly augmented an important element of all aspects of the innate and adaptive immune system.
Blasko et al. (2009)IFN-gammaT cellsThe effect of G-1 appears indirect, as the GPR30 agonist did not directly influence IFN-gamma or IL-17 production by purified T cells.
Nau et al. (1999)gamma interferonT-cellThe ability of osteopontin to facilitate the clearance of mycobacteria was most pronounced early after infection and appeared to be independent of known mediators of resistance to infection by mycobacteria: antigen-specific T-cell immunity, gamma interferon production, and nitric oxide production.
Gamboa-León et al. (2007)IFN-gammaT cellsGarlic extract may thus act on both T cells and macrophages to stimulate IFN-gamma production and NO synthesis for parasite killing.
Yamamoto et al. (2005)IFN-gammaT cellsA large number of T cells from mice sensitized and challenged with OVA produced high level of IL-4 and IL-5 but not IFN-gamma after stimulation with OVA.
Rescigno et al. (2000)IFN-gammaT cellFinally, during cognate DC-T cell recognition, IL-12 (p70) could not be detected at early or late time points, indicating that Fas-induced, IFN-gamma secretion is independent of IL-12.
Cunningham et al. (2004)IFN-gammaT cellCD28-requirement for this switching shows its T cell dependence. rFliC was unable to induce markers of Th1 activity including IL-12, T-bet and IFN-gamma.
Perry et al. (1999)gamma interferonT cellsA role for major histocompatibility complex class II-restricted, interleukin-12-dependent CD4(+) T cells has been established, but the functional activity of these cells does not depend on secretion of gamma interferon.
White and Harty (1998)IFN-gammaT cellsPerforin-deficient CD8+ T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD95 and IFN-gamma but requires TNF-alpha.
White and Harty (1998)IFN-gammaT cellsThese results indicate that single Ag-specific CD8+ T cells derived from PO mice can mediate antilisterial immunity by a mechanism that is independent of CD95 or IFN-gamma, but requires TNF-alpha.