Viewing affirmative mentions of positive regulation of Cd8a (M. musculus) in T cells

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Samberg et al. (1989)CD8T cellWe suggest that T cell priming requires an efficient interaction of CD8 with the class I alpha 3 domain, and this shows some species restriction.
Lyman et al. (2004)CD8T cellThese results suggest that an initial induction of a vigorous CD8(+) T cell response to TMEV is critically important for the resistance to virally induced demyelinating disease.
Berg et al. (2006)CD8T cellsAntigen associated with apoptotic cell material is processed and cross-presented by LSEC to CD8+ T cells, leading to induction of CD8+ T cell tolerance.
Fan and Singh (2002)CD8T cellsVaccination of such mice with plasmid DNA vectors encoding these epitopes induced CD8(+) T cells that killed anti-DNA antibody-producing B cells, reduced serum anti-DNA antibody levels, retarded the development of nephritis, and improved survival.
Usherwood et al. (2000)CD8T cellHere we used the murine gammaherpesvirus system to examine the expression of the latency-associated M2 gene during latency and the induction of the CD8(+) T cell response to this protein.
Ng et al. (2009)CD8T cellsRESULTS AND CONCLUSIONS: We show that CD8(+) T cells are induced by a single intranasal vaccination with lipopeptide, they remain at substantial levels in the lungs and are efficiently boosted upon challenge with virulent virus to provide late control of pulmonary viral loads.
Zhang et al. (1998)CD8 alphaT cellsThese results indicate that stage-specific expression of CD8 alpha in developing T cells is mediated by the differential activity of multiple functionally distinct cis-active transcriptional control mechanisms.
Furuichi et al. (2005)CD8T cellsRESULTS: DNA immunization induced HBV-specific CD8(+) T cells.
McKenna and Kapp (2006)CD8T cellCD8(+) T cell numbers were significantly increased in eyes of mice primed with E.G7-OVA, but few were detected in primary ocular tumors.
Goossens et al. (1995)CD8T cellsMonocytogenes, (b) why all this information allows us to consider the use of L monocytogenes of attenuated virulence as relevant live recombinant vectors in order to deliver heterologous proteins to the class I processing and presentation pathway, and to induce CD8 T cells along the type 1 pathway.
Kern et al. (2010)CD8T-cellBACKGROUND & AIMS: Dendritic cell activation through ligation of pattern recognition receptors leading to full functional maturation causes induction of CD8(+) T-cell immunity through increased delivery of costimulatory signals instead of tolerance.
Kern et al. (2010)CD8T cellsRESULTS: LSECs expressed numerous pattern recognition receptors that allowed for sentinel function, but ligand-induced activation of these receptors was not sufficient to overcome tolerance induction of CD8(+) T cells.
Feik et al. (2005)Cd8aT cellThese results indicate that E8(III) is one of the cis-elements that contribute to the activation of the Cd8a and Cd8b gene complex during T cell development.
Kabingu et al. (2007)CD8T cellThis inhibition was accompanied by an increase in splenic anti-tumour cytolytic activity and by an increase in CD8(+) T cell infiltration into untreated tumours.
Rizzitelli et al. (2005)CD8T cellIn contrast, similar activation of CD8- DC produced a more modest increase in capacity to stimulate CD4 T cell proliferation and no increase in capacity to stimulate IFN-gamma production.
Hamilton and Harty (2002)CD8T cellThis protection was enhanced by diversifying the memory CD8(+) T cell compartment, even in the absence of a large increase in Ag-specific CD8(+) memory T cells.
Mueller and Ahmed (2009)CD8T cellsVirus-specific CD8(+) T cells in lymphoid and nonlymphoid tissues were increased in both number and ability to produce cytokines in these mice soon after infection.
Wei and Sherman (2007)CD8T cellsCross-priming is the process in which Ag-presenting dendritic cells (DCs) acquire, process, and present Ags scavenged from other cells, and use these cells to activate naive CD8 T cells.
U'Ren et al. (2006)CD8T cellsWe found that although plasmid DNA vaccines generated large increases in antigen-specific CD8(+) T cells, they failed to elicit significant antitumor immunity.
Liu et al. (2007)CD8T cellsFor DNA doses ranging from 1 to 100 microg, the studies revealed greater than 10-fold increases in anti-Gag CD8 T cells following a DNA prime or a DNA prime and a constant modified vaccinia Ankara (MVA) boost.
Chen et al. (1999)CD8T cellDNA vaccination is highly efficient at inducing CD8(+) T cell responses in animal models.
Vezys et al. (2000)CD8T cellExpression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction.
Nakayama et al. (1994)CD8T cellsThe number of peripheral CD8+ T cells was restored by transfer of an exogenous CD8 beta gene into CD8 beta-deficient T cells.
Sedlik et al. (2000)CD8T-cellIn this study, we demonstrate that strong CD8(+) class I-restricted cytotoxic responses are induced upon intraperitoneal immunization of mice with different peptides, characterized as CD8(+) T-cell epitopes, bound to 1-microm synthetic latex microspheres and injected in the absence of adjuvant.
Ryan et al. (2008)T-CD8T cellWe found that immunization enhanced the accumulation of adoptively transferred T-CD8 at the tumor site, but that the timing of immunization was critical for optimal T cell expansion.
Ryan et al. (2008)T-CD8T cellA more rapid accumulation of T-CD8 was achieved when mice were conditioned with agonist anti-CD40 antibody before adoptive transfer due to increased T cell activation against the endogenous tumor antigen.
Lynch and Shevach (1993)CD8T cellsGamma delta T cells promote CD4 and CD8 expression by SCID thymocytes.
He et al. (2008)CD8T cellsThe results showed that a significantly higher expression of CD94-NKG2A heterodimer on CD8+T cells was induced following OVA inoculation into the anterior chamber, and that AC-injection of antigen and immunization have a synergistic effect on the increase of CD8+CD94+T cells.
Foster et al. (2010)CD8T cellDonor CD8 T cell activation is critical for greater renal disease severity in female chronic graft-vs.
Snyder et al. (2009)CD8T cellsMurine CMV (MCMV) establishes a systemic, low-level persistent infection resulting in the accumulation of CD8(+) T cells specific for a subset of viral epitopes, a process called memory inflation.
Snyder et al. (2009)CD8T cellMoreover, the increased viral activity did not drive increased CD8(+) T cell division or substantial dysfunction in any MCMV-specific population that we studied.
Ishimitsu et al. (2001)CD8T cellThese results suggest that overexpression of IL-15 in vivo suppresses Th2-mediated-allergic airway response via induction of CD8+ T cell-mediated Tc1 response.
Cho et al. (2009)CD8T cellThe localized expression of GITR-L on tumor cells led to a significant increase in CD8+ T cell infiltration compared to the levels seen in control tumors.
Getts et al. (2010)CD8T cellSpecific tolerization of SJL CD8(+) T cells specific for the immunodominant TMEV VP3(159)(-)(166) epitope has no effect on viral load or development of clinical TMEV-IDD, but adoptive transfer of activated CD8(+) VP3(159)(-)(166)-specific T cell blasts shortly after TMEV infection to boost the early anti-viral response leads to clearance of CNS virus and protection from subsequent TMEV-IDD.
Ito et al. (2002)CD8T cellsIn addition, even in the absence of up-regulation of pre-TCR expression, a similar increase of CD8(+) T cells was also observed in TCRalpha(-/-) mice overexpressing Egr-1, which lowers the threshold of signal strength required for positive selection.
Kurts (2008)CD8T cellThe induction of robust CD4(+) and CD8(+) T cell responses is a central aim in antiviral and anticancer vaccination.
Li et al. (2007)CD8T lymphocytesIn vivo Ab depletion confirmed that the antitumor effect was primarily CD8+ T cells and CD4+ T lymphocytes were required for the induction of CD8+ CTL response in B16F10-SLC-3P-Fc+anti-CTLA-4 mAb-immunized mice.
Cheng and Greenberg (2002)CD8T cellFollowing lymphocytic choriomeningitis virus infection, GMIL2R transgenic mice exhibited an increase in both the peak CD8(+) T cell response achieved and the size of the resulting memory pool established.
Hamdy et al. (2007)CD8T cellsParticulate delivery of OVA and MPLA to the DCs lead to markedly increase in in vitro CD8(+) T cell T cell proliferative responses (stimulation index >3000) and >13-folds increase in in vivo clonal expanded CD4(+) T cells.
Hamdy et al. (2007)CD8T cellCodelivery of antigen and MPLA in PLGA-NP offers an effective method for induction of potent antigen specific CD4(+) and CD8(+) T cell responses.
Andersson et al. (1995)CD8T cellsFlow cytometric analysis of splenocytes from mice infected with lymphocytic choriomeningitis virus revealed marked and long-standing up-regulation of LFA-1 expression on CD8+, but not on CD4+ T cells.
Chakravarty et al. (2008)CD8T-cellHowever, the requirement for CD8(+) T-cell-mediated IFN-gamma production in protective immunity to this pathogen has not been directly tested.
Belyakov et al. (2006)CD8T cellIntranasal immunization was more effective at inducing CD8(+) T cell immunity in the lung, and protection, than i.m. immunization.
Belyakov et al. (2006)CD8T cellThis study demonstrates for the first time a protective adjuvant effect of CpG ODN for a live viral vector vaccine that may overcome CD4 deficiency in the induction of protective CD8(+) T cell-mediated immunity.
McBride et al. (2006)CD8T cellOur data showed that cell-associated dsRNA, but not soluble dsRNA, enhanced both tumor-specific CD8(+) and CD4(+) T cell responses.
Zhang et al. (2006)CD8T cellDespite limited trafficking, memory CD4 T cells remain capable of providing help for the induction of anti-donor CD8 T cell and alloantibody responses.
Potter et al. (2001)CD8T cellIt is not known whether SMACs are required for CD8 T cell activation.
Whitmire et al. (2000)CD8T cellsSo while there is long-term memory in both the CD8 and CD4 compartments, the rules regulating the activation of CD8 and CD4 T cells and the overall magnitude of the responses are different.
Smith et al. (1996)CD8T cellsCD8 expression on the surface of developing thymocytes is essential for the positive selection and maturation of CD8 single positive T cells.
Curnow et al. (1994)CD8T cellPositive selection of class I-restricted T cells has been suggested to always require the surface expression of CD8 molecules on CD4+8+ thymocytes, whilst negative selection was found to be differentially dependent, relating to the antigen being engaged by the T cell receptor (TCR).
Liu et al. (2000)CD8T cellsWe propose that when the intrinsic capacity of neurons to inhibit HSV-1 reactivation from latency is compromised, production of HSV-1 immediate early and early proteins might activate CD8(+) T cells aborting virion production.
Däubener et al. (1985)Lyt-2T cellsAn age related increase in both Lyt-2 antigen density and CTLp frequency was parallelled by the rapid increase in the total number of splenic T cells during the second and third postnatal week, reaching 60-70% of adult values.
Peng et al. (2007)CD8T cellsRESULTS: CD4 autoreactive T cells underwent full activation when stimulated with high or medium concentrations of immunizing peptide, whereas a high dose of antigenic peptide resulted in only modest activation of CD8 autoreactive T cells.
Manohar et al. (1984)Ly-2T cellsThere was a slight increase in the ratio of Ly-2- to Ly-2+ T cells.
Thompson et al. (2010)CD8T cellsActivated CD8 T cells were present in tumors within 24 h of adoptive transfer and proliferation of these cells was also evident 4-5 d later in mice treated with FTY720 to prevent infiltration of cells activated in LNs.
Rosato et al. (2006)CD8T cellsThe parameters tested were 1) percentage of in vivo vaccine-induced tumor-specific CD8+ T cells; 2) results of ELISPOT tests from fresh splenocytes; 3) percentage of tumor-specific CD8+ T cells in culture after in vitro restimulation; 4) in vitro increase of tumor-specific CD8+ T cell population expressed as fold of expansion; and 5) antitumor lytic activity of restimulated cultures.
Chapatte et al. (2006)CD8T-cellThese results show that immunization with rec. lv induces not only a strong antigen-specific CD8+ T -cell response but also a long-lasting T-cell memory against a bona fide tumor-associated antigen.
Bartholdy et al. (2004)CD8T cellSingle-epitope DNA vaccination prevents exhaustion and facilitates a broad antiviral CD8+ T cell response during chronic viral infection.
Rodriguez et al. (2001)CD8T-cellTwo overlapping subdominant epitopes identified by DNA immunization induce protective CD8(+) T-cell populations with differing cytolytic activities.
Rodriguez et al. (2001)CD8T cellsFinally, lytic activity differs among CD8(+) T-cell populations with different epitope specificities, suggesting that vaccines can be designed to selectively induce CD8(+) T cells with distinct functional attributes.
Murali-Krishna et al. (1998)CD8T cellsIn contrast to previous estimates, we found that 50-70% of the activated CD8 T cells were LCMV specific.
Murata et al. (1996)CD8T cellThe induction of secondary CD8+ T cell responses appears to be highly restricted, as suggested by the lack of in vivo expansion of antigen-specific CD8+ T cells after repeated immunization with the same virus.
Wu et al. (2001)CD8T-cellsDietary fish oil increases CD8+ T-cells and decreases autoreactive T-cell activity in autoimmune NZB/W F1 mice.
Nicholson et al. (1996)CD8T lymphocytesAdoptively transferred CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice.
Huck et al. (2008)CD8T cellPre-treatment with LPS also improved the ability of DC to induce CD8(+) T cell expansion and anti-tumor responses, regardless of the route of DC administration.
Marten et al. (2003)CD8T-cellThe data further suggest peripheral acquisition of cytolytic function, thus enhancing CD8+ -T-cell effector function upon cognate antigen recognition in the CNS.
Deb et al. (2010)CD8T cellWe have previously observed that genetic deletion of the CD8+ T cell effector molecule perforin leads to preservation of motor function and preservation of spinal axons in chronically demyelinated mice.
Shimada et al. (1996)Lyt-2T cellsThe anti-parasite DTH response in BM-infected mice was significantly enhanced by depletion of Lyt-2+ T cells, while significantly reduced by depletion of L3T4+ T cells.
Ng et al. (2009)CD8T cellsOBJECTIVES: To examine the role of vaccine-induced CD8(+) T cells in altering the course of disease due to highly virulent H1N1 influenza virus in the mouse model.
Dubois et al. (2010)CD8T cellsThese findings demonstrated that neonatal induction of regulatory CD8(+) T cells was able to modulate key parameters of later allergic sensitization in a bystander manner, without recognition of MHC class I molecules.
Lang et al. (2008)CD8T cellWe have analyzed the role of platelet-derived vasoactive serotonin during virus-induced CD8(+) T cell-dependent immunopathological hepatitis in mice infected with the noncytopathic lymphocytic choriomeningitis virus.
Anraku et al. (2002)CD8T-cellKunjin virus replicon vaccine vectors induce protective CD8+ T-cell immunity.
Anraku et al. (2002)CD8T-cellA single immunization with any of these KUN replicon vaccines induced CD8+ T-cell responses at levels comparable to those induced by recombinant vaccinia virus encoding the same immunogen.
Peng et al. (2000)CD8T cellBecause soluble CD8alpha homodimers can antagonize CD8 T cell activation in vitro, we asked whether secretion of soluble CD8 would effect cytotoxic T cell responses in vivo.
Cuff et al. (2010)CD8T cellNotably, activation of CD8+ T cell responses by an unrelated stimulus, in this case infection with influenza virus, increased the number of pulmonary tumor nodules.
Obar et al. (2006)CD8T-cellBy comparing the immune response to this virus with a revertant virus that can persist, we were able to dissect the changes in the antiviral CD8(+) T-cell response that are induced by virus persistence.
Urbani et al. (2005)CD8T cellPatients with severe hepatitis, but not those with mild disease, showed an extremely vigorous CD8 T cell response narrowly focused on a single epitope (NS3 1073-1081), which cross-reacted with an influenza neuraminidase sequence.
Holman et al. (2005)CD8T cellsWe address these issues by testing the role of CD8 and the impact of CD8 Abs on the binding of normal and mutant multimers to Ag-specific mouse T cells.
Smith and Cheers (2005)CD8T cellsHowever, this response was dependent upon the presence of structurally intact LLO, suggesting a requirement for the innate recognition of LLO in the activation of the CD4(+) and CD8(+) T cells.
Shaw and Starnbach (2006)CD8T-cellThese results have implications for vaccine design, and they suggest that use of a toxin-based vector to target antigen to DC may be an effective way to induce a CD8+ T-cell response.
Mendez-Fernandez et al. (2005)CD8T-cellTheiler's murine encephalomyelitis virus (TMEV) infection of the brain induces a virus-specific CD8(+) T-cell response in genetically resistant mice.
Sakamoto et al. (1988)Lyt-2T cellsThe induction in the Lyt-2+ T cell-containing chamber of anti-tumor effect to be delivered into the other chamber was dependent on the co-existence of Ia-positive adherent cells along with Lyt-2+ T cells.
Huang et al. (2010)CD8T cellThere is also evidence for loci with specific effects: the single largest QTL effect on CD4+ versus CD8+ T cell subsets scarcely contributes to KI67 counts.
Irie et al. (1995)CD8T cellTo better understand these differences, we introduced the CD8 beta gene into a T cell hybridoma which only expressed the CD8 alpha alpha homodimer.
Boulanger et al. (2010)CD8T cellThis alteration of the CD8(+) T cell hierarchy was a consequence of tapasin editing and not a consequence of the alteration of the T cell repertoire in tapasin-deficient mice, because bone marrow chimeric mice (wild-type recipients reconstituted with tapasin knockout bone marrow) showed the same hierarchy as the tapasin knockout mice.
Harty et al. (2000)CD8T cellThus, the requirement for CD8(+) T cell- derived cytokines in resistance against most pathogens remains to be defined.
Strehl et al. (2006)CD8T cellIn summary, our studies demonstrate that induction of I-proteasomes is required for CD8(+) T cell-mediated elimination of L. monocytogenes from nonlymphoid but not lymphoid tissues.
Suda and Zlotnik (1992)CD8T cellHowever, along with the induction of CD8 alpha and CD8 beta expression, the expression of other T cell differentiation markers (including CD2, CD25, and CD44) also changed in a manner corresponding to physiologic differentiation.
Kowalczyk et al. (2001)CD8T cellsIn regressing tumors expressing an appropriate target antigen for the vaccine-induced CD8(+) T cells, a strong increase of the tumor antigen-specific T cell population was observed over time.
Lin et al. (2009)CD8T cellsDuring mild respiratory influenza infection in which virus is rapidly cleared, the inducible costimulatory receptor 4-1BB is only transiently induced on lung T cells and 4-1BB ligand (4-1BBL) is completely dispensable for the initial CD8 T cell response and mouse survival.
Perteguer et al. (2001)CD8aT cellsThe greatest increase in CD8a+ and TCRalphabeta- T cells was found in mice that had been subjected to infection only.
Zhang et al. (2001)CD8alphaT cellsIn contrast, on the wild-type (WT)/CD8(+/+) or CD8alpha(-/-)KO backgrounds, a CD8alpha Tg directed by cis-mechanism I alone is activated during the double negative [DN] to double positive [DP] transition and expressed up to the CD3(low/intermediate) DP stage but not in more mature DP or SP thymocytes or peripheral T cells.
Witte et al. (1999)CD8alphaT cellIn order to now examine the role of CD8beta in TCR recognition, the CD8alpha cDNA alone or in combination with CD8beta cDNA was transfected into the mouse T cell hybridoma, N15wt, specific for VSV8/Kb.
Richie et al. (1988)Lyt-2T-cellTo address this issue, we have studied alpha/beta T-cell antigen receptor gene and protein expression on normal thymocyte subsets of AKR/J mice, as well as on a panel of AKR/J primary thymic lymphomas characterized for CD4 (L3T4) and CD8 (Lyt-2) differentiation antigen expression.