Viewing negative mentions of positive regulation of Cd8a (M. musculus) in T cells

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Ng et al. (2009)CD8T cellAlthough current inactivated vaccines are unable to induce heterosubtypic CD8(+) T cell immunity, we have shown that lipopeptides are particularly efficient in this regard.
Chen et al. (1999)CD8T cellPrevious studies have shown that the Sendai virus HN protein does not induce a CD8(+) T cell response in C57BL/6 mice.
Obar et al. (2006)CD8T cellsThese data show persistence of gammaherpesvirus type 68 alters the properties of CD8(+) T cells and illustrates that immune surveillance does not require CD8 T cells with the same attributes as "classical" memory CD8(+) T cells.
Fung-Leung et al. (1993)CD8 alphaT cellsThe results suggest that the cytoplasmic portion of CD8 alpha is not absolutely required but dramatically enhances the efficiency of thymic maturation of CD8+ T cells.
Rizzitelli et al. (2005)CD8T cellsIn contrast to CD8- DC, the quiescent CD8+ DC did not induce IFN-gamma production from CD4 T cells.
Kuklin et al. (2000)CD8T cellThus, alpha(4)ss(7) facilitates normal intestinal immune trafficking to the gut, but it is not required for effective CD8(+) T cell immunity.
Brooks et al. (1999)CD8T cellsThe B-cell-deficient mice show no increase in Vbeta4(+) CD8(+) T cells.
Schmidt-Ullrich and Eichmann (1990)Lyt-2T cellsHowever, results on T cells unrelated to C196 suggests that the site whose methylation appears to be critical in C196 is not responsible for Lyt-2 transcription in all T cells.
Martin (1996)CD8T cellsFinally, donor CD4 cells and CD8 cells were equivalently effective for preventing rejection of F1 marrow in parental recipients, suggesting that veto activity is not restricted solely to the CD8 subset of murine T cells.
Søndergaard et al. (2009)CD8T cellOverall, our results show that endogenous IL-21/IL-21R is not required for NK, NKT, and CD8(+) T cell-mediated tumor immunity, but restricts Ag-specific CD8(+) T cell expansion and rejection of immunogenic tumors, indicating novel immunosuppressive actions of this cytokine.
Hörnquist et al. (1996)CD8T cellsIn CD8-/- mice the CD4+ T cells were increased, with the exception that in the intraepithelial compartment the CD3+ T cells were predominantly DN gamma delta T-cell receptor (TCR)+ T cells.
van den Berg et al. (2010)CD8T cellsNormal CD8(+) T cell tolerance was observed in MHC class II deficient mice, indicating that CD4(+) T cells are not required for both oral and nasal CD8(+) T cell tolerance induction.
French et al. (2009)CD8T cellDespite the role of CD8 in MHC class I recognition by alphabeta T cells, beta(2)-microglobulin (beta(2)m)-associated MHC class I molecules were not required for CD8(+) gammadelta T cell homeostatic expansion.
Vissinga et al. (1990)CD8T cellFrom these data it can be concluded that the reduced DTH responses in old mice are not solely due to CD8+ suppressor cell activity and/or lack of IL-2, but that rather intrinsic defects of the CD4+ T cell population appear to play a major role in the impaired DTH reactivity during ageing.
Bergmann et al. (2003)CD8T cellUntreated PKO/GKO mice were unable to control the infection and died of lethal encephalomyelitis within 16 days, despite substantially higher CD8(+) T cell accumulation in the CNS compared with controls.
Fleissner et al. (2010)CD8T cellsInterestingly, co-culture of HA-specific CD8+ T cells with DCs in the presence of HA peptide or HA peptide in combination with RA does not lead to a clear conversion into CD8+Foxp3+ T cells (Figure 5C).
Lohman et al. (1996)CD8T-lymphocyteThus, CD95 is not required for the immune downregulation of the CD8+-T-lymphocyte response following acute LCMV infection.
Andreasen et al. (1999)CD8T cellsFollowing injection of the IFN inducer poly(I:C), proliferation of memory (CD44(hi)) CD8(+) T cells but no phenotypic or functional activation was observed.
Wang et al. (2006)CD8T cellCD8(+) T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon.
Lang et al. (2007)CD8T cellsMice treated with GP61-IFA had similar frequencies of tet-gp33+ CD8+ T cells after high dose LCMV infection as IFA only treated mice suggesting that tolerisation does not influence exhaustion of CD8+ T cells (Figure S3).
Xu et al. (1997)CD8T cellsThese results indicate that coincidental priming of CD4+ (and CD8+) T cells by LC does not augment CD8+ T cell development in CHS.
Han et al. (2008)CD8T cellsThis combination did not decrease but rather increased the number of tumor-specific CD8(+) T cells primed by vaccinia virus-mediated vaccination; the resulting antitumor effects were further improved up to 60 days as compared with monotherapy after tumor challenge, and the survival of tumor-bearing mice was dramatically prolonged.
Schlecht et al. (2004)CD8T-cellWe also show that immature pDCs are unable to induce effector or regulatory CD8(+) T-cell responses.
Zhou et al. (2008)CD8T cellsMany of these molecules were highly upregulated in the CD8+ NKT-like cells but not upregulated in the cultured CD4+ T cells or activated CD8+ T cells.
Kianizad et al. (2007)CD8T cellsOur data also suggest that immunologic tolerance is more stringent for CD4(+) T cells than CD8(+) T cells, providing a mechanism of peripheral tolerance where autoreactive CD8(+) T cells fail to be activated due to a lack of autoreactive CD4(+) T cells specific for the same antigen.
Barouch-Bentov et al. (2005)CD8T cellUsing CD8(+) T cells from TCR-transgenic mice crossed to protein kinase C-theta (PKCtheta)-deficient mice, we report that PKCtheta is not required for Ag-induced CD8(+) T cell proliferation, but is important for T cell survival and differentiation into functional, cytokine-producing CTLs.
Hussell and Openshaw (2000)CD8T cellIL-12-activated NK cells reduce lung eosinophilia to the attachment protein of respiratory syncytial virus but do not enhance the severity of illness in CD8 T cell-immunodeficient conditions.
Hawkins et al. (2003)CD8T-cellLPS in DNA vaccines is not required for CD8(+) T-cell responses.
Barlow et al. (2004)CD8T lymphocytesDevelopment of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytes.
Lee et al. (2003)CD8T cellsThese studies highlight a new function for macrophage-derived chemokine by demonstrating that it possesses in vivo antitumor activity with CD8 T cells as the effector cells, and interestingly, that the CD4 cell/MHC II pathway of CD8 cell activation is not required for the antitumor effects of this chemokine.
Wang et al. (1993)CD8T cellsHigh concentration of calcium ionophore alone induces the expression of J11d antigen, but not of CD4, CD8, and activation antigens such as interleukin 2 receptor as well as transferrin receptor by J11d- DN T cells from lpr mice.
Kemball et al. (2009)CD8T cellWith this enhanced detection system we show that CVB3 induces essentially no detectable in vivo primary CD8+ T cell response.
Kemball et al. (2009)CD8T cellThe absence of CD8+ T cell responses is especially dramatic: rCVB3.6 fails to induce a detectable primary CD8+ T cell response even when the frequency of epitope-specific precursors is artificially increased by ?
Kemball et al. (2009)CD8T cellsWe report herein that CVB3, despite replicating to remarkably high titers in vivo (up to 1010 PFU/gram in some tissues), does not induce marked activation of CD4+ or CD8+ T cells.
Alexander et al. (1996)CD8T cellWe have recently analyzed the functional significance of T cell cytotoxic pathways and found that neither the Fas nor CD8+ cytotoxic pathways are required for murine cardiac allograft rejection.
Bolinger et al. (2008)CD8T-cellLikewise, transplantation of fully vascularized heart or liver grafts from Tie2-LacZ mice into nontransgenic recipients did not suffice to activate beta-gal-specific CD8(+) T cells, indicating that CD8(+) T-cell responses against mhAg cannot be initiated by ECs.
Takamura et al. (2010)CD8T cells-primed memory CD8+ T cells are not activated by residual antigen in the MLN
Dobrzanski et al. (2006)CD8T cellThis suggested that CD8-mediated type 1 antitumor responses cannot only promote accumulation of distinct endogenous CD4 and CD8 T cell subpopulations, but also facilitate and preferentially modulate their localization kinetics, persistence, states of activation/differentiation, and function within the primary tumor environment at various stages of tumor progression.
Ribeiro et al. (2010)CD8T cellThus, vaccines tested in recent efficacy trials failed to induce CD8+ and especially CD4+ T cell responses in a significant proportion of vaccinees.
Lee et al. (2004)CD8T cellWe show that enforced dual costimulation through 4-1BB and OX40, but not through CD40, induced profound specific CD8 T cell clonal expansion.
Mukherjee et al. (2005)CD8T cellsExperiments using purified CD4(+) and CD8(+) T cells from IGRP peptide-primed mice also showed a predominant CD4(+) T cell response with no significant activation of CD8(+) T cells.
Blank et al. (2005)CD8T cellOur results suggest that ICAM-1 contributes to but is not absolutely required for CD8+ T cell-mediated tumor rejection in vivo and dominantly acts at the level of priming rather than the effector phase of the antitumor immune response.
Seymour et al. (1998)CD8T cellsThis T cell unresponsiveness was shown not to require CD8+ or TCR-gamma/delta+ T cells or IFN-gamma.
Serra et al. (2002)CD8T cellsIn contrast, reexpression of RAGs could not be induced in the CD8(+) T cells of B6 mice expressing an ovalbumin-specific, K(b)-restricted TCR, or in the CD8(+) T cells of NOD mice expressing a lymphocytic choriomeningitis virus-specific, D(b)-restricted TCR.
Bhadra et al. (2010)CD8T cellThis suggests that absence of IL-15 or IL-7 alone does not affect CD8+ T cell activation during acute Toxoplasmosis.
Stefanski et al. (2001)CD8T cellNeither E1 nor SIY transgenes increased the polyclonal CD8 T cell repertoire size in non-TCR-transgenic animals, arguing that single class I binding peptides do not detectably affect the size of the CD8 T cell repertoire when expressed at low levels.
Olson and Varga (2007)CD8T cellWe also demonstrate that FI-RSV immunization does not induce a measurable RSV-specific CD8 T cell response and that priming FI-RSV-immunized mice for a potent memory RSV-specific CD8 T cell response abrogates pulmonary eosinophilia after subsequent RSV challenge.
Curnow et al. (1995)CD8T cellsTg-TCR/CD3lo CD4-CD8- T cells expressing the NK1.1 marker were observed only for a Tg-TCR whose stimulation by antigen was independent of CD8.
Brunsing et al. (2008)CD8T cellsIn T cells, IRE activity was not detected in the more mature CD4(+) T-cell population but was active in the CD8(+) cytotoxic T-cell population.
Cohen et al. (2010)CD8T cellEvaluation of absolute numbers/gram of tumors for Teffs and Tregs paralleled the frequency data, showing decreased Tregs without major increases in CD8+ T cell numbers/gram of tumor (Figure S3).
Flores et al. (2009)CD8T cellsWe found that unlike conventional DCs, immune complex (IC) exposed murine pDCs neither up-regulated costimulatory molecules nor activated Ag-specific CD4(+) and CD8(+) T cells.
Rosenberg et al. (2010)CD8T cellsCD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance.
Majlessi et al. (1996)CD8T cellsIn this physiological model, which involves neither superantigens nor TCR-transgenic T cells, the responsive or tolerant state in Igha mice is assessed in vivo by the capacity to induce or not a T CD8(+)-dependent suppression of IgG2ab allotype production in Igha/b recipients of these cells.
Tenbusch et al. (2008)CD8T cellA single injection of DNA encoding either OVA or GM-OVA did not result in any detectable CD8+ T cell responses, while a single adenoviral vector immunization with either antigen resulted in similar levels of tetramer-positive and IFN-?
Tenbusch et al. (2008)CD8T cellIn contrast, CD8+ T cell responses after the adenoviral GM-OVA boost were not enhanced by priming with GM-OVA DNA (Fig 3A, B).
Banuelos et al. (2004)CD8T cellsCONCLUSIONS: These data document that (1) both CD4CD25 and CD4CD25 cells are required for induction of skin allograft survival, (2) CD4CD25 T cells are not required for alloreactive CD8 T cell deletion, and (3) CD4CD25 regulatory cells are not critical for islet allograft tolerance.
Slifka et al. (2001)CD8T-cellDespite the high virus titers, rCVB3 infection of naive mice failed to induce a strong CD8+ T-cell response to the encoded epitope; this has implications for the proposed role of "cross-priming" during virus infection and for the utility of recombinant picornaviruses as vaccine vectors.
Fritsch-Stork et al. (2006)CD8T cellsSurprisingly, though, the supernatants of the hnRNP-A2 specific CD8+CD28- TCCs derived from SLE patients did not inhibit proliferation of CD4+ T cells, but instead enhanced anti-CD3/anti-CD28 induced stimulation, similar to supernatants derived from CD4+CD28+ TCCs.
Li et al. (2004)CD8T cellFurther functional analyses of Mig indicate that expression in tumors can induce CD4+ but not CD8+ T cell infiltration.
Zhang et al. (2006)CD8T cellsIL-15 as a gene adjuvant had no significant effect on humoral immune responses induced by hepatitis B virus core gene DNA vaccine, but increased the memory antigen-specific CD8(+) T cells induced by hepatitis B virus core gene DNA vaccine.
SEDEGAH et al. (2007)CD8T cellsIn BALB/c mice, CD8+ T cells have been shown to be responsible for the immunity against PySPZ after immunization with radiation-attenuated PySPZ (8–10), while protection induced in BALB/c mice after immunization with irradiated PbSPZ is independent of CD8+ T cells (11).
Hughes et al. (2008)CD8T cells+ T cells in samples stimulated with no peptide from the frequency of CD8+ IFN-?
Overwijk et al. (2000)CD8T-cellParadoxically, tumor-specific CD8+ T-cell levels were not increased in these patients.
Oehme et al. (2005)CD8T cellsThymic and splenic cell numbers as well as CD4/CD8 cellularity were normal in lck FLIP(S)-transgenic animals, which in contrast to CD95-deficient mice do not accumulate Thy1(+) B220(+) CD4(-) CD8(-) peripheral T cells. c-FLIP(S) overexpression leads to a significant decrease in activation-induced T cell proliferation in vitro.
Xia et al. (2010)CD8T cellsHowever, BTLA expression did not increase in CD8+ T cells after HSV-1 infection (Figure 1C).
Giese and Davidson (1995)CD8T cellsThe accumulation of B220+ CD4- CD8- (DN) T cells in C3H-lpr/lpr mice is not accelerated by the stimulation of CD8+ T cells or B220+ DN T cells with staphylococcal enterotoxin B and occurs independently of V beta 8+ T cells.
Liu et al. (2007)CD8T cellsThe therapeutic effect was dependent on CD8 but not on CD4 T cells.
Ito and Seishima (2010)CD8T cellsHowever, CTLA-4 is probably not required for anergy induction in CD8-positive T cells, because 2C T cells from CTLA-4 KO mice are equally susceptible to anergy as T cells from their wild-type littermates.
Giri et al. (2008)CD8T cellsexpression in both CD8+ and CD4+ T cells while exosomes from uninfected cells failed to induce IFN-?.
Farah et al. (2001)CD8T lymphocytesSystemic depletion of CD4+ and CD8+ T lymphocytes alone did not increase the severity of oral infection compared to that of controls.
Salucci et al. (2006)CD8T-cellImmunization of CEA-transgenic mice with an adenoviral vector coding for CEA induced a significant CD8+ T-cell response specific to CEA but failed to induce CEA-specific CD4+ T cells and antibodies.
Tundup et al. (2008)CD8T cellsNo significant increase in CD4+ (0.14%) and CD8+ (0.61%) T cells were observed when cells from naïve mice or mice immunized with buffer only (data not shown) were stimulated with different species of proteins.
Schmidt et al. (2010)CD8T cellHomologous boosting markedly expands RAS-induced memory CD8 T cell populations but fails to confer protective immunity to C57BL/6 mice
Jabeen et al. (2008)CD8T cellsHowever, the monomeric mutants failed to induce in vivo recruitment of activated CD8+ T cells.
Span et al. (1996)CD8T-lymphocytesExcept for a trend toward an increased CD4/CD8 ratio, no statistically significant differences for B- and T-lymphocytes could be observed.
Hessel et al. (2010)CD8T cellsThe H1/CA peptide pool stimulated surprisingly high amounts of CTLs, around 3–5% of total CD8 T cells were specific for H1, whereas the N1-specific peptide pool used as a negative control, did not induce significant levels of CD8 T cells (P>0.05), Fig. 4B).
Kim et al. (2010)CD8T-cellsCD4+ T-cells decreased markedly at day 2 PI (P < 0.05), whereas CD8+ T-cells, NK cells, and macrophages did not show significant changes, except a slight, but significant, increase of CD8+ T-cells at day 6 PI.
Takano et al. (2007)CD8T cellOrally administered capsicum extract and capsaicin did not change the T cell subset (CD4(+) and CD8(+)), Th1 (IFN-gamma(+)) and T2 (IL-4(+)) ratio.
White et al. (1993)CD8CTLImmunization of B10.Br (H-2k) mice with L(RLF), but not with RLF, induced CD8+ CTL specific for the P. falciparum CS protein CTL epitope, amino acid residues 368-390.
Lü et al. (1995)CD8T-cellsFollowing infection, both schistosome species induced higher CD3+CD4+, but not CD3+CD8+ T-cells in mediastinal nodes, and the peak was earlier with S. japonicum (about seven days after infection) than with S. mansoni (about 10 days).