Viewing affirmative mentions of positive regulation of Cd4 (M. musculus) in T cells

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Kumar (1989)CD4T lymphocytesCells expressing the CD4 and CD8 antigens were both increased in number, with the former accounting for approximately two-thirds of the T lymphocytes.
Chhikara et al. (2001)CD4T cellPrimary tumors that received the combination therapy had a marked increase in CD4 T cell infiltrate.
Zhao et al. (2007)CD4T cellsInduction of labor in humans appears to be associated with a decrease of CD4(+)CD25(high) Tregs and increase of CD4(+)CD25(low) T cells.
Krieger et al. (2000)CD4T cellsThis subpopulation of T cells was distinguished by up-regulation of cell surface CD4 expression.
Krieger et al. (2000)CD4highT cellsAdoptive transfer of CD4high, but not CD4normal T cells, just before skin engraftment in CD4 knockout mice, reconstituted rejection.
Kao et al. (2008)CD4T cellThe mechanism underlying the transient accumulation of CD4 at the immunological synapse (IS) and its significance for T cell activation are not understood.
Mittler and Lee (2004)CD4T cellsDespite the increased CD4 T cell growth in aged hosts, similar numbers of memory DO11.10 T cells were found in young and in aged hosts.
Yen et al. (2002)CD4T cellInduction of CD4 T cell changes in murine AIDS is dependent on costimulation and involves a dysregulation of homeostasis.
Li et al. (2007)CD4T cellsWe demonstrate that encephalitogenic T cells, following antigen recognition, up-regulate cell surface expression of CD4.
Nowak et al. (2003)CD4T cellsIt was associated with an increase in both CD4 and CD8 T-cell infiltration of the tumor, but depletion studies clearly showed that CD4 T cells were not a necessary component of the cure.
Yoshida et al. (1999)CD4T cellsThe antiviral effect was also indicated by the increase of CD4+T cells proportion in the i-IEL.
Hendricks et al. (1992)CD4T lymphocytesWe hypothesized that the increased density of LC in RE HSV-1-infected corneas at the time of T lymphocyte infiltration contributed to the preferential activation of CD4 T lymphocytes in these corneas.
Skoberne et al. (2002)CD4T cellThese data indicate that the suppressive effect of LLO on the antilisterial CD4 T cell response is maintained only in infected APC and support the hypothesis that cross-priming plays a role in the induction of the strong CD4 T cell response in Listeria-infected mice.
Lau et al. (2002)CD4T-cellSustained serological clearance of hepatitis B e antigen was associated with activation of CD4 positive HBV-specific T-cell reactivity and were of T-helper 1.
Myrick et al. (2002)CD4T cellsHowever, heterozygosity for the H2 complex was suggestively associated (LOD score of 2.43) with increases in CD4 T cells among T cell precursors in the thymus.
Whitmire et al. (2000)CD4T cellsCD4 T cells are also activated after LCMV infection, but relatively less is known about the magnitude and duration of the CD4 response.
Whitmire et al. (2000)CD4T cellsSo while there is long-term memory in both the CD8 and CD4 compartments, the rules regulating the activation of CD8 and CD4 T cells and the overall magnitude of the responses are different.
Kumar and Miller (1990)CD4T cellsThese results suggest that induction of immunity against virulent malarias requires both induction of CD4+ T cells and certain splenic alterations caused by parasite infection or S. typhimurium.
Mizoguchi et al. (2003)CD4T cellUnexpectedly, in the present studies, the lack of CD5 led to a remarkable increase of a CD4(+) TCRgammadelta T cell subset in CD5(-/-)beta(-/-) mice.
Van Oers et al. (1992)CD4T cellsAugmented CD4 expression was found to markedly alter CD8-dependent negative and positive selection of T cells specific for the male (H-Y) antigen presented by H-2Db major histocompatibility complex class I molecules.
Anderson and Coleclough (1993)CD4T cellsPhorbol esters are known to induce a loss of CD4 from the surface of mouse and human T cells, presumably through activation of protein kinase C.
Anderson and Coleclough (1993)CD4T cellsWhereas PMA causes the disappearance of almost all CD4 from the surface of mouse CD4+8+ thymocytes, it induces only a partial (approximately 60%) and transient (10 to 12 h) loss of CD4 from the surface of mouse peripheral T cells, with no effect on CD8 expression.
Zhang et al. (2008)CD4T cellsMoreover, these in situ generated and activated DCs markedly stimulated activation of antigen-specific CD4 and CD8 T cells by augmenting their numbers, as well as function, even in a tumor-bearing tolerogenic environment.
Kohm et al. (2004)CD4T cellTaken together, these findings suggest a dual functional role for GITR as GITR cross-linking both inactivates T(R) cells and increases CD4(+)CD25(-) T cell effector function, thus enhancing T cell immunity.
Gangappa et al. (1999)CD4T cellsThese results indicate bystander activation of CD4(+) T cells in a virus-induced inflammatory milieu.
Donaldson et al. (1994)CD4T cellWe report here that this retroviral infection leads to induction of a Thy-CD4+T cell subpopulation capable of transferring all the symptoms of MAIDS disease to normal B6 and B6 nu/nu.
Sparks-Thissen et al. (2005)CD4T cellCD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNgamma.
Zhang et al. (1994)CD4T cellGenerally, there was an increase in the CD4:CD8 ratio in the peripheral lymphoid organs during the onset of insulitis which was largely due to an increase in the CD4 T cell population while the ratio decreased after the onset of diabetes.
Howard et al. (1998)CD4T lymphocytesLatent infection was characterized by an accumulation of both naive, activated and memory CD4 and CD8 T lymphocytes in the lung and mediastinal lymph nodes.
Wallace et al. (1992)CD4T cellsCD4 expression is differentially required for deletion of MLS-1a-reactive T cells.
Wallace et al. (1992)CD4T cellsHowever, in instances where the TCR affinity for Mls-1a is low, as in the case of V beta 7+ T cells, CD4 expression was required for clonal deletion.
Robbins et al. (2004)CD4T cellConsequently, smoke exposure shifted the activated CD4:CD8 T cell ratio from 3 to 1.5 when compared with sham exposure.
Liu et al. (2000)CD4T cellsAntigen-specific T cells detected by the tetramers can up-regulate their CD4 expression on the cell surface after being restimulated with the GAD peptides in vitro.
Fehr et al. (2005)CD4T cellRapid peripheral deletion of donor-specific CD8 T cells precludes an ongoing requirement for CD4 T cell-mediated regulation.
Peters et al. (2009)CD4T cellsCD4 T cell cooperation is required for the in vivo activation of CD4 T cells.
Peters et al. (2009)CD4T cellsWe address here the role of CD4 T cell cooperation in the activation of CD4 T cells.
Laxmanan et al. (2001)CD4T-lymphocytesUsing a murine B-cell lymphoma, 2C3, we earlier demonstrated induction of splenic CD4+ and CD8+ T-lymphocytes directed to idiotypic Ig of the tumor.
Honda et al. (1998)CD4T cellsRather, the activation of autoreactive CD4 T cells and the IL-2 production from them were observed.
Mo et al. (2005)CD4T cellIn this study, we show that the female gender is associated with increased CD4(+) T cell CCR1-CCR5 gene and protein expression in mice.
Kitchen et al. (2005)CD4T cellWe have previously demonstrated that costimulation of purified human CD8+ T cells induces de novo expression of the CD4 molecule and that ligation of CD4 on this cell type modulates CD8+ T cell activity in vitro.
Young et al. (2008)CD4T cellsMice that are chronically exposed to 20% (w/v) ethanol in water develop immunodeficiency and have T cells with abnormal activation profiles, reduced total numbers, increased CD4/CD8 ratios, and an increased memory/naïve phenotype ratio.
Yu et al. (2007)CD4T cellPreviously, we have shown that expression of stabilized beta-catenin, the major transcriptional cofactor of T cell factor, results in increase in both CD4SP and CD8SP thymocytes with a preferential effect on CD8SP thymocytes.
Braciak et al. (2003)CD4T cellsImmunization of B10.PL mice with a recombinant adenovirus expressing the TCR Vbeta8.2 chain (Ad5E1 mVbeta8.2), resulted in induction of regulatory type 1 CD4 T cells, directed against the framework region 3 determinant within the B5 peptide (aa 76-101) of the Vbeta8.2 chain.
Sohn et al. (1998)CD4T cellsIn these mice, loss of Jak3 expression was associated with a failure to proliferate in response to antigen receptor crosslinking, the accumulation of T cells manifesting an activated cell surface phenotype, and an increased CD4/CD8 ratio among peripheral T cells, all of which are characteristics that were observed in Jak3-/- animals.
Brohée and Nève (1995)L3T4T lymphocytesNo effect is discernible on CD5+ T lymphocytes, but L3T4 and Lyt2 subpopulations increase in size.
Utsuyama et al. (1991)L3T4T cellsL3T4(CD4)+ T cells were more easily induced than Lyt-2(CD8)+ T cells by aging thymus, resulting in an increase of the ratio of L3T4+/Lyt-2+ T cells with advancing age of thymus donors.
Michael (1991)L3T4T cellsBoth forms of the peptide stimulated in vivo induction of L3T4+ (CD4), and Lyt-2+ (CD8) T cells.
Tada et al. (1990)L3T4T-cellThese results indicate that selective impairment of L3T4+ T cell-mediated immunity is induced in the tumor-bearing state and that such an impairment is ascribed to the dysfunction of L3T4+ T cells themselves, but not of APC required for the activation of L3T4+ T-cell subset.
Weston et al. (1988)L3T4T cellThere is an increase in the expression of Thy-1, L3T4, IL-2R, T cell activating protein, T cell receptor, and T3 complex on the surface of cultured cells.
Okumura et al. (1999)CD4T lymphocytesIn the ovariectomized (OVX) group, the peripheral CD4/CD8 ratio was significantly increased and the ratio of natural killer (NK) cells (CD3-NK1.1+; CD3 negative, NK1.1 positive) to T lymphocytes was decreased compared to the sham control group.
Sobel et al. (2002)CD4T cellsOn the non-autoimmune C57BL/6 (B6) background, the chromosome 7-derived lupus susceptibility loci Sle3 and Sle5 have been shown to mediate an elevated CD4:CD8 ratio with an increase in activated CD4(+) T cells, decreased susceptibility to apoptosis, and a break in humoral tolerance.
Kemp and Bruunsgaard (2001)CD4T cellsTreatment of T cells with phorbol esters, such as phorbol myristate acetate (PMA), induces downregulation of CD4, making unambiguous identification of this subset difficult.
Ridgway et al. (1998)CD4T cellsFollowing antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo.
Ridgway et al. (1998)CD4T cellsWe demonstrate that T cells up-regulate the cell surface expression of CD4 following Ag recognition, which identifies Ag-specific T cells in vitro and in vivo and allows their characterization.
Ji et al. (2005)CD4T cellsAlthough activation of CD4(+) T cells mediates pathogenesis in Leishmania amazonensis (La)-infected mice, these susceptible mice do not develop a polarized Th2 response, suggesting a unique mechanism of disease susceptibility.
Khan et al. (1996)CD4T cellsFurther noted was a clonal activation of several CD4(+) T cell to mitogen or parasite antigen stimulation was observed, in particular Vbeta5 T cells.
Kurts (2008)CD4T cellThe induction of robust CD4(+) and CD8(+) T cell responses is a central aim in antiviral and anticancer vaccination.
Hamdy et al. (2007)CD4T cellCodelivery of antigen and MPLA in PLGA-NP offers an effective method for induction of potent antigen specific CD4(+) and CD8(+) T cell responses.
Lieberman et al. (1995)CD4T cellsIn addition, analysis of both thymocytes and peripheral T cells in these double-transgenic mice indicate that CD4 overexpression also leads to a striking enhancement of T cell maturation in 2B4 TCR-transgenic mice.
Hessel et al. (2010)CD4T cellsIn the lungs, a rapid increase of HA-specific CD4- and CD8 T cells was observed in vaccinated mice shortly after challenge with influenza swine flu virus, which probably contributes to the strong inhibition of pulmonary viral replication observed.
Iwashiro et al. (2001)CD4T-cellThe second mechanism of IFN-gamma-mediated antiviral activity was an enhancement of CD4(+) T-cell-mediated cytolytic activity.
Parent et al. (2005)CD4T cellsToward that end, we report here the identification of three distinct epitopes within the Y. pestis V protein that activate CD4 T cells in C57BL/6 mice.
Burke et al. (2004)CD4T cellsHowever, accumulation of CD4(+) T cells in both sites in the intradermally immunized group was significantly greater than in intravaginally or systemically immunized mice.
Zhou et al. (2005)CD4T cellsThese data suggest that the cellular immune response to acute neurotropic JHMV infection requires a distinct CD4(+) T cell component, but is independent of a requirement for IL-2 for induction, activation, recruitment, and/or maintenance of CD8(+) T cells within the CNS during acute infection.
Eroukhmanoff et al. (2009)CD4T-cellT-cell tolerance induced by repeated antigen stimulation: selective loss of Foxp3- conventional CD4 T cells and induction of CD4 T-cell anergy.
Elvang et al. (2009)CD4T cellsMice vaccinated with the rH4/Ad-H4 combination showed an increase in CD4 T cell activity indicating that rH4 primed CD4 T cells can be boosted by Ad-H4 immunization.
Frausto et al. (2007)CD4T cellsThe inoculation of MOG peptides into C57BL/6 mice induces CD4(+) and CD8(+) T cells, and recent work has shown that adoptive transfer of the latter population, after extensive in vitro stimulation, can cause EAE in naïve recipient mice.
Wang et al. (1996)CD4T cellProtection against malaria by Plasmodium yoelii sporozoite surface protein 2 linear peptide induction of CD4+ T cell- and IFN-gamma-dependent elimination of infected hepatocytes.
Katchar et al. (2007)CD4T cellsConsistent with this, a marked increase in the number of CCR6-bearing lamina propria CD4(+) and CD8(+) T cells was also observed in TNBS-treated animals.
Hopkins et al. (2005)CD4T-cellsIn conclusion, the data presented indicates that subcutaneous administration to mice of SMX-NO, but not the parent drug, stimulated the secretion of high levels of IL-5 from activated CD4(+) T-cells, which is consistent with the clinical profile of the drug.
Dobrzanski and Yang (1992)CD4T lymphocyteThis study demonstrates that prolonged exposure with Staph aureus antigen enhances the cell number and expression of CD4 surface antigen among T lymphocyte subpopulations actively synthesizing DNA in draining MALNs.
Dobrzynski and Herzog (2005)CD4T cellsTolerance induction is associated with activation of regulatory CD4(+) T cells capable of suppressing antibody formation to factor IX protein.
Björck et al. (2008)CD4T cellWe show that murine pDC, as well as myDC, express Fcgamma receptors (CD16/CD32) and can use these receptors to acquire Ag from immune complexes (IC), resulting in the induction of robust Ag-specific CD4(+) and CD8(+) T cell responses.
Gonzalez et al. (2002)CD4T cellsFollowing the transfer of alloreactive CD4(+) and CD8(+) TCR Tg T cells into sublethally irradiated hosts, both Tg T cells populations expand, develop effector function, and cause GVHD.
Tebbey et al. (1998)CD4T cellTherefore, we have identified an association between peptide 184- 198 of natural G protein and the CD4(+) T cell-mediated induction of pulmonary eosinophilia after live RSV challenge.
Bani et al. (2006)CD4T cellsTreatment with extract showed significant increase in CD4 and CD8 counts as compared to control and cyclopsorin A, with a faster recovery of CD4+ T cells in immunesuppressed animals.
Barouch et al. (2002)CD4T cellCoadministration of a plasmid expressing GM-CSF with the gp120 DNA vaccine led to only a marginal increase in gp120-specific splenocyte CD4(+) T cell responses.
Finco et al. (1997)CD4T cellInduction of CD4+ T cell depletion in mice doubly transgenic for HIV gp120 and human CD4.
Yang et al. (2008)CD4T cellIn unmanipulated dnTGFbetaRII mice, there was a marked increase in CD4(+) and CD8(+) T cell biliary infiltrates with AMA.
Halim et al. (2000)CD4T cellUsing a test recombinant, we showed that prior exposure to the parental CB4-P virus did not affect the ability of the recombinant to induce a CD4(+) T cell response against the foreign sequence.
Zariffard et al. (2009)CD4T cellsFlow cytometric and mRNA analysis of human CD4 in vaginal tissue suggested that HSV-2 infection increased the number of T cells expressing human CD4 in vaginal tissue.
Behrens et al. (2004)CD4T cellThis requirement for activated CD4 T cell help for induction of primary CD8 T cell-mediated immunity to tissue Ags contrasts recent reports suggesting that help is only important for CTL memory.
Buckner and Ziegler (2004)CD4T cellsAdditionally, in vitro induction of TR cells by activation of CD4+CD25- T cells in the presence of TGF-?
Chirmule et al. (1998)CD4T cellsEvaluation of the E1 deletion vector in C57BL/6 mice demonstrated dose-dependent activation of both CD4 T cells (i.e., TH1 and TH2 subsets) and neutralizing antibodies to viral capsid proteins.
McAdam et al. (2000)CD4T cellsWe used two methods to investigate the role of ICOS in activation of CD4(+) T cells.
Salinas-Carmona et al. (2006)CD4T cellsAn increase in CD45R and CD4 T cells was unrelated to protective immunity.
Smith and Cheers (2005)CD4T cellsHowever, this response was dependent upon the presence of structurally intact LLO, suggesting a requirement for the innate recognition of LLO in the activation of the CD4(+) and CD8(+) T cells.
Lech et al. (2008)CD4T cellIn the absence of Sigirr, CD4 T cell numbers were increased and CD4(+)CD25(+) T cell numbers were reduced.
Akkerman et al. (2004)CD4T cellThese findings indicate that CD4+T cell activation through CD28 is critical for disease initiation in this model but plays little role in disease progression or tissue damage.
Sharma et al. (2000)CD4T lymphocytesIn immunocompetent mice, intratumoral SLC injection led to a significant increase in CD4 and CD8 T lymphocytes and dendritic cells, infiltrating both the tumor and the draining lymph nodes.
Ellies et al. (1996)CD4T cellsPositive selection in these mice results in an increase in the production of CD8 and CD4 SP T cells, respectively, which express the transgenic TCR.
Krishnamurthy et al. (2008)CD4T cellTCR transgenic mice with CD8(+) T cells specific for IGRP(206-214) (NOD8.3 mice) develop accelerated diabetes that requires CD4(+) T cell help.
Suda and Zlotnik (1992)CD4T cellsIn this study, we screened cytokines for their capacity to induce CD4 or CD8 in murine thymic pre-T cells cultured with IL-7.
Humphreys et al. (2007)CD4T cellsHere, we show that T cell immunity in the salivary glands is limited by the induction of CD4 T cells expressing the regulatory cytokine interleukin (IL)-10.
Humphreys et al. (2007)CD4T cellsThe mucosa-specific protection afforded by IL-10R blockade was associated with an increased accumulation of CD4 T cells expressing interferon gamma, suggesting that IL-10R signaling limits effector T cell differentiation.
Alam et al. (2010)CD4T-cellsActivation of diabetogenic CD4 T-cells by purified B-cells was assessed in both groups.