Viewing negative mentions of positive regulation of Cd4 (M. musculus) in T cells

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Chesnutt et al. (1998)CD4T cellsThese findings indicate that (1) lymphoproliferation in MRL/lpr mice does not require the expression of CD4; (2) autoantibody production in MRL/lpr mice is dependent on the expression of CD4 and not on the accumulation of DN T cells; and (3) the development of nephritis in MRL/lpr mice involves both CD4-dependent and CD4-independent mechanisms.
Lamontagne et al. (2001)CD4T cellsThese results indicate that the attenuated phenotype of the YAC-MHV3 virus is related to two different mechanisms: the first involves no increase of intrahepatic CD4(+)alphabeta - TCR(inter) or NK-T cells, while the second favors the recruitment and activation of CD8(+) cells in liver.
van den Berg et al. (2010)CD4T cellDifferent mechanisms regulate CD4(+) T cell independent induction of oral and nasal tolerance of CD8(+) T cells.
Hanson et al. (2004)CD4T cellImmunization with this peptide (tumor-derived extracellular signal-regulated kinase-II (tERK-II)) induced Ag-specific CD4(+) T cell effector function, but did not directly prime CD8(+) T cells.
Fehr et al. (2010)CD4T cellsBy generating mice lacking NFAT1 in CD4 but not CD8 cells, we demonstrate that NFAT1 is neither required for CD4 tolerance induction nor for their regulatory function on CD8 T cells.
Maury et al. (2001)CD4T cellsIn contrast, nonalloreactive T cells started to divide later and did not up-regulate CD69, CD25, and CD4.
Stoitzner et al. (2005)CD4T cellThe latter modality, however did not induce strong CD4 T cell tolerance in this model.
Marathias et al. (1994)CD4T cellsCD4 expression on pulmonary T cells did not increase after 72 hours of ex vivo culture in complete medium but was restored toward control levels by stimulation with phytohemagglutinin, anti-CD3, or interleukin-2.
Bardos et al. (2003)CD4T cellsSimilarly, depletion of the CD4+CD25+ T cells did not enhance the onset of the disease or disease severity in severe combined immunodeficient mice.
Barclay et al. (2008)CD4T cellDuring the peak of infection (days 6–8), competition was CD4+T cell independent so that the extent of competitive suppression of clone DK was similar in intact control and CD4+T cell-depleted mice (figure 2a,c; table 3).
Veillette and Fournel (1990)CD4T-cellContrary to what we have previously reported for an antigen-dependent murine T-cell clone, as well as murine thymocytes, the CD4 induced activation of p56lck observed in fibroblasts does not result in marked changes in Lck tyrosine phosphorylation, suggesting that other lymphoid specific components may be required for these tyrosine phosphorylation changes.
Pasare and Medzhitov (2004)CD4T cellIn addition we show that a TLR-induced signal(s) is required for memory CD4 T cell differentiation, but not for activation of memory T cells.
Inobe and Schwartz (2004)CD4T cellCTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance.
Zhong et al. (2000)CD4T cellThis vaccination strategy induced strong CD4+ T cell memory to the peptide, but did not induce Abs specific for the Sendai virus virion.
Denecke et al. (2010)CD4+T-cellsHowever, these phenotypical changes did not correspond with functional properties as intracellular cytokine production by CD4+T-cells was not enhanced.
Schulz and Mellor (1996)CD4T cellIn contrast, tolerance to MHC class II-restricted self peptides derived by processing of such MHC I antigens is not induced in the CD4 T cell compartment.
Tian et al. (2005)CD4T cellInterestingly, DC were not required for the secondary CD4+ T cell response following Mtb infection in peptide-vaccinated mice.
Peters et al. (2009)CD4T cellWe also conclude from these observations that there is no requirement for a microbial or danger signal for CD4 T cell activation.
van Wijk et al. (2007)CD4T cellRESULTS: Oral tolerance to PE could not be induced in CD4+CD25+ T cell-depleted mice.
Catalfamo et al. (2008)CD4T cellsRapid activation-induced CTLA-4 surface expression in mouse CD4+CD25+ T cells is independent of protein synthesis and Rab-27a.
Coudert et al. (2002)CD4T cellThus, Th2 differentiation is a major pathway of alloreactive CD4 T cell development during solid organ transplant rejection, as long as host NK and CD8 T cells are not activated.
Tada et al. (1990)L3T4T-cellThese results indicate that selective impairment of L3T4+ T cell-mediated immunity is induced in the tumor-bearing state and that such an impairment is ascribed to the dysfunction of L3T4+ T cells themselves, but not of APC required for the activation of L3T4+ T-cell subset.
Sugihara et al. (1989)L3T4T cellThyroiditis was also induced by injection of Lyt-1dull L3T4+ but not of Lyt-1dull Lyt2+ T cells, indicating the critical role of a part of L3T4+ T cell subset (Lyt-1dull L3T4+ T cell subpopulation) in inducing thyroiditis.
Viguier et al. (1987)L3T4T cellsUsing a large panel of human cells with various haplotypes, our results also showed that (a) nonpolymorphic determinants of HLA class II antigens trigger dominantly the murine T cells and (b) the xenogeneic response required I-E and L3T4 accessory molecules and was not inhibited with anti I-A and monomorphic anti-HLA class II antigen monoclonal antibodies.
Lütjen et al. (2006)CD4T cellsCollectively, these findings illustrate that CD4 T cells are not required for the induction and maintenance of parasite-specific CD8 T cells but, depending on the stage of infection, the infected organ and parasite challenge infection regulate the functional activity of intracerebral CD8 T cells.
Chun et al. (2004)CD4T cellAfter treatment of sLAG-3Ig in fetal thymic organ culture from DO11.10 transgenic mouse, CD4(+) T cell precursors were increased in the positive selection but not affected in the negative selection.
Shu et al. (2007)CD4T cellsSinomenine did not significantly alter the expression of bcl-2 in activated CD4(+) primary T cells, suggesting that bcl-2 might not be involved in sinomenine-induced T cells apoptosis.
Broomfield et al. (2009)CD4T cellBecause local imiquimod treatment did not induce significant CD4 T cell responses, we investigated the efficacy of combining imiquimod with agonistic CD40 Ab (as a surrogate for CD4 T cell help).
Chen et al. (2008)CD4T-cellStudies using the 4.1 TCR transgenic system found thymic or peripheral deletion as well as anergy and ignorance do not contribute to CD4 T-cell tolerance induction in NOR mice (13).
Kemball et al. (2009)CD4T cellsWe report herein that CVB3, despite replicating to remarkably high titers in vivo (up to 1010 PFU/gram in some tissues), does not induce marked activation of CD4+ or CD8+ T cells.
Marrack et al. (1983)L3T4T cellThese results showed that the L3T4 molecule was not required for surface expression of, or functional activity of, the T cell receptor for Ag/MHC.
Schallenberg et al. (2010)CD4T cellsThe results indicated that DC-targeted T reg cell conversion of adoptively transferred TCR transgenic CD4+ T cells is not enhanced in IL-6 gene-targeted recipients or upon treatment of IL-6–proficient recipients with neutralizing anti–IL-6 mAbs (unpublished data).
Krishna and Varki (1997)CD4T cellsTethering 9-O-acetylated mucins with the Influenza C probe with or without secondary cross-linking did not cause activation of CD4 T cells.
McCausland et al. (2007)CD4T cellSAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase.
Chensue et al. (1986)L3T4T cellsIn contrast, PGF did not ameliorate splenomegaly, but caused increases in splenic asialo-GM1 (natural killer cells) and L3T4 (helper) positive T cells.
Rozzo et al. (1994)CD4T cellStrains without lupus-like disease, including NZB.H-2b mice, demonstrated no increase in CD4+ T cell numbers with age.
Krulová et al. (2002)CD4T-cellThe results thus show CD4(+) T-cell-dependent, alloantigen-induced production of NO by graft-infiltrating macrophages and the role of NO in the rejection reaction.
CHOI and KROPF (2009)CD4T cellsWe can exclude that apoptosis was more prominent in any of the cultures, since there was no increase in caspase+ CD4+ T cells (P.
Suto et al. (2008)CD4T cellsUnder Th17-polarizing conditions, IL-21–producing CD4+ T cells were also detected at day 1, but the frequency of IL-21–producing CD4+ T cells was not increased thereafter (Fig. 4).
Ribeiro et al. (2010)CD4T cellThus, vaccines tested in recent efficacy trials failed to induce CD8+ and especially CD4+ T cell responses in a significant proportion of vaccinees.
Span et al. (1996)CD4T-lymphocytesExcept for a trend toward an increased CD4/CD8 ratio, no statistically significant differences for B- and T-lymphocytes could be observed.
Barlow et al. (2004)CD4T lymphocytesDevelopment of dermatitis in CD18-deficient PL/J mice is not dependent on bacterial flora, and requires both CD4+ and CD8+ T lymphocytes.
Qi and Staerz (1998)CD4T cellsAs a consequence CD4+ T cells with specificity to Hab-coated stimulator cells cannot engage their CD4 molecules and are no longer activated.
Bix et al. (1998)CD4T cellsHere, we show that this bias arises not from an increase in the amount of IL-4 produced per cell, but rather from an increase in the proportion of CD4(+) T cells that commit to IL-4 expression.
Iijima et al. (2008)CD4T cellsHSV-2 virus (4–7), suggesting that the protection requires CD4 T cells but not CTL or Ab responses.
Chentoufi et al. (2010)CD4T-cellInterestingly, surgical closure of NLDs did not significantly alter local ocular mucosal CD4(+) T-cell responses induced following topical ocular immunization but did significantly enhance systemic CD4(+) T-cell responses (as measured by both T-cell proliferation and gamma interferon (IFN-gamma) production; P < 0.005).
Espinoza et al. (2010)CD4T cellSurprisingly, in our model, no increase in CD4+ T cell activation was observed.
Tacchini-Cottier et al. (2004)CD4T cellsNotch1 expression on T cells is not required for CD4+ T helper differentiation.
Wang et al. (1993)CD4T cellsHigh concentration of calcium ionophore alone induces the expression of J11d antigen, but not of CD4, CD8, and activation antigens such as interleukin 2 receptor as well as transferrin receptor by J11d- DN T cells from lpr mice.
Suffner et al. (2010)CD4T cellIn contrast, Foxp3.LuciDTR-3 mice displayed only approximately 70% Treg depletion without concomitant activation of CD4(+) T cells and represented, therefore, a suitable model to study Treg homeostasis in an environment where other T cell populations were not altered.
Lei et al. (2008)CD4+T cellsHowever, the frequency of CD4+CD25+Foxp3+T cells was not increased in mice with penetrating ocular injury 24 h or 48 h following an AC injection of antigen.
Zhou et al. (2008)CD4T cellsMany of these molecules were highly upregulated in the CD8+ NKT-like cells but not upregulated in the cultured CD4+ T cells or activated CD8+ T cells.
Wainberg et al. (1993)CD4T lymphocytesInfection by HIV-1 of monocyte cell lines, in contrast to T lymphocytes, did not lead to decreased steady-state levels of CD4 mRNA.
Rynda et al. (2008)CD4T cellsNo FoxP3(+)CD25(+)CD4(+) T cells were induced in OVA-psigma1-dosed IL-10-deficient (IL-10(-/-)) mice, and despite showing increased TGF-beta1 synthesis, these mice were responsive to OVA.
Radosevi? et al. (2008)CD4T-cellWhile the virosomal adjuvanted pandemic influenza vaccine efficiently induced CD4(+) T-cell response, with no further increase upon adjuvation, the CD8(+) T-cell responses induced with virosomal adjuvanted vaccine could be significantly improved upon additional adjuvation with MATRIX-M or MF59.
Lopes and DosReis (1996)CD4T-cellIn vivo injection of anti-CD3 into acutely infected mice, but not into control mice, led to splenocyte DNA fragmentation and failed to increase splenic CD4+ T-cell numbers.
Kursar et al. (2008)CD4T cellIn splenectomized lymphotoxin-beta receptor-deficient mice, lacking all secondary lymphoid tissues, oral infection with L. monocytogenes failed to induce bacteria-specific CD4(+) and CD8(+) T cell responses.
Tundup et al. (2008)CD4T cellsNo significant increase in CD4+ (0.14%) and CD8+ (0.61%) T cells were observed when cells from naďve mice or mice immunized with buffer only (data not shown) were stimulated with different species of proteins.
Eto et al. (1991)CD4T cellsAt this stage, the Thy-1.1+ T cells were not detected in the C3H thymus, suggesting that the obvious decrease of CD4(+)-V beta 3+ T cells of AKR origin was not due to intrathymic clonal deletion in the recipient C3H mice.
Rao et al. (1996)CD4T cellsT cell subset depletions demonstrated that the in vivo activity of IL-12 was largely independent of CD4+ T lymphocytes, whereas the in vivo activity of a B7-1 rVV required both CD4+ and CD8+ T cells to elicit maximal therapeutic effect.
Zola et al. (2009)CD4T cellsThis effect on colonization did not require either CD4- or CD8-positive T cells.
Mendel and Shevach (2006)CD4T cellsHere, we demonstrate that the OX40L can be induced on murine CD4(+) and CD8(+) T cells after 6 days of culture under T helper type 1 (Th1) conditions, but not under Th2 conditions.
Brawand et al. (2000)CD4T cellsDespite minor alterations in the TCR repertoire of CD8+ T cells in the transgenic lines, precursors of functional tumor-specific CD8+ T cells exist but could not be activated most likely due to a lack of appropriate CD4+ T cell help.
Wernimont et al. (2010)CD4T cellCalpain 4 is not required for CD4+ T cell migration
Wernimont et al. (2010)CD4T cellCalpain 4 is not required for CD4+ T cell proliferation
Wernimont et al. (2010)CD4T cellCalpain 4 is not required for CD4+ T cell apoptosis
Farah et al. (2001)CD4T lymphocytesSystemic depletion of CD4+ and CD8+ T lymphocytes alone did not increase the severity of oral infection compared to that of controls.
Shim et al. (2010)CD4T cells-producing cells were increased in CD4+ and CD8+ T cells from mice immunized with PEI/pci-S whereas IL-17-producing cells were increased only in CD4+, not CD8+ T cells.
Cho et al. (2001)CD4T cellIn addition, the in vivo proliferative responses elicited by a non-APC-specific plasmid administration were dependent on TAP, but were independent of CD4(+) T cell help.
Mintern et al. (2002)CD4T cellThese findings suggest that when precursor frequencies are high, priming of CD8 T cell responses may not require CD4 T cell help.
Lee et al. (2003)CD4T cellsThese studies highlight a new function for macrophage-derived chemokine by demonstrating that it possesses in vivo antitumor activity with CD8 T cells as the effector cells, and interestingly, that the CD4 cell/MHC II pathway of CD8 cell activation is not required for the antitumor effects of this chemokine.
Nakano et al. (1996)CD4T lymphocytesWe investigated the immune response of lymph node cells to the viral SAG encoded by endogenous Mtv-2 (vSAG-2) by i.v. injecting splenocytes from Mtv-2+ mice into Mtv-2- congenic counterparts. vSAG-2 stimulation induced blastogenesis and DNA synthesis but not subsequent specific expansion of V beta 14+CD4+ or CD8+ T lymphocytes.
Mortaz et al. (2009)CD4T cellsThe role and amounts of CD4+T cells in COPD is not well documented but early studies reported that cigarette smoke exposure led to a specific decrease in the percentage of activated CD4+T cells, but not CD8+T cells in the lung [37].
Li et al. (2004)CD4T cellFurther functional analyses of Mig indicate that expression in tumors can induce CD4+ but not CD8+ T cell infiltration.
Aude-Garcia et al. (2000)CD4T cellsSecond, there is a strikingly different distribution of the Valpha2 family members in CD4 and CD8 populations of Vbeta6 but not of Vbeta8.2 T cells, irrespective of the presence of Mtv-7 SAg.
Uren et al. (2003)CD4T cellSubsequent experiments showed that OVA-specific CD4(+) T cell expansion following OVA feeding was not elevated in pIgR(-/-) mice.
Garcia and Miller (1998)CD4T cellsCD4 T cells from old mice have baseline levels of Zap-70 activity similar to those seen in activated T cells from young mice, and these levels do not increase after CD3/CD4 cross-linking.
Giri et al. (2008)CD4T cellsexpression in both CD8+ and CD4+ T cells while exosomes from uninfected cells failed to induce IFN-?.
Sanni et al. (2002)CD4T cellUK donors with positive IL-10 production to peptides pools 2 and 3 had no positive CD4 T cell response.
Mantel et al. (2007)CD4T cellUpon administration of rmIL-4 plus anti-IL-4 mAb complexes, the total number of CD4+CD25+ T cell, as well as the Foxp3+ T cells diminished by half (Figure S2G and S2H), confirming that the lower percentage was not due to an increase in the CD4+CD25– cells, but a real decrease of CD4+CD25+ T cells.
van Oers et al. (1993)CD4T cellsFurthermore, constitutive phosphorylation of TCR zeta in T cells occurred independently of antigen stimulation and did not require CD4 or CD8 coreceptor expression.
Nico et al. (2010)CD4T cellsThis is not the case for the NH36sap vaccine which stimulates similar proportions of both subsets of T cells (the mean of CD4?
Brod et al. (1990)CD4T cellThe addition of excess rIL-4 increased the expression of CD8 on the surface of CD4+ T cell clones but did not increase CD4 expression on CD8+ T cell clones.
Hele et al. (2001)CD4T-cellSuga et al [49], studying the involvement of RANTES, showed that treating isografts with recombinant RANTES did not induce fibroproliferative airway obliteration despite increasing CD4+ T-cell migration.
Takano et al. (2007)CD4T cellOrally administered capsicum extract and capsaicin did not change the T cell subset (CD4(+) and CD8(+)), Th1 (IFN-gamma(+)) and T2 (IL-4(+)) ratio.
Jin et al. (2010)CD4T-cellsHowever, PIKA did not activate CD4+ and CD8+ T-cells [138].
Popmihajlov et al. (2008)CD4T cellsA saturating IL2 concentration (10 nM) did not accelerate FOXP3 expression by either CD4+ or CD8+ T cells (Fig 2).
Maruyama et al. (2007)CD4T cellsThe antigen-independent activation of type 1 CD4 T cells accelerate the clearance of pathogens by activating innate immune cells with type 1 cytokines.
Gonzalo et al. (1995)CD4T cellsHere we show that cellular interactions mediated by ICAM-1 are not essential for the induction of anergy or for the deletion of CD4+ V beta 8+ or CD8+ V beta 8+ T cells, but are required for the proliferation of these peripheral T lymphocytes.
Eylar et al. (1995)CD4T-cellsThese data are not compatible with the TH1/TH2 switch hypothesis since IL-4 production is decreased, not increased for CD4+ HIV+ T-cells and while IL-2 production is decreased with PMA, it is not decreased significantly with anti-CD28.
Siracusa et al. (2008)CD4T cellHowever, these same cells did not mediate antigen-specific T cell proliferation and dampened the proliferation of CD3/CD28-activated CD4+ T cells.