Viewing affirmative mentions of negative regulation of Cd8a (M. musculus) in T cells

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Araki et al. (2004)CD8T cellsThe suppression of HTNV-specific CD8(+) T cells in the present model appears to occur at the periphery.
Kim and Welsh (2004)CD8T cellsComprehensive early and lasting loss of memory CD8 T cells and functional memory during acute and persistent viral infections.
Kim and Welsh (2004)CD8T cellMemory CD8 T cell loss occurred very early (day 2) after infection, and was thereafter sustained, consistent more with an active deletion model than with a competition model.
Maile et al. (2006)CD8T cellReduced expression of CD8 acts to limit a T cell response to HY peptide by limiting the avidity window of effective signal transduction.
Maile et al. (2006)CD8T cellsWe show here that CD8(lo) T cells can suppress naive CD8(+) T cell responses to HY antigen in vitro and male skin graft rejection in vivo after adoptive transfer into female recipients.
Potula et al. (2006)CD8T lymphocytesAlcohol-mediated immunosuppression in ethanol-fed mice was manifested by a significant decrease in CD8(+)/interferon-gamma(+) T lymphocytes, a fivefold increase in viremia, and diminished expression of immunoproteasomes in the spleen.
Lang et al. (2008)CD8T cellLack of platelet-derived serotonin in serotonin-deficient mice normalized hepatic microcirculatory dysfunction, accelerated virus clearance in the liver and reduced CD8(+) T cell-dependent liver cell damage.
Fung-Leung et al. (1994)CD8 alphaT cellsCD8 alpha expression on thymocytes and peripheral T cells also decreased to 44 and 53% of the normal levels, respectively.
Furuichi et al. (2005)CD8T cellTherefore, we examined whether CD25(+)CD4(+) regulatory T (Treg) cells might be involved in a inhibition of CD8(+) T cell priming or in the modulation of the magnitude of the 'peak' antiviral CD8(+) T cell response primed by DNA immunization.
Zhang et al. (1995)CD8T cellsDown-regulation of CD8 on mature antigen-reactive T cells as a mechanism of peripheral tolerance.
Zhang et al. (1995)CD8T cellsOur data suggest that down-regulation of CD8 on the Ag-reactive T cells accounts, at least partially, for the disappearance of HY-reactive T cells from the periphery.
Sawada et al. (1993)CD8T lymphocytesInterestingly, CD8 expression was hardly suppressed in CD4-CD8+ peripheral T lymphocytes, suggesting that the mechanisms of suppression of CD8 is developmentally regulated.
Sawada et al. (1993)CD8T cellsWe propose that the suppression of CD8 expression at CD4-CD8+ stage involves an additional mechanism of negative selection of thymic T cells.
Salem and Hossain (2000)CD8T cellsIn contrast to the effect of acute depletion of CD8(+) T cells before infection, the depletion after infection had no effect on the viral load or number and cytolytic function of NK cells.
Gillanders et al. (1997)CD8T cellsIn addition, CD8+ 1B2+ 2C T cells that survive deletion have decreased CD8 expression levels and a significantly reduced in vitro proliferative response to specific alloantigen (clonal anergy).
Cano et al. (2000)CD8T cellsHistopathologically, depletion of CD8(+) T cells did not disorganize the focal granulomatous lesions developed by both mouse strains.
Perteguer et al. (2001)CD8aT cellsIn the latter, a decrease of CD8a + T cells was noted.
Alyea et al. (2004)CD8T cellsA CD8 murine monoclonal antibody-coated high-density microparticle (HDM) has been developed, which allows for the rapid depletion of CD8+ T cells from apheresis products by gravity sedimentation.
Hoeveler and Malissen (1993)CD8T cellIn marked contrast, the CD8 alpha polypeptides bearing substitutions of both cytoplasmic cysteine residues were totally impaired in their ability to complement the co-expressed T cell receptor.
Zhang et al. (2009)CD8T cellsImportantly, in mice that received GC, there was a significant decrease in the frequency and absolute number of autoreactive liver-infiltrating CD8(+) T cells, accompanied by a significant decrease in activated CD44(high) CD8(+) T cell populations.
Nakagawa et al. (2004)CD8T cellsThese CD8(+) T cells exhibited an antitumor cytotoxicity toward not only B16 cells, but also EL-4 cells, and their cytotoxicity significantly decreased by the depletion of CD122(+)CD8(+) T cells.
Taruishi et al. (2007)CD8T cellsThese results indicate that hantavirus strongly suppresses the production of N-specific CD8(+) T cells throughout the course of infection in persistently infected mice.
Elftman et al. (2010)CD8T cellThe systemic elevation of psychological stress-induced glucocorticoids strongly suppresses CD8(+) T cell immune responses resulting in diminished antiviral immunity.
Nussbaum and Whitton (2004)CD8T cellApproximately 90% of virus-specific CD8(+) T cells die during the contraction phase and, herein, we have attempted to increase the memory pool by reducing CD8(+) T cell death.
Sakaguchi and Sakaguchi (1992)CD8T cellsCsA abrogates the production of CD4+T cells and CD8+T cells in the thymus.
Grayson et al. (2006)CD8T-cellThese experiments demonstrate the critical role of Bim during chronic viral infection to down-regulate CD8(+) T-cell responses and have implications for designing strategies for optimizing immunotherapies during situations where antigen persists, such as chronic infection, autoimmune syndromes, and cancer.
Lustgarten et al. (2004)CD8T cellsThere is a clear decrease in CD8(+) T cell effector function with aging, a loss once thought to be intrinsic to the CD8(+) T cells.
Zhai et al. (2002)CD8T cellsIndeed, unlike anti-CD154 monotherapy, transient depletion of CD8(+) T cells around the time of cardiac engraftment significantly improved the efficacy of delayed CD154 blockade in sensitized hosts.
Ou et al. (2001)CD8T-cellIn this work we studied the down-regulation of the virus-specific CD8(+)-T-cell response during a persistent infection of adult mice, with particular emphasis on the contribution of the interferon response in promoting host defense.
Luo et al. (2004)CD8T cellThe therapeutic effects of hMIP-1beta gene therapy were greatly reduced following in vivo depletion of both CD4(+) and CD8(+) T cells, but were unaffected by depletion of single T cell subsets.
Vizler et al. (1995)CD8T cellsThe effect of the ATS treatment does not rely solely upon the elimination of T cells, since flow cytofluorometric analysis revealed only a partial depletion of both the CD4+ and CD8+ T cells of the ATS-pretreated animals.
Kienzle et al. (2005)CD8T cellsExposure to IL-4 during activation of naive murine CD8+ T cells leads to generation of IL-4-producing effector cells with reduced surface CD8, low perforin, granzyme B and granzyme C mRNA, and poor cytolytic function.
Kienzle et al. (2005)CD8T cellAlthough IL-4 was not required at later times, CD8 T cell clones continued to lose surface CD8 expression with prolonged culture, suggesting commitment to the CD8low phenotype.
Belyakov et al. (2006)CD8T cellThis study demonstrates for the first time a protective adjuvant effect of CpG ODN for a live viral vector vaccine that may overcome CD4 deficiency in the induction of protective CD8(+) T cell-mediated immunity.
Tvinnereim et al. (2002)CD8T-cellChallenge of these immune mice with recombinant L. monocytogenes resulted in rapid control of the infection and decreased CD8(+)-T-cell responses against both the secreted and nonsecreted form of the recombinant antigen compared to the response of naïve mice.
Drake and Lukacher (1998)CD8T cellHere, we investigated the tumorigenicity of polyoma virus in adult mice rendered CD8+ T cell-deficient by homozygous (-/-) disruption of the beta 2-microglobulin (beta 2m) or CD8 alpha (CD8) genes.
Oizumi et al. (2008)CD8T cellHere, we show that established tumors suppress CD8 T cell clonal expansion in vivo, which is normally observed in tumor-free mice upon antigen-specific glycoprotein (gp) 96-chaperone vaccination.
Hoshino et al. (2007)CD8T cellsWe related the latent viral loads, numbers of CD8(+) T cells, and reactivation rates by mathematical equations.
Seavey and Mosmann (2009)CD8T cellThe estradiol-induced mucus barrier may thus prevent exposure to antigens delivered intravaginally, supplementing additional estradiol-dependent mechanism(s) that inhibit CD8(+) T cell priming after insemination or vaginal vaccination.
Seavey and Mosmann (2009)CD8T cellEstradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization.
Grinshtein et al. (2006)CD8T cellsSurprisingly, the numbers of antigen-specific CD8(+) T cells in lethally irradiated mice beyond 6 weeks postimmunization were comparable to the numbers found in nonirradiated controls.
Kim and Welsh (2004)CD8T cellIn this study, the patterns and significance of virus-induced memory CD8 T cell depletion were examined in mice immune to heterologous (Pichinde, vesicular stomatitis, vaccinia) viruses and subsequently challenged with acute or persistent lymphocytic choriomeningitis virus infections.
Kim and Welsh (2004)CD8T cellMemory CD8 T cell loss was comprehensive and occurred in both lymphoid and peripheral tissues of the immune host.
Flood et al. (1998)CD8T cellLoss of resistance to a highly immunogenic tumor with age corresponds to the decline of CD8 T cell activity.
Mody et al. (1994)CD8T cellsIn vivo depletion of murine CD8 positive T cells impairs survival during infection with a highly virulent strain of Cryptococcus neoformans.
Donawho et al. (1996)CD8T lymphocytesAnalysis of lymphoid cells in growing tumors indicated that the number of CD8+ T lymphocytes was reduced in the UV-irradiated site.
Seavey and Mosmann (2009)CD8T cellWe previously demonstrated that estradiol, which induces an estrus-like state, prevented CD8(+) T cell priming during intravaginal immunization of mice.
Hovav et al. (2007)CD8T cellThis resulted in decreased magnitude, accelerated contraction and differentiation, and surprisingly greater secondary CD8(+) T cell responses.
Kim and Welsh (2004)CD8T cellThis study therefore links an early virus-induced lymphopenia to a subsequent long-term loss of CD8 T cell memory and offers a new mechanism for immune deficiency during persistent viral infections.
Ogunwale et al. (2009)CD8T cellsThis may explain the observed reduction in CD8+ T cells observed in patients with metal-on-metal implants.
McKenna and Chen (2010)CD8T lymphocytesConsistent with that notion are observations from transplantable tumor models in mice demonstrating that the tumoricidal activity of CD8(+) cytolytic T lymphocytes (CTL) may be inhibited directly by interfering with CTL effector function in the eye or indirectly by abrogating the effector function of CD8+ T cell-activated intratumoral macrophages that are critical for ocular tumor rejection.
Takahashi et al. (1990)Lyt-2T cellThe response to Concanavalin A (Con A) of spleen cells from BALB/c mice was depressed, and both L3T4+ and Lyt-2+ T cell subpopulations were decreased following the infection, whereas the response to Con A of A/J mice was increased and the T cell subpopulations were not altered significantly.
Nishimura et al. (2009)CD8T cellsThe infiltration by CD8(+) T cells preceded the accumulation of macrophages, and immunological and genetic depletion of CD8(+) T cells lowered macrophage infiltration and adipose tissue inflammation and ameliorated systemic insulin resistance.
Ruckwardt et al. (2009)CD8T-cellFinally, decreasing regulatory T-cell control of the CD8(+) T-cell response had a greater effect on response of the dominant K(d)-restricted M2 epitope consisting of amino acids 82 to 90 (K(d)M2(82-90)) than on the subdominant D(b)M(187-195) epitope response, indicating that regulatory T cells modulate immunodominance disparities in epitope-specific CD8(+) T-cell responses following primary RSV infection.
Liu et al. (2003)CD8T-cellHowever, in both experiments, the total magnitude of the CD8+-T-cell pool was significantly diminished in those that had been infected with gammaHV68 and the influenza A virus.
Baptista et al. (2010)CD8T cellsIt was shown that Plasmodium berghei ANKA-induced cerebral malaria was prevented in 100% of mice depleted of CD8+ T cells 1 day prior to the development of neurological signs.
Moretto et al. (2001)CD8T cellThis is the first evidence of a parasitic infection in which down-regulation of CD8+ T cell immune response in the absence of gamma(delta) T cells has been demonstrated.
Shimada et al. (1996)Lyt-2T cellsThe anti-parasite DTH response in BM-infected mice was significantly enhanced by depletion of Lyt-2+ T cells, while significantly reduced by depletion of L3T4+ T cells.
Badovinac et al. (2003)CD8T cellsUsing an adoptive transfer system with low numbers of trackable nontransgenic memory CD8(+) T cells, we showed that secondary responses can be comprised of both primary (naive) and secondary (memory) CD8(+) T cells after bacterial (Listeria monocytogenes) and/or viral (lymphocytic choriomeningitis virus) infections.
Badovinac et al. (2003)CD8T cellsHowever, similar numbers of Ag-specific CD8(+) T cells were found 8 days postinfection no matter how many memory cells were present at the time of infection.
Anam et al. (2004)CD8T cellsThis study seeks to determine if either the targeted depletion of CD4 and/or CD8 pos T cells or costimulation blockade can substitute for ALS and preserve the efficacy of this regimen.
Anam et al. (2004)CD8T cellsIn contrast, depletion of both CD4 and CD8 pos T cells resulted in durable multilineage chimerism, indefinite allograft acceptance (>350 days), and donor-specific tolerance to secondary skin grafts.
Anam et al. (2004)CD8T-cellCONCLUSION: Either combined CD4 and CD8 T-cell depletion or alphaCD154 blockade can effectively substitute for ALS in producing chimerism and tolerance in this model.
Tarleton (1990)CD8T cellsHowever, CD8 depletion had no effect on suppressed immune responses, suggesting their function in T. cruzi-infected mice is related more to the cytotoxic activity or cytokine-producing capacity of this subpopulation of T cells.
Johnson and Truitt (1992)CD8T cellsEx vivo depletion of donor CD8+ T cells also reduced GVH-associated mortality, but the use of both CD8 and NK depletion offered no improvement over either alone, suggesting an interaction between CD8+ and NK 1.1+ cells.
Badovinac et al. (2003)CD8T cellsDepletion of CD8(+) T cells or treatment with anti-IFNgamma antibody rescued vaccinated mice from mortality.
Jonji? et al. (1990)CD8T lymphocytesEfficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes.
Bucks et al. (2009)CD8T cellsOur findings show that Ag alone is sufficient to drive CD8(+) T cell impairment, that Ag-driven loss of virus-specific CD8(+) T cells is TRAIL mediated, and that removal of Ag reverses exhaustion.
Salem and Hossain (2000)CD8T cellsIn vivo acute depletion of CD8(+) T cells before murine cytomegalovirus infection upregulated innate antiviral activity of natural killer cells.
Salem and Hossain (2000)CD8T cellsIn this study, we investigated the effect of depletion of CD8(+) T cells on the activity of natural killer (NK) cells at an early phase of murine cytomegalovirus (MCMV) infection.
Salem and Hossain (2000)CD8T cellsIn conclusion, the results suggest that an acute depletion of CD8(+) T cells before MCMV infection effectively upregulated the antiviral activity of NK cells.
Myoung et al. (2007)CD8T cellThe level of both virus-specific CD8+ and CD4+ T cell responses is significantly reduced in mice infected with these variant viruses.
Müller et al. (1998)CD8T cellsProtection was abrogated by in vitro depletion of CD8+ T cells prior to transfer of bone marrow.
Siders et al. (2002)CD8T cellsDepletion of CD8(+) T cells, as opposed to natural killer (NK) or CD4(+) T cells, essentially abrogated the therapeutic effect of lipid+pNull complex, thus supporting the involvement of cytotoxic CD8(+) T cells in the antitumor response.
Anderson and Coleclough (1993)CD8T cellsWhen T cells are exposed to a combination of PMA and the calcium ionophore, ionomycin (Cal), surface CD4 virtually disappears for a period of at least 24 h, and CD8 expression is also diminished.
Anderson and Coleclough (1993)CD8T cellsThere appear, therefore, to be two distinct mechanisms for the removal of CD4 and CD8 from mouse peripheral T cells: one induced by PMA alone, the second by the combination of PMA and Cal.
Cano et al. (2000)CD8T cellsDepletion of CD8(+) T cells in vivo impairs host defense of mice resistant and susceptible to pulmonary paracoccidioidomycosis.
Cano et al. (2000)CD8T cellsTreatment with anti-CD8 monoclonal antibodies caused a selective depletion of pulmonary and splenic CD8(+) T cells in both mouse strains.
Cano et al. (2000)CD8T-cellFurthermore, CD8(+) T-cell depletion did not modify delayed-type hypersensitivity reactions of A/Sn mice but increased these reactions in B10.A mice.
Zhang et al. (2001)CD8alphaT cellsDespite loss of CD8alpha expression at the DP CD3(low/intermediate) stage, increased populations of mature CD3(hi)CD4(-)CD8(-) thymocytes and CD3(+)CD4(-)CD8(-) peripheral T cells were detected.
Salem and Hossain (2000)CD8T cellFor CD8(+) T cell depletion, mice were intraperitoneally treated with anti-CD8 mAb, purified from 2.43 hybridoma, for 2 consecutive days before or after infection.
Gahring and Weigle (1990)CD8T cellRemoval of CD8+ cells from lymph node T cells of either young or aged C57BL/6 mice did not increase the antigen-specific proliferative response, suggesting that loss of CD8+ suppressors during the aging process is not responsible for the high level of antigen-specific T cell proliferation in aged C57BL/6 mice.
Yuen et al. (2010)CD8T cellVACV gene A47L is of interest because it is highly transcribed, has no sequence similarity to any nonpoxvirus gene, and contains a larger-than-expected number of CD8(+) T cell epitopes.
Matsushita et al. (2008)CD8T cellsHowever, the reduction in Tregs with CY was also associated with the concomitant reduction of CD8(+) T cells and a lack of tumor antigen priming.
Das and Janeway (1999)CD8alphaT cellsDevelopment of CD8alpha/alpha and CD8alpha/beta T cells in major histocompatibility complex class I-deficient mice.
Kambe et al. (1994)Lyt-2T cellsThese spleen T cells, purified by passing through a nylon fiber column, could be demonstrated to have Thy-1.2 and Lyt-2.1 antigens, and not L3/T4 antigens.
Erard et al. (1985)Lyt-2T cellDifferential requirements for the induction of interleukin 2 responsiveness in L3T4+ and Lyt-2+ T cell subsets.
McElrath et al. (1988)Ly-2T cellsThis was associated with a sharp decline in the L3T4+ T cells of the granulomas and the maintenance of the Ly-2+ subset.
Maile et al. (2005)CD8T cellsSecond, we used genetically lowered CD8(int) T cells from heterozygote CD8(+/0) mice.
Maile et al. (2005)CD8T cellsAll three models demonstrated that lowering CD8 levels resulted in the requirement for a higher avidity peptide-MHC interaction with the TCR to respond equivalently to unmanipulated CD8(high) T cells of the same specificity.
Zipris et al. (1991)CD8T lymphocytesBy onset of diabetes, an even greater decrease (approximately 35%) of CD4+CD8+ and a reciprocal increase of CD4-CD8- T lymphocytes were apparent and accompanied by the same depletion (3%) of V beta 8 lo T lymphocytes.
Bryson et al. (1990)CD8T cellIn vivo depletion of CD8+ T cells was not a prerequisite for enhancement of the SMLR as several mAb to CD8 augmented the SMLR independent of their capacity to cause CD8 T cell depletion.
Chattopadhyay et al. (2008)CD8T cellWe show that: (i) neither ACAID-mediated suppression of DTH to ovalbumin nor splenic Tregs/suppressor T cells was induced in DBA/2J mice that received an injection of antigen into the AC; (ii) splenic CD8+ Tregs from ACAID-induced DBA/2NCr mice suppressed the initiation of DTH when transferred to DBA/2J mice; (iii) following injection of antigen into the AC, intravenous administration of splenocytes or Peripheral Blood Mononuclear Cells (PBMC) isolated from DBA/2NCr but not from DBA/2J mice transferred suppression of DTH to DBA/2NCr mice; (iv) antibodies to CD94/NKG2A reduced the ACAID CD8+ T cell-mediated suppression of DTH and (v) The deficiency of such immune regulation in DBA/2J mice also correlated with a decreased number of Qa-1(b+) B cells, F4/80+ cells, a deficient number of CD94/NKG2AR and Qa-1 tetramer binding by CD8+ T cells.
Deepe (1994)CD8T cellsTreatment with anti-CD8 mAb caused a selective depletion of CD8+ T cells in naive mice infected with H. capsulatum.
Lohman et al. (1996)CD8T-lymphocyteThus, CD95 is not required for the immune downregulation of the CD8+-T-lymphocyte response following acute LCMV infection.