Viewing affirmative mentions of negative regulation of Cd4 (M. musculus) in T cells

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Choquet-Kastylevsky et al. (2001)CD4T-lymphocytesPretreatment with the enzymatic inducers phenobarbitone and betanaphtoflavone, or depletion in CD4(+) T-lymphocytes were not successful either.
Frick et al. (2009)CD4T lymphocyteThis was evidenced by a decrease of mitogen-induced T-cell proliferation, a reduction in CD4(+)T lymphocyte number and a decrease of tumor necrosis factor-alpha (TNF-alpha) and Interferon-gamma (IFN-gamma) production in stressed mice.
Shimizu and Moriizumi (2003)CD4T cellAdvancing age is associated with significant alterations in immune functions, including a decline in CD4 T cell function, in both mice and humans.
Ayash-Rashkovsky et al. (2005)CD4T cellRapid loss of the human CD4+ T cells, decrease in CD4/CD8 ratio, and increased T cell activation accompanied the viral infection.
Cohen et al. (1993)CD4T cellThe murine retroviral model of AIDS (MAIDS) also displays progressive immunodeficiency, but depletion of the CD4+ T cell subset is not characteristic of the disease.
Dondji et al. (2010)CD4T cellsIn addition, depletion of CD4(+) T cells was associated with impaired cellular and humoral (serum and mucosal) immune responses to hookworm antigens.
Ha et al. (2001)CD4T cellsDespite reduction in CD4(+) T-cell numbers, evident in all three lymphoid compartments of the malnourished mice by d 6, energy-restricted mice maintained the numbers of CD4(+)CD45RA(+) T cells at the level found in the zero-time control group.
Taniuchi et al. (2002)CD4T lymphocytesIn mice, mutations in individual sites resulted in variegated, but heritable, derepression of CD4 in mature CD8(+) T lymphocytes, whereas compound mutations resulted in full derepression.
Fecci et al. (2007)CD4T cellPURPOSE: Patients with malignant glioma suffer global compromise of their cellular immunity, characterized by dramatic reductions in CD4(+) T cell numbers and function.
Cheng et al. (1996)CD4T cellThe CD4+ to CD8+ T cell ratios and blastogenic responses to lipopolysaccharide (LPS), but not to concanavalin A, were decreased in immunosuppressed mice compared with nonimmunosuppressed mice.
Mizoguchi et al. (2003)CD4T cellsFactors contributing to the down-regulation of CD4(+) TCRgammadelta T cells have not been identified.
Oliveira et al. (2008)CD4T cellFurthermore, reduced or blocking levels of CD4 expression, can convert T cell responses from stimulatory to inhibitory 48.
Tsuji et al. (1997)CD4T cellsDepletion of CD4, but not of CD8, T cells blocked rejection.
Anderson and Coleclough (1993)CD4T cellsPhorbol esters are known to induce a loss of CD4 from the surface of mouse and human T cells, presumably through activation of protein kinase C.
Anderson and Coleclough (1993)CD4T cellsWhereas PMA causes the disappearance of almost all CD4 from the surface of mouse CD4+8+ thymocytes, it induces only a partial (approximately 60%) and transient (10 to 12 h) loss of CD4 from the surface of mouse peripheral T cells, with no effect on CD8 expression.
Anderson and Coleclough (1993)CD4T cellsThere appear, therefore, to be two distinct mechanisms for the removal of CD4 and CD8 from mouse peripheral T cells: one induced by PMA alone, the second by the combination of PMA and Cal.
Arora et al. (2006)CD4T cellsWe also examined changes in the pulmonary architecture and found that depletion of CD4(+) T cells was associated with a significant reduction in mucus production and goblet cell metaplasia in these mice.
Arora et al. (2006)CD4T cellsOverall, our results show that depletion of CD4(+) T cells prevents the development of Th2 responses seen during ABPM.
Fleming et al. (1993)CD4T cellsAge influences recovery of systemic and mucosal immune responses following acute depletion of CD4 T cells.
Bird et al. (1995)CD4T cellsDepletion of CD4 T cells in mice prior to immunization with 100 micrograms P. gingivalis OM resulted in significantly depressed serum levels of anti-P. gingivalis antibody and an increase in the physical signs of disease compared with both the immunized and control groups.
Zipris et al. (1991)CD4T lymphocytesBy onset of diabetes, an even greater decrease (approximately 35%) of CD4+CD8+ and a reciprocal increase of CD4-CD8- T lymphocytes were apparent and accompanied by the same depletion (3%) of V beta 8 lo T lymphocytes.
Morrison and Morrison (2001)CD4T cellsResolution of secondary Chlamydia trachomatis genital tract infection in immune mice with depletion of both CD4+ and CD8+ T cells.
Morrison et al. (1994)CD4T cellThese results demonstrate that selective decrease of CD4 increased antigen-specific T cell responses.
Xiao et al. (2007)CD4T cellIn our previous report, we described a novel non-peptidic organic ligand of CD4 D1, designated J2, as a potential inhibitor of CD4 D1 and thus CD4-dependent T cell responses in vitro.
Mountz et al. (1990)CD4T cellsThis supports the hypothesis that in lpr/lpr mice, self-reactive CD4+ T cells are eliminated in the thymus, and that these cells lose expression of CD4 and acquire expression of 6B2 in the periphery.
Brabletz et al. (1999)CD4T cellsWe show that ZEB binds to the 5'E-box in the CD4-3 element of the proximal CD4 enhancer in competition with the transcriptional activators E12 and HEB, thereby reducing CD4 expression on CD4 single-positive but not CD4/CD8 double-positive T cells.
Mastino et al. (1992)CD4T-cellselective and dramatic decrease of CD4+CD8+ double-positive, CD3/T-cell-receptor-?
Killeen et al. (1993)CD4T cellsStudies using CD4-transgenic mice indicate that development of single positive T cells involves stochastic downregulation of either CD4 or CD8, coupled to activation of a cytotoxic or helper program, respectively, and subsequent selection based on the ability of the TCR and remaining co-receptor to engage the same MHC molecule.
Silveira et al. (2006)CD4T lymphocytesIts use results in a profound decrease in CD4 positive T lymphocytes.
Silveira et al. (2006)CD4T lymphocytesWe followed a cohort of 449 consecutive transplant recipients who received alemtuzumab to determine the occurrence of bloodstream infections, particularly those previously associated with decrease in CD4 positive T lymphocytes.
Wallace et al. (1992)CD4T cellsMice deficient for CD4 expression provide a unique model system to study the contribution of the CD4 molecule in negative selection of T cells reactive against the major histocompatibility complex class II-associated retroviral self-superantigen, Mls-1a.
Wang et al. (2001)CD4T cellsWe show that loss of CD4 decreases the steady-state proliferation of T cells as monitored by in vivo labeling with bromo-deoxyuridine.
Brown et al. (1997)CD4T cellWe have examined the role of CD4 in peripheral T cell differentiation by studying helper T cells from mice with a congenital defect in CD4 expression.
Nagai et al. (2000)CD4T cellsThis mouse model not only demonstrates the depletion of CD4(+) T cells as a useful strategy for cancer gene therapy with interleukin-12 but also provides a model for human melanoma-associated vitiligo.J Invest Dermatol 115:1059-1064 2000
He et al. (1999)CD4T cellsCONCLUSIONS: These results demonstrate that the inhibition of intestinal allograft rejection associated with mAb treatment is not attributable solely to depletion of CD8 or CD4 T cells.
Martignoni et al. (2008)CD4T cellsHere, we observed a significant depletion of both CD4 and CD8 T cells in human patients after blunt trauma.
Pazirandeh et al. (2004)CD4T cellsFurthermore, CD4(+) T cells were more affected than CD8(+) T cells, resulting in a decrease in the CD4/CD8 T-cell ratio.
Murali-Krishna et al. (1996)L3T4T cellSpecific depletion of Lyt 2.2+, L3T4+ or Thy-1+ T cell populations before adoptive transfer abrogated the protective ability of transferred effectors.
Sano et al. (1988)L3T4T cellThe results are discussed in relation to the selective suppression of the L3T4+ but not of Lyt-2+ T cell function in the tumor-bearing state.
Hanna et al. (2006)CD4T cellsFlow cytometry analysis showed that downregulation of murine CD4 was severely decreased or abrogated on Tg T cells expressing respectively Nef(RD35/36AA) and Nef(D174K).
Kemp and Bruunsgaard (2001)CD4T cellsTreatment of T cells with phorbol esters, such as phorbol myristate acetate (PMA), induces downregulation of CD4, making unambiguous identification of this subset difficult.
Rijhsinghani et al. (1997)CD4T cellAll CD4 and CD8 defined T cell subsets were reduced with a disproportionate loss of CD4+ single positive (SP), CD8+ SP: CD4+CD8+ double positive (DP) cells.
Cheng and Lopez (1998)CD4T cellsInterestingly, phosphatidyl serine (PS) down-regulated the IFN-gamma production of CD4+, but not that of CD8+, T cells.
Marodon and Rocha (1994)CD4T cellsFurther differentiation results in CD4 down-regulation and the transition from DPTcR(hi) into CD8+CD4(lo) TcR(hi)HSA(lo) and +D8SPTcR(hi)HSA- T cells.
Luo et al. (2004)CD4T cellThe therapeutic effects of hMIP-1beta gene therapy were greatly reduced following in vivo depletion of both CD4(+) and CD8(+) T cells, but were unaffected by depletion of single T cell subsets.
Lu et al. (2002)CD4T cellsThe therapeutic effects of H5BVIFN-beta were not observed in nude mice and were diminished in syngeneic mice depleted of CD4(+) and CD8(+) T cells.
Berges et al. (2006)CD4T lymphocytesA central hallmark of HIV infection is the gradual depletion of CD4 T lymphocytes, which are primary targets of HIV infection.
Berges et al. (2006)CD4T cellFive of seven infected mice exhibited depletion of CD4 T cells for at least 9 weeks (Fig. 6B–D), whereas none of the uninfected mice showed any CD4 T cell loss (Fig. 6A).
Berges et al. (2006)CD4T cellCD4 T cell depletion was first detected at 3 weeks post-infection and in one case persisted through at least 24 weeks (mouse #16) as shown in Fig. 6B.
Berges et al. (2006)CD4T cellOn subsequent analysis at 30 weeks, this mouse continued to display CD4 T cell depletion at 6% of initial levels (data not shown).
Berges et al. (2006)CD4T cellA representative FACS plot showing selective CD4 T cell loss over a 20 week time period for mouse #16 is shown in Fig. 6E.
Berges et al. (2006)CD4T cellMouse #16 displayed a more sustained CD4 T cell depletion at 6, 9, 11, 20, 24 and 30 weeks post-infection (up until the last time point evaluated).
Cowdery et al. (1991)CD4T cellsTwice-weekly injections of 50 micrograms of monoclonal antibody GK1.5 for a period of three weeks resulted in a 50% reduction of splenic CD4 T cells.
Sacquin et al. (2008)CD4T cellsAfter a single injection of P9, the number of IFN-gamma secreting CD4+ T cells was also reduced in mice 8- to 10-wk postinfection compared with healthy mice.
Vizler et al. (1995)CD4T cellsThe effect of the ATS treatment does not rely solely upon the elimination of T cells, since flow cytofluorometric analysis revealed only a partial depletion of both the CD4+ and CD8+ T cells of the ATS-pretreated animals.
Myoung et al. (2008)CD4T-cellInterestingly, P1-Tg mice with the B6 background showed severe reductions in both CD4(+) and CD8(+) T-cell responses to capsid epitopes, while P1-Tg mice with the SJL background displayed transient reductions following viral infection.
Müller and Kyewski (1995)CD4T cellHere, we show that antibody-mediated TcR signaling in mice deficient for CD4 or MHC class II expression induces polyclonal differentiation of the CD4 T cell lineage.
Dearstyne and Kerkvliet (2002)CD4T cellOur results show that the TCDD-induced decrease in CD4(+) T cell number correlated with an increase in the percentage of dead cells, but not with cells expressing an early apoptotic phenotype.
Pelchen-Matthews et al. (1993)CD4T cellsThe phorbol ester phorbol myristate acetate (PMA) induces a rapid downregulation of CD4 from the surface of T cells and lymphocytic cell lines, as well as from CD4-transfected nonlymphoid cells.
Edling et al. (2001)CD4T cellThese combined results suggest the potential therapeutic value of 802-2 for inhibition of CD4(+) T cell neuroimmunological responses.
Nakamura et al. (1996)CD4T lymphocytesInhibition of protein kinase C-mediated CD4 down-regulation by oxidative stress in T lymphocytes.
Demols et al. (2000)CD4T-cellThe severity of pancreatitis is also reduced by in vivo CD4(+) (but not CD8(+)) T-cell depletion and in Fas ligand-targeted mutant mice.
Faubel et al. (2005)CD4T-cellPeripheral CD4 T-cell depletion is not sufficient to prevent ischemic acute renal failure.
Faubel et al. (2005)CD4T cellsRESULTS: Flow cytometry of lymph nodes and immunohistochemistry of kidneys demonstrated complete depletion of CD4+ T cells in mice with ischemic ARF treated with GK 1.5.
Via and Shearer (1988)L3T4T cellsSurprisingly, the suppressor cells are also L3T4+ T cells and can suppress the IL-2 production of congenic MRL/+ L3T4+ Th to MHC-self-restricted antigens.
Fei et al. (2010)CD4T cells90%), and negative depletion of CD4+CD25- T cells, as measured by flow cytometry (FACSan, Becton Dickinson, Franklin Lake, NJ, USA).
Li et al. (1995)CD4T cellsBombesin also reversed IV TPN decreases in CD4+ and CD8+ T cells in the intraepithelial spaces and Peyer's patches and prevented the decrease in the CD4/CD8 ratio in the lamina propria.
Anam et al. (2004)CD4T cellsThis study seeks to determine if either the targeted depletion of CD4 and/or CD8 pos T cells or costimulation blockade can substitute for ALS and preserve the efficacy of this regimen.
Anam et al. (2004)CD4T cellsIn contrast, depletion of both CD4 and CD8 pos T cells resulted in durable multilineage chimerism, indefinite allograft acceptance (>350 days), and donor-specific tolerance to secondary skin grafts.
Alderuccio et al. (2000)CD4T cellsDespite the reduction in intrathymic CD4(+) T cells, V(beta)8. 3-expressing T cells comprised the majority (>90%) of peripheral spleen and lymph node T cells.
Skowronski et al. (1993)CD4T cellsThe differential effects of the two HIV-1 nef alleles in transgenic mice correlate with down-regulation of CD4 antigen expression on thymic T cells.
Kabelitz et al. (1997)CD4T cellsCytotoxicity assays performed with purified gammadelta T cells as effectors and resting or preactivated autologous CD4 T cells as targets failed to reveal evidence for autoreactive cytotoxicity of Vgamma3/Vdelta3 cells as a possible mechanism of CD4 T-cell deficiency in this patient.
Jamali et al. (1992)CD4T cellsActivation of T cells by exposure to anti-CD3 rendered them resistant to antibody-mediated CD4 depletion.
Jamali et al. (1992)CD4T cellsActivating T cells with immobilized anti-CD3 before addition of anti-CD4 prevented down-regulation of CD4.
Burns et al. (1999)CD4T cellWhile many of these defects were transient, the significant decrease in CD4(+) versus CD8(+) T cell ratio persisted peripherally.
Belyakov et al. (2006)CD4T cellThis study demonstrates for the first time a protective adjuvant effect of CpG ODN for a live viral vector vaccine that may overcome CD4 deficiency in the induction of protective CD8(+) T cell-mediated immunity.
Zhang et al. (2007)CD4T cellCD137 is expressed on activated T cells and ligands to this costimulatory molecule have clinical potential for amplifying CD8 T cell immunity to tumors and viruses, while suppressing CD4 autoimmune T cell responses.
Watanabe et al. (2008)CD4T cellsIntracellular IFN-gamma staining revealed that the transfer of MDSC resulted in a decrease in numbers of tumor-specific CD4(+) and CD8(+) T cells.
Welsh et al. (2010)CD4T cellsUsing immunodominant viral peptides specific for identification of either CD4(+) or CD8(+) T cells, stress reduced IFN-gamma-producing virus-specific CD4(+) and CD8(+) T cells in the spleen and CD8(+) T cells in the CNS.
Mansouri et al. (2003)CD4T-cellHere, we show that M153R also downregulates the T-cell coreceptor CD4 and we study the molecular mechanism by which M153R achieves the downregulation of CD4 and MHC-I.
Hsiung et al. (1994)CD4T-lymphocytesBoth liquid control and liquid ethanol diets caused a slight decrease in the CD4:CD8 ratios of splenic T-lymphocytes.
Ly et al. (2005)CD4T cellDietary n-3 polyunsaturated fatty acids suppress splenic CD4(+) T cell function in interleukin (IL)-10(-/-) mice.
Nozawa et al. (2001)CD4T cellHowever, a clear inhibition of donor CD4(+) T cell expansion and activation has not been observed.
Bry et al. (2006)CD4T-cellHowever, deficiency of CD4+ T-cell-expressed IFN-gamma did not adversely impact survival or development of protective antibody in adoptively transferred CD4(-/-) recipients, though it impacted Th1 antibody responses.
Kvist et al. (2009)CD4T cellsTreatment with Daivobet® also induced a highly significant reduction in CD3, CD4, CD8 and CD45RO positive T cells (Table 1).
Mottram et al. (1998)CD4T cellRedefining peripheral tolerance in the BALB/c to CBA mouse cardiac allograft model: vascular and cytokine analysis after transient CD4 T cell depletion.
Grosenbach et al. (2010)CD4T cellsAfter lethal challenge with the Western Reserve strain of vaccinia, Nude, SCID, and J(H) knockout mice additionally depleted of CD4(+) and CD8(+) T cells were not fully protected by ST-246, although survival was significantly extended.
Simon et al. (2007)CD4T cellsAdministration of 1 mg PC61 results in an approximate 4-fold reduction in the number of CD4+CD25+cells and an approximate 2-fold reduction in FoxP3+ T cells for around 3 wks after injection (Fig. 3B).
Robinson et al. (2009)CD4T cellsDepletion of CD4(+) T cells eliminated both the elevation in plasma IFN-gamma and aspartate aminotransferase, whereas depletion of CD8(+) T cells did not.
Dyson and Elliott (1999)CD4T cellsThymocytes and peripheral T cells escaping deletion by Mtv sag display a small reduction in the level of cell surface CD4.
Ravli?-Gulan et al. (1999)CD4T cellsSingle depletion of CD4 or CD8+ T cells did not change this ability.
Lei et al. (2008)CD4T cellsCONCLUSIONS: Penetrating ocular injury preformed shortly (24 h-48 h) after an AC injection of an antigen was able to abrogate ACAID and was associated with a decreased production of TGF-beta1 and IL-10, an increased production of IFN-gamma, and a decreased expression of CD4(+)CD25(+)Foxp3(+)T cells.
Robbins et al. (2008)CD4T cellSmoke-induced defects in DC function leading to impaired CD4(+) T cell function could inhibit tumor surveillance and predispose patients with chronic obstructive pulmonary disease to infections and exacerbations.
Ford et al. (2003)CD4T cellThis reduction was characterized by decreased CD4(+) T cell infiltration of the CNS of CD43(-/-) mice but similar numbers of Ag-specific T cells in the periphery, suggesting a defect in T cell trafficking to the CNS.
Kozar et al. (2003)CD4T cellsThe antitumor efficacy of combined treatment was abrogated in scid/scid mice, and after depletion of CD4(+) and CD8(+) T cells.
Crisi et al. (1996)CD4T cellsIn spite of the age-related decrease in overall CD4/CD8 T cell ratios in all organs, the mice with relatively high V beta 17a + T cells exhibited proportionally more CD4+ cells in that V beta population.
Maas et al. (1993)CD4T cellsFurthermore, it was shown that depletion of both the CD8+ and CD4+ T cells from the suspensions used in the transfer studies, resulted in a significant decrease of tumor inhibition.