Viewing affirmative mentions of gene expression of TNF (H. sapiens) in T cells

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Kinkhabwala et al. (1990)tumor necrosis factor/cachectinT cellsCell surface expression of tumor necrosis factor/cachectin by activated normal human T cells.
Kinkhabwala et al. (1990)TNFT cellsGiven the central role of T cells in antigen-specific immunity, we examined whether activated T cells express TNF on their cell surface.
Lang et al. (1995)TNFT cellEarly activation of human V gamma 9V delta 2 T cell broad cytotoxicity and TNF production by nonpeptidic mycobacterial ligands.
Lang et al. (1995)TNFT cellTo investigate the early events of V gamma 9V delta 2 T cell activation, we have analyzed induction of cytotoxicity and TNF production of T cell clones by these molecules.
Lang et al. (1995)TNFT cellSimilarly, TUBag, but not dephosphorylated TUBag, induced massive TNF production by V gamma 9V delta 2 T cell clones only, which already was significant 20 min after exposure.
English et al. (1988)TNFT cellsWe analyzed LT and TNF production by blood mononuclear cells and purified T cells using Northern blot analysis to detect specific messenger ribonucleic acid and specific assays to detect LT and TNF protein in culture supernatants.
English et al. (1988)TNFT cellsCompared to LT, TNF messenger ribonucleic acid and protein were produced more rapidly both by total mononuclear cells and by T cells in response to mitogen stimulation.
Cuturi et al. (1987)TNFT cellsNK cells produce TNF only when stimulated with phorbol diester and calcium ionophore, and they do so at a much lower level than T cells.
Sander and Boeryd (1996)TNF-alphaT cellsTNF-alpha expression seemed to selectively affect the capability of T cells to infiltrate the tumors since TNF-alpha+ tumors were found to have significantly lower levels of infiltrating CD3+ cells, while there was no difference in numbers of mac387+ cells.
Sander and Boeryd (1996)TNF-alphaT-cellThese results demonstrate that TNF-alpha is variably expressed in primary malignant melanoma in vivo and that the T-cell response to TNF-alpha-expression NMM is inhibited.
Sandmand et al. (2003)TNF-alphaT lymphocytesOBJECTIVE: The aim of the present study was to investigate if high plasma levels of TNF-alpha are associated with increased production of TNF-alpha by T lymphocytes in elderly humans.
Sandmand et al. (2003)TNF-alphaT lymphocytesMETHODS: TNF-alpha production by CD4+ and CD8+ T lymphocytes was measured by flow cytometry following stimulation with phorbol 12-myristate 13-acetate and ionomycin in 28 young controls, 14, 81-year-olds and 25 centenarians.
Sandmand et al. (2003)TNF-alphaT lymphocytesAn increased percentage and number of T lymphocytes from the 81 year olds expressed TNF-alpha, whereas centenarians did not show this altered TNF-alpha secretion profile.
Fallahi-Sichani et al. (2010)TNFT cellsInterestingly, PPD-bead granuloma T cells and B cells did not express quantifiable amounts of mTNF, although proinflammatory T cells have been reported to produce TNF in Mtb-infected mice [68].
Imanishi et al. (1995)Tumor necrosis factorT-cellsTumor necrosis factor (TNF) production from T-cells stimulated with superantigenic exotoxins, staphylococcal enterotoxin B and streptococcal pyrogenic exotoxin A was investigated in the presence of cells bearing distinct isotypes of HLA class II molecules.
Imanishi et al. (1995)TNFT-cellThe main T-cell subset for TNF production was investigated in parallel.
Imanishi et al. (1995)TNFT-cellsAlthough both CD4+ T-cells and CD8+ T-cells produced TNF-alpha and TNF-beta in response to toxin stimulation in the presence of HLA class II+ cells, the former T-cell subset was the major source of producers of TNF-alpha and TNF-beta.
Tanaka et al. (2001)TNFT cellCONCLUSIONS: Our results suggest that subsets of T cell populations and their function may be reduced in human obesity, and that this may be related, at least in part, to the elevated TNF-alpha production.
Jiang et al. (1999)TNFT-cellHowever, in contrast to rolipram, another TNF alpha inhibiting agent, vesnarinone failed to inhibit TNF alpha production by myelin basic protein specific T-cell lines.
Nielsen et al. (2004)TNFalphaT cellIn a second design approach, three TNFalpha monomers were linked by two T cell epitopes and expressed as a single chain TNFalpha trimer.
Burger et al. (2004)TNFT cellswas induced by membranes of stimulated T cells in the three types of target cells, whereas CD40LT induced TNF production in IFN?
Debets et al. (1988)TNF-alphaT cellsThe induction of TNF-alpha production by supernatants of proliferating T cells could largely be abrogated by passaging the supernatants on an anti-IFN-gamma column before adding them to the monocytes.
Debets et al. (1988)TNF-alphaT cellIt is therefore concluded from this study that the production of TNF-alpha by monocytes can be induced by proliferating T cells and that this induction can largely be attributed to the T cell lymphokine IFN-gamma.
Männel and Jänicke (1989)TNFT cellCells of the proerythromyeloid cell line K562 and of the T cell line Jurkat were able to induce an increase in TNF-, IL1 alpha-, and IL1 beta-mRNA expression in human peripheral blood derived monocytes in vitro.
Steffen et al. (1988)tumor necrosis factor-alphaT cellsSimultaneous production of tumor necrosis factor-alpha and lymphotoxin by normal T cells after induction with IL-2 and anti-T3.
Ye et al. (2006)TNF-alphaT-cellOn the contrary, the human DCs engineered to express TNF-alpha can (i) stably maintain their cellular maturation and (ii) efficiently stimulate T-cell proliferation even during culturing ex vivo in medium without TNF-alpha stimulation.
Weill et al. (1996)tumor necrosis factor alphaT lymphocytesInduction of tumor necrosis factor alpha expression in human T lymphocytes following ionizing gamma irradiation.
Weill et al. (1996)TNF-alphaT cellsTogether these data suggest that T cells are responsible for the irradiation-induced expression of TNF-alpha and GAPDH.
Kobayashi et al. (1987)TNFT-cellWe report in this paper that a human T-cell hybridoma, AC5-8, produces TNF in addition to LT depending on the kind of stimuli used.
Buonaguro et al. (1992)TNFT cellsHere we demonstrate that HIV-1 activates the expression of TNF but not of IL-1 and IL-6 in acutely and chronically infected T cells.
Buonaguro et al. (1992)TNFT cellsT cells chronically infected with pol-defective HIV-1 provirus constitutively express both Tat and TNF at levels significantly higher (fivefold) than those seen in control cells, and treatment with phorbol myristate acetate greatly enhances Tat expression and TNF production.
Marino et al. (2007)TNFT cellThis supports the idea that macrophages are key in establishing latency via TNF production, while T cell–derived TNF is essential, but not sufficient, for protection against Mtb infection, as shown in experimental data in mice [38].
Probert et al. (1993)TNFT cellTo evaluate the biologic potential of T cell-specific TNF production in vivo, we have generated transgenic mice constitutively expressing TNF in their T cell compartment.
Probert et al. (1993)TNF mRNAT cellsTransgenic mice that express human TNF mRNA in T cells develop marked histologic and cellular changes locally in their lymphoid organs and a lethal wasting syndrome associated with widespread vascular thrombosis and tissue necrosis.
Probert et al. (1993)TNFT cellTransgenic mice that express TNF constitutively in the T cell compartment offer a unique in vivo system by which to analyze the molecular character of systemic vs contact-dependent and paracrine modes of TNF action.
Goldfeld et al. (1992)TNF-alphaT lymphocytesOriginally identified as a monocyte factor, our studies and those of others have demonstrated that B and T lymphocytes produce TNF-alpha when stimulated by a variety of inducers.
Ramírez et al. (1999)TNF-alphaT cellsThe expression of TNF-alpha by CD4(+) T cells can be inhibited by either, wortmannin (WN) or LY 294002, two phosphatidylinositol 3-kinase (PI 3-K) inhibitors.
Ramírez et al. (1999)TNF-alphaT cellsTherefore, both PI 3-K and p38 MAPK signaling pathways control TNF-alpha production in T cells.
Turner et al. (1987)tumor necrosis factorT cellsHuman T cells from autoimmune and normal individuals can produce tumor necrosis factor.
Turner et al. (1987)tumor necrosis factorT cellT cell clones derived from patients with autoimmune diseases were found to be capable of producing tumor necrosis factor (TNF).
Turner et al. (1987)TNFT cellTNF production was not limited to T cells from autoimmune individuals, since the T cell tumor HUT78 and T cells purified from the peripheral blood of healthy individuals also made TNF.
Turner et al. (1987)TNF mRNAT cellUnlike the T cell clones, HUT78 produced greater amounts of LT mRNA than TNF mRNA.
Turner et al. (1987)TNFT cellsThe evidence suggests that T cells can produce TNF and have the potential to deliver by themselves the dual and synergistic signals of TNF/LT and IFN-gamma to target cells, a process which may be of importance in the pathogenesis of human autoimmunity.
Liu and Whisler (1998)TNF-alphaT cellAberrancies in T cell expression of tumor necrosis factor-alpha (TNF-alpha) are frequently observed in inflammatory states characterized by oxidative stress due to excessive generation of hydrogen peroxide (H2O2) and other reactive oxygen species (ROS).
Liu and Whisler (1998)TNF-alphaT cellsIn this study, we examined the possible effects of oxidative stress on the expression of TNF-alpha protein and transcriptional activation of the TNF-alpha promoter in human T cells.
Liu and Whisler (1998)TNF-alphaT cellsResults show that exposure of resting T cells to micromolar concentrations of H2O2 did not induce TNF-alpha protein production or transcriptional activation of the TNF-alpha promoter.
Liu and Whisler (1998)TNF-alphaT cellsHowever, oxidative signals resulted in a dose-dependent suppression of TNF-alpha protein production and transcriptional activation in T cells stimulated with the lectin phytohemagglutinin (PHA) and phorbol myristate acetate (PMA).
Liu and Whisler (1998)TNF-alphaT cellThus, T cell expression of TNF-alpha at the protein and transcriptional levels is highly regulated by changes in cellular redox, and the CRE/kappa3 composite site is important for both activation and redox regulation of the TNF-alpha promoter.
Bhattacharyya et al. (1998)TNF-alphaT cellsMast cells cocultured with activated T cells released histamine and beta-hexosaminidase and produced tumor necrosis factor alpha (TNF-alpha), an effect that peaked at 20 h.
Burger et al. (2004)TNFT cellsThe production of TNF and IL-1beta was induced by membranes of stimulated T cells in the three types of target cells, whereas CD40LT induced TNF production in IFN-gamma-macrophages only.
Burger et al. (2004)TNFT cellsThese results demonstrate that CD40L is not required in monocyte activation by direct cellular contact with stimulated T cells, although soluble CD40LT induces the production of TNF in IFN-gamma-macrophages.
Dunn et al. (2000)TNFalphaT cellsWe have shown that BT treatment of both human T cells and monocytes is associated with an increase in surface tumor necrosis alpha (TNFalpha) expression.
Christmas et al. (1987)tumour necrosis factorT cellsProduction of interferon and tumour necrosis factor by cloned human natural cytotoxic lymphocytes and T cells.
Christmas et al. (1987)TNFT cellThus, neither gamma-IFN nor TNF production were shown to correlate well with the capacity of NK-derived or T cell clones to effect cytotoxic action towards K562 in vitro.
Muñoz-Fernández et al. (1997)TNF-alphaT lymphocytesPrimary resting T lymphocytes produced TNF-alpha and supported HIV replication after T-cell receptor activation.
Lee et al. (1993)TNF-alphaT-cellsPurified T-cells did not produce significant levels of TNF-alpha, even in the presence of IL-1 and IL-6.
Sung et al. (1988)TNFT cellsThis synergistic response to anti-CD3 mAb and PMA provided further evidence that T cells were the source of TNF synthesis in these cultures.
Scheurich et al. (1987)TNFT lymphocytesThe expression of specific tumor necrosis factor (TNF) membrane receptors and biological effects of recombinant TNF (rTNF)-alpha on normal human T lymphocytes were studied.
Andersson et al. (1989)tumor necrosis factor alphaT cellCharacterization of individual tumor necrosis factor alpha-and beta-producing cells after polyclonal T cell activation.
Andersson et al. (1989)TNFT cellsThe majority of these early TNF alpha-producing cells were monocytes as judged by two-color staining and morphology, but a small fraction of CD4- and CD8-positive T cells was found up to 72 h.
Andersson et al. (1989)TNFT cellsThe number of TNF beta-producing cells was much larger than that of TNF alpha-producing cells, and approximately 90% of them were CD4-positive T cells.
Andersson et al. (1989)TNFT cellsThe remaining TNF beta production occurred in CD8-positive T cells and in B cells.
Imanishi et al. (1995)TNFT cellsIFN-gamma-stimulated human vascular endothelial cells function as accessory cells for superantigen-induced TNF production in human T cells.
Sessa et al. (2009)TNFT cellsC. pneumoniae induced apoptosis in T cells as well as in co-cultures of T cells and infected macrophages by marked decrease in GSH/GSSG ratio and increased production of TNF-alpha, respectively.
Tadmori et al. (1991)Tumor necrosis factor alphaT cellsTumor necrosis factor alpha (TNF-alpha) is expressed in secreted and cell surface (csTNF-alpha) forms by activated monocytic and T cells.
Rossol et al. (2005)TNFT cellThe addition of sera from healthy controls to the co-cultures was found to inhibit T cell induced production of TNF-?
Andersson and Matsuda (1989)TNFT cellThe majority of the TNF alpha-producing mononuclear cells at 24 h were of the CD4+ T cell lineage in the staphylococcal enterotoxin A- or anti-CD3 mAb-activated cultures.
Macchia et al. (1993)TNF-alphaT cellsFreshly isolated CD4+ T cells from HIV-infected individuals express TNF-alpha on the cell membrane and induce TNF-alpha-mediated immunoglobulin production by B cells.
Schmidt et al. (1999)TNFT cellsThe results demonstrate the importance of activated T cells for suppression of TNF expression by rVagHis in vitro.
Aringer and Smolen (2003)TNFT cellsThe level of TNF expression both in its membrane-associated form as well as in its soluble form thus contributes importantly to the development of T cells, of B cells and of dendritic cells (see later), and to the interactions between these cells, and it may constitute one important determinant of the type and level of immune responses.
von Fliedner et al. (1992)TNF-alphaT cellsWhile it is well established that activated T cells can produce tumor necrosis factor alpha (TNF-alpha), it is less clear whether this function is confined to a given subset, e.g., memory cells.
von Fliedner et al. (1992)TNF-alphaT lymphocytesTo approach this question, we investigated the production of TNF-alpha by human peripheral blood T lymphocytes activated with anti-CD28 mAb since this activation pathway is known to potentiate cytokine production.
von Fliedner et al. (1992)TNF-alphaT cellsThe enhancement of TNF-alpha production was already apparent after incubation of T cells for 6 hr.
von Fliedner et al. (1992)TNF-alphaT lymphocytesTo determine the source of the cells producing high amounts of TNF-alpha, T lymphocytes were separated into two subpopulations, namely naive cells (expressing the CD45RA isoform) and memory cells (expressing the CD45RO isoform).
Ledru et al. (2000)TNF-alphaT cellsA dramatic polarization to TNF-alpha synthesis of both CD4 and CD8 T cells was observed in all patients.
Ledru et al. (2000)TNF-alphaT cellsBecause it was previously shown that TNF-alpha synthesis by T cells was highly controlled by apoptosis, concomitant synthesis of TNF-alpha and priming for apoptosis were also analyzed.
Ledru et al. (2000)TNF-alphaT cellsThe accumulation of T cells primed for TNF-alpha synthesis is related to their escape from activation-induced apoptosis, partly due to the cosynthesis of interleukin-2 (IL-2) and TNF-alpha.
Hurme (1988)Tumor necrosis factorT cellsTumor necrosis factor (TNF) is also produced by activated macrophages, and it has recently been shown that it can enhance the proliferation of mature, human T cells.
Israël et al. (1989)TNFT lymphocytesWe have investigated the effect of TNF, a cytokine produced during most immunologic and inflammatory reactions, on HIV genome expression in human T lymphocytes.
Israël et al. (1989)TNFT lymphocytesSuch findings are compatible with the hypothesis that TNF production participates in the pathogenesis of AIDS by enhancing HIV replication in T lymphocytes.
Kobayashi et al. (1990)TNF-alphaT cellIt was found that the HTLV-1-infected T cell lines examined produced large amounts of both TNF-alpha and TNF-beta.
Brother et al. (1996)TNFT cellHere we show that because of this similarity of mechanisms, the expression of an RNA species encoding polymeric-TAR sequences and known to inhibit Tat-mediated HIV-1 gene expression also blocks TNF gene expression in response to Tat, but not TNF promoter activation induced by human T cell leukemia/lymphotropic virus type I Tax protein.
Meraviglia et al. (2011)TNFT cellsT cells produce both TNF-?
Macedo et al. (2011)TNFT cellsIn their study, CD4+ T cells are the main producer of TNF-?
López et al. (2010)TNFT cellIL-10 is an important immunoregulatory cytokine that inhibits T cell function by suppressing the expression of proinflammatory cytokines such as TNF?