Viewing affirmative mentions of gene expression of PTPRC (H. sapiens) in T cells

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Nakano et al. (1990)CD45T cellIt was shown that CD45 expression varies among B-lineage cells depending on cell differentiation, in contrast to its stable expression on leukemic T cell (6/6, positive) and myeloid (5/5, positive) lineage cell lines.
Stein-Oakley et al. (1989)CD45RT cellsRecent work has demonstrated a division of T lymphocytes into 2 subpopulations with distinct functions on the basis of their expression of the CD45R antigen (CD45R+ "naive" and CD45R- "memory" T cells).
Stein-Oakley et al. (1989)CD45RT cellsThis study analyzes CD45R expression on circulating T cells and T cells infiltrating renal allografts in patients undergoing rejection and/or cyclosporine nephrotoxicity.
Stein-Oakley et al. (1989)CD45RT cellsThe percentage of circulating T cells that expressed CD45R in patients with rejecting (63 +/- 4) or stable grafts (66 +/- 3) was not different from values obtained for normal donors (62 +/- 3).
Stein-Oakley et al. (1989)CD45RT cellsIn contrast, the percentage of T cells expressing CD45R infiltrating rejecting grafts was 21 +/- 2 and was not affected by the stage of rejection; in patients with CsA toxicity the value was 22 +/- 6.
Stein-Oakley et al. (1989)CD45RT cellsThe reduced proportion of T cells that expressed CD45R in the allograft may reflect a change in status from the naive state due to alloantigenic stimulation (which can be demonstrated in vitro) and/or a propensity of memory T cells to enter or be retained in an allograft.
Michie et al. (1992)CD45R0T cellsExpression of CD45R0 in T cells may therefore be reversible.
Mattila and Tarkkanen (1998)CD45T lymphocytesDifferentiation of T lymphocytes in the human adenoid as measured by the expression of CD45 isoforms.
Mattila and Tarkkanen (1998)CD45T lymphocyteEncounter of antigen by T lymphocyte on antigen-presenting cells results in changes in the expression of several cell surface molecules, including the abundant cell surface glycoprotein CD45.
Arlettaz et al. (1999)CD45RAT cellsIn addition, re-expression of CD45RA by former CD4(+)CD45RA(-) T cells can be accurately monitored in the pool of recipient T cells that, in the absence of recipient stem cells, can not be replenished with CD45RA(+) T cells through the thymic pathway.
Arlettaz et al. (1999)CD45RAT cellsWe found that CD4(+)CD45RA(-)RO(+) recipient T cells could re-express CD45RA but never reverted to a genuine CD4(+)CD45RA(+)RO(-) naive phenotype.
Arlettaz et al. (1999)CD45T cellsWe conclude that CD4(+)CD45RA(-)RO(+) T cells may re-express CD45(high) isoforms but remain distinguishable from naive cells by their lower expression of CD45RA / RC and co-expression of CD45RO.
Gil et al. (2005)CD45RAT lymphocytesCD45RA and RO expression was determined in circulating T lymphocytes by flow cytometry.
Ibrahim et al. (1993)CD45RAT cellsSubsets of T cells express different isoforms of the leukocyte common antigen CD45; those expressing the glycoprotein 220 isoform (CD45RA) have been characterized as naive in their response to antigens, and those expressing the glycoprotein 180 isoform (CD45RO) as memory T cells.
Ibrahim et al. (1993)CD45ROT cellsA majority of T cells expressed CD45RO in cases of moderate rejection (11 of 14 or 79%), compared to only 1 of 13 (8%) cases of mild rejection.
Lynch and Weiss (2000)CD45T cellsMultiple isoforms of the protein tyrosine phosphatase CD45 are expressed on the surface of human T cells.
Chaiworapongsa et al. (2002)CD45T lymphocytesThe expression of CD45 isoforms on the surface of human T cells has been used to classify CD4(+) T lymphocytes into nave cells (CD45RA+) and memory T cells (CD45RO+).
Merkenschlager and Beverley (1989)CD45T cellsOn the basis of differential CD45 expression, human T cells can be separated into approximately reciprocal populations.
Merkenschlager and Beverley (1989)CD45R0T cellsCD4 T cells that proliferate in response to memory-dependent (recall) antigens have been shown to selectively express CD45R0.
Merkenschlager and Beverley (1989)CD45T cellsWe extend these observations to a model for cytotoxic responses that allows the functional analysis of CD8 T cells with differential CD45 expression.
Merkenschlager and Beverley (1989)CD45T cellIn combination with earlier work, these results suggest that differential expression of CD45 isoforms is associated with memory formation for different classes of immune responses in both major T cell lineages.
Lightstone and Marvel (1993)CD45RAT cellHowever, our studies in the mouse and more recent studies in rat and human suggest that expression of CD45RA more closely correlates with the state of responsiveness of the T cell. 5.
Deans et al. (1991)CD45T cellsIf correct, this demands that unlike peripheral T cells, differentiation of MN thymocytes should be accompanied by prolonged expression of high molecular mass CD45 isoforms.
Cosenza-Nashat et al. (2006)CD45ROT cellsWhile the expression of CD45RO in CNS-infiltrating T cells is well known (55), its expression in microglia and macrophages is less well appreciated.
Ibrahim et al. (1995)CD45ROT cellsPredominant infiltration of rejecting human renal allografts with T cells expressing CD8 and CD45RO.
Ibrahim et al. (1995)CD45T cellsSubsets of T cells have been identified by the expression of different isoforms of CD45.
Ibrahim et al. (1995)CD45RAT cellsSome T cells expressing CD45RA (gp220) have been characterized as "naive" in their response to antigens including alloantigens, whereas T cells expressing CD45RO (gp180) have been characterized as "memory" T cells.
Zapata et al. (1994)CD45RCT cellsImmunofluorescence analysis of PBLs showed that CD45RC is expressed at high levels on B, NK, and CD8+ T cells, although a subset of CD4+ T cells was found to be negative.
Zapata et al. (1994)CD45T cellTogether these results support both the existence of a tight regulation of the expression of CD45 specificities during lymphocyte activation and thymocyte maturation and also that CD45RC is selectively expressed by mature medullary thymocytes during T cell ontogeny.
Yamada et al. (1990)CD45T cellsEffect of activation of protein kinase C on CD45 isoform expression and CD45 protein tyrosine phosphatase activity in T cells.
Yamada et al. (1990)CD45T cellsIn this study, we examined the effects of activation of protein kinase C (PKC) on the phosphorylation and expression of CD45 isoforms and PTPase activity in human T cells.
Slukvin et al. (1996)CD45ROT cellsCONCLUSIONS: The significantly raised percentage of intradecidual T cells expressing CD45RO suggest decidual accumulation of antigen-committed memory cells.
Fujii et al. (1992)CD45T cellsWe report studies on CD45 isoform expression on various subsets of human T cells using two- and three-color flow cytometry and cell depletion.
Fujii et al. (1992)CD45T cellsThus, in terms of CD45 isoform expression, single-positive thymocytes are more like double-positive cells than cord blood T cells.
Robichaud et al. (2002)CD45ROT cellsNuclear factor of activated T cells is a driving force for preferential productive HIV-1 infection of CD45RO-expressing CD4+ T cells.
Robichaud et al. (2002)CD45ROT cellsHuman immunodeficiency virus type-1 (HIV-1) preferentially replicates in CD4-expressing T cells bearing a "memory" (CD45RO+) rather than a "naive" (CD45RA+/CD62L+) phenotype.
Robichaud et al. (2002)CD45T cellsThrough the use of CD4+ Jurkat T cells specifically expressing distinct CD45 isoforms (i.e.
Robichaud et al. (2002)CD45ROT cellCD45RABC or CD45RO), we demonstrated that a difference in CD45 isoform expression conferred preferential replication of HIV-1 to CD45RO-expressing T cell clones following a physiological CD3/CD28 stimulation.
Tong et al. (2005)CD45T cellsExpression of the CD45 isoforms is tightly regulated in peripheral T cells such that resting cells predominantly express the larger CD45 isoforms, encoded by mRNAs containing two or three variable exons.
Tong et al. (2005)CD45T cellsIn contrast, activated T cells express CD45 isoforms encoded by mRNAs lacking most or all of the variable exons.
Sen et al. (2008)CD45T cellsT cells from OT-II mice (expressing CD45.2) were enriched as described above, and labeled with 4 M CFSE at 37C for 15 min. ?
Dallas et al. (2007)B220T-cellMost of the early T-cell reconstitution originated from cells that expressed lymphoid-associated antigens: B220, Thy1, CD25, and/or IL7Ralpha, whereas the most efficient thymic repopulation on a per cell basis originated from the smaller number of cultured cells that did not express lymphoid-associated antigens.
Windhagen et al. (2007)CD45T cellWe have shown previously that aberrant expression of CD45RA isoforms enhances the intensity of T cell receptor (TCR) signalling.
Fujimura et al. (2005)CD45RT cellGanp-Tg mice showed a high incidence of lymphomagenesis (29.5%) after aging with a non-B/non-T cell surface phenotype having slight CD45R/B220 expression and Ig transcripts of rearranged VH-DH-JH IgH loci.
Mamoune et al. (2000)CD45T cellsAbnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis.
Lacoste et al. (2000)CD45T-cellBoth the cell line and the lymphoma cells expressed CD38 and CD45 antigens but no classical B-cell or T-cell lineage-restricted antigens.
Ramage et al. (1999)CD45T cellT cell responses to heat-shock protein 60: differential responses by CD4+ T cell subsets according to their expression of CD45 isotypes.
Young et al. (1997)CD45T cellsOur data support the view that in human peripheral blood, CD45R0bright and CD45RAbright expression identify memory and naive CD4+ T cells, respectively.
Fiore et al. (1997)CD45T-cellTo further evaluate T-cell involvement in HCV-induced hepatic disease, the authors analysed, in a cohort of chronic hepatitis C patients, the intrahepatic T-cell expression of CD45 isoforms by using specific monoclonal antibodies.
Stulnig et al. (1995)CD45T lymphocytesThe most striking age-related changes included increases in HLA-DR+ T lymphocytes, and the shift in the expression of CD45 isoforms from the CD45RA+CD45RO-to the CD45RA-CD45RO+ subset.
Aversa et al. (1994)LCAT cellsThus, A6 was shown to recognize the lower MW isoforms of LCA which are expressed on functional T cell subsets including memory, activated, and alloreactive T cells.
Robinson et al. (1993)CD45T lymphocytesT lymphocytes may be separated into subsets according to their expression of CD45 isoforms.
Ibrahim et al. (1993)CD45T cellsExamination of cells expressing CD45 isoforms also revealed a suggested increase (P < .04) in CD45RO+ "memory" but not in CD45RA "naive" T cells infiltrating portal areas.
Yamada et al. (1992)CD45T cellsCD45 isoform expression on human neonatal T cells: expression and turnover of CD45 isoforms on neonatal versus adult T cells after activation.
Yamada et al. (1992)CD45T cellsThe de novo synthesis of CD45 isoforms in neonatal T cells was essentially the same as that in the adult T cells.
Lucivero et al. (1991)CD45T cellsAt this stage of development, variable proportions of T and B lymphocytes express surface molecules, such as the CD1, CD10, CD38, CD45RA, indicative of a precursor or 'naive' state; on the other hand, the CD57 molecule is not detectable on the membrane of NK and T cells, and the RO isoform of the CD45 leukocyte antigen is synthesized by a low percentage of T cells.
Smart et al. (1989)CD45T lymphocytesExpression of CD6 and the UCHL1-defined CD45 (p180) antigen by human colonic T lymphocytes.
Brod et al. (1989)T-200T cellUnderstanding T cell expression of higher molecular weight isoforms of the T-200 complex (CD45R) may be important because of their association with regulation of immune responses.
Rudd et al. (1987)T200T lymphocytesThe T4 (CD4) subset of T lymphocytes has been subdivided into two major subsets, a suppressor/inducer subset (T4+,2H4+) and a helper subset (T4+,2H4-) on the basis of the differential expression of the L-C/T200 (CD45) antigens.
Peyron et al. (1991)CD45T cellThe possible regulatory role of the CD45 protein tyrosine phosphatase in this process was explored by studying the functional properties of cellular variants of the Jurkat T cell line which have been selected to have normal levels of the TCR-CD3 complex, but low or negative expression of CD45.
Schraven et al. (1989)CD45RT cellEmploying T cell subsets negatively selected for the expression of CD45R molecules defined by the mAb anti-2H4 or UCHL1, respectively, it is demonstrated that resting T cells expressing the 2H4 molecules proliferate much stronger to TA/211 than the UCHL1+ T cell subset.
Schraven et al. (1989)CD45T cellsTogether with the finding that the 2H4+ T cell subset can be activated by the concomitant binding of anti-CD2 antibodies plus anti-2H4, these data strongly suggest that the high molecular weight species of CD45 expressed by unprimed T cells are themselves involved in T cell activation via the alternative pathway.
Kristensson et al. (1992)CD45RAT cellsHuman CD4+ T cells expressing CD45RA acquire the lymphokine gene expression of CD45RO+ T-helper cells after activation in vitro.
Kristensson et al. (1992)CD45RT cellsCD4+ T cells were separated into subpopulations according to their expression of different isoforms of the CD45R molecule, i.e.
Schraven et al. (1994)CD45T-lymphocytesSince tyrosine phosphorylation of LPAP is undetectable in T-lymphocytes expressing enzymatically active CD45, these data suggest that LPAP likely represents a novel substrate for CD45.
Ordonez et al. (2009)CD45T cellsHow expression of the CD45 isoform could influence cytokine profiles of CD4 T cells is not clear.
Ordonez et al. (2009)CD45RCT cellsThe level of CD45RC expression identifies two subsets within human CD4 T cells with differential cytokine production
Ordonez et al. (2009)CD45RAT cellTo purify CD45RAhigh and CD45RAlow CD4 T cell subsets, the CD45RClow CD4 subpopulation, purified by magnetic beads, were labeled with anti-CD45RA mAb and separated on a Coulter cell sorter according to CD45RA expression.
Ordonez et al. (2009)CD45RCT lymphocytesIn the rat, the level of CD45RC isoform expression divides CD4 and CD8 T lymphocytes in two subpopulations.
Mackall et al. (1995)CD45RAT lymphocytesThe absolute numbers of CD4+ T lymphocytes in peripheral blood and the expression of CD45 isoforms (CD45RA and CD45RO) on these lymphocytes were studied serially during lymphocyte regeneration after the completion of therapy.
Kanegane et al. (1991)CD45T cellsDifferential expression of various isoforms of leukocyte common antigen (CD45), which arises from alternate mRNA splicing, identifies naive and memory populations of human T cells.
Hviid et al. (1993)CD45T cellsThe transition from naive, unprimed T cells to memory cells capable of responding to recall stimulating has been associated with a switch in surface expression of CD45 from the CD45RA isotype to CD45RO.
Hviid et al. (1993)CD45T cellsIn the present study we have examined the expression of LFA-1 on subsets of human peripheral T cells, and related it to the expression of markers of cellular activation and CD45 isotypes, and thus to immunological memory.
Brod et al. (1989)CD45RT cellLymphokine regulation of CD45R expression on human T cell clones.
Brod et al. (1989)CD45RAT cellBy direct single cell cloning, we observed a number of long-term T cell clones that expressed CD45RA (2H4).
Brod et al. (1989)CD45RAT cellsThese results indicate that CD45RA expression may define T cell lineages of activated T cells partially controlled by the cytokines IL-1 and IL-6.
Brod et al. (1989)CD45RAT cellsFurther, these results may associate regulatory actions of IL-1 and IL-6 with their ability to increase CD45RA expression in subpopulations of human T cells.
Beckman et al. (1994)CD45RAT cellsA population of CD4+ T cells co-expressing intermediate levels of both CD45RA and CD45RO, namely CD45RA+/CD45RO+, appeared to be the major producers of IL-6.
Merritt et al. (1996)CD45ROT lymphocytesCoexpression of GD3 ganglioside with CD45RO in resting and activated human T lymphocytes.
Ma et al. (2004)CD45T cellsAutomatic generation of lymphocyte heterogeneity: Division-dependent changes in the expression of CD27, CCR7 and CD45 by activated human naive CD4+ T cells are independently regulated.
Braakman et al. (1991)CD45ROT cellsNaive and primed alpha beta T cells can be distinguished on the basis of their differential expression of CD45RA and CD45RO, respectively.
Braakman et al. (1991)CD45RAT cellsHere, we show that these CD45RO- V delta gamma delta T cells all express CD45RA and the CD45RO+ V.9-V delta 2 gamma delta cells lack expression of CD45RA.
Braakman et al. (1991)CD45ROT cellsThe V delta T cells acquired CD45RO expression and lost part of their surface CD45RA, following in vitro activation with phytohaemagglutinin or IL-2.
Braakman et al. (1991)CD45ROT cellsMoreover, all cloned V.9-V delta 2 and V delta 1 T cells and NK cells express CD45RO and lack expression of CD45RA.
Lamprecht et al. (2003)CD45RAT cellsThe cell-surface expression of CD45RO, CD45RA, CD62L, CCR3, CCR5 and CXCR3 was determined on blood-derived T cells by four-color flow cytometric analysis.
Salmon et al. (1994)CD45T cellsThis report is focused on a spectrum of primed CD4+ T cells characterized by an inverse relationship between the expression of two CD45 epitopes: CD45RB and CD45RO.