Viewing affirmative mentions of gene expression of KLRD1 (H. sapiens) in T cells

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Rubio et al. (1993)Kp43T cellsKp43 is a cell surface molecule expressed by NK cells, gamma delta T lymphocytes, and a small subset of CD56+ alpha beta T cells.
Rubio et al. (1993)Kp43T lymphocytesThe expression of Kp43 on freshly isolated gamma delta T-cell populations derived from fetal and adult tissues was biased toward memory V gamma 2+/V delta 2+ T lymphocytes and appeared to be up-regulated after activation.
Panzara et al. (1992)cell receptorT cellUsing nonradioactive probes labeled with horse radish peroxidase, the system presented here allows for the rapid elucidation of the T cell receptor repertoire expressed in cells or tissue samples, such as those derived from autoimmune lesions.
Sugita et al. (2010)CD94T cellsWe investigated both inhibitory NK receptor (CD94/NKG2A) expression and stimulatory NKR (NKG2D) expression on T cells after stimulation with cytokines (IL-12 or IL-15).
Masilamani et al. (2008)CD94T cellsThe CD94/NKG2A inhibitory receptor, expressed by natural killer and T cells, is constantly exposed to its HLA-E ligand expressed by surrounding cells.
Zeddou et al. (2007)CD94T lymphocytesThe percentage of CD8+ T lymphocytes expressing the CD94/NKG2A inhibitory heterodimer was very significantly decreased in HIV-1-infected patients in comparison with non-infected controls.
Zeddou et al. (2007)CD94T lymphocytesWithin the HIV infected patients, the proportion of CD8+ T lymphocytes and NK cells expressing CD94/NKG2A was higher in subjects with undetectable viral loads in comparison with their viraemic counterparts.
Zeddou et al. (2007)CD94T lymphocytesNo significant difference was detected in the proportion of CD8+ T lymphocytes expressing the activatory CD94/NKG2C heterodimer between the HIV-1 infected patients and the healthy donors, nor between the vireamic and avireamic HIV-1 infected patients.
Zeddou et al. (2007)CD94T lymphocytesIn conclusion, chronic stimulation with HIV antigens in viraemic patients leads to a decreased rather than increased CD94/NKG2A expression on CD8+ T lymphocytes and NK cells.
Marusina et al. (2005)CD94T cellsCD94/NKG2A is an inhibitory receptor expressed by most human NK cells and a subset of T cells that recognizes HLA-E on potential target cells.
Mingari et al. (2005)CD94T cellAlthough T cell activation, in the presence of certain cytokines, can induce the expression of the CD94-NKG2A heterodimeric receptor, the mechanism leading to the expression of killer immunoglobulin-like receptors (KIRs) is still unknown.
Wischhusen et al. (2005)CD94T cellsThe nonclassical MHC class I molecule HLA-E is the only known ligand for CD94/NKG2A and CD94/NKG2C expressed on NK and CD8+ alphabeta and gammadelta T cells.
Tanaka et al. (2005)CD94T cellsThe immunosuppressive agent FK506 enhances the cytolytic activity of inhibitory natural killer cell receptor (CD94/NKG2A)-expressing CD8 T cells.
Tanaka et al. (2005)CD94T cellsWe found that there was no effect of FK506 on the expansion of inhibitory NKR CD94/NKG2A-expressing T cells from granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells (G-PBMCs).
Jacobs et al. (2004)CD94T cellsAltered coexpression of lectin-like receptors CD94 and CD161 on NK and T cells in HIV patients.
Perrin et al. (2002)CD94T cellThe functional consequences of CD94/NKG2A expression were explored at the clonal level, using a T cell clone that exhibited substantial variation in the expression of this heterodimer.
Perrin et al. (2002)CD94T cellsOur data indicate that some astrocytoma infiltrating lymphocytes express functional inhibitory CD94/NKG2A, raising the possibility that they may represent silent T cells specific for self-antigens (Ags) expressed on tumor cells.
Pedersen et al. (2002)CD94T cellsDifferential expression of inhibitory or activating CD94/NKG2 subtypes on MART-1-reactive T cells in vitiligo versus melanoma: a case report.
Pedersen et al. (2002)CD94T cellsThese self reactive T cells expressed CD94/NKG2 major histocompatibility complex class I specific C-type lectin-like receptors.
Borrego et al. (2002)CD94T cellsHuman CD94/NKG2A is an inhibitory receptor that recognizes HLA-E and is expressed by NK cells and a subset of T cells.
Michaëlsson et al. (2002)CD94T cellIt interacts with CD94/NKG2 receptors expressed on the surface of natural killer (NK) cells and T cell subsets.
Costa et al. (2001)CD94T-lymphocytesAfter 24 months CD8 T-lymphocytes expressing p58.1, p58.2, p70, p140 and CD94/NKG2A returned to levels indistinguishable from those of the healthy controls.
Poccia et al. (1997)CD94T cellsWe have shown that Vgamma9Vdelta2 T cells express the inhibitory CD94/NKG2 receptor for HLA class I molecules.
Mingari et al. (1995)CD94T lymphocytesCytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production.
Semino et al. (1995)CD94T-cellCytolytic T-cell clones, expressing the CD94 antigen, are inhibited by the HLA-B7 allele on endometrial cells.
Brooks et al. (1997)CD94T cellsCD94 is a C-type lectin expressed by natural killer (NK) cells and a subset of T cells.
Lieto et al. (2003)CD94T cellCD94 is a C-type lectin required for the dimerization of the CD94/NKG2 family of receptors, which are expressed on NK cells and T cell subsets.
Zeddou et al. (2005)CD94T lymphocytesProstaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway.
Zeddou et al. (2005)CD94T cellsAs previously described, anti-CD3 mAb-mediated activation induced the expression of CD94/NKG2A on a small fraction of CD8+ T cells.
Zeddou et al. (2005)CD94T cellsInterestingly, when low concentrations of PGE2 or 8-CPT-cAMP were present during the culture, the proportion of CD8+ T cells expressing CD94/NKG2A was two- to five-fold higher.
Zeddou et al. (2005)CD94T cellsWe further demonstrated that cross-linking of CD94 on CD8+ T cells expressing the CD94/NKG2A heterodimer inhibits their cytotoxic activity in a bispecific antibody redirected lysis assay.
Zeddou et al. (2005)CD94T lymphocytesOur findings clearly demonstrate that the PGE2/cAMP/PKA type I axis is involved in the expression of CD94/NKG2A receptor on human CD8+ T lymphocytes.
Zeddou et al. (2007)CD94T lymphocytesCD94/NKG2A is normally expressed on most NK cells and on a small fraction of CD8+ T lymphocytes.
Zeddou et al. (2007)CD94T cellsIt is presently unknown if HIV infection has similar effects on the expression of the CD94/NKG2A inhibitory receptor by CD8+ T cells.
Zeddou et al. (2007)CD94T lymphocytesA few studies have shown that CD94 expression by CD8+ T cells is increased during HIV infection [9-11] and have led to postulate that increased expression of the CD94/NKG2A inhibitory receptors is one of the mechanisms rendering HIV-specific CD8+ T lymphocytes unable to control HIV-1 infection [12].
O'Keeffe et al. (2008)CD94T-cellsBecause it is suggested that T-cells expressing natural killer cell receptors (NKR) play important roles in regulating human autoimmune diseases, we have quantified populations of T-cells expressing the NKR CD56, CD161 and CD94 in the peripheral blood of MS patients, in healthy control subjects (HS) and in patients with other neurological diseases (OND).
Mingari et al. (1998)CD94T cellsHLA class I-specific inhibitory receptors in human T lymphocytes: interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T cells.
Mingari et al. (1998)CD94T cellsWe show that, in the presence of interleukin 15 (IL-15), T cells (depleted of NKR+ cells) responding to toxic shock syndrome toxin 1 de novo express CD94, a molecule that is part of a heterodimeric NKR with a broad specificity for different HLA class I alleles.
Mingari et al. (1998)CD94T cellThe expression of CD94/NKG2A led to an impairment of allo-specific cytolytic activity by mixed lymphocyte culture-derived T cell populations or clones.
Folch et al. (2000)cell receptorT cellProtein displays of the human T cell receptor alpha, beta, gamma and delta variable and joining regions.
Rosenberg et al. (1992)cell receptorT cellMore recently, molecular studies of the T cell receptor have characterized patterns of T cell receptor expression in humans and have lead to the identification of regions of the T cell receptor critical for antigen recognition.
Vermijlen et al. (2010)CD94T cellsT cells (CD94/NKG2A/NKG2C, CD158a/h [KIR2DL1/KIR2DS1], and CD158b/j [KIR2DL2/KIR2DS2]) or a significant fraction of ??
Tilburgs et al. (2009)CD94T cellsFurthermore, a small proportion of decidual T cells express the HLA-E specific CD94-NKG2A inhibitory and CD94-NKG2C activating receptors.
Gumá et al. (2005)CD94T cellCD8(+) TCRalphabeta CD94/NKG2C(+) T cell clones, that displayed different combinations of KIR and CD85j receptors, expressed KARAP/DAP12 which was co-precipitated by an anti-CD94 mAb.
Saito et al. (2003)CD94T-cellIn the present study we demonstrate that CD3+ T cells that bind tetramers of HLA-E and express its ligand, the NK-cell inhibitory receptor CD94/NKG2A, were significantly decreased in frequency in patients with human T-cell lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) but not in asymptomatic HTLV-1 carriers.
Brooks et al. (1999)CD94T cellsThe CD94/NKG2 receptors expressed by subpopulations of NK cells and T cells have been implicated as receptors for a broad range of both classical and nonclassical HLA class I molecules.
Pérez-Villar et al. (1995)CD94T lymphocyteWe originally characterized the Kp43 (CD94) surface Ag, whose expression is restricted to human NK cells and a minor T lymphocyte subset.
Tsokos (1994)cell receptorT cellThe fraction of T cells that are involved in the pathogenesis of the disease is characterized in terms of T cell receptor expression, production of inappropriate quantities of lymphokines, and ability to provide help to B cells to produce autoantibodies.
André et al. (1999)CD94T cellThe combination of KIR and CD94/NKG2 dimers expressed on NK and T cell subsets defines a repertoire of MHC class I recognition.
André et al. (1999)CD94T cellsBy contrast, the percentages of NK and T cells which express CD94 dimers increase in parallel with the disease.
Derre et al. (2002)CD94T lymphocytesExpression of CD94/NKG2-A on human T lymphocytes is induced by IL-12: implications for adoptive immunotherapy.
Derre et al. (2002)CD94T cellsWe show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8(+) T cells in culture, and that this induction was mediated neither by IFN-gamma nor by IL-15.
Derre et al. (2002)CD94T cellsWe also show, using the redirected killing assay, that IL-12-induced expression of both CD94 and NKG2-A led to the acquisition by T cells of a functional inhibitory receptor.
Derre et al. (2002)CD94T cellExpression of the CD94/NKG2-A inhibitory receptor was also induced by IL-12 during T cell Ag stimulation so that in the presence of this cytokine a high proportion of melanoma-reactive CTL induced from PBL by melanoma peptide stimulation expressed this receptor.
Sheu et al. (2005)CD94T lymphocytesIn kinetic coculture assay, cervical cancer cells can promote the expression of CD94/NKG2A on CD8(+) T lymphocytes.
Sheu et al. (2005)CD94T lymphocyteKinetic cytotoxicity assays showed that up-regulated expressions of CD94/NKG2A restrain CD8(+) T lymphocyte cytotoxicity.
Bukowski et al. (1999)cell receptorT cellApproximately 4% of peripheral blood T cells in humans express a T cell receptor with markedly restricted germline gene segment usage (V gamma 2 V delta 2).
Sugita et al. (2010)CD94T cellsThe proportion and absolute number of CD94/NKG2A-expressing T cells expanded by IL-12 were significantly larger than those of the cells expanded by IL-15.
Oliveira et al. (2010)CD94T cellsThe nonclassical major histocompatibility complex (MHC) Qa-1b accommodates monomorphic leader peptides and functions as a ligand for germ line receptors CD94/NKG2, which are expressed by natural killer cells and CD8+ T cells.
van Velzen et al. (2009)CD94T cellsFinally, TG-infiltrating T cells expressed the T cell inhibitory molecules CD94/NKG2A and PD-1, and the interacting TG-SGC expressed the cognate ligands HLA-E and PD-L1, respectively.
Sáez-Borderías et al. (2009)CD94T cellThe inhibitory CD94/NKG2A and activating CD94/NKG2C killer lectin-like receptors specific for HLA-E have been reported to be selectively expressed by discrete NK and T cell subsets.
Lieto et al. (2006)CD94T cellsCD94/NKG2A is an inhibitory receptor expressed by natural killer (NK) cells and a subset of CD8+ T cells.
Serra et al. (1993)cell receptorT cellMoreover, truncations of the stimulatory antigenic peptide resulted in the production of T cell receptor antagonists, which inhibited the response of the T cells to antigen at 10-100-fold lower concentrations than conventional MHC blockers.
John et al. (1989)cell receptorT cellSurface expression of the T cell receptor complex requires charged residues within the alpha chain transmembrane region.
Seo et al. (2007)CD94T cellsInhibitory CD94/NKG2A and activating CD94/NKG2C receptors are expressed on natural killer, CD4, and CD8 T cells and recognize human leukocyte antigen (HLA)-E, resulting in the modulation of cytotoxic activity and cytokine production.
Romero et al. (2001)CD94T cellsExpression of CD94 and NKG2 molecules on human CD4(+) T cells in response to CD3-mediated stimulation.
Romero et al. (2001)CD94T cellsUsing highly purified peripheral CD4(+) T cells, we found expression of both CD94 and NKG2A 15 days after CD3-mediated stimulation of cells.
Zeddou et al. (2007)CD94T lymphocytesThe percentage of CD8+ T lymphocytes expressing the CD94/NKG2A inhibitory heterodimer was very significantly decreased in HIV-1-infected patients in comparison with non-infected controls.
Zeddou et al. (2007)CD94T lymphocytesWithin the HIV infected patients, the proportion of CD8+ T lymphocytes and NK cells expressing CD94/NKG2A was higher in subjects with undetectable viral loads in comparison with their viraemic counterparts.
Zeddou et al. (2007)CD94T lymphocytesNo significant difference was detected in the proportion of CD8+ T lymphocytes expressing the activatory CD94/NKG2C heterodimer between the HIV-1 infected patients and the healthy donors, nor between the vireamic and avireamic HIV-1 infected patients.
Zeddou et al. (2007)CD94T lymphocytesIn conclusion, chronic stimulation with HIV antigens in viraemic patients leads to a decreased rather than increased CD94/NKG2A expression on CD8+ T lymphocytes and NK cells.
Zeddou et al. (2007)CD94T cellsThere was a dramatic decline in the proportion of CD8+ T cells expressing the CD94/NKG2A heterodimer in HIV-infected patients in comparison with uninfected controls (mean ± SEM, 4.91 ± 0.49% n = 46 vs. 17.93 ± 3.26% n = 10 p < 0.0001) (Figure 1D).
Zeddou et al. (2007)CD94T cellsSimilarly, the proportion of CD8+ T cells expressing the CD94/NKG2C was lower in HIV infected patients than in controls but the difference was not statistically significant (mean ± SEM, 1.73 ± 0.59% n = 16 vs. 5.45 ± 2.25 % n = 10, p = 0.1626) (data not shown).
Tilburgs et al. (2009)cell receptorT cellAlthough the function of NK cell receptor expression on T cells is not completely understood, various studies have shown that they are involved in down regulation of T cell receptor (TCR)-mediated activation and influence effector functions, like cytotoxicity and cytokine production.
van Stijn et al. (2008)CD94T cellsStrikingly, a strong induction of CD94 on CD3(+) T cells was observed with surface expression of activating CD94(dim) NKG2C dimers appearing before inhibitory CD94(bright) NKG2A ones.
Nicol et al. (2000)NK cell-receptorT-cellOBJECTIVE: Human invariant Valpha24+ natural killer T (NKT) cells, a subpopulation of NK cell-receptor (NKR-P1A)-expressing T cells with an invariant Valpha24JalphaQ T-cell receptor (TCR), are stimulated by the glycolipid a-galactosylceramide (KRN7000), in a CD1d-dependent, TCR-mediated fashion.
Brewer and Ericson (2005)cell receptorT cellWe describe here a real-time reverse transcription polymerase chain reaction-based method, which allows efficient automation and integration of amplification, detection, and analysis with sequence-specific detection of all T cell receptor beta variable gene families, subfamilies, and alleles.
Brewer and Ericson (2005)cell receptorT cellComprehensive gene expression analysis of the T cell receptor repertoire of an individual can be very useful in evaluating the immune response in a variety of conditions.
Brewer and Ericson (2005)cell receptorT cellAn improved methodology to detect human T cell receptor beta variable family gene expression patterns.
Chang et al. (2005)CD94T cellIncreased expression of CD94/NKG2A restricted to tumor-infiltrating CD8+ T cell subsets may shape the cytotoxic responses, which indicate a possible role of tumor escape from host immunity in human EC.
Troncone et al. (1996)cell receptorT cellGood markers of potential CD include the presence of serum endomysial antibodies, a high count of intraepithelial lymphocytes and subtle pathological alteration such as increased density of intraepithelial lymphocytes expressing gamma delta T cell receptor, signs of activated mucosal cell-mediated immunity, coeliac-like intestinal antibody pattern, and positive rectal gluten challenge.
Carena et al. (1997)CD94T cellsWe studied the functional interaction between TCR-gamma/delta and CD94, this inhibitory receptor being expressed on the majority of gamma/delta T cells.
Salerno and Dieli (1998)cell receptorT cellsT cells expressing the gamma delta T cell receptor have been found in many species.
Gunther et al. (2005)CD94T cellsA large proportion of CD3(-)7(+) cells expressed CD56, CD94, and CD161, and whereas CD3(+) T cells also expressed CD161, they only rarely expressed CD56 or CD94.
Battistini et al. (1997)CD94T cellsIn circulating gamma delta T cells, approximately 80% expressed CD94, approximately 25% expressed NKR-P1A, and approximately 20% expressed p58, values substantially higher than those found on alpha beta T cells from the same donors.
Hoang et al. (1991)cell receptorT cellThis suppressor function is mediated by a CD8-dependent soluble factor and is not related to the expression of the gamma delta T cell receptor.
Krensky (1996)cell receptorT cellHuman cytolytic T lymphocytes specific for autologous Burkitt's lymphoma express the gamma, delta T cell receptor and recognize immunoglobulin idiotype in an MHC-unrestricted manner.
Exley et al. (1997)cell receptorT cellsA subset of human CD4-CD8- T cells that expresses an invariant Valpha24-JalphaQ T cell receptor (TCR)-alpha chain, paired predominantly with Vbeta11, has been identified.
van Erk et al. (2006)cell receptorT cellImmune response and signal transduction, specifically T cell receptor signaling and nuclear transcription factor kappaB signaling, were the overrepresented functional groups in the set of 141 genes that were differentially expressed in response to both breakfasts.
Rothenberg et al. (1996)cell receptorT cellsThese T cells expressed predominantly the gamma delta T cell receptor and mediated non-MHC-restricted cytotoxicity against EBV-infected target cells.
Wang et al. (2008)KLRD1T cellsFirst discovered in NK cells, the expression of inhibitory receptors (KLRG1, KLRB1, KLRC1, and KLRD1) [47,48], and activating receptor KLRC2 [49] has also been reported in activated CD8+ T cells, involved in TCR signalling, but not in activated CD4+ T cells or naive T cells.