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Cao et al. (2003)CD25T cellsIn summary, it is striking that in addition to all activated, potentially pathological T cells the synovial fluid from RA patients also contains CD25-expressing CD4(+) T cells with a regulatory capacity.
Zwickey et al. (2007)CD25T cellsCD25 expression on T cells was significantly increased for subjects ingesting Echinacea at 24 h with notable increases in activation from Astragalus and Glycyrrhiza.
Hamid et al. (1992)CD25T cellsHowever, CD25 was also expressed on non-CD3+ cells, assumed to be non-T cells.
Hamid et al. (1992)CD25T lymphocytesThus the majority of cells expressing CD25 in various types of atopic allergic inflammation in man were T lymphocytes.
Saifuddin et al. (1998)CD25T-cellTransfer of host T-cell membrane HLA-DR and CD25 to target cells by human retroviruses.
Zhuang et al. (2010)CD25T cellsCD4(+), CD8(+), and CD25(+) T cells that infiltrated tumors were detected and counted by immunohistochemistry.
Kuroiwa et al. (2004)CD25T cellsIn addition, no differences were observed in the expression of CD25 antigen, which represents an activated state of T cells.
Revillard (1990)CD25T lymphocytesLymphocyte counts are diminished and T lymphocytes present several alterations, including defective IL-2 synthesis, spontaneous expression of the p55 (CD25) chain of IL-2 receptor with high serum levels of this molecule, and defective T helper function in antibody production.
Shindo et al. (1990)CD25T-cellUsing KOLT-2 monoclonal antibody (mAb) recognizing a 44,000 molecular weight (MW) T-cell activation antigen (CD28), we observed the co-expression of KOLT-2 (CD28) antigen and Tac (CD25) antigen, associated with a 55,000 MW chain of the interleukin-2 receptor (IL-2R) complex.
Shibuya et al. (1989)CD25T cellIn fact, the expression of both IL-2 and IL-2 receptor (IL-2R, p55, CD25) genes is transiently induced upon T cell activation through the interaction of antigen/major histocompatibility complex (MHC) and T cell receptor complex.
Kanavaros et al. (1988)CD25T-cellFurthermore, the aggressive character of this T malignant lymphoma (T-ML) could be related to the expression of T-cell activation markers HLA-DR and Tac/CD25 and the proliferation-associated antigen Ki-67 on a high proportion of tumor cells.
Abe et al. (2008)CD25T cellsFoxp3 is a master gene of Treg cells, a novel subset of CD4(+) T cells primarily expressing CD25.
Abe et al. (2008)CD25T cellsThe majority of CD4(+)CD25(+) T cells in HCs were positive for Foxp3, but not all CD4(+)CD25(+) T cells in ACs were positive, indicating that Foxp3 expression is not always linked to CD25 expression in normal T cells.
Abe et al. (2008)CD25T cellsLeukemic (ATL) T cells constitutively expressing CD25 were characteristic of heterogeneous Foxp3 expression, such as intra- and inter-case heterogeneity in intensity, inconsistency with CD25 expression, and a discrepancy in the mRNA and its protein expression.
Sakaguchi (2004)CD25T cellsNaturally occurring CD4+ regulatory T cells, the majority of which express CD25, are engaged in dominant control of self-reactive T cells, contributing to the maintenance of immunologic self-tolerance.
Stanzani et al. (2004)CD25T cellsCD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans.
Stanzani et al. (2004)CD25T cellsTo determine whether a similar relationship exists in humans, we quantitated the coexpression of CD25 on CD4(+) and CD8(+) T cells within 60 donor grafts infused into matched siblings and examined GVHD incidence in the respective recipients.
Stanzani et al. (2004)CD25T cellsRecipients in whom GVHD developed received donor grafts containing significantly higher frequencies of CD4(+) T cells coexpressing CD25 than those who did not (median, 9.26% vs 2.22%; P =.004).
Stanzani et al. (2004)CD25T cellsFrequencies of donor graft CD8(+) T cells coexpressing CD25 were also higher (0.65% vs 0.14%; P =.002).
Clausen et al. (2003)CD25T-cellsThus, we separately assessed the proliferative and cytotoxic potential of CD56+ CD3- natural killer (NK) and CD56+ CD3+ T-cells in relation to their expression of CD25, CD69, and CD16 in vitro.
Chattopadhyay et al. (2006)CD25T cellsCD4+ T cells naturally expressing CD25 molecules (natural T regulatory cells (Tregs)) have a role in maintaining self tolerance and in regulating responses to infectious agents, transplantation Ags, and tumor Ags.
Biancotto et al. (2008)CD25T cellsIn these tissues, apoptosis was selectively increased in T cells expressing CD25/HLA-DR and p24gag but not in cells expressing either of these markers alone.
Haas et al. (2005)CD25T cellsThe human counterpart of this subset of T cells expresses high levels of CD25 and its role in human autoimmune disorders is currently under intense investigation.
Cerf-Bensussan et al. (1990)CD25T cellsIt was preceded by appearance of pericryptic CD3+CD4+ or CD8+ T cells of recipient origin, increasing numbers of which expressed CD25.
Glisic-Milosavljevic et al. (2007)CD25T cellsThe 1% of cells expressing the highest level of CD25 were collected and defined as CD4+CD25+high T cells, known to be enriched for Tregs[25].
Allakhverdi et al. (2006)CD25T cellsOBJECTIVE: We sought to examine whether CD4+ T cells bearing CD103 are suppressor cells, regardless of CD25 coexpression.
Jiang et al. (2003)CD25T-cellThe suppressive T-cell line showed sustained high CD25 expression.
Yamagiwa et al. (2001)CD25T cellsThe costimulatory effects of TGF-beta on naive CD4+ T cells up-regulated CD25 and CTLA-4 expression, increased their transition to the activated phenotype, but decreased activation-induced apoptosis.
Yamagiwa et al. (2001)CD25T cellsAlthough <1% of naive CD4+ T cells expressed CD25, depletion of this subset before priming with TGF-beta markedly decreased the generation of suppressive activity.
Makita et al. (2004)CD25T cellsAll human LP CD4(+) T cells regardless of CD25 expression constitutively expressed CTLA-4, glucocorticoid-induced TNFR family-related protein, and Foxp3 and proliferate poorly.
Makita et al. (2004)CD25T cellsIn LP CD4(+)CD25(+) T cells, however, cells expressing CD25 at high levels (CD4(+)CD25(bright)) suppressed the proliferation and various cytokine productions of CD4(+)CD25(-) T cells.
Becker et al. (2007)CD25T cellsWe demonstrate that CD4-activated CD25(+) Tregs suppress the proliferation of CD4(+) and CD8(+) T cells, their IL-2 and IFN-gamma production as well as the capacity of CD8(+) T cells to re-express CD25.
Engstrand et al. (2006)CD25T cellsA similar pattern was seen for CD3(+) T cells as well as for T cells expressing CD25 or MHC class II antigens.
Kobayashi et al. (1989)CD25T cellSurface and cytoplasmic expression of CD25 antigen in adult T cell leukemia/lymphoma cells have been reported, but similar events concerning CD2 and CD13 antigens have not been described previously.
Webb et al. (2009)CD25T-cellThe expression of T-cell activation markers CD25 and CD70 was assessed by flow cytometry.
Bīrsan et al. (2003)CD25T cellRESULTS: Not only lymphocyte proliferation, but also expression of various T cell surface antigens (CD25, CD11a, CD95, CD154) was suppressed by FK778.
Putnam et al. (2005)CD25T cellsIn humans, a subset of CD4+CD25+ T cells expressing high levels of CD25 (CD4+CD25high) with characteristics identical to murine CD4+CD25+ was recently described.
Salerno et al. (2006)CD25T cellRESULTS: Exposure to MF for 2 h and subsequent in vitro stimulation in the presence of the appropriate mitogen, caused a decrease of interferon-gamma production, a decrease of cell proliferation, a decrease of expression of CD25 and a decrease of cytosolic free calcium concentration in exposed CD4(+) T cell lines.
Cavani et al. (2003)CD25T cellsCD4(+) T cells isolated from the peripheral blood of six healthy, nonallergic individuals showed a limited capacity to proliferate in response to nickel in vitro, but responsiveness was strongly augmented (mean increment +/- SD, 240 +/- 60%) when cells were depleted of CD25(+) Treg.
Cavani et al. (2003)CD25T cellsApproximately 30% of circulating CD25(+) Treg expressed the cutaneous lymphocyte-associated Ag (CLA), and CLA(+)CD25(+) Treg were more efficient than CLA(-)CD25(+) cells in suppressing nickel responsiveness of CD25(-) T cells.
Brusko et al. (2009)CD25T cellsTreg and conventional T cells have classically been selected based upon their expression of the membrane-bound form of CD25 under baseline conditions [1].
Yagi et al. (2004)CD25T cellThe FOXP3 gene and its protein product were preferentially expressed in peripheral CD25(+)CD4(+) T cells, in particular CD25(+)CD45RO(+)CD4(+) T cells in normal individuals and, interestingly, in some human T cell leukemia virus type 1-infected T cell lines, which constitutively express CD25.
Wing et al. (2002)CD25T cellsAdult peripheral blood contained two populations of CD4(+) T cells that expressed CD25 at different densities.
Brusko et al. (2009)CD25T cellIt has been known since 1985 that production of the soluble form of CD25 (sCD25) associates with T cell activation in vitro [6].
Ning et al. (2005)CD25T cellsCD3, CD4, CD8, and CD25 expressed on T cells were analyzed by flow cytometry after coculture with MSCs for 0, 24, 72 hours and 7 days respectively.
Ning et al. (2005)CD25T cellsCD3, CD4, CD8 and CD25 expressed on T cells had no significant difference between experimental groups and control group.
Powell et al. (2008)CD25T cellsIn preclinical studies, incubation of human peripheral blood mononuclear cell with RFT5-SMPT-dgA mediated a partial reduction in the levels of CD25+, Foxp3-expressing CD4+ T cells in vitro.
Anraku et al. (2008)CD25T-cellMETHODS: We performed an immunohistochemical analysis of 32 extrapleural pneumonectomy specimens to assess the distribution of T-cell subtypes (CD3(+), CD4(+), and CD8(+)), regulatory subtypes (CD25(+) and FOXP3(+)), and memory subtype (CD45RO(+)) within the tumor.
Forrest et al. (2005)CD25T cellsWe found by flow cytometry that T cells obtained pre-transplant and stimulated ex-vivo with phytohemeagglutinine upregulated the IL-2R alpha-(CD25) and beta-(CD122) chains as expected.
Maeta et al. (1998)CD25T lymphocytesActivated T lymphocytes release a soluble form of IL-2R (SoIL-2R) into the bloodstream, which can be detected by CD25 monoclonal antibody.
Loureiro et al. (2000)CD25T cellsWe present a rare case of adult T cell leukemia/lymphoma (ATL) in which leukemic T cells expressed CD4 and CD25 surface antigens and infiltrated mammary glands during clinical course of the disease.
Dennett et al. (2002)CD25T cellsAge associated decline in CD25 and CD28 expression correlate with an increased susceptibility to CD95 mediated apoptosis in T cells.
Dennett et al. (2002)CD25T cellsActivation of T cells resulted in initial up-regulation of CD25, CD95 and CD28, although expression of CD25 and CD28 subsequently decreased with increasing PD.
Ennis et al. (2008)CD25T-cellUpon inclusion of HUCPVC with activated T-cell lines, the expression of both CD25 and CD45 showed a significant decrease.
Baratelli et al. (2005)CD25T cellsPhenotypic analysis revealed that PGE2 diminished CD25 expression in both CD4+CD25dim T cells and CD4+CD25bright T reg cells.
Rickert et al. (2006)CD25T cellsIn immobilized form, this protein efficiently stimulated alloreactive T cells to proliferate and produce interleukin (IL)-2 and interferon (IFN)-gamma in a concentration-dependent manner, up-regulating CD25 and CD69 expression.
Sakaguchi et al. (2007)CD25T cellsCharacterization of this autoimmune-suppressive CD4(+) T cell population revealed that they constitutively expressed the CD25 molecule, which made it possible to distinguish them from other T cells, delineate their developmental pathways, in particular their thymic development, and characterize their potent in vivo and in vitro immunosuppressive activity.
Strauss et al. (2007)CD25T cellsThe rapamycin-expanded CD4(+)CD25(high) T cell populations retained a broad TCR repertoire and, like CD4(+) CD25(+) T cells freshly obtained from the peripheral circulation, constitutively expressed CD25, Foxp3, CD62L, glucocorticoid-induced TNFR family related protein, CTLA-4, and CCR-7.
Dengler and Pober (2000)CD25T cellsEC caused activation and expansion of memory but not naive CD8+ T cells, which differentiated into EC-selective CTL that retained high surface expression of CD69, CD25, and CD62L and displayed low intracellular perforin content.
Talpur et al. (2006)CD25T-cellCD25 expression is correlated with histological grade and response to denileukin diftitox in cutaneous T-cell lymphoma.
Colantonio et al. (2002)CD25T cellsInterestingly, amongst circulating memory CD4(+)CD45RO(+) T cells, chemotactic responsiveness to CCL1 is restricted to cells expressing CD25 and/or CLA surface markers for regulatory T cells (Treg) and skin-homing T cells and maximal responsiveness is observed on CLA(+)CD25(+)T cells.
Górski et al. (1993)CD25T cellsAt concentrations of 10-100 nM the drug inhibited phytohaemagglutinin-induced expression of CD25 and HLA-D (by approximately 50%), but not phorbol myristate acetate-induced expression of CD69 on purified human T cells.
Stroopinsky et al. (2009)CD25T cellsStimulation of CD25(-) PBMC with allogeneic PBMC resulted in production of CD4(+)CD25(high) T cells.
Jonuleit et al. (2002)CD25TregThis explains previously published conflicting data on the role of TGF-beta in CD25(+) Treg cell-induced immunosuppression.
Arvand et al. (1996)CD25T cellFluorescence-activated cell sorter analysis of the patient's peripheral blood lymphocytes revealed generally enhanced expression of the T cell activity markers CD25 and human leukocyte antigen-DR and a marked increase in the number of gamma delta T cells, largely of the V delta 1-bearing subpopulation.
Ho et al. (1995)CD25T cellsPeripheral B cells, NK cells, CD4+ and CD8+ T cells, and the expression of CD69, CD25, HLA-DR, and CD71 antigens on the T cells were serially examined by dual-color flow cytometry.
Seki et al. (1999)CD25T cellsOur results suggest a possible interaction between activated T cells bearing CD25 and beta-chemokines, especially MIP-1alpha, which may contribute to the pulmonary involvement in HTLV-1 carriers.
Heinschink et al. (2000)CD25T-lymphocytesExpression of HLA-DR on T-lymphocytes was not influenced by PHA, whereas CD25 expression and MFI significantly increased.
Crellin et al. (2007)CD25T cellsIn order to avoid the pitfalls associated with cell isolation based on CD25 expression, we developed methodology to analyze subpopulations of FOXP3 positive and negative cells from ex vivo CD4(+) T cells.
Tassignon et al. (2001)CD25T lymphocytesIn this study, we show that azodicarbonamide prevents the progression of human CD4+ T lymphocytes into the G1 phase of the cell cycle, inhibits their blastogenesis, down-regulates their membrane expression of CD25 and CD69, and decreases their transcription of cytokine genes.
Scottą et al. (2008)CD25T cellsThe addition of exogenous IL-2 did not influence either FOXP3 or CD25 expression but rescued CD28-activated T cells from apoptosis.
Glisic-Milosavljevic et al. (2007)CD25T cellsSome of the possible causes include insufficient amount of ambient IL2[32], mutations in FoxP3[33] prevention of CD4+CD25+high T cells development or non-functional TGF-?
Glisic-Milosavljevic et al. (2007)CD25T-cellCD4+CD25+high T-cell apoptosis was significantly different across the clinical groups Kruskal-Wallis p<0.0001; ANOVA F?
Allakhverdi et al. (2006)CD25T-cellIn vitro-generated alloantigen-primed CD103+ cells coexpressed CD25, suppressed T-cell activation, and contained more FoxP3 mRNA than the CD103- CD25+ cells isolated from the same cultures.
Takahashi et al. (2006)CD25T cellsThen the proportion of CD45RO+CD25+ in peripheral blood CD4+ T cells was analyzed in patients and healthy controls by flow cytometry.
Fehse et al. (2000)CD25T lymphocytesEfficient depletion of alloreactive donor T lymphocytes based on expression of two activation-induced antigens (CD25 and CD69).
Haczku et al. (1996)CD25T-lymphocytesExpression of surface CD3, CD4 and CD8 and the activation marker CD25 was quantified on T-lymphocytes using flow cytometry.
Haczku et al. (1996)CD25T-lymphocytesIn contrast, CD25 expression on both CD4 and CD8 T-lymphocytes was inhibited by both drugs to an equivalent extent over the same range of concentrations.
Vayuvegula et al. (1990)CD25T cellsParaformaldehyde-fixed monocytes pulsed with anti-CD3 MoAb induced significantly less DNA synthesis, HLA-DR expression, and CD25 antigen expression on autologous T cells as compared to responses induced by unfixed anti-CD3-pulsed monocytes.
Bouic et al. (1996)CD25T-cellsIn vitro, ESF (1 was able to significantly enhance the expression of CD25 and HLA-Dr activation antigens on T-cells and increased the secretion, into the medium, of IL-2 and gamma interferon.
Jana et al. (2010)CD25T cellIn human subjects 1–3% of the CD4+ T cell population expressing the highest levels of surface CD25 demonstrates regulatory properties [6].
Chen et al. (2005)CD25T cellWe further show that this receptor is active by demonstrating that the ligand 1alpha,25-dihydroxyvitamin D3 (vitD3) significantly inhibits in a dose-dependent fashion phospholigand-induced gammadelta T cell expansion, IFN-gamma production, and CD25 expression.
Wakamatsu et al. (1999)CD25T cellsWhereas the virus-infected T cells expressed higher levels of HLA-DR, CD25, CD80, and CD86 Ags than apoptosis-resistant PHA-blasts, the T cell apoptosis was enhanced by addition of exogenous IL-2.
Godkin et al. (2008)CD25T cellsBACKGROUND: Data from rodent models suggest that a subpopulation of CD4+ T cells, characterized by the constitutive expression of CD25, play a key role in regulating many immune responses.
Broady et al. (2009)CD25T cellsWe found that exposure of peripheral blood mononuclear cells (PBMCs) or conventional T cells to rATG resulted in induction of transient rather than stable expression of CD25 and FOXP3.
Takahashi and Sakaguchi (2003)CD25T cellsThe CD25+CD4+ regulatory T cells are produced by the normal thymus as a functionally distinct subpopulation of T cells.
Wing et al. (2003)CD25T cellsWe demonstrate that adult human CD25+ cells regulate the response to myelin oligodendrocyte glycoprotein (MOG), as depletion of CD25(+) cells increases responses of PBMC and the addition of purified CD25+ cells suppresses MOG-specific proliferation and IFN-gamma production of CD4(+)CD25(-) T cells.
von Bergwelt-Baildon et al. (2006)CD25T-cellCD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition.
Gualco et al. (2009)CD25T-cellHuman T-cell lymphotropic virus (HTLV-1) is linked to the development of adult T-cell leukemia/lymphoma (ATLL), which frequently expresses CD25.
Everts et al. (2010)CD25T cellsIn addition, these T cells expressed lower levels of the activation markers HLA-DR and CD25 [25] (Fig. 4C).
Rowbotham et al. (2008)CD25T-cellsGli2DeltaC2 T-cells were hyper-responsive to activation by ligation of CD3 and CD28: they expressed cell surface activation markers CD69 and CD25 more quickly, and proliferated more than wild-type T-cells.
Lin et al. (2003)CD25T-cellT-cell activation was analyzed with the expression of surface markers (CD45RO/CD69/CD25).
Lin et al. (2003)CD25T cellsAlthough activated CB CD4+ T cells expressed comparable level of CD69/CD25 expression to adults, IFN-gamma production of activated CB CD4+ T cells was markedly deficient compared with that of corresponding APB CD4+ T cells.
Sullivan et al. (2002)CD25T-cellCD4(+) CD25(+) T-cell production in healthy humans and in patients with thymic hypoplasia.
Preffer et al. (1986)CD25T cellsThe cultured cells were almost all Leu-4+ (CD3) T cells (89% +/- 4), which expressed the activation markers DR (82% +/- 6) and the IL 2 (CD25) receptor (15% +/- 4).
Michaėlsson et al. (2008)CD25T cellsIn order to assess the frequency of TReg cells in HTLV-1 infected subjects, we measured the expression of CD25, CTLA-4, CD127 and GITR on CD4+ T cells by flow cytometry.
Terrazzano et al. (2005)CD25T cellsIn the GPI(-) T cells, severe defects in T cell receptor-dependent proliferation, interferon-gamma production, CD25, CD54, and human leukocyte antigen-DR surface expression were observed.
Amlot et al. (1996)CD25T cellsThe percentage of T cells expressing CD25 and CD26 varied no more than repeated estimation of the CD4 T cell subset, whereas other actags showed greater variability.