Viewing affirmative mentions of gene expression of IL17A (H. sapiens) in T cells

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Wróbel et al. (2003)IL-17T cellsHuman interleukin-17 (IL-17) is a proinflammatory cytokine produced by activated CD4 T cells.
Van Kooten et al. (1998)IL-17T cellsIL-17 is specifically produced by activated T cells, whereas biological activities are restricted to the activation of nonhematopoietic cells.
Van Kooten et al. (1998)IL-17T cellsIL-17 expression could also be found in in vitro cultured and activated graft-infiltrating T cells.
Lemmers et al. (2009)IL-17T lymphocytesPeripheral blood mononuclear cells of patients with alcoholic liver disease produced higher amounts of IL-17, and their CD4(+) T lymphocytes disclosed an IL-17-secreting phenotype.
Tesmer et al. (2008)IL-17T-cellSUMMARY: Our understanding of the role of T cells in human disease is undergoing revision as a result of the discovery of T-helper 17 (Th17) cells, a unique CD4(+) T-cell subset characterized by production of interleukin-17 (IL-17).
von Delwig et al. (2010)IL-17T cellsFurthermore, citrullinated aggrecan peptide-stimulated PBMCs from RA patients produced high levels of the proinflammatory cytokine interleukin-17 (IL-17), accompanied by an induction of IL-17+CD4+ T cells.
Dodon et al. (2004)interleukin 17T cellsTax protein of human T-cell leukaemia virus type 1 induces interleukin 17 gene expression in T cells.
Cirée et al. (2004)IL-17T-cellExpression and activity of IL-17 in cutaneous T-cell lymphomas (mycosis fungoides and Sezary syndrome).
Cirée et al. (2004)IL-17T cellsThese cutaneous T-cell lymphomas were selected because they are usually CD3+ CD4+ CD45RO+, a phenotype similar to nontransformed T cells producing IL-17.
Cirée et al. (2004)IL-17 mRNAT cellsWe show that in vitro activated malignant T cells derived from MF or SS patients express IL-17 mRNA and secrete this cytokine.
Fouser et al. (2008)IL-17AT cellsT-helper 17 (Th17) cells are a new lineage of CD4(+) T cells that are characterized by their production of interleukin-17A (IL-17A).
Paun et al. (2011)IL-17T cellsMoreover, Irf5-/- and WT mice showed comparable frequencies of IL-10- and IL-17-producing CD4+ T cells at d28 pi (data not shown).
Kabelitz and Schreiber (2009)interleukin-17T-cellsIn addition, recent evidence indicates that the newly discovered interleukin-17 producing Th(17) T-cells play an important role in promoting inflammatory reactions and tissue destruction in autoimmune diseases.
Mascarell et al. (2009)IL17T cellsSuch resident lingual CD4(+) T lymphocytes comprise both suppressive T cells as well as cells with memory/effector functions (i.e. expressing IFN gamma, IL4, IL10 and IL17 genes following stimulation), irrespective of the presence of the mucosal addressing marker CD103.
Kondo et al. (2009)IL-17T cellsCutting edge: Phenotypic characterization and differentiation of human CD8+ T cells producing IL-17.
Garrett-Sinha et al. (2008)IL-17AT-cellRECENT FINDINGS: A major paradigm shift in understanding how CD4+ T cells contribute to autoimmunity recently occurred with the discovery of a new T-cell population that produces the cytokine IL-17 (IL-17A), termed 'Th17'.
Shah et al. (2010)IL-17T cellsLikewise, patients with SLE have elevated amounts of IL-17 in serum and plasma, with an increased frequency of T cells producing IL-17 in peripheral blood [5,21-24].
Shah et al. (2010)IL-17T cellsHere we demonstrate that patients with SLE have an increased frequency of circulating CD4+ T cells producing IL-17, which correlates with disease activity, compared with healthy subjects, whereas both groups maintain similar frequencies of Th1 cells.
Shah et al. (2010)IL-17T cellsThese findings suggest that the balance of Th17 and Th1 responses as well as IL-6 production is dysregulated in SLE, leading to increased IL-17 production from CD4+ T cells, an increase that may contribute to disease pathogenesis.
Shah et al. (2010)IL-17T cellsAfter stimulating PBMCs for 4 hours with PMA and ionomycin, we identified CD4+ T cells producing IL-17, IFN-?
Shah et al. (2010)IL-17T cellsWe next determined the ratio of CD4+ T cells producing IL-17 to the same cells producing IFN-?
Shah et al. (2010)IL-17T cellsThe frequency of CD3+ T cells producing IL-17 (total IL-17+ T cells) correlated with SLEDAI scores (r = 532; P = 0.006).
Shah et al. (2010)IL-17T cellsIL-17 can be produced from different types of immune cells including CD4+ T cells, CD8+ T cells, and ??
Shah et al. (2010)IL17T cellsIn addition, IL17 gene expression was detected in T cells infiltrating the kidneys and in urine sediments of lupus patients [38,39].
Takahashi et al. (2005)Interleukin-17T cellsBACKGROUND: Interleukin-17 (IL-17) is exclusively produced by activated T cells, and this cytokine can induce inflammatory responses, support immune responses (Th1), and stimulate osteoclastic bone resorption in combination with receptor activator of NF-kappaB (RANK) and RANK ligand (RANKL).
Shin et al. (1999)IL-17T lymphocytesExpression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway.
Shin et al. (1999)IL-17 mRNAT cellsOur data showed that IL-17 mRNA was highly expressed in memory human peripheral CD8(+)45RO+T cells and CD4(+)45RO+T cells when peripheral blood mononuclear cells were first stimulated with ionomycin/PMA.
Shin et al. (1999)IL-17T cellsIL-17 expression in memory CD8(+)T cells required accessory signals since culture of ionomycin/PMA-activated CD8(+)45RO+T cells alone did not result to IL-17 expression.
Gerhardt et al. (2009)IL-17AT-cellsIL-17A is a pro-inflammatory cytokine produced by the newly identified Th17 subset of T-cells.
Maek-A-Nantawat et al. (2007)IL-17Th17We assessed IL-17 expression in the CD4(+) T cells (Th17) of 40 asymptomatic HIV-infected treatment-naive patients compared with 40 HIV-seronegative volunteers.
Maek-A-Nantawat et al. (2007)IL-17T cellsIn conclusion, HIV infection is associated with a significant increase in IL-17 production in both CD4(+) and CD4() T cells in peripheral blood.
Maek-A-Nantawat et al. (2007)IL-17T cellsIL-17 expression was further inducible by PMA/ionomycin stimulation in vitro only in CD4(+) T cells.
Brucklacher-Waldert et al. (2009)IL-17AT cellsIn this study, we report that a subset of human and mouse CD4(+) T cells as well as human Th17 T cell clones express IL-17A on their surface upon stimulation.
Gullick et al. (2010)IL-17T cellsOf note, in our studies, the vast majority of cells producing IL-17 in PB, SF or ST were T cells (% CD3+ mean ± SD in PB 95±4.5; SF 95±4.5; ST 95.6±7.8%, Fig. 3).
Gullick et al. (2010)IL-17T cellsWe then assessed if the presence of CD4+ T cells expressing IL-17, IFN?
Gullick et al. (2010)IL-17T cellsOur demonstration that the local presence of IL-17 producing CD4+ T cells (either Th17 or IL-17+IFN?
Witowski et al. (2000)IL-17T cellsBecause IL-17 production is restricted to activated T lymphocytes, the effects exerted by IL-17 may help one to understand the contribution of T cells to the inflammatory response.
Evans et al. (2009)IL-17AT cellsTh17 cells are a recently defined subset of proinflammatory T cells that contribute to pathogen clearance and tissue inflammation by means of the production of their signature cytokine IL-17A (henceforth termed IL-17).
Evans et al. (2009)IL-17T cellsWe propose that, in humans, newly recruited memory CD4(+) T cells can be induced to produce IL-17 in nonlymphoid inflamed tissue after cell-cell interactions with activated monocytes.
Pongcharoen et al. (2007)IL-17T cellsCONCLUSION: IFN-gamma and IL-17 are mainly produced by activated T cells but IL-1beta is primarily produced by monocytes, thus suggesting that immunoregulatory factors of JEG-3 cells selectively inhibit cytokine production by activated T cells rather than that of the monocytes.
Lindén (2001)IL-17T-lymphocytesIL-17 is produced and released as a free protein from T-lymphocytes of the memory (CD45RO+) subset.
Lee et al. (2010)IL-17T cellsWe report here the presence of 2 distinct CD4(+) T-cell populations with and without expression of IL-1RI that correlates with the capacity to produce IL-17 in naive and memory CD4(+) T cells of human peripheral blood.
Lee et al. (2010)IL17T-cellIL-1RI(+) memory CD4(+) T cells had increased gene expression of IL17, RORC, and IRF4 even before T-cell receptor triggering, indicating that the effect of IL-1beta is programmed in these cells via IL-1RI.
Lee et al. (2010)IL-17T cellsFurthermore, IL-17 production from the cytokine-treated naive CD4(+) T cells was induced by IL-1beta and this induction was blocked by IL-1R antagonist.
Shin et al. (1998)IL-17T lymphocytesIn the present study, the expression of interleukin 17 (IL-17) by human CD8(+) T lymphocytes and its regulation following PKA activation was determined and compared with that of interferon gamma (IFN-gamma) and IL-10.
Shin et al. (1998)IL-17 mRNAT cellsIL-17 mRNA was highly expressed in human CD8(+) T lymphocytes at least at the same level than in CD4(+) T cells that were isolated from peripheral blood mononuclear cells (PBMC).
Shin et al. (1998)IL-17 mRNAT cellExpression of IL-17 mRNA in CD8(+) T cell was induced by prior activation of PBMC for 18 h with Ca2+ ionophore and phorbol myristate acetate (PMA).
Shin et al. (1998)IL-17T cellsTaken together, these results provide evidence that human CD8(+) T cells are also the source of massive expression of IL-17, and that PKA plays a prominent role in the switch of CD8(+) T cells to a Th2 like profile and an inhibition of IL-17 expression, thus suggesting that the activation of cAMP signal transduction pathway may have consequences for the relative role of CD8(+) T cells in the immune and inflammatory process.
Scriba et al. (2008)IL-17T cellDistinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.
Scriba et al. (2008)IL-17T cellsSpecific IL-17- and IL-22-producing CD4(+) T cells were distinct from each other and from Th1 cytokine-producing cells.
Scriba et al. (2008)IL-17T cellsIL-17- and IL-22-producing CD4(+) T cells may play important roles in the human immune response to mycobacteria.
Zhu et al. (2008)IL-17T cellsIn contrast to the murine model, however, our studies revealed that IL-17 expression was largely restricted to macrophages rather than T cells.
Zhu et al. (2008)IL-17T cellsTo our surprise, in our study there was little evidence of T cells expressing IL-17 in the tumours of breast cancer patients.
Ma et al. (2008)IL-17T cellsIn the present study, we assessed the effect of a selective PDE4 inhibitor Zl-n-91 on IL-17 production by PBMCs and by purified CD4(+) T cells following stimulation.
Ma et al. (2008)IL-17T cellsThe results for the first time demonstrated that the addition of Zl-n-91 into cell cultures of PBMCs and purified CD4(+) T cells could result in the suppression of IL-17 production at the protein and mRNA levels.
Ma et al. (2008)IL-17T cellsFurther analysis indicated that Zl-n-91 had a direct inhibitory effect on the IL-17 production by memory Th17 cells via the suppression of activation, proliferation and division of CD4(+) T cells.
Kreindler et al. (2009)IL-17AT cellInterleukin-17A (IL-17A), which has a receptor at the basolateral membrane of airway epithelia, is a T cell cytokine that has been shown to increase mucus secretion and antimicrobial peptide production by human bronchial epithelial (HBE) cells.
Chen et al. (2011)IL-17T cellsSince our study did not show significant correlation between CD8 T cells and IL-17, the results of our report may suggest that intratumoral expression of IL-17 may involve other mechanisms and anti-tumor effector cells alternative to the presence of CD8 T cells.
Dodon et al. (2004)IL17T cellIndeed, IL17 mRNA was highly expressed in HTLV-1-infected T cells as well as in Tax-expressing Jurkat T cells, whereas it was not detectable in HTLV-1-negative T cell lines.
Cirée et al. (2004)IL-17T cellsInterleukin-17 (IL-17) is a proinflammatory cytokine mainly produced by activated CD4+ CD45RO T cells.
Chizzolini et al. (2008)IL-17T-cellFurthermore, in CD4+ T-cell lines, the production of IL-17 segregated with the CCR6+ subset.
Chen et al. (2007)IL-17T cellsCONCLUSION: The present data demonstrate the differential regulation of IL-17 and RORgammat expression in human CD4+ T cells compared with murine cells.
Nistala et al. (2008)IL-17T cellsproduction in IL-17+, CD4+ T cells showed that a significant proportion of cells that produced IL-17 also produced IL-22 and similarly demonstrated coexpression of IL-17 and IFN?
Nistala et al. (2008)IL-17T cellsIt is now vital to have a detailed analysis of IL-17producing T cells in human disease in order to better understand their role in disease pathogenesis and to design appropriately targeted therapies.
Nistala et al. (2008)IL-17T cellsHowever, again, the site of inflammation showed a dysregulation, in that typically, more than half of those T cells producing IL-17 were within the IFN?
Shah et al. (2010)IL-17T cellsWe believe that further studies are warranted to determine the mechanism for increased IL-17 production from CD4+ T cells in human lupus.
Stamp et al. (2004)interleukin 17T lymphocytesUpregulation of synoviocyte COX-2 through interactions with T lymphocytes: role of interleukin 17 and tumor necrosis factor-alpha.
Ortega et al. (2009)IL-17Th17Our results show that CD8+IL-17+ cells from psoriasis-inflamed skin tissue produce TNF-alpha and IFN-gamma (Th1-related cytokines) as well as IL-17, IL-21, and IL-22 (Th17-related cytokines) efficiently.
Di Sabatino et al. (2008)IL17T cellTGFbeta blockade downregulated T cell apoptosis, and induced a significant increase in IFN gamma, TNFalpha, IL2, IL6, IL8 and IL17 production.
Li et al. (2000)IL-17T cellsWhereas expression of IL-17 is restricted to activated T cells, the IL-17 receptor is found to be widely expressed, a finding consistent with the pleiotropic activities of IL-17.
Gullick et al. (2010)IL-17T cellsIn our experiments the vast majority of cells in PB, SF and ST producing IL-17 were T cells, although our protocol used T cell stimulation with PMA and ionomycin.
Luzza et al. (2000)IL-17T cellIn the present study we investigated whether HP infection is associated with an increased production of IL-17, a T cell-derived cytokine capable of modulating IL-8 gene expression.
Chabaud et al. (1998)IL-17T cellsIL-17 is a cytokine produced by CD4 T cells that activates the production of inflammatory mediators by synoviocytes.
Chabaud et al. (1998)IL-17T cellsThus, some RA synovium T cells producing IL-17 can activate mesenchymal cells leading to an increased proinflammatory pattern sensitive to Th2 cytokine regulation.
Barnas et al. (2010)IL-17AT cellsThe tumor fibroblasts significantly enhance the production of IFN-gamma and IL-17A by the tumor-associated T cells following a CD3/CD28-induced activation of the T cells.
Boniface et al. (2010)IL-17T cellsIn addition to IL-17 single-producing T cells, IL-17/IFN-gamma double-positive T cells are found in significantly elevated numbers in inflamed tissues or blood from patients with chronic inflammatory disorders.
Kuang et al. (2010)IL-17T cellsTumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients.
de Beaucoudrey et al. (2008)IL-17T cellsMutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells.
de Beaucoudrey et al. (2008)IL-17T cellThese data suggest that IL-12Rbeta1- and STAT-3--dependent signals play a key role in the differentiation and/or expansion of human IL-17-producing T cell populations in vivo.
Albanesi et al. (1999)IL-17T cellSkin affected with ACD to nickel and skin-derived, nickel-specific CD4+ T cell lines expressed IFN-gamma, TNF-alpha, and IL-17 mRNAs.
Shin et al. (1998)IL-17T cellsData demonstrated a significant inhibition of IL-17 as well as of IFN-gamma mRNA expression in CD8(+) T cells isolated from activated PBMC cultured in the presence of either dibutyryl cAMP (db-cAMP) or PGE2.
Molet et al. (2001)IL-17T lymphocytesBACKGROUND: IL-17 is a cytokine that has been reported to be produced by T lymphocytes.
Molet et al. (2001)IL-17T cellsWe demonstrated that in addition to T cells, eosinophils in sputum and bronchoalveolar lavage fluids expressed IL-17.
Wright et al. (2007)IL-17AT cellsFurthermore, we find that in addition to the homodimers of IL-17F and IL-17A, activated human CD4+ T cells also produce the IL-17F/IL-17A heterodimer.
Acosta-Rodriguez et al. (2007)IL-17T cellsWe report here that expression of CCR6 and CCR4 together identified human memory CD4+ T cells selectively producing IL-17 and expressing mRNA encoding the human ortholog of mouse RORgammat, a transcription factor, whereas CCR6 and CXCR3 identified T(H)1 cells producing interferon-gamma and T helper cells producing both interferon-gamma and IL-17.