Viewing affirmative mentions of gene expression of IL10 (H. sapiens) in T cells

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Mori and Prager (1998)Interleukin-10T-cellInterleukin-10 gene expression and adult T-cell leukemia.
Mori and Prager (1998)IL-10T-cellSince little is known regarding IL-10 expression in leukemic T-cells, we examined clinical specimens of patients with adult T-cell leukemia (ATL) for IL-10 expression.
Mori and Prager (1998)IL-10T-cellIL-10 is constitutively produced by ATL cells and also by human T-cell leukemia virus type I (HTLV-I)-infected cell lines.
Thye et al. (2009)IL-10T-lymphocytesAfter phagocytosis of the pathogen, macrophages, T-lymphocytes and other cells produce IL-10 [42][44].
Boulland et al. (1998)IL-10T-cellIt was found that 8 of 11 (73%) anaplastic large cell lymphomas (ALCLs), 2 of 11 (18%) pleomorphic T-cell lymphomas, and 3 of 7 (43%) nasal NK-cell lymphomas exhibited a large number of IL-10-expressing cells, whereas only rare scattered cells were detected in angioimmunoblastic (11 of 11) and in gammadelta T-cell lymphomas (6 of 6).
Jimenez and Rosenbloom (1985)CSIFT-lymphocyteFrom the 10 lines tested (4 T- and 6 B-lymphocyte cell lines), we found 2 T-lymphocyte cell lines which produced CSIF constitutively.
Terai et al. (2009)IL-10T cellTransfection of IL-10-producing melanoma cells with the monomeric IL-10 immunoadhesin plasmids totally captured endogenously produced IL-10 and enhanced T cell responses against allogeneic melanoma cells.
Zhao et al. (2010)IL10T cellsTo understand the mechanism(s) underlying the overexpression of IL10 and IL13 in SLE CD4+ T cells, we investigated the methylation status of CpG islands within known regulatory domains for these genes.
Parry et al. (1997)IL-10T cellsStimulation of monocyte IL-10 production was abrogated when T cells were separated physically from monocytes within the tissue culture well.
Parry et al. (1997)IL-10T cellFurthermore, T cell membrane TNF-alpha was shown to be one of the contact-mediated signals regulating monocyte IL-10 production.
Sumiyoshi et al. (2006)Interleukin-10T-lymphocyteInterleukin-10 expression is positively correlated with oxidized LDL deposition and inversely with T-lymphocyte infiltration in atherosclerotic intimas of human coronary arteries.
Chehimi et al. (1996)IL-10T cellOn the other hand, HIV infection of selected CD4+ T cell clones generated in a Th1- or Th2-like environment, differentially up-regulated IL-10 production, with significantly higher production by Th2 clones.
Katsikis et al. (1994)IL-10T cellTaken together, the above findings suggest that IL-10 is spontaneously produced in RA and OA and is an important immunoregulatory component in the cytokine network of RA, regulating monocyte and in some cases T cell cytokine production.
Birkeland et al. (1999)IL-10T-cellInterleukin-10 (IL-10) is a pleiotropic cytokine, produced primarily by T-helper 2 (Th2) lymphocytes in the later stages of T-cell activation, suggested to play a role in EBV-associated PTLD.
Mahanty et al. (1996)IL-10T cellThere was a negative correlation between PAg driven IL-10 production by PBMC and PAg-specific T cell proliferation in the MF group.
Kanda (1999)interleukin-10T cellsGangliosides GD1a and GM3 induce interleukin-10 production by human T cells.
Kanda (1999)IL-10T cellsThese results suggest that GD1a and GM3 may induce IL-10 production in T cells by regulating the PTK-dependent signaling pathway.
Enzmann et al. (2001)IL-10T-cellCONCLUSIONS: The IL-10-producing hTERT-RPE1 cells had an immunosuppressive action on T-cell proliferation in vitro.
Xystrakis et al. (2006)IL-10T cellsAddition of vitamin D3 with dexamethasone to cultures of SR CD4+ T cells enhanced IL-10 synthesis to levels observed in cells from glucocorticoid-sensitive patients cultured with dexamethasone alone.
Nagata et al. (2002)IL-10T-lymphocytesInterleukin 10 (IL-10) is an immunosuppressive cytokine produced by T-lymphocytes, and is a regulatory molecule for angiogenesis in various cancers.
Daftarian et al. (1995)IL-10T cellsAnalysis of the source of the IL-10-producing cell subset in PBMC demonstrated that in HIV+ individuals, IL-10 is produced by monocytes, while in HIV- controls, it is produced by both T cells and monocytes.
Delpuech et al. (2001)interleukin-10T cellsThe hepatitis C virus (HCV) induces a long-term increase in interleukin-10 production by human CD4+ T cells (H9).
Delpuech et al. (2001)IL-10T cellTherefore, we investigated whether the exposure of the CD4+ T cell line H9 to HCV could induce activation of cells through synthesis of IL-10.
Curreli et al. (2002)interleukin-10T cellsIFN-alpha2b increases interleukin-10 expression in primary activated human CD8+ T cells.
Curreli et al. (2002)IL-10T cellsWe demonstrate here that interferon-alpha2b (IFN-alpha) increases the expression of IL-10 in activated primary CD8(+) T cells.
Mori and Prager (1997)IL-10T-cellResting HuT 78, a T-cell line derived from a Sezary lymphoma, produced significant amounts of IL-10 compared with another T-cell line, Jurkat.
Mori and Prager (1997)IL-10T-cellTo elucidate the mechanisms by which the IL-10 is expressed, we have analyzed their activity in human T-cell lines.
Mori and Prager (1997)IL-10 geneT cellsThese novel findings may account for the specific IL-10 gene expression in T cells.
Daftarian et al. (1996)IL-10T cellsIL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha.
Daftarian et al. (1996)IL-10T cellsTo further clarify the monokine(s) responsible for IL-10 induction, we stimulated monocyte-depleted PBMC, purified CD4+, and CD8+ T cells with PHA and measured IL-10 production by ELISA and semiquantitative reverse transcriptase-PCR following monokine(s) addition.
Daftarian et al. (1996)IL-10T cellsSimilarly, IL-12 and IL-6 induced IL-10 production by purified CD4+ and CD8+ T cells.
Daftarian et al. (1996)IL-10T cellsTaken together, these findings suggest that IL-10 production by human T cells and monocytes is differentially regulated.
Daftarian et al. (1996)IL-10T cellsIL-12 and/or IL-6 can induce the expression of IL-10 by PHA-stimulated T cells, whereas TNF-alpha induces IL-10 production by monocytes.
Roncarolo et al. (2006)IL-10T-cellWe propose to use the term Tr1 cells for all IL-10-producing T-cell populations that are induced by IL-10 and have regulatory activity.
Braunstein et al. (1997)interleukin-10T cellsT cells of the human intestinal lamina propria are high producers of interleukin-10.
Seneviratne et al. (2002)IL-10T cellsThe specific T cells were able to produce IFN-gamma efficiently, but their IL-10 production was significantly reduced in severely affected atopics.
Ilan et al. (2010)IL-10T cellRESULTS AND DISCUSSION: Oral OKT3 enhanced T cell proliferation, suppressed Th1 and Th17 responses by 43% and 41%, respectively, increased TGF-beta/IL-10 expression and decreased IL-23/IL-6 expression by dendritic cells, and affected the IgG repertoire as measured by antigen arrays.
Guazzarotti et al. (2009)IL-10T lymphocytesResults showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented.
Furio et al. (2009)IL-10T cellsPoly(I:C)-Treated human langerhans cells promote the differentiation of CD4+ T cells producing IFN-gamma and IL-10.
Lundin et al. (2007)interleukin-10T-cellThe local and systemic T-cell response to Helicobacter pylori in gastric cancer patients is characterised by production of interleukin-10.
Bianco et al. (2005)IL10T cellsPeripheral CD4+ T cells, obtained by magnetic bead vs negative purification, were studied using a computer-assisted enzyme-linked immunospot assay (ELISPOT) to assess the number of IFN-gamma-, interleukin (IL)5-, and IL10-gamma-producing cells (no./10(6) CD4+ cells) after allogeneic stimulation.
Lagler et al. (2003)interleukin-10T cellsCellular profile of cytokine production in a patient with visceral leishmaniasis: gammadelta+ T cells express both type 1 cytokines and interleukin-10.
Vigouroux et al. (2003)interleukin 10T-cellHowever, we observed a 35% inhibition of proliferation and a >65% reduction in cytotoxic-T-cell activity, and interleukin 10 production was increased ninefold.
Lazetic et al. (2002)interleukin 10T cellIn contrast, CTLA-4BP inhibited human mixed leukocyte reaction (MLR) and enhanced interleukin 10 production in MLR, supporting a role for CTLA-4BP in inducing T cell anergy and tolerance.
Peng et al. (1997)interleukin 10T cellsInterleukin 12 and B7/CD28 interaction synergistically upregulate interleukin 10 production by human T cells.
Gerosa et al. (1996)interleukin-10T cellInterleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.
Gollob et al. (1996)interleukin-10T cellEarly message expression of interleukin-4 and interferon-gamma, but not of interleukin-2 and interleukin-10, reflects later polarization of primary CD4+ T cell cultures.
Pierkes et al. (1999)IL-10T-cellBACKGROUND: Recent studies provide evidence that venom immunotherapy (VIT) alters the pattern of cytokine production by inducing an allergen-specific T-cell shift in cytokine expression from TH2 (IL-4, IL-5) to TH1 (IFN-gamma) cytokines and also inducing the production of IL-10.
Pierkes et al. (1999)IL-10T cellsCONCLUSION: These data indicate that T cells (producing IL-10 and IFN-gamma after VIT) play a key role for the inhibition of histamine and sulfidoleukotriene release of effector cells.
Shimamoto et al. (2007)IL-10T cellsInterestingly, approximately 4% of mucosal NKR(+) T cells expressing IL-10 were detected by in vitro stimulation with PMA and ionomycin.
Tinkle et al. (1999)IL-10T lymphocyteTo test this hypothesis, we used bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN-gamma, and TNF-alpha, and on T lymphocyte proliferation.
Tinkle et al. (1999)IL-10T lymphocyteOur data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte proliferation.
Li et al. (2005)IL-10T lymphocytesCD4+CD25+ T lymphocytes were identified in the perigranulomatous clusters but were not associated with IL-10 production.
Chan et al. (2007)IL-10T cellIn general, all these polysaccharides did not polarize T cells into either T(h)1 or T(h)2 or regulatory T cells, except for crude spore polysaccharides-treated DCs which could suppress T cell proliferation with IL-10 production.
Chheda et al. (1996)interleukin-10T cellsDecreased interleukin-10 production by neonatal monocytes and T cells: relationship to decreased production and expression of tumor necrosis factor-alpha and its receptors.
Chheda et al. (1996)IL-10T cellsIn experiments with enriched populations of neonatal T cells, the addition of PMA failed to augment IL-10 production.
Fujiwara et al. (1996)IL-10T lymphocytesCell separation experiments indicated that cells producing IL-10 when stimulated with M. tuberculosis or LPS were monocytes, not T lymphocytes.
Thompson et al. (2007)IL-10T cellsAlso, rosiglitazone specifically induces the production of IL-10 from TCR-activated human CD4+ T cells and that this effect is PPAR-gamma-dependent.
van Roon et al. (1996)IL-10T cellsIL-10 and IL-4, both produced by type 2 T cells, are cytokines with the capacity to down-regulate proinflammatory responses.
Schlaak et al. (1994)IL-10T cellsIt is because of these pleiotropic immunoregulatory effects that the detection of IL-10 in the supernatants of T cells, B cells, macrophages and other cells is important for many scientific questions.
Aman et al. (1996)interleukin-10T cellsInterferon-alpha stimulates production of interleukin-10 in activated CD4+ T cells and monocytes.
Aman et al. (1996)interleukin-10T cellsIn the present study, we investigated the effect of interferon-alpha (IFN-alpha) on the expression of interleukin-10 (IL-10) mRNA and protein synthesis in human monocytes and CD4+ T cells.
Zhang et al. (2006)IL-10T cellsIntracellular cytokine staining showed that T cells are a major source of IFN-gamma and IL-10.
Chhabra et al. (2008)IL-10T cellFor example, IL-12 producing DC generate Th1 type T cell response whereas IL-10 producing DC is usually tolerogenic.
Mori et al. (1996)Interleukin-10T-cellInterleukin-10 gene expression in adult T-cell leukemia.
Byrnes et al. (1999)IL-10T cellsEnhancement of IL-10 production by MIP-3beta correlated with the inhibition of IL-12 p40 and TNF-alpha production by monocytes and with the impairment of IFN-gamma production by T cells, which was reversed by addition of anti-IL-10 Abs to the cultures.
Bosma et al. (2008)interleukin-10T cellsDexamethasone transforms lipopolysaccharide-stimulated human blood myeloid dendritic cells into myeloid dendritic cells that prime interleukin-10 production in T cells.
Bosma et al. (2008)interleukin-10T cellsIn contrast, simultaneous treatment with dex and LPS yielded tolerogenic MDC, that had a reduced expression of CD86 and CD83, that poorly stimulated allogeneic T-cell proliferation and production of T helper 1 (Th1) cytokines, and primed production of the immunoregulatory cytokine interleukin-10 (IL-10) in T cells.
Cohen et al. (1997)IL-10T cellsWe confirm that IL-10 is produced comparatively late after the activation of human T cells via CD3 stimulation, after IL-2 and IFN-gamma.
Cohen et al. (1997)IL-10T cellFurthermore we show that IL-10 production by human T cell lines, such as IFN-gamma and IL-2, is inhibited by the immunosuppressive drugs cyclosporin A and FK506.
Cohen et al. (1997)IL-10T cellsSince IL-2 is the major growth factor for T cells and is detected before IL-10, we focused on this factor as a potential activator of IL-10 production.
Cohen et al. (1997)IL-10T cellsWe showed that IL-10 production by human T cell lines stimulated by immobilized anti-CD3 in the presence of neutralizing Abs to IL-2 and IL-2R (anti-CD25) was inhibited, whereas addition of exogenous IL-2 enhanced IL-10 production, indicating that IL-10 production by human T cells can be driven by stimulation via IL-2.
Ostrowski et al. (2001)IL-10T cellsCirculating frequencies of CD4(+) T cells constitutively producing IL-10, however, were significantly higher in individuals with progression or active replication.
Ostrowski et al. (2001)IL-10T cellsIn 17 of 30 HIV-1-infected individuals, gag antigen was observed to induce IL-10 production from CD4(+) T cells.
Ostrowski et al. (2001)IL-10T cellsIn 2 individuals, early treatment of acute HIV-1 infection "rescued" low to undetectable gag-specific IFN-gamma-producing CD4(+) T cell responses and dramatically down-regulated constitutive IL-10 production from circulating CD4(+) T cells.
Liopeta et al. (2009)IL-10T lymphocytesHowever, the mechanism of cAMP mediated regulation of IL-10 production by T lymphocytes remains unclear.
Liopeta et al. (2009)IL-10T lymphocytesThese results suggest that the inhibitory effect of cAMP on IL-10 production by normal peripheral T lymphocytes is cell type and stimulus specific, exerted on multiple levels and involves MEF2 transcription factor.
Liopeta et al. (2009)IL-10T lymphocytescAMP regulates IL-10 production by normal human T lymphocytes at multiple levels: a potential role for MEF2.
Oberholzer et al. (2002)IL-10T cellHowever, transduction with vectors expressing human IL-10 limit DC maturation and associated T cell activation in the draining lymph node.
Rafiq et al. (2001)IL-10T cellsRegulation of the IL-10 production by human T cells.
Rafiq et al. (2001)IL-10T cellsThe IL-10 production was studied in cultures of freshly isolated human T cells.
Ruiz-Perez et al. (2005)IL-10T cellsIL-10 production by these T cells and their ability to prevent fibrosis is controlled by the inducible costimulator (ICOS)-ICOS ligand pathway.
Blaser et al. (1999)IL-10T cellsIntracytoplasmatic cytokine staining revealed that IL-10 was initially produced by activated allergen-specific T cells.
Arosio et al. (2010)IL-10T cellsThis SNP alters transcriptional activation with a gene dosage-related effect, so GG genotype correlates with high, GA with intermediate, and AA with low IL-10 production after stimulation of T cells in vitro [12].
Meyaard et al. (1996)IL-10T cellsIL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses.
Meyaard et al. (1996)IL-10T cellsOur results showed that upon stimulation with CD2 mAb, IL-12 was capable of inducing human T cells to produce IL-10.
Meyaard et al. (1996)IL-10T cellsIL-12 was able to induce IL-10 production in primary T cells in the absence or the presence of accessory cells and in short-term cultures of established T cell clones.
Chabot et al. (2001)IL-10T lymphocytesThis study shows that the PMA/IFN gamma-treated U937 cell line shows similarities to microglia in its interaction with activated T lymphocytes, in that the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-4, IL-10 and IL-12 is induced.
Garcia et al. (2009)IL-10T cellsc-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells.
Garcia et al. (2009)IL-10T cellsIn the present study, we demonstrate that IL-12p70 induces IL-10 production from human memory CD4+ T cells via a PI3K-dependent signaling mechanism.
Garcia et al. (2009)IL-10T cellsThese studies identify the cellular mechanism by which IL-12 induces IL-10 production from human memory CD4+ T cells.