Viewing affirmative mentions of gene expression of IL6 (H. sapiens) in T cells

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Ming and Granelli-Piperno (1990)IL-6T cellsDistinctive features in the production of IL-6 by human T cells.
Yasukawa et al. (1987)IL-6T cellThe BSF-2/IL-6 mRNA was found to be constitutively expressed in a human T cell leukemia virus-1 transformed T cell line, TCL-Na1, a bladder cell carcinoma line, T24, and an amnion derived cell line, FL.
Aarden and van Kooten (1992)IL-6T cellsUnder most conventional stimulation conditions T cells themselves produce little or no IL-6.
Horii et al. (1988)BSF-2T cellsMacrophage-dependent synthesis of BSF-2/IL-6 by T cells.
Horii et al. (1988)BSF-2 mRNAT cellsThis was caused by different kinetics of BSF-2 mRNA expression in distinct subpopulations of MNC; M phi expressed BSF-2 mRNA at 5 h in the absence of any stimulation, and mitogen-stimulated T cells and B cells expressed BSF-2 mRNA 48 h after stimulation.
Horii et al. (1988)BSF-2T cellsImmunohistochemical staining of the cells with anti-BSF-2 antibody demonstrated that macrophages, T cells and B cells could produce BSF-2.
Horii et al. (1988)BSF-2T cellsThe requirement of macrophage for BSF-2 production in T cells could be replaced by TPA but not by IL-1 or BSF-2.
Villiger et al. (1991)IL-6T lymphocytesIL-6 production by human T lymphocytes.
Villiger et al. (1991)IL-6T cellAlthough this cytokine is produced by diverse cell types, it is not known whether it is produced by T lymphocytes under physiologic conditions or which agents can induce T cell expression of IL-6.
Villiger et al. (1991)IL-6T cellWe analyzed the production of IL-6 by human peripheral blood T cells, human thymocytes, and human T cell lines.
Nakajima et al. (1989)BSF-2T cellsHIV-induced BSF-2 production was seen in monocyte/macrophages, but not in T cells.
Tanaka et al. (1997)IL-6T cellsThe in vivo administration of recombinant adenovirus vector expressing IL-6 cDNA induced CD8+ human CTLs specific for autologous human tumor cells from human precursor T cells.
Muraoka et al. (1993)interleukin-6T-cellThe interleukin-6 (IL-6) gene is expressed by various stimuli including cytokines or viral infections, such as human T-cell leukemia virus type I (HTLV-1).
Spörri et al. (1997)IL-6T cellAutologous versus allogeneic T cell-stimulated IL-6 production by dermal fibroblasts.
Tanner and Menezes (1994)IL-6T cellsExpression of IL-6 in T cells appears to be due mainly to CsA.
Venkataraman (1994)IL-6T cellThey also indicate that a subset of CD4+ Leu-8+ T cells might be involved in feedback inhibition of PHA-induced T cell-mediated IL-6 production.
Galandrini et al. (1991)IL6T-cellThe majority of several hundred T-cell clones, both CD4+ and CD8+, produced IL6 in response to relatively high doses of IL2.
Colombatti et al. (2001)IL-6T-cellWe found that T-cell adhesion and T-cell soluble factors induce IL-6 gene expression in U251 astrocytes through distinct signaling pathways, respectively, resulting in the activation of NF-kappaB and IRF-1 transcription factors.
Oyaizu et al. (1991)interleukin-6T-cellHuman immunodeficiency virus type 1 envelope glycoproteins gp120 and gp160 induce interleukin-6 production in CD4+ T-cell clones.
Oyaizu et al. (1991)IL-6T cellsIn addition, we have shown that the envelope glycoproteins act directly on CD4(+)-cloned T cells to induce IL-6 production in the absence of monocytes.
Yamashita et al. (1994)IL-6T cellsAccumulating evidence suggests that the infection of T cells and other cell types with human T-lymphotropic virus type 1 (HTLV-1) results in the constitutive expression of IL-6.
Mori et al. (1994)IL-6T-cellFreshly isolated leukemic cells from patients with adult T-cell leukemia (ATL) and human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of interleukin-6 (IL-6) protein and mRNA.
Rifas and Avioli (1999)IL-6T cellsPurified T cells were activated with a combination of anti-CD3 and anti-CD28 antibodies, cocultured with hOBs in direct physical contact or separated by a transwell system, and conditioned media (CM) were assayed for IL-6 production.
Rifas and Avioli (1999)IL-6T cellAfter a 72 h incubation period, activated T cell-hOB interaction resulted in a 100-fold increase of IL-6 production over basal levels.
Rifas and Avioli (1999)IL-6T cellThe immunosuppressant cyclosporine A (CsA) inhibited T cell tumor necrosis factor alpha and IL-6 production but did not inhibit the T cell induction of IL-6 from hOB.
Rifas and Avioli (1999)IL-6T cellsThese findings suggest that activated T cells produce a novel, potent, IL-6 inducing factor that may be responsible for the bone loss observed in RA patients.
Morgan et al. (1990)IL-6T cellsFc region fragments induce both monocytes and T cells to produce IL-6.
Ilan et al. (2010)IL-6T cellRESULTS AND DISCUSSION: Oral OKT3 enhanced T cell proliferation, suppressed Th1 and Th17 responses by 43% and 41%, respectively, increased TGF-beta/IL-10 expression and decreased IL-23/IL-6 expression by dendritic cells, and affected the IgG repertoire as measured by antigen arrays.
Queen et al. (2005)interleukin-6T lymphocytesOncostatin M is a pleiotropic cytokine belonging to the interleukin-6 family that is expressed by several cell types including activated human T lymphocytes, macrophages, and neutrophils.
Ono et al. (1997)interleukin-6T-cellAccumulation of the human T-cell leukemia virus type-1-infected cells and constitutive expression of viral and interleukin-6 messenger ribonucleic acids.
Wang et al. (1993)interleukin-6T-cellThe effects of synthetic alkyl ((alkyl 6-deoxy-a-D-gluco-heptopyranosyluronate) 6-deoxy-a-D-gluco-heptopyranoside) uronates, a novel type of mirror pseudo cord factor, on the in vitro modulation of interleukin-6 production and T-cell proliferation in human peripheral blood mononuclear cells, were investigated.
Mori et al. (1995)interleukin-6T cellOBJECTIVE: To determine the effect of the human T cell leukemia virus type I (HTLV-I) tax gene on interleukin-6 (IL-6) production and gene transcription in synovial cells, we established the synovial cell line, E-11, from a patient with rheumatoid arthritis.
Andersson and Matsuda (1989)IL 6T cellPolyclonal T cell activation with staphylococcal enterotoxin A or anti-CD3 mAb induced a biphasic production pattern of IL 6 as well as TNF alpha.
Wognum et al. (1993)IL-6T lymphocytesCD8+ T lymphocytes also expressed IL-6 receptors but at lower levels than CD4+ cells.
Tseng et al. (2010)IL-6T cellThymic interleukin-6 (IL-6), which is produced primarily by thymic epithelial cells, is an important cytokine for T cell growth and differentiation in the thymus.
Lapeña et al. (1996)interleukin-6T lymphocytesIncreased production of interleukin-6 by T lymphocytes from patients with multiple myeloma.
Lapeña et al. (1996)interleukin-6T lymphocytesWe have investigated the production of interleukin-2 (IL-2) and interleukin-6 (IL-6) by T lymphocytes from 14 patients with multiple myeloma (MM) and 16 healthy controls.
Lapeña et al. (1996)IL-6T lymphocytesThe IL-6 production by PHA-stimulated T lymphocytes from the MM patients was significantly higher than in healthy controls (p < 0.01).
Zeng et al. (1998)interleukin-6T cellsEP4/EP2 receptor-specific prostaglandin E2 regulation of interleukin-6 generation by human HSB.2 early T cells.
Okada et al. (1997)IL-6T cellAccordingly, in inflamed periodontal tissues, gingival fibroblasts and periodontal ligament fibroblasts stimulated with pro-inflammatory cytokines such as IL-1 or TNF-alpha, may produce IL-6, and this production can be differentially modulated by endogenous PGE2, IL-6sR, T cell-derived cytokines such as IFN-gamma or IL-4, and glucocorticoids.
Mori et al. (1993)IL-6T-cellFreshly isolated leukemic cells from patients with adult T-cell leukemia (ATL) produce high levels of interleukin 6 (IL-6), which is suggested to play an important role in thrombocytosis, elevation of C-reactive protein, and hypercalcemia in ATL.
Mori et al. (1993)IL-6T-cellIn this study, we investigated the effects of T-cell growth factors such as interleukin 2 (IL-2) and interleukin 4 (IL-4) on IL-6 production by ATL cells in vitro.
Lal et al. (1993)IL-6T-cellRecent reports of constitutive IL-6 production from spontaneously proliferating cells from human T-cell leukemia virus (HTLV)-infected individuals led us to examine the expression of IL-6 and LIF during HTLV infection.
Lal et al. (1993)IL-6T-cellNorthern blot analysis of T-cell lines generated from individuals infected with HTLV-I (MT-2, HuT-102, FS, EG, SP) and HTLV-II (Mo-T, H2A, H2E) demonstrated a marked increase in constitutive expression of LIF and IL-6 transcripts, as compared with uninfected cell lines (HuT-78, Jurkat).
Hirohata et al. (1992)IL6T cellsStreptococcal-related antigens stimulate production of IL6 and interferon-gamma by T cells from patients with Behcet's disease.
Hirohata et al. (1992)IL6T cellThe enhancement of T cell IL6 production was not related to the presence of HLA-B51, which has been shown to be frequently associated with Behçet's disease.
Hustmyer et al. (1992)IL-6T-cellThe influence of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the proliferation of lymphocytes and on the production of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and interferon-gamma (IFN-gamma) was examined in normal human peripheral blood mononuclear cells (PBMC) activated in vitro either by phytohaemagglutinin (PHA) or by the monoclonal antibody to the T-cell receptor OKT3, or by the combination of each of these two stimuli with phorbol myristate acetate (PMA). 1,25(OH)2D3 inhibited the proliferative response of PBMC to PHA; this effect, however, was abrogated by the addition of PMA (1.6 nM), and it was reversed from inhibition to stimulation by higher concentrations of the phorbol ester.
van Haarst et al. (1996)IL-6T-cellWe also investigated whether subsets of LAF cells (i.e., positive or negative for CD1a and purified by FACS sorting) differed in T-cell stimulatory capacity and in the ability to produce IL-1, IL-6, TNF-alpha, and S100.
Kharkevitch et al. (1994)IL-6T-cellSpecific IL-4, IL-6 or IL-10 production by the CD4+ M73 T-cell line and its clone was inhibited by anti-class II DR (but not anti-class I) MAb, whereas their specific cytotoxicity was inhibited by anti-class I (but not anti-class II) MAb.
Kharkevitch et al. (1994)IL-6T-cellCD4+ potential T-cell clones, but not CD8+ clones, that were established from freshly isolated TILs without in vitro sensitization by autologous tumor cells also produced IL-4, IL-6 and IL-10 but not IFN-gamma or tumor necrosis factor (TNF) alpha in an autologous tumor-specific fashion.
Kharkevitch et al. (1994)IL-6T-cellPMA and PHA stimulated these potential T-cell clones, regardless of their specific lymphokine production, to produce IL-3, IL-4, IL-6, IL-8, IL-10, GM-CSF, TNF alpha and IFN-gamma.
Nilsson et al. (1994)IL-6T-cellKU812 was also shown to express receptors for both TNF-alpha and IL-6 after 3 days cultivation with conditioned media from the Mo T-cell line.
Villiger et al. (1991)IL-6T cellScreening of various human T cell lines showed that all cell lines infected with HTLV-1 secrete IL-6 activity and express IL-6 mRNA.
Banning et al. (1998)IL-6T-cellsThe differential regulation of sIL-6R and IL-6 production by T-cells might be relevant for the immunomodulatory potential of the sIL-6R with respect to the interaction of T- and non-T-cells.
Lal and Rudolph (1991)interleukin-6T-cellConstitutive production of interleukin-6 and tumor necrosis factor-alpha from spontaneously proliferating T cells in patients with human T-cell lymphotropic virus type-I/II.
Déchaud et al. (1998)IL-6T lymphocytesIn tubal infertility and endometriosis, the lack of expression of IL-6 in T lymphocytes could participate in impaired embryo implantation.
Santhanam et al. (1991)IL-6T-cellThe aberrant overexpression of interleukin 6 (IL-6) is implicated as an autocrine mechanism in the enhanced proliferation of the neoplastic cell elements in various B- and T-cell malignancies and in some carcinomas and sarcomas; many of these neoplasms have been shown to be associated with a mutated p53 gene.
Prinz et al. (1990)IL 6T cellsOf several cytokines tested [interleukin (IL) 1 to IL 6, interferon-gamma (IFN-gamma), tumor necrosis factor-alpha] only IL 4 and IFN-gamma significantly modified allergen-induced Fc epsilon RII/CD23 expression on T cells.
Tosato and Pike (1988)IL-6T cellsThis effect is observed with highly purified T cells and is masked by the addition of as few as 2% monocytes, suggesting that accessory cells are not required and that IFN-beta 2/IL-6 acts directly on the T cells.
Tosato and Pike (1988)IL-6T cellsStudies of the time requirements of IFN-beta 2/IL-6 and of PHA in the response of T cells show that optimal co-stimulation occurs when both IFN-beta 2/IL-6 and PHA are added together at the outset of culture, suggesting that IFN-beta 2/IL-6 acts predominantly on resting T cells.
Härtel et al. (2006)IL-6T lymphocytesThe production of IL-2 and IL-6 protein in T lymphocytes was even strongly affected by SFA than the mRNA expression of the respective cytokine.
Wognum et al. (1993)IL-6T lymphocytesIn contrast, IL-6 receptors on both CD4+ and CD8+ T lymphocytes were detectable at biotin-IL-6 concentrations as low as 10 pmol/L, indicating that these cells bind IL-6 with high affinity.
Di Sabatino et al. (2008)IL6T cellTGFbeta blockade downregulated T cell apoptosis, and induced a significant increase in IFN gamma, TNFalpha, IL2, IL6, IL8 and IL17 production.
Nieters et al. (2001)IL-6T-cellWe investigated, in a random sample of a German population, the association of polymorphisms in the genes encoding the cytokines interleukin 2 (IL-2), interleukin 4 receptor (IL-4R), interleukin 6 (IL-6), interleukin 10, interferon gamma (IFNG), tumor necrosis factor (TNF) and intercellular adhesion molecule 1 (ICAM-1) with (1) secreted levels of the respective proteins after T-cell stimulation and (2) data on selected diseases obtained from a questionnaire.
Linardopoulos et al. (1992)interleukin-6T cellsIn the lesions of human autoimmune disease, such as the synovial membrane in rheumatoid arthritis, the T cells are activated as shown by a variety of phenotypic and functional changes including the expression of HLA-DR and the production of interleukin-6 (IL-6).
Lorré et al. (1994)interleukin-6T cellsInterleukin-1 and B7/CD28 interaction regulate interleukin-6 production by human T cells.
Lorré et al. (1994)IL-6T cellsProduction of interleukin-6 (IL-6) by the Th2 subset of murine T cells supposedly contributes to regulation of humoral immunity.
Lorré et al. (1994)IL-6T cellsLittle information exists on IL-6 production by human T cells.
Lorré et al. (1994)IL-6T cellsIn the presence of IL-1 beta, both CD4+ and CD8+ T cells were able to produce IL-6.
Lorré et al. (1994)IL-6T cellsWe also demonstrated that phorbol 12-myristate 13-acetate (PMA) or triggering of the CD28 molecule is an effective helper signal for IL-6 production by anti-CD3-stimulated T cells.
Lorré et al. (1994)IL-6T cellsWe conclude that IL-6 production by T cells is not induced by T cell receptor triggering alone, but different intracellular signaling pathways activated by IL-1 beta, CD28 ligation, or PMA efficiently coinduce IL-6 production.
Mori et al. (1993)interleukin 6T-cellInhibitory effect of interleukin 4 on production of interleukin 6 by adult T-cell leukemia cells.
Kraan et al. (2004)IL6T cellsCONCLUSION: The differential effect on IFNgamma and IL6 production supports the hypothesis that activated T cells are preferentially inhibited by leflunomide.
Mattoli et al. (1990)IL-6T-cellThe T-cell activating factors were interleukin (IL) 1- and 6-like substances, as demonstrated by the ability of specific antisera to inhibit most of the biological effect, and by the ability of recombinant IL-1 and IL-6 to reproduce it.
Chauhan et al. (1993)IL-6T cellsFinally, given that PWM induces B-cell differentiation in an interleukin-6 (IL-6)-mediated, T-cell-dependent manner, the relationship of c-jun and IL-6 gene expression in PWM-stimulated T cells was examined.
Chauhan et al. (1993)IL-6T cellsBecause the IL-6 promoter has several potential transcriptional control elements, one of which is an AP-1-binding site, future experiments will evaluate the role of c-jun in the regulation of PWM-induced IL-6 synthesis by T cells.
Kanda and Tamaki (1999)IL-6T cellsGD1b inhibited IL-6 and IL-10 production of CD4+ T cells, without affecting those of CD8+ T cells, monocytes, or B cells.
Sperber et al. (1993)IL-6T cellsInterleukin 1 alpha (IL-1-alpha), IL-6 and tumor necrosis factor alpha (TNF-alpha) production were measured from the stimulated monocytes and IL-2, IL-4 and gamma interferon (IFN-gamma) were measured from the stimulated T cells.
Porgador et al. (1992)IL-6T-cellIt seems therefore that the reduction of metastatic competence of IL-6 transfectants is primarily a function of stimulation by the transfectants of host T-cell immune responses.
Hirohata et al. (1992)IL6T cellsT cells from 17 patients with Behcet's disease, but not those from 13 healthy individuals or from 13 patients with other rheumatic diseases, were stimulated to produce greater amounts of interleukin 6 (IL6) by addition of RRE KTH-1 antigens [stimulation index: 3.96 +/- 0.56 and 1.35 +/- 0.28 or 1.83 +/- 0.43 (mean +/- SEM), respectively].
Törnblom et al. (2005)IL-6t cellsThe protein levels of IL-8, IL-6, monocyte chemotactic protein-1 (MCP-1), regulated upon activation normal t cells expressed and secreted (RANTES) and tumour necrosis factor-alpha (TNF-alpha) were quantified in tissue homogenates by ELISA or Immulite.
van Haarst et al. (1996)IL-6T-cellIn the study reported here we investigated the capability of LAF cells to produce interleukin-1 (IL-1), IL-6, and tumor necrosis factor alpha (TNF-alpha), and the role of these cytokines in allogeneic T-cell stimulation by LAF cells.
Kishikawa et al. (1993)IL-6T lymphocytesLocalization of T lymphocytes and macrophages expressing IL-1, IL-2 receptor, IL-6 and TNF in human aortic intima.
Svinarich et al. (1998)interleukin-6T cellExpression of granulocyte colony-stimulating factor, regulated on activation normal T cell expressed and secreted, and interleukin-6 was examined by Northern analysis and enzyme-linked immunosorbent assay.