Viewing affirmative mentions of gene expression of IL5 (H. sapiens) in T cells

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Staples et al. (2003)IL-5T cellsBoth peripheral blood mononuclear cells (PBMC) and primary human T cells display similar patterns of IL-5 expression when stimulated with both phorbol-12-myristate 13-acetate and phytohaemagglutinin.
Mordvinov et al. (1999)IL5T-cellsThe production of interleukin-5 (IL5) and interleukin-4 (IL4) by activated T-cells is important in the pathogenesis of helminth infections and allergy.
Mordvinov et al. (1999)IL5T-cellHuman Jurkat cells express IL4 but one of the main factors restricting studies of human IL5 expression has been the lack of human T-cell lines which express significant levels of IL5 in an inducible fashion.
Mordvinov et al. (1999)IL5T-cellWe report that the human T-cell leukemia cell line (PER-117), previously shown to produce IL2, also produces IL5 and IL4, and is a useful model for the study of the regulation of IL5 and IL4 gene expression.
Bossios et al. (2010)IL-5T-lymphocytesThe primary source of IL-5 is T-lymphocytes, although other sources may exist.
Valentine and Sewell (1998)IL-5T-cellIn this report, we have analysed DNA regulatory regions associated with inducible IL-5 expression in the human HSB-2 T-cell line.
Yamaoka and Kolb (1993)IL-5T cellsPreincubation of T cells with very low concentrations (10(-12) to 10(-8) M) of LTB4 induced concentration-dependent IL-5 production, the event occurring after the first 24 h of cultivation.
Resino et al. (2001)IL-5T cellsImpaired interleukin-5 (IL-5) production by T cells as a prognostic marker of disease progression in human immunodeficiency virus type 1 (HIV-1)-infected children.
Yoshida et al. (1996)interleukin-5T lymphocytesLocal production of interleukin-5 by T lymphocytes is associated with recruitment of eosinophils in patients with eosinophilic granuloma of the soft tissue.
Yoshida et al. (1996)IL-5T lymphocytesThese findings suggest that locally produced IL-5 from T lymphocytes may enhance the infiltration of eosinophils into the eosinophilic granuloma.
Yamaoka et al. (1994)IL-5T cellsOf particular interest, Peak E-stimulated human splenic T cells produced bioactive and immunoreactive IL-5.
Mori et al. (1997)IL-5T lymphocytesOBJECTIVE: We investigated the production of IL-5, a potent growth factor and chemotactic factor for eosinophils, by CD4+ T lymphocytes in patients with asthma.
Mori et al. (1997)IL-5T cellsRESULTS: After nonspecific stimulation, IL-5 production by CD4+ T cells from both atopic and nonatopic subjects with asthma was significantly enhanced compared with that by cells from healthy controls.
Mori et al. (1997)IL-5T cellThe same gene segment was not transcribed in IL-5-nonproducing T cell clones, suggesting that human T cell IL-5 synthesis is regulated at the transcriptional level.
Ogawa et al. (2000)IL-5T cellsIL-5 synthesis by T cells of allergic subjects is regulated at the transcriptional level.
Ogawa et al. (2000)IL-5T cellsCONCLUSION: IL-5 synthesis by nontransformed T cells of allergic subjects is enhanced at the level of gene transcription.
Mori et al. (2000)IL-5T cellsGel shift analysis clarified that the inducible binding was more prominent and the constitutive binding was less in IL-5-producing T cells derived from asthma patients compared to IL-5-nonproducing cells derived from control subjects.
Thurau et al. (1998)IL-5T cellsRSV infection as well as IL-5 production in T cells were confined to the CD8 subpopulation.
Thurau et al. (1998)IL-5T cellsPurified T cells did not show any increase in IL-5 generation.
Kaminuma et al. (1997)IL-5T cellTwo differential effects of cyclic adenosine 3',5'-monophosphate on IL-5 production by antigen-specific human T cell line.
Kaminuma et al. (1997)IL-5T cellsAs we have recently found that IL-2 stimulates IL-5 production, the effects of cAMP on IL-5 synthesis of T cells was investigated in this study.
Kaminuma et al. (1997)IL-5T cellProstaglandin E2 and forskolin raised intracellular cAMP level of Dermatophagoides farinae extract-reactive human T cell line and inhibited T cell receptor-stimulated IL-5 production.
Kaminuma et al. (1997)IL-5T cellRecombinant human IL-2 itself induced IL-5 production, suggesting that IL-5 production stimulated through T cell receptor is dependent on the autocrine production of IL-2.
Kaminuma et al. (1997)IL-5T cellsOur study clearly indicated that cAMP regulates IL-5 production of human T cells by two differential effects.
Rolfe et al. (1997)IL-5 messenger RNAT-lymphocytesWe investigated the mechanisms controlling IL-5 messenger RNA (mRNA) expression in human T-lymphocytes in the presence of CsA or FK506.
Ogawa et al. (2002)IL-5T cellsMechanisms that underlie the regulation of IL-5 gene expression in human peripheral T cells remain incompletely defined because of the low efficiency of transfection of plasmid constructs into non-transformed T cells.
Ogawa et al. (2002)IL-5NFATCyclosporin A equivalently suppressed DNA-binding activity of the composite NFAT/AP-1 site, promoter activity and protein production of IL-5.
Ogawa et al. (2002)IL-5T cellsIn conclusion, these data suggests that the composite NFAT/AP-1 binding element (- 115 to - 100) plays a crucial role in IL-5 synthesis by peripheral T cells of asthmatic patients.
Mori et al. (1999)IL-5T cellRegulatory mechanisms of human T cell IL-5 synthesis: differential roles of the proximal promoter-binding proteins in IL-5 gene transcription.
Mori et al. (1999)IL-5T cellT cell IL-5 synthesis is regulated at the transcriptional level.
Selleri et al. (2008)IL-5T cellsGM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells.
Mueller et al. (2003)IL-5T cellsA PPARgamma ligand, 15-deoxy-delta(12,14)-prostaglandin J(2), significantly inhibited production of the T(H)2 type cytokine IL-5 from T cells activated in vitro.
Krouwels et al. (1998)interleukin-5T cellHistamine affects interleukin-4, interleukin-5, and interferon-gamma production by human T cell clones from the airways and blood.
Winkler et al. (1998)IL-5T cellsThe frequency of IL-4- and IL-13-producing CD4(+) cells gradually decreased, whereas the frequency of T cells producing IL-2(+)-IFN-gamma+, IL-4(-)-IL-5(+), and IL-4(+)-IL-5(+) cytokines as well as IL-4(+)-IFN-gamma+ and IL-13(+)-IFN-gamma+ cytokines was not significantly altered.
Bulgarini et al. (1989)TrfT lymphocytesOur results show that Zn2+ enhances the level of DNA synthesis in human T lymphocytes stimulated by a mitogenic lectin, phytohemagglutinin (PHA); this effect seems to be mediated through an enhanced expression of both interleukin-2 (IL-2) and transferrin (Trf) receptors.
Rodrigues et al. (1996)IL-5T-lymphocyteThe analysis was performed on IL-5 levels produced by blood mononuclear cells of these subjects after in vitro restimulation with either parasite extracts (IL-5/schistosomula sonicates [SS] phenotype) or a T-lymphocyte mitogen (IL-5/phytohemagglutin [PHA]).
Sheller et al. (2002)IL-5T lymphocyteCONCLUSIONS: Misoprostol reduces the formation of IL-5 late after allergen challenge, perhaps by inhibiting eosinophil, mast cell, and/or T lymphocyte production of IL-5.
De Boer et al. (1999)interleukin-5T cellsRole of nuclear factor of activated T cells (NFAT) in the expression of interleukin-5 and other cytokines involved in the regulation of hemopoetic cells.
Sewell et al. (1992)interleukin 5T cellsExpression of interleukin 5 by the CD4+CD45R0+ subset of human T cells.
Krug et al. (1998)interleukin-5T cellsFrequencies of T cells expressing interleukin-4 and interleukin-5 in atopic asthmatic children.
Krug et al. (1998)IL-5T cellsThese findings indicate that in asthmatic children the frequencies of Th2-type-producing T cells are increased and that expression of IL-4 and IL-5 is regulated independently.
Mori et al. (1997)interleukin-5T-cellTwo distinct pathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids.
Mori et al. (1997)IL-5T-cellTo delineate the regulatory mechanisms of human IL-5 synthesis, we established allergen-specific CD4+ T-cell clones from asthmatic patients.
Mori et al. (1997)IL-5T-cellGC efficiently suppressed IL-5 synthesis of T-cell clones activated via either T-cell receptor (TCR) or IL-2 receptor (IL-2R).
Mori et al. (1997)IL-5T-cellOur results showing that GC suppressed IL-5 production by human CD4+ T cells activated by two distinct stimuli, TCR and IL-2R stimulation, underscore the efficacy of GC in the treatment of allergic diseases via suppression of T-cell IL-5 synthesis.
Van Straaten et al. (1994)interleukin 5T cellsThe regulation of interleukin 5 and interleukin 3 gene expression in human T cells.
Van Straaten et al. (1994)IL-5T cellThese data indicate that the selective expression of IL-5 by human T cells can either be explained by activation of a selective intracellular signalling pathway or by selective activation of a T cell subset.
Crocker et al. (1996)IL-5T cellsProduction of IL-4 and IL-5 by T cells appears to be associated with a high affinity cyclic AMP (cAMP) phosphodiesterase (PDE).
Yamagata et al. (1997)interleukin-5T-cellTriple synergism of human T-lymphotropic virus type 1-encoded tax, GATA-binding protein, and AP-1 is required for constitutive expression of the interleukin-5 gene in adult T-cell leukemia cells.
Yamagata et al. (1997)interleukin-5T-cellAccumulated evidence demonstrates that adult T-cell leukemia (ATL) is frequently associated with eosinophilia, and human T-lymphotropic virus type 1 (HTLV-1)-infected cells frequently express interleukin-5 (IL-5).
Jung et al. (1995)interleukin-5T cellsInterleukin-4 and interleukin-5 are rarely co-expressed by human T cells.
Jung et al. (1995)IL-5T cellsHere we show, using a flow cytometric intracellular staining technique, that IL-4 and IL-5 are predominantly produced by different human peripheral CD4+ and CD8+ T cells, whereas interferon (IFN)-gamma and IL-2 are produced by the same cells.
Jung et al. (1995)IL-5T cellsWe conclude that the simultaneous production of IL-4 and IL-5 is a feature of repetitively activated human T cells.
Enokihara et al. (1989)interleukin-5T cellsT cells from eosinophilic patients produce interleukin-5 with interleukin-2 stimulation.
Enokihara et al. (1989)IL-5T cellsThese results suggest that IL-5 plays an important role in the induction of selective eosinophilia in humans and that IL-5 is produced from T cells with IL-2 stimulation.
Schrezenmeier et al. (1993)Interleukin-5T lymphocytesInterleukin-5 is the predominant eosinophilopoietin produced by cloned T lymphocytes in hypereosinophilic syndrome.
Schrezenmeier et al. (1993)IL-5TLCUnder the same experimental conditions, all HES-derived TLC, but only one third of tested TLC from healthy donors, expressed IL-5 mRNA 5 days after stimulation.
Schrezenmeier et al. (1993)IL-5T lymphocytesOur in vitro results suggest that IL-5 produced by activated CD4+ T lymphocytes plays a crucial role in the induction of eosinophilia in HES.
Mori et al. (1996)IL-5T cellA critical role of IL-2 for the production and gene transcription of IL-5 in allergen-specific human T cell clones.
Mori et al. (1996)IL-5T cellRecombinant IL-2 induced gene expression and protein synthesis of IL-5 in T cell clones that produced IL-5 upon antigenic stimulation.
Mori et al. (1996)IL-5T cellsIL-2 produced at the site of allergic inflammation might facilitate eosinophilic inflammation by inducing IL-5 production in T cells.
Zea et al. (2004)IL5T cellsIn contrast, T cells stimulated and cultured in absence of L-arginine, present a sustained down-regulation of CD3zeta preventing the normal expression of the TCR, exhibit a decreased proliferation, and a significantly diminished production of IFNgamma, IL5, and IL10, but not IL2.
Mori et al. (1999)IL-5T-cellIL-5 synthesis was not only induced by T-cell receptor stimulation but also by IL-2 receptor stimulation.
Mori et al. (1997)IL-5T cellsIL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506.
Mori et al. (1997)IL-5T cellRegulation of T cell IL-5 synthesis was investigated using human Th cell clones.
Mori et al. (1997)IL-5T cellsImmunosuppressant FK506 suppressed IL-5 synthesis of T cells activated through TCR in a dose-dependent manner.
Staples et al. (2003)IL-5T cellsHowever, although dexamethasone was a potent inhibitor of both IL-5 release and messenger RNA accumulation from PBMC and T cells, dexamethasone had no effect on the luciferase activity of a reporter construct under the control of an IL-5 promoter region transiently transfected into primary human T cells.
Schwarz et al. (1993)IL5T cellsTwo different types of differentiated T cells can be characterised according to the pattern of cytokine production of T cells: IL2 and IFN gamma are typically produced by T helper 1 (Th 1) cells, whereas predominantly T helper 2 (Th 2) cells produce IL4, IL5 and IL10.
Valentine and Sewell (1998)IL-5T-lymphocytesIL-5 mRNA is transiently expressed by activated T-lymphocytes.
Schwenger et al. (2001)Interleukin-5T-cellInterleukin-5 (IL-5) is a T-cell cytokine involved in Type 2 diseases and is commonly described as being coordinately regulated with other Type 2 cytokines, such as IL-4 and IL-13.
Yoshida et al. (1996)IL-5T lymphocytesIL-5 mRNA expression was detectable in the CD3+T lymphocytes but not in eosinophils from granuloma tissue.
Mori et al. (1995)interleukin-5T cellAllergen-specific human T cell clones produce interleukin-5 upon stimulation with the Th1 cytokine interleukin-2.
Mori et al. (1995)IL-5T cellHuman recombinant IL-2 induced these T cell clones to express IL-5 mRNA and produce IL-5 protein in a dose-dependent manner.
Mori et al. (1995)IL-5T cellsIL-2 did not induce IL-4 production, indicating a discrete signal requirement for IL-4 versus IL-5 production by T cells.
Mori et al. (1995)IL-5T cellsIL-2 produced at the site of allergic inflammation may contribute to IL-5 production by T cells in vivo.
Kaminuma et al. (1997)IL-5T cellProstaglandin E2 suppressed T cell receptor-stimulated mRNA expression of IL-2 as well as IL-5 in the T cell line, whereas it potentiated IL-5 mRNA expression stimulated by recombinant human IL-2.
Lorentz et al. (1999)IL-5T cellsIL-5-positive T cells were not detected, likely because they do not store IL-5.
Yagi et al. (1997)interleukin-5T cellsWells' syndrome: a pathogenic role for circulating CD4+CD7- T cells expressing interleukin-5 mRNA.
Blumenthal et al. (1999)IL-5T-cellsStudying the regulation of IL-5 gene expression by Ets transcription factors, we found that Ets1 and Ets2, but not Elf-1, were able to activate the human IL-5 promoter in Jurkat T-cells.
Blumenthal et al. (1999)IL-5T-cellThe synergism of GATA3 with either Ets1 or Ets2 may play an important role in calcium- or Tax1-dependent regulation of IL-5 expression in Th2 cells or in HTLV-I transformed adult T-cell leukemia cells, respectively.
Orson et al. (1983)TRF-ST cellsProduction of the TRF-S required the presence of both T cells and adherent cells in culture and was found in the highest concentrations at 3-4 d of culture.
Stein and Rothenberg (2005)interleukin-5T-cellAs such, anti-interleukin-5 therapy is expected to be very useful, especially for patients with the clonal T-cell variant that secretes high levels of interleukin-5.
Ochi et al. (2002)IL-5T cellsIncreased IL-13 but not IL-5 production by CD4-positive T cells and CD8-positive T cells in multiple sclerosis during relapse phase.
Ochi et al. (2002)IL-5T cellsHowever, IL-5-producing T cells did not vary regardless of clinical phase or type.
Kaminuma et al. (1999)IL-5T cellPGE2, forskolin and db-cAMP suppressed IL-5 production by human T cell line following T cell receptor (TCR)-stimulation.
Krug et al. (1998)IL-5T cellsA substantial proportion of T cells coproducing IL-4 and IL-5 was not detectable in children and adults.
Mori et al. (1997)IL-5T-cellHuman IL-5 promoter/enhancer-luciferase gene construct transfected to T-cell clones was transcribed on either TCR or IL-2R stimulation and was clearly downregulated by dexamethasone, indicating that the approximately 500-bp human IL-5 gene segment located 5' upstream of the coding region contains activation-inducible enhancer elements responsible for the regulation by GC.