Viewing affirmative mentions of gene expression of IL4 (H. sapiens) in T cells

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Whitehead et al. (1998)Interleukin 4T-lymphocytesInterleukin 4 (IL-4) is a cytokine produced by activated T-lymphocytes with pluripotent activities including growth inhibition of various tumor cell lines in vitro and immune- mediated tumor growth inhibition in in vivo animal tumor models.
Leader et al. (2006)IL-4T-cellsThese results indicate that we have produced recombinant rabbit IL-4 that exhibits expected biological activity on rabbit B and T-cells.
Kurtzhals et al. (1992)IL-4T cellsThe findings suggest that proliferating antigen-specific T cells were the source of IL-4 in these experiments.
Kurtzhals et al. (1992)IL-4T cellsThe method should prove useful for comparing the IL-4 producing ability of antigen-specific T cells from different individuals.
Bradding et al. (1992)IL-4T lymphocytesWe propose that mast cell activation in an allergic response provides a rapid and local pulse of IL-4 into the local environment essential for the triggering of T lymphocytes into sustained IL-4 production and to initiate inflammatory cell accumulation and activation.
Plackett et al. (2004)interleukin-4T cellsNK T cells increase in number and have greater interleukin-4 production with age.
Wu et al. (1991)IL4T cellsGiven that glucocorticoids (GCS) were reported to increase the production of interleukin 4 (IL4) by mouse T cells and that GCS are widely used to treat allergic diseases it was important to examine the effect of these agents on IL4 production by human lymphocytes.
Ishibashi et al. (1995)Interleukin-4T lymphocyteInterleukin-4 (IL-4) is a pleiotropic immunomodulatory cytokine produced mainly by T lymphocyte.
Bullens et al. (1998)IL-4T cellsEffects of anti-IL-4 receptor monoclonal antibody on in vitro T cell cytokine levels: IL-4 production by T cells from non-atopic donors.
Bullens et al. (1998)IL-4T cellsThe use of a MoAb to the IL-4 receptor alpha-chain (IL-4Ralpha) enabled us to demonstrate that IL-4 production in vitro is usually underestimated, due to in vitro consumption, even in cultures of purified T cells.
Bullens et al. (1998)IL-4T cellsMoreover, we found that even stimulation with a soluble antigen (tetanus toxoid) induces IL-4 production by T cells from healthy non-atopic donors.
Bullens et al. (1998)IL-4T cellsConsumption of IL-4 by different cell types during in vitro cultures might have interfered with previous attempts to quantify IL-4 production by human T cells.
Valapour et al. (2002)IL4 geneT cellsHistone deacetylation inhibits IL4 gene expression in T cells.
Valapour et al. (2002)IL4 geneT cellsOBJECTIVE: We sought to define the role of histone acetylation in the regulation of IL4 gene expression in human T cells.
Valapour et al. (2002)IL-4T cellsRESULTS: IL-4 production from activated peripheral blood T cells was enhanced by the histone deacetylase inhibitor trichostatin A.
Breit et al. (1996)IL-4T cellsUnder these conditions, antigen-specific IL-4 producing T cells were generated in 35/40 cultures.
Breit et al. (1996)IL-4T cellsPrimed T cells that were IL-4- when cultured with IL-2 only developed an IL-4 producing phenotype when primed and expanded in the presence of exogenous IL-4.
Breit et al. (1996)IL-4T cellsT cells primed in the presence of either endogenous or exogenous IL-4 produced 10-200-fold more IL-4 than T cells primed in the presence of anti-IL-4 antibody or sIL-4R.
Dean et al. (1992)IL-4T-lymphocytesNative IL-4 has properties that exemplify many of the immune recognition-induced lymphokines and is produced principally by activated T-lymphocytes CD4+.
Demeure et al. (1995)interleukin-4T cellsHuman naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions.
Nagano et al. (1992)interleukin-4T-cellWhen we stimulated the Dp-induced T-cell clones with Cy, 3 of the 40 clones (7.5%) showed a significant proliferation, and 2 of the 3 clones produced interleukin-4 and interferon-gamma, indicating their helper function.
Howells et al. (1991)IL4T cellsSince IL4 and IFN-gamma are produced by T cells, which are frequently associated with vascular endothelium during chronic inflammation, IL4 is likely to be an important cytokine in the regulation of IL6 and perhaps other cytokine production by endothelium in vivo.
Maher et al. (1991)interleukin-4T cellsHuman interleukin-4 (IL-4) is a 20kDa cytokine produced by activated T cells and has an extensive range of stimulatory and inhibitory effects on the wide range of cells which express its receptor.
Romagnani et al. (1989)IL-4T cellThe addition to B cell cultures of anti-IL-4 antibody abolished not only the IgE synthesis induced by recombinant human IL-4, but also that induced by IL-4-producing T cell clones or their phytohemagglutinin-induced supernatants.
Guo et al. (2001)interleukin-4T cellsYin-Yang 1 activates interleukin-4 gene expression in T cells.
Guo et al. (2001)IL-4 geneT cellsIn addition, cotransfected YY-1 enhanced both IL-4 promoter activity and endogenous IL-4 gene expression in nontransformed peripheral blood T cells.
Ambrus et al. (1985)HMW-BCGFT cellHigh molecular weight B cell growth factor (HMW-BCGF) produced by a T cell line was purified to homogeneity and demonstrated to bind specifically to activated human B cells.
Dokter et al. (1993)interleukin-4T cellsHuman T cells were studied with regard to the regulation of interleukin-4 (IL-4) and IL-3 gene expression.
Dokter et al. (1993)IL-4T cellsTaken together, the data show that expression of the IL-4 and IL-3 genes in human T cells is controlled by different activation pathways that affect the gene regulation at transcriptional and posttranscriptional levels.
Berman et al. (1996)IL-4T cellsIL-4 production by PBMC or T cells was strongly impaired in IDDM patients at diabetes onset (p < 0.0001).
Hirano et al. (2004)IL-4T cellsRegarding the inhibitory activity of flavonoids on IL-4 synthesis by T cells, peripheral blood mononuclear cells were cultured with flavonoids in anti-CD3-antibody-bound plates for 2 days.
Hirano et al. (2004)IL-4T cellsAt higher concentrations, these flavonoids suppressed IL-4 production by T cells.
Mordvinov et al. (1999)IL4T-cellsThe production of interleukin-5 (IL5) and interleukin-4 (IL4) by activated T-cells is important in the pathogenesis of helminth infections and allergy.
Mordvinov et al. (1999)IL4T-cellHuman Jurkat cells express IL4 but one of the main factors restricting studies of human IL5 expression has been the lack of human T-cell lines which express significant levels of IL5 in an inducible fashion.
Mordvinov et al. (1999)IL4T-cellWe report that the human T-cell leukemia cell line (PER-117), previously shown to produce IL2, also produces IL5 and IL4, and is a useful model for the study of the regulation of IL5 and IL4 gene expression.
Tejada-Simon et al. (2002)interleukin-4T-cellThe resulting HHV-6-specific T-cell lines obtained from MS patients exhibited skewed cytokine profiles characterized by the inability to produce interleukin-4 (IL-4) and IL-10.
Wichmann et al. (2002)IL-4T-cellVitality and proliferation were tested using the MTT assay and T-cell function by the expression of cytokines (ELISA, intracellular cytokine staining, and real-time polymerase chain reaction (RT-PCR) for interferon-gamma (IFN-gamma) and interleukin-4 (IL-4).
van der Pouw-Kraan et al. (1993)IL-4T cellsBoth fresh T cells and T helper 2-like clones produced IL-4 when stimulated with anti-CD2 in combination with anti-CD28.
van der Pouw-Kraan et al. (1993)IL-4T cellsHowever, whereas T cell clones showed enhanced IL-4 production when phorbol 12-myristate 13-acetate (PMA) was used in addition to anti-CD2 and anti-CD28, IL-4 production by fresh T cells was inhibited by the presence of PMA.
van der Pouw-Kraan et al. (1993)IL-4T cellPrestimulation of fresh T cells led to the following observations: (a) activation in the absence of PMA led to a reversal of the PMA effect and (b) within 2 days these cells resembled T cell clones in that IL-4 production was no longer inhibited by PMA.
van der Pouw-Kraan et al. (1993)IL-4T cellsOur data show that the capacity of cultured T cells to produce IL-4 is determined and fixed during the first 2-3 days of stimulation.
Kopitar et al. (2007)IL-4T cellsThere was a significantly increased response in expression of IFN-gamma and IL-4 molecules by DCs stimulated T cells in subjects that successfully eradicated H. pylori compared with those who failed to eradicate the infection.
Paul et al. (2006)IL-4T cellsThus, the interaction of the three transcription factors leads both to Th2 fate determination and selective outgrowth of differentiated Th2 cells and are thus responsible for a robust differentiation process resulting in the appearance of CD4 T cells capable of producing IL-4 and its related cytokines.
Passacantando et al. (2006)IL4T cellsIn SF, significantly more CD4+/OX40+ T cells expressed interleukin-4 (IL-4) and IL4/IFN-gamma than IFN-gamma alone.
Dean et al. (2002)IL-4T cellsCharacterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: production of IL-4.
Gan et al. (2001)IL-4T cellsIL-2 and IL-4 mRNAs and surface expression of FasL were detected only in activated T cells in the time period examined.
Hagendorens et al. (2000)interleukin-4T-lymphocytesDetermination of T-cell subpopulations and intracellular cytokine production (interleukin-2, interleukin-4, and interferon-gamma) by cord blood T-lymphocytes of neonates from atopic and non-atopic parents.
Furlan et al. (2000)interleukin-4T cellsInterferon-beta treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-gamma and interleukin-4.
Mackey et al. (1998)interleukin-4T cellIn this context effective antigen presentation involves not only T cell expansion and long-term survival but also the ability of the APC to guide the T cell response toward the Th1 (interferon-gamma producing) or the Th2 (interleukin-4 producing) phenotype.
Krouwels et al. (1998)interleukin-4T cellHistamine affects interleukin-4, interleukin-5, and interferon-gamma production by human T cell clones from the airways and blood.
Terada et al. (1993)IL-4T cellsIn contrast, early events, including c-fos, IL-2, and IL-4 mRNAs expression, and IL-2 receptor (p55) expression, were only marginally affected, if at all, in PHA-stimulated T cells.
Naujokas et al. (1992)IL-4T cellsCytokine responsiveness of interleukin-4 (IL-4)-producing T cells (IL-4p) during primary in vitro stimulation was investigated.
Ellis et al. (1991)IL 4T cellsAntigen presentation by dendritic cells provides optimal stimulation for the production of interleukin (IL) 2, IL 4 and interferon-gamma by allogeneic T cells.
Roura-Mir et al. (1997)IL-4T lymphocytesHowever, the larger T lymphocytes, presumably activated and responsible for the autoimmune damage, predominantly produced IL-4 in GD and IFN-gamma in HT.
Roura-Mir et al. (1997)IL-4T cellThe specificity of the Th2 responses in GD was suggested by the enrichment in IL-4 production after antigen-specific expansion of two oligoclonal T cell lines.
Dokter et al. (1992)Interleukin-4T cellsInterleukin-4 (IL-4) receptor expression on human T cells is affected by different intracellular signaling pathways and by IL-4 at transcriptional and posttranscriptional level.
Dokter et al. (1992)IL-4T cellsTo understand the biologic effects of IL-4 on human T cells, we studied the regulation of IL-4 receptor (IL-4R) gene expression.
Dokter et al. (1992)IL-4T cellsThese data indicate that expression of IL-4 receptors on human T cells can be modulated by different intracellular signaling pathways at both transcriptional and posttranscriptional levels.
Raziuddin et al. (1998)interleukin-4T-cellRegulation of interleukin-4 production and cytokine-induced growth potential in peripheral T-cell non-Hodgkin's lymphomas.
Raziuddin et al. (1998)IL-4T cellsBecause IL-4 was shown to be a locally active cytokine with a wide range of immunoregulatory properties, regulation of IL-4 production by IFN-gamma and IL-2 in malignant T cells may be one of the important parameters to be assessed in the design of anticancer-specific immunotherapy.
Mitre and Nutman (2006)IL-4T cellHelminth infections typically provoke type 2 immune responses characterized by eosinophilia, elevated levels of Ag-specific and polyclonal IgE, and T cell production of type 2 cytokines such as IL-4, IL-5, and IL-13.
O'Hehir et al. (1989)IL-4T cellsThe helper activity was interleukin-4 (IL-4) dependent as only cloned T cells expressing detectable mRNA for IL-4 were able to induce IgE synthesis without the addition of exogenous IL-4.
Paliard et al. (1991)IL-4T cellThe T cell clones isolated in IL-4 produced, in general, more IL-4 and less IL-2 than the clones isolated and cultured in IL-2.
Yang et al. (1995)IL-4T cellsIt was recently demonstrated that naive human and mouse CD4 T cells release low but sufficient levels of interleukin (IL)-4 at priming to support their development into IL-4 producers.
Yang et al. (1995)IL-4T cellsTo determine whether this IL-4 is produced by a minor subset of cells, freshly isolated human naive CD4 T cells were directly cloned by limiting dilution in the absence of exogenous IL-4.
Bömmel et al. (2000)IL-4T cellsMETHODS: IL-4 production by primary human T cells was assessed by ELISA and messenger RNA transcription was detected by Northern blotting.
Bömmel et al. (2000)IL-4T cellsRESULTS: Pyrene induced transcription of IL-4 messenger RNA and expression of IL-4 protein in primary human T cells.
Secrist et al. (1996)interleukin-4T cellsLigation of TAPA-1 (CD81) or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific CD4+ T cells.
Secrist et al. (1996)IL-4T cellsFurthermore, anti-CD81 mAb enhanced IL-4 synthesis in CD4+ T cells only when CD4+ T cells were cultured with B cells but not monocytes as APC, indicating that anti-CD81 mAb affected IL-4 synthesis in T cells via interactions with B cells.
Secrist et al. (1996)IL-4T cellIn addition, anti-CD81 mAb enhanced IL-4 production but reduced CD4+ T cell antigen-specific proliferation, demonstrating that IL-4 production and proliferation by CD4+ T cells were inversely related.
Stütz et al. (2005)IL-4T cellDespite production levels of IL-4 below conventional detection limits, CD45RA+ T cell-derived IL-4 could clearly activate STAT6.
Grunow et al. (1996)IL4T-cellAnergy induction in human CD4+ T-cell clones by stimulation with soluble peptides does not require cell proliferation and is accompanied by elevated IL4 production.
Crocker et al. (1996)IL-4T cellsProduction of IL-4 and IL-5 by T cells appears to be associated with a high affinity cyclic AMP (cAMP) phosphodiesterase (PDE).
Blotta et al. (1996)IL-4T lymphocytesCross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.
Blotta et al. (1996)IL-4T lymphocytesAlthough there is good evidence that the induction of IL-4 synthesis in CD4+ T lymphocytes is favored by Ag presentation by B cells and not macrophages, the precise molecular signals provided by B cells to T cells that enhance IL-4 synthesis are not clear.
Blotta et al. (1996)IL-4T cellWe found that IL-4 synthesis was greatly enhanced by triggering of CD40L on the T cell surface in conjunction with ligation of CD3/TCR and CD28, whereas ligation of CD3/TCR and CD28 in the absence of CD40L triggering resulted in little or no IL-4 synthesis.
Blotta et al. (1996)IL-4T lymphocytesThese studies confirm that IL-4 synthesis can be induced in normal T lymphocytes in the absence of exogenous IL-4, and demonstrate that CD40L costimulation is of fundamental importance in regulation of IL-4 production.
Or et al. (1992)IL-4T cellsThe production of IL-2 and IL-4 by competent T cells could not be enhanced by the noncorresponding lymphokine.
Gordon et al. (1985)BCGFT-cellFurthermore, all lines responded by enhanced proliferation to supernatants from a BCGF-producing T-cell hybridoma.
Ohshima et al. (1998)interleukin-4T cellsOX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors.
Ohshima et al. (1998)IL-4T cellsWe show here that ligation of OX40 Ag, a member of the tumor necrosis factor receptor (TNF-R) family, on activated umbilical cord blood CD4(+) T cells upregulates IL-4 production at priming and thereby promotes their development into effector cells producing high levels of the type 2 cytokines IL-4, IL-5, and IL-13.
Howe et al. (2005)IL-4T-cellSplit-well analyses of limiting dilution cultures suggested that virtually all putative T-cell clones produced either IFN-gamma alone or both IFN-gamma and IL-4.
Yamaoka et al. (1994)IL-4T cellsInterleukin 4 (IL-4)-induced IgE production by normal peripheral blood mononuclear cells (PBMC) and E- cells (PBMC partially depleted of T cells) was significantly enhanced by leukotriene B4(LTB4) in a dose-dependent manner, whereas LTB4 by itself was not effective for IgE production.
Jung et al. (1995)Interleukin-4T cellsInterleukin-4 and interleukin-5 are rarely co-expressed by human T cells.
Jung et al. (1995)IL-4T cellsHere we show, using a flow cytometric intracellular staining technique, that IL-4 and IL-5 are predominantly produced by different human peripheral CD4+ and CD8+ T cells, whereas interferon (IFN)-gamma and IL-2 are produced by the same cells.
Jung et al. (1995)IL-4T cellsWe conclude that the simultaneous production of IL-4 and IL-5 is a feature of repetitively activated human T cells.