Viewing negative mentions of gene expression of IL4 (H. sapiens) in T cells

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Killar et al. (1987)IL 4T cellNone of the Ia-restricted, L3T4+ cloned T cell lines that failed to produce IL 4/BSF-1 could provide helper function.
Zhou et al. (2007)IL-4T cellsTo clarify the discrepancy by using simpler experimental systems, human Jurkat T cells that express IL-4 but not interferon-gamma, even if stimulated with phorbol 12-myristate 13-acetate plus ionomycin, were used for CIITA transfection.
Blotta et al. (1996)IL-4T cellWe found that IL-4 synthesis was greatly enhanced by triggering of CD40L on the T cell surface in conjunction with ligation of CD3/TCR and CD28, whereas ligation of CD3/TCR and CD28 in the absence of CD40L triggering resulted in little or no IL-4 synthesis.
Bacchetta et al. (1990)IL-4T cellWe demonstrate that these donor-derived T cell clones, specifically reacting with the MHC Ag expressed on the recipient cells, do not produce IL-4 and do not express IL-4 mRNA upon Ag or polyclonal stimulations.
Bacchetta et al. (1990)IL-4T cellsThe finding that some of these clones produce significant levels of IL-5 but no IL-4 indicates that the IL-4 and IL-5 genes are not always coexpressed in activated human T cells.
Lewis et al. (1991)IL-4T cellsReduced lymphokine production by neonatal T cells correlated with their lack of a CD45R- (putative memory T cell) population; cells with this surface phenotype comprised 30-40% of the adult CD4+ T cells and were highly enriched for IL-4 and IFN-gamma, but not IL-2 production.
Oishi et al. (2000)IL-4T cellsWe also found that Valpha24+ Vbeta11+ DN T cells from healthy subjects predominantly produced interferon-gamma (IFN-gamma) but not IL-4 upon activation.
Jung et al. (1996)IL-4T cellsCollectively, our data indicate that IL-13 is produced by peripheral blood T cells which also produce IL-4, but not IFN-gamma, and by naive CD45RA+ T cells which, in contrast, fail to produce IL-4.
Maggi et al. (1997)IL-4T-cellWhile the great majority of CD8+ T-cell clones generated from HIV-seronegative individuals produced interferon (IFN)-gamma, but not interleukin-4 (IL-4), that is a type 1 cytotoxic (Tc1) profile, high numbers of CD8+ T-cell clones generated from HIV-seropositive individuals produced IL-4 in addition to IFN-gamma or IL-4 alone, thus showing a type 0 cytotoxic (Tc0)- or a type 2 cytotoxic (Tc2) profile, respectively.
Nakahara et al. (2004)IL-4T cellsAlthough autologous T cells primed by the ovalbumin (OVA)-pulsed mature DCs produced IFN-gamma, but not IL-4, OVA-pulsed SP600125-treated mature DCs could initiate IL-4 production from autologous T cells.
Peng et al. (1997)IL-4T cellsIL-4 and IL-5 were produced by CD45RO+ T cells but not by CD45RA+ T cells, indicating that anti-CD2 in this system costimulated type 2 cytokine production by differentiated memory cells.
Demeure et al. (1996)IL-4T-cellThe CD31 antigen (PECAM-1) has been reported to be a stable marker for a human CD4 T-cell subpopulation unable to produce interleukin-4 (IL-4).
Katamura et al. (2000)IL-4T cellsTo further analyze the mechanism of acquiring IL-4-producing ability by naive CD4+ T cells, the effects of IL-7 on human cord blood CD4+ T cells were compared with those of IL-4, which induced the ability to produce IFN-gamma but not IL-4.
Di Nuzzo et al. (2002)IL-4T-cellsIFN-gamma mRNA was clearly detectable in nonirradiated control skin, and IFN-gamma protein was found in 2% of the dermal CD3pos T-cells, whereas IL-4 mRNA was hardly detectable, and no IL-4 protein was found.
Santangelo et al. (2002)IL-4T cellsAlthough fibroblasts, like naive and Th1 cells, did not express IL-4 or IL-13, DHS and unmethylated CpG sites that were distinct from the Th2-specific sites were observed, suggesting that chromatin structure in this cluster not only varies in T cells according to IL-4/IL-13 expression but is also tissue specific.
Vyas et al. (1999)IL-4T cellsWe postulate that the differential expression of the gamma-chain subunit, in the presence and absence of IL-4, may provide a tool for identifying functionally distinct subpopulations of CD8 T cells.
Jung et al. (1996)IL-4T cellsAnalysis of intracellular cytokine production by single CD45RA+ and CD45RO+ T cells indicated that IL-13 continued to be produced for more than 24 h after stimulation, whereas IL-4 could not be detected after 24 h.
Mobbs et al. (2002)IL-4T-cellIL-4 and IFN-gamma mRNA were not detected in any of the NPAs.These findings provide the first direct evidence in infants that in RSV bronchiolitis there are divergent T-cell responses and suggest that more than one mechanism may be responsible for immune-mediated disease enhancement.
Dokter et al. (1994)IL-4T cellsIn accordance with the mRNA results, IL-4 protein was not detected in supernatants of unstimulated T cells or T cells exposed to IL-7.
Dick et al. (1996)IL-4T cellsProliferating cells secrete interferon-gamma (IFN-gamma) and release large amounts of soluble interleukin-2R (sIL-2R) into the culture supernatant but produce no detectable interleukin-4 (IL-4), a phenotype typical of the T-helper (Th)1 subset of CD4+ T cells.
Davis et al. (2001)IL-4T cellsSignificantly fewer cells produced IL-4 alone (1 ± 0%) as compared with normal blood (P < 0.05) or RAPB (P < 0.05) T cells, whereas no significant difference was observed in the number of cells that produced the combination of IL-4 and IFN-?
Sieling et al. (2000)IL-4T cellIn the presence of CD1(+) APCs, DN T cell lines from SLE patients produced both IL-4 and IFN-gamma, whereas DN T cells from healthy donors produced IFN-gamma, but no IL-4.
Marshall et al. (1993)IL-4T cellsFurthermore, we observed that human CD4+ T cells from either allergic or nonallergic individuals failed to produce significant quantities of IL-4, IL-5, or IL-10 even after several rounds of stimulation with soluble protein (nonallergen) antigens such as tetanus toxoid or Var. z.
Doherty et al. (1999)IL-4T cellsFlow cytometric analysis of cytokine production by fresh hepatic lymphocyte subsets activated by CD3 cross-linking or PMA and ionomycin stimulation indicated that NT cells and T cells could produce IFN-gamma, TNF-alpha, IL-2, and/or IL-4, but little or no IL-5, while NK cells produced IFN-gamma and/or TNF-alpha only.
Katamura et al. (2000)IL-4T cellsRESULTS: Interleukin-7 preserved the population of CD4+CD31- T cells in cord blood and induced their IL-4-producing ability without T cell receptor (TCR) stimulation, while IL-4 induced CD31 on CD31- T cells and could not induce their IL-4-producing ability.
Kemp et al. (1993)IL-4T-cellTwo of the T-cell clones produced large amounts of IL-4 without production of IFN-gamma, seven clones produced both IFN-gamma and IL-4, and eight produced only IFN-gamma.
Tramsen et al. (2009)IL-4T cellsUpon restimulation, the generated T cells produced IFN-gamma, but no IL-4 or IL-10, indicating a T(H)1-cell population.
Del Prete et al. (1991)IL-4T-cellsPatients with hyper-IgE had significantly lower proportions of T-cells that produce IFN and TNF, but not IL-2 or IL-4.
Wimalasundera et al. (1997)interleukin-4T cellsResponding T cells were CD4-positive and produced interleukin-2 and interferon-gamma but no interleukin-4.
Kuge et al. (1995)IL-4T cellsDuring lysis of SEA-coated tumor cells, SEA-reactive CD4+ T cells produced high levels of IL-2 and IFN-gamma but not IL-4 in an Ag-specific manner.
Burns and Littlefield (1993)IL-4T cellsAlthough anergic T cells responded normally to interleukin-2 (IL-2), these T cells did not produce IL-2 or IL-4 when peripheral blood mononuclear cells presented MBP or MBP peptides.
Hauser (1992)IL-4T cellsT cells activated in this manner and subsequently cultured with IL-2 mediated contact sensitivity in vivo and produced IL-2 but no IL-4 upon restimulation in vitro.
Wang et al. (2006)IL-4T cellsOur findings indicated that HHV-6-specific IL-10-producing CD4+ T cells from HHV-6-infected individuals possess T regulatory type 1 cell activity: immunosuppression, high levels of IL-10 production, with a few cells expressing IFN-gamma, but none expressing IL-4.
Santin et al. (2000)IL-4T cellsAnalysis of intracellular cytokine expression showed that the striking majority of E7-pulsed DC activated CD8+ T cells strongly expressed IFN-gamma, TNF-alpha and IL-2 but not IL-4.
Rodríguez-Zapata et al. (2010)IL-4T lymphocytesFlow cytometry studies showed that the intracytoplasmic expression of IFN-gamma, IL-2, and TNF-alpha, but not that of IL-4, by phorbol myristate-activated CD4(+) CD3(+) and CD8(+) CD3(+) T lymphocytes was significantly increased in untreated brucellosis patients and was also partially normalized after antibiotherapy.
Pappas et al. (2006)IL-4T lymphocytesUpon activation with PMA and ionomycin, the purified CD4+CCR4+ T lymphocytes produced IL-4 and no IFN-gamma.
Parronchi et al. (1992)IL-4T cellThese data indicate that the majority of human T cell clones that produce IFN-gamma, but not IL-4 (Th1-like), as well as of T cell clones that produce IFN-gamma in combination with IL-4 (Th0-like) are cytolytic.
Smith-Norowitz et al. (2008)IL-4T cellsCD8(+)CD60(+) T cells of the RS patients produced IL-2, IL-4, IL-10, IL-12, IFN-alpha. and IFN-gamma, but not IL-6 or IL-13.
Kobayashi et al. (2002)IL-4T cellThe K14-responsive T cell line produced IFN-gamma, but little IL-4 when stimulated with irradiated autologous PBMC pulsed with this peptide.
Butch et al. (1993)IL-4T cellsFreshly isolated GC T cells consistently expressed IL-4 mRNA (11 of 12 tonsils), whereas CD57- Th cells (mostly non-GC Th cells) were often negative for IL-4 mRNA.
Pon and Freedman (2003)IL-4T cellsAll transformed gammadelta T cells analyzed, regardless of their compartment of origin, strongly expressed intracytoplasmic IFN-gamma and TNF-alpha, but little IL-2 or anti-inflammatory IL-4 or IL-10.
D'Amico et al. (2006)IL-4T cellsNoticeably, growth of CD4 T cells was maintained (45% of total cells), which actively produced Th1 cytokines (IFN-gamma, TNF-alpha, IL-2), but not IL-4, IL-5 and IL-10.
Umetsu et al. (1988)IL-4T cellIn marked contrast to murine IL-2 secreting Th1 clones which do not produce IL-4 or IFN-gamma, we observed that some human T cell clones secrete IL-2, and IFN-gamma as well as IL-4.
Nielsen et al. (1994)IL-4T cellThus, T cell lines producing interferon (IFN)-gamma but not IL-4 (TH1-like) as well as T cells producing both cytokines (THO-like) responded to class II mAb.
Grigoryev et al. (2009)IL-4T cellsas determined by intracellular cytokine staining while no detectable IL-10 or IL-4 producing cells were detected in either control or stimulated CD4+ T cells.
O'Keeffe et al. (2004)IL-4T cellsUpon stimulation in vitro, CD161+ T cells produced IFN-gamma and TNF-alpha but not IL-4.
Dunne et al. (2001)IL-4T cellsBoth cytokines stimulated cytotoxicity by NK and CD56(+) T cells against K562 targets, but not the production of IFN-gamma, TNF-alpha, IL-2, or IL-4.
Tsark et al. (2001)IL-4T cellsIL-4 was not expressed by cells exposed to either stimulus, demonstrating a profound inability of the bnx/hu T cells to produce this cytokine.
Chen et al. (2006)IL-4T cellsWe have shown that IL-23-dependent, pathogenic T cells produced IL-17 A, IL-17 F, IL-6, and TNF but not IFN-gamma or IL-4.
Maggi et al. (1988)IL 4T cellAlthough 21 out of 503 (4%) CD4+ T cell clones produced IL 4, but not IFN-gamma or IL 2, and 208 (41%) produced IL 2 and/or IFN-gamma, but not IL 4, a total number of 185 (37%) CD4+ clones showed the ability to produce IL 4 plus IL 2 and/or IFN-gamma.
Teraki and Shiohara (2003)IL-4T cellsIntracellular staining demonstrated that most intraepidermal CD8+ T cells were capable of producing IFN-gamma and TNF-alpha but produced little IL-2 and IL-4.
Eberl et al. (2002)IL-4T cellsIn contrast, Vgamma9/Vdelta2 T cells grown with IL-21 differentiated into putative central memory CD45RO(+) T cells that did not produce TNF-alpha, IFN-gamma, or IL-4, and maintained expression of CD62L, CD81, and CCR7.
Sender et al. (2010)IL-4T cellIL-23 propagates development of Th17 cells, a novel T cell subset which produces IL-17 but no interferon-gamma or IL-4.
Putheti et al. (2010)IL-4T cells-alone induced generation of 2% or 4% of CD4+IL-9+ T cells, whereas no IL-9 was expressed in the absence of IL-4 or TGF-?.
Dugas et al. (1993)IL-4T cellIn the present study we showed that IL-9, another T cell-derived cytokine, markedly potentiated IgE production induced by suboptimal doses of IL-4, whereas no effect of IL-9 was observed in the absence of IL-4.
Vultaggio et al. (2008)IL-4T-cellT-cell clones generated from the oral mucosa of one HIV-infected patient with POPC produced IL-4, but not IFN-gamma (Th2 phenotype), whereas clones obtained from vaginal mucosa from one RVC patient or one healthy donor showed a Th1 profile.
Weber et al. (1993)interleukin 4T cellsThey retained the membrane phenotype of activated T cells and secreted the cytokines interferon gamma and lymphotoxin, but interleukin 4 was not detected.
Dawson et al. (2008)IL-4T cells-selective retinoid, Am-80, failed to affect IL-4 production by antigen-stimulated murine Th2 clones [23] or antigen-stimulated murine T cells [21] and in vitro antigen-stimulated murine T cell IL-4 synthesis was stimulated by 9-cis-RA and an RXR-selective retinoid, but not by ATRA or an RAR-selective retinoid [49].
Piuvezam et al. (1993)IL-4T cellT cell lines generated against Tct proliferated in response to parasite lysate only in the presence of autologous APC and produced IL-2, IL-6, and IFN-gamma but not IL-4 in response to PMA plus ionomycin.
Ohkuri et al. (2009)IL-4T cellsCulture of CD4(+) T cells with IFN-gamma-treated PBMC-derived adherent cells in the presence of helper epitope peptide resulted in a great expansion of MAGE-A4-reactive Th cells producing IFN-gamma , but not IL-4.
Wu et al. (1993)IL-4T cellsIL-12 also induces neonatal CD4 T cells to produce lymphotoxin but not IL-2, TNF-alpha, or IL-4.
Wu et al. (1993)IL-4T cellsUsing a three-step culture system, we next show that IL-12 induces the maturation of resting naive CD4 T cells into cells producing both IL-2 and IFN-gamma but not IL-4 upon stimulation with PMA and ionomycin.
Chou et al. (1994)IL-4T cellThis lymphokine mRNA profile differed from a BP-specific T cell line that produced message for IFN-gamma and GM-CSF but low or absent levels of IL-4 and IL-5.
Flohé et al. (2003)IL-4T cellsAgain, a Th1 bias was noted in that cocultures of allogeneic T cells and HSP60-treated DC released IFN-gamma but only small amounts of IL-10 and no detectable IL-4.
Wierenga et al. (1990)IL-4T lymphocytesThe present results suggest that CD4+ T lymphocytes that produce IL-4, but not IFN-gamma, occur in high frequencies in the allergen-specific T cell repertoires of atopic donors, which may have important implications for the pathomechanism of atopic disease.
Komai-Koma et al. (2009)IL-4T cellsFurthermore, LPS can synergize with IL-12 to polarize the CD8(+) T cells into cytotoxic T-cell 1 (Tc1) that produce IFN-gamma but not IL-4, with or without TCR activation.
Sjöstedt et al. (1992)IL-4T-cellIL-4 was not detected in the culture medium of any of the T-cell subsets.
Duftner et al. (2006)IL4T cellsBoth, CD4(+) and CD8(+)CD28(-) T cells of patients with AS produced more IFNgamma, TNFalpha, and IL10 than their CD28(+) counterparts (p<0.05), and lacked the production of IL2 and IL4.
Subauste et al. (1995)IL-4T cellsV gamma 9+V delta 2+ gamma delta T cells were cytotoxic for T. gondii-infected cells in an MHC-unrestricted manner, and produced IFN-gamma, IL-2, TNF-alpha, but not IL-4 when incubated with cells infected with the parasite.
Bamford et al. (1998)IL-4T cellsFurthermore, freshly isolated gastric T cells produced little IL-4 and virtually no IL-5 or tumor necrosis factor beta.
Björk et al. (1992)IL-4T-lymphocyteThe T-lymphocyte-derived cytokines TNF-beta, IL-2, IFN-gamma and IL-4 were never detected in the cultures.
Munk et al. (1996)interleukin-4T cellsAfter in vitro stimulation with O. volvulus in the presence of interleukin-2, Vdelta1+ T cells produced interferon-gamma but not interleukin-4 and exhibited NK cytolytic activities.
Westra et al. (2000)interleukin-4T cellsCulture supernatants of PB T cells stimulated with recombinant gH(t(His)):gL contained high levels of interferon-gamma and no detectable interleukin-4, indicating their Th1 phenotype.