Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in T cells

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Duprez et al. (1988)interleukin 2T cellWe have described a human tumor T cell line, IARC 301, which constitutively expresses high affinity interleukin 2 (IL2) receptors, and showed that after binding to its receptors, IL2 is endocytosed and degraded.
Lorberboum-Galski et al. (1990)IL2T cellsTo produce a molecule that will kill activated T cells as well as lymphomas and leukemias expressing interleukin 2 (IL2) receptors, we have created a recombinant chimeric protein in which IL2 is attached in peptide linkage to a truncated mutant form of Pseudomonas exotoxin (PE) (Lorberboum-Galski, H., FitzGerald, D.J.P., Chandhary, V.K., Adhya, S., and Pastan, I. (1988) Proc.
Lorberboum-Galski et al. (1990)IL2T cellsOur results indicate that IL2-PE664Glu should be evaluated as an immunosuppressive agent for the treatment of human immune disorders in which activated T cells expressing the IL2 receptor are prominent.
Gillis et al. (1981)TCGFT cellCultures from old donors produced less T cell growth factor (TCGF) and incorporated less tritiated thymidine (3H-Tdr) than did similar cultures from young donors in the presence of either mitogen.
Gillis et al. (1981)TCGFT cellTCGF production or responsiveness was not associated with the presence of "suppressor" activity in elderly T cell preparations.
Inouye et al. (1980)TCGFT lymphocytesTCGF production for cloning and growth of functional human T lymphocytes.
Inouye et al. (1980)TCGFT cellIn an effort to increase the potency of T cell growth factor (TCGF), several variables were examined for their effects on the production of TCGF.
Kaplan et al. (1988)IL-2T cellsAlthough it is possible that the epitopes seen were present on a distinct molecule independent of secreted IL-2, the distribution on a variety of T cells and regulation via cellular activation suggest that the surface expression of IL-2 epitopes is in some way related to the soluble lymphokine.
Chouaib and Fradelizi (1982)IL2T lymphocytesThe mechanism of IL2 production by T lymphocytes has been clearly established in Mice.
Chouaib and Fradelizi (1982)IL2T lymphocytesWe have observed that a complete depletion of adherent monocytes abrogates IL2 production by T lymphocytes.
Chouaib and Fradelizi (1982)IL2T cellThese results suggest that activation of a radiosensitive T cell by monokines is required for the inhibition of IL2 production.
Zissel et al. (1996)IL-2T cellAccessory function allows antigen-presenting cells to produce sufficient secondary signals for optimum T cell proliferation and interleukin-2 (IL-2) production.
Meuer et al. (1982)IL 2T lymphocytesCellular origin of interleukin 2 (IL 2) in man: evidence for stimulus-restricted IL 2 production by T4+ and T8+ T lymphocytes.
Meuer et al. (1982)IL 2T cellThe human T cell subset(s) responsible for production of interleukin 2 (IL 2) was investigated in the present study.
Meuer et al. (1982)IL 2T cellMitogen stimulation led to secretion of equivalent amounts of IL 2 from both the major T cell subsets; in contrast, after allogeneic activation, IL 2 was produced predominantly from the T4+ subset.
Meuer et al. (1982)IL 2T cellThe stimulus dependency of IL 2 production suggests that the individual functional repertoires of T4+ and T8+ T cell subsets may be linked to unique surface receptors and/or interaction molecules involved in cell triggering rather than a restricted capacity to produce lymphokine.
Weaver et al. (2007)IL-2T cellsThe cytokine interleukin-2 (IL-2) is produced by T cells when they recognize a foreign antigen.
Katsiari and Tsokos (2006)IL-2T cellsT cells from patients with SLE produce decreased amounts of interleukin-2 (IL-2), a central cytokine in the regulation of the immune response.
Petrov and Lijnen (2000)IL-2T-cellIL-2 receptor expression in the cells was monitored using antiactivated T-cell antigen (Tac) antibody, and the IL-2 production in the cell supernatants of the cultures was determined by an enzyme amplified sensitive immunoassay.
Williams et al. (1996)IL-2T cellDGLA suppresses T cell activation and production of interleukin-2 (IL-2).
Williams et al. (1996)IL-2T cellIL-2 production by the human T cell line Jurkat is dependent on a fall in mRNA for c-myc and a rise in mRNA for c-fos.
Schleuning et al. (1993)Interleukin-2T-cellThe effect of the phenothiazine derivative fluphenazine has been studied in the human leukemic T-cell line H33-HJ JA1, which is an Interleukin-2 (IL-2) producing cell line derived from Jurkat cells.
Gazzolo and Duc Dodon (1987)IL-2T lymphocytesThe mitogenic or antigenic stimulation of T lymphocytes in the presence of accessory cells results in the synthesis of interleukin-2 (IL-2), which, on interacting with de novo synthesized receptors on the membrane, induces the proliferation and differentiation of T cells.
Gazzolo and Duc Dodon (1987)IL-2T-cellIndeed, binding of viral particles to these cells induces IL-2 production and IL-2 receptor expression, and triggers T-cell proliferation.
Bruserud and Moen (1984)interleukin 2T lymphocytesProduction of interleukin 2 containing growth medium for cloning of human T lymphocytes.
Bruserud and Moen (1984)IL-2T cellsFollowing these studies a simple and efficient method producing IL-2 for cloning of human T cells was developed.
Krajewski et al. (1983)interleukin 2T cellsColony formation and interleukin 2 production by leukaemic human T cells.
Krajewski et al. (1983)IL-2T cellPHA-induced colony formation and interleukin 2 (IL-2) production were studied in four patients with T cell leukaemia (three cases OKT4+/T helper and one case OKT8+/T cytotoxic suppressor).
Bonnard et al. (1979)TCGFT cellsThese experiments suggested specific absorption of TCGF by activated T cells, and led us to develop a model of ligand-activated TCGF-induced proliferation of T cells: Ligands induce production of TCGF by T-producer cells and deliver a first signal to the T-responder cells.
Zaizov et al. (1986)IL-2T cellIn vitro restoration by interleukin-2 (IL-2) of the impaired natural killer cell activities, IL-2 receptor expression, and T cell proliferation in hemophilia.
Pahlavani and Richardson (1996)IL-2T cellsThe age-related decline in IL-2 production has been shown to arise from a decline in IL-2 transcription, and a recent study suggests that the transcription factor NFAT (nuclear factor of activated T cells) may play a role in the decline in IL-2 transcription.
Kolitz et al. (1985)IL 2T-cellThe biochemistry and molecular biology of IL 2 and its gene are reviewed, along with data regarding the IL 2 receptor, normal T-cell activation, abnormalities in IL 2 production and response in immunodeficiency states and leukemia, and initial explorations of IL 2 in the treatment of human cancer.
Welte et al. (1984)IL-2T cellOKT3 monoclonal antibody at low, nonmitogenic concentrations (25 pg/ml) or IL-2 alone at optimal concentrations (20 U/ml) did not induce IL-2 receptor expression, as measured by Tac antibody or by T cell proliferation.
Lamb et al. (1983)IL-2T-lymphocyteInfluenza virus immune human T-lymphocyte clones maintained in continuous culture in TCGF were analysed for helper activity and interleukin-2 (IL-2) production.
Lamb et al. (1983)IL-2T cellsConversely, the T cells that produced IL-2 were unable to provide either specific or non-specific helper function.
Arya et al. (1984)TCGFT lymphocytesTCGF is produced by a subset of T lymphocytes, and this production is regulated at the TCGF mRNA level.
Vie and Miller (1986)IL 2T cellsEstimation by limiting dilution analysis of human IL 2-secreting T cells: detection of IL 2 produced by single lymphokine-secreting T cells.
DeFreitas et al. (1986)IL-2T-cellWe report here that both antigen- and mitogen-induced T-cell lines and clones obtained from peripheral blood and cerebrospinal fluid of multiple sclerosis patients show prolonged expression of IL-2 receptors.
Gulino et al. (1990)interleukin-2T-cellT-cell restricted and unrestricted expression of transfected human interleukin-2 gene: phorbol ester- and calcium-inducible versus constitutive expression.
Gulino et al. (1990)IL-2T cellsInterleukin-2 (IL-2) gene expression is tightly controlled and generally limited to antigenic stimulation of T cells.
Gulino et al. (1990)IL-2 geneT cellsPhorbol ester and calcium ionophore did not modulate the expression of the transfected IL-2 gene in NIH-3T3 and HeLa cells, while these agents increased its expression in transfected BFS lymphoma T cells.
Gulino et al. (1990)IL-2 geneT cellsWe conclude that when transfected into lymphoid and non-lymphoid cells the intact human IL-2 gene is constitutively expressed, while its phorbol ester/calcium-mediated inducible expression is restricted to T cells.
Toossi et al. (1986)IL-2T cellSuppression by adherent cells was operative in one group of patients; adherent cell depletion increased their T cell production of IL-2 7.2-fold.
Domingo et al. (1985)interleukin-2T lymphocytesT8-depleted and unfractionated T lymphocytes allogeneically stimulated and cultured in the presence of pregnancy sera exhibit an inhibition of cellular proliferation and interleukin-2 synthesis, respectively.
Maeda (1992)IL-2T cellHTLV-I-infected cells express IL-2 receptors, and HTLV-I-infected T cell lines can be established from most of ATL patients in culture in the presence of IL-2.
Krönke et al. (1986)interleukin 2T-cellsThese retrovirus infected T-cells express large numbers of receptors for interleukin 2 (or T-cell growth factor).
Eylar et al. (1996)Il-2T cellsHowever, we find that purified human T cells deteriorate if maintained in ascorbate in culture for 18 hrs. or more; viability and Il-2 synthesis are over 90% curtailed by ascorbate at 50 micrograms/ml.
Waldmann (1986)IL-2T cellsAntigen or mitogen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2) as well as the expression of specific cell surface receptors for this lymphokine.
Waldmann (1986)IL-2T-cellFailure of the production of either IL-2 or its receptor results in a failure of the T-cell immune response.
Sasagawa et al. (2006)interleukin-2T cellsEchinacea alkylamides inhibit interleukin-2 production by Jurkat T cells.
Sasagawa et al. (2006)IL-2T cellsThus, alkylamides present in E. purpurea suppress the ability of activated Jurkat T cells to produce IL-2 independently of direct, cytotoxic effects.
Strauchen (1989)IL-2T-cellIL-2 receptor expression is strongly associated with several forms of human lymphoproliferative disease including adult T-cell leukemia-lymphoma, hairy cell leukemia, Hodgkin's disease, and peripheral T-cell lymphoma in which it may play a pathogenetic role.
Dautry-Varsat et al. (1988)IL-2T-cellThe effect of cyclosporin A (CsA), a potent immunosuppressive agent, on a human T-cell line, IARC 301, which constitutively secretes interleukin-2 (IL-2) and expresses high-affinity IL-2 receptors, was investigated.
Dautry-Varsat et al. (1988)IL-2T cellsWe also show for the first time, that CsA not only can inhibit IL-2 production of T cells upon activation, but that it can also prevent ongoing constitutive IL-2 synthesis of a T-cell line.
Puppo et al. (1987)interleukin 2T lymphocytesThe production of interleukin 2 (IL2), and the expression of HLA Class II antigens and IL2 receptors by PHA-activated T lymphocytes were also evaluated.
Toossi et al. (1989)interleukin 2T-cellRegulation of human T-cell production of interleukin 2 by Leu 11 (CD16) positive large granular lymphocytes.
Weiss et al. (1984)IL 2T cellsThe role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.
Hori et al. (1987)IL 2T cellAs abnormal IL 2 receptor expression was also seen originally in the fresh leukemic cells, the establishment of this cell line with IL 2 suggests that IL 2-mediated T cell proliferation is involved in the leukemogenesis of some cases of HTLV-negative T-CLL.
Waldmann et al. (1984)IL-2T cellThe size of the IL-2 receptors expressed on the cloned normal B cell lines was similar (53,000-57,000 daltons) to that of receptors on phytohemagglutinin-stimulated T cell lymphoblasts.
Baroja and Ceuppens (1987)interleukin-2T-cellsHuman T-cells produce interleukin-2 (IL-2) in response to in vitro stimulation with mitogens and antigens.
Baroja and Ceuppens (1987)IL-2T-cellsPrecise measurement of IL-2 production in vitro is hampered by binding of IL-2 to IL-2 receptors on activated T-cells which results in IL-2 consumption.
Claudette et al. (1990)interleukin 2T cellMechanism of phosphatidylserine-induced inhibition of interleukin 2 synthesis in the human T cell line Jurkat.
Claudette et al. (1990)Interleukin-2T cellsTreatment of Jurkat T cells with PS, results in a strong decrease of Interleukin-2 synthesis.
Henics et al. (1994)interleukin-2T cellThe MLA 144 gibbon T cell line is infected with a type C retrovirus and constitutively expresses interleukin-2 (IL-2) and granulocyte macrophage colony-stimulating factor (GM-CSF).
Mertelsmann et al. (1981)TCGFT-cellMononuclear blood cells from patients with different types of leukemia, and from controls as well as cells from established lymphoblastic cell lines were analyzed with respect to terminal transferase (TdT) activity and T-cell growth factor (TCGF; Interleukin 2, IL-2), to determine the significance of TCGF production and response as functional markers for human leukemias.
Yoshimura and Kahan (1985)IL-2T cellIL-2 production was measured by the capacity of lymphocyte supernates to trigger proliferation of a human IL-2-dependent T cell line.
Manger et al. (1986)IL-2T cellAnother T cell line, HUT 78, also produces IL-2 in response to a rise in [Ca++]i and PMA; however, in HUT 78, PMA alone induces low levels of IL-2 production that is not blocked by CsA.
Manger et al. (1986)IL-2T cellThese data suggest that CsA does not globally inhibit IL-2 gene expression, but rather interferes with signaling events of T cell activation.
Roosnek et al. (1985)interleukin 2T cellsThe requirements for lectin-induced interleukin 2 (IL2) production by human T cells have been investigated.
Roosnek et al. (1985)IL2T cellsWith two different types of T cells, the Jurkat T cell lymphoma and highly purified HLA class II- peripheral T cells, the amount of IL2 produced was strongly dependent on the lectin concentration used.
Gerez et al. (1995)Interleukin-2T cellsInterleukin-2 (IL-2) regulates the clonal expansion of activated T cells and is produced in limited amounts during an immune response.
Kabelitz and Al-Gorany (1989)IL-2T cellEsculetin inhibits T cell activation without suppressing IL-2 production or IL-2 receptor expression.
Kabelitz and Al-Gorany (1989)IL-2T cellsEsculetin did not inhibit interleukin-2 (IL-2) production, nor did it interfere with the appearance of IL-2 receptors on stimulated T cells, as judged by immunofluorescence using anti-Tac monoclonal antibody.
Kabelitz and Al-Gorany (1989)IL-2T-cellThese results show that esculetin inhibits T-cell activation at a site distal to production of IL-2 and IL-2 receptor expression.
Beaurain et al. (1989)IL-2T cellThe production and targeting of a major T cell derived lymphokine, Interleukin 2 (IL-2), were studied in 23 uremic patients undergoing regular hemodialysis treatment and 20 uremic patients prior to the onset of renal replacement therapy.