Viewing negative mentions of gene expression of IL2 (H. sapiens) in T cells

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Müller-Quernheim et al. (1986)IL 2 geneT cellsThe sarcoid lung T cells, however, did not express the IL 2 gene constitutively; when placed in culture with no stimulation and evaluated after 24 hr, they demonstrated down regulation of the amounts of IL 2 mRNA transcripts, despite the fact that they were capable of re-expressing the IL 2 gene and releasing more IL 2 in response to added activation signals.
Waldmann et al. (1985)IL-2T-cellsResting T-cells do not express IL-2 receptors, but receptors are rapidly expressed on T-cells following interaction of antigens, mitogens, or monoclonal antibodies with the antigen-specific T-cell receptor complex.
Waldmann et al. (1985)IL-2T-cellNormal resting T-cells and most leukemic T-cell populations do not express IL-2 receptors; however, the leukemic cells of the 11 patients examined who had human T-cell lymphotropic virus-associated adult T-cell leukemia expressed the Tac antigen.
Wiskocil et al. (1985)IL 2T cellIn the resting state, the T3-positive, human T cell line Jurkat does not synthesize detectable amounts of either interleukin 2 (IL 2) or gamma-interferon (IFN-gamma).
Waldmann et al. (1984)IL-2T cellsResting T cells do not express IL-2 receptors but receptors are rapidly expressed on T cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen specific T-cell receptor complex.
Waldmann et al. (1984)IL-2T-cellNormal resting T cells and most leukemic T-cell populations do not express IL-2 receptors however the leukemic cells of all patients with human T-cell leukemia/lymphoma virus (HTLV-I) associated, adult T-cell leukemia (ATL) examined expressed the Tac antigen.
Waldmann (1987)IL-2T cellsResting T cells do not express IL-2 receptors, but receptors are rapidly expressed on T cells following interaction of the antigen-specific T-cell receptor complex with appropriately processed and presented antigens.
Waldmann (1987)IL-2T-cellNormal resting T cells and most leukemic T-cell populations examined did not express IL-2 receptors; however, the leukemic cells of all patients with human T-cell lymphotrophic virus (HTLV-I)-associated adult T-cell leukemia (ATL) expressed the Tac antigen.
Brunvand et al. (1993)IL-2T cellTo determine if the trans-activators documented in T cell nuclear extracts actually bind the IL-2 promoter in vivo, ligation mediated PCR (LMPCR) genomic footprinting was performed on the IL-2 promoter in both activated and non-activated T cells and HL60 promyelocytes, which do not express the IL-2 gene.
Lopez et al. (1998)IL-2T cellThese findings show that human breast cancer tumor-induced repression of IL-2 RNA translation is the basis of failure of TIL to express the IL-2 receptor and subsequent T cell hyporesponsiveness.
Schwab et al. (1990)IL-2T cellsHowever, T cells from old donors that do not express high affinity IL-2 binding sites express both the IL-2 binding 55 and 75 kd chains.
Nakamura et al. (1991)IL-2T cellsIn accordance with the magnitude of IL-2 responsiveness, freshly isolated CD8+ T cells expressed significant amounts of p75 IL-2 receptor, while fresh CD4+ T cells did not express p75 IL-2 receptor.
Hurez et al. (2003)IL-2T cellsT cells destined to produce IL-2 required prolonged interactions with DCs, whereas most T cells established only transient interactions with DCs and were activated, but did not express IL-2.
Kirkpatrick et al. (1985)IL-2T-cellThis observation is interpreted as indicating that failure to produce IL-2 by AIDS patients is most likely due to depletion of IL-2-producing cells, although an abnormality of T-cell function has not been excluded.
Palacios (1984)IL 2T cellsThe capacity for circulating human T cells which have or lack receptors for interleukin 2 (IL 2) to produce IL 2, interleukin 3 (IL 3), and interferon-gamma (IFN-gamma) under the stimulus of phytohemagglutinin was studied.
Palacios (1984)IL 2T cellsTac- T cells produced IL 2 and IL 3 but not IFN-gamma.
Grabstein et al. (1986)IL 2T lymphocytesIn populations of peripheral blood T lymphocytes, the production of IL 2 and IFN-gamma were not necessarily coordinately expressed.
Wakasugi et al. (1985)IL 2T cellsPurified T cells incubated for 3 days with PHA neither proliferate nor express IL 2 receptors as detected by FACS analysis with the use of anti-Tac antibodies.
Sieg et al. (2001)IL-2T-cellSubnormal T-cell production of interleukin-2 (IL-2) in human immunodeficiency virus (HIV) disease has been described; however, it is not clear whether failure to synthesize IL-2 represents a selective or global defect in T-cell cytokine production.
Waldmann (1986)IL-2T-cellResting T cells do not express IL-2 receptors, but receptors are rapidly expressed on T cells following interaction of the antigen-specific T-cell-receptor complex with appropriately processed and presented antigens.
Waldmann (1986)IL-2T-cellNormal resting T cells and most leukemic T-cell populations examined did not express IL-2 receptors; however, the leukemic cells of all patients with human T-cell lymphotrophic virus (HTLV-I)-associated adult T-cell leukemia (ATL) expressed the Tac antigen.
Matsuzaki et al. (1986)IL-2T-cellThe T-cell hybridomas became infected but did not produce IL-2 unless simultaneously exposed to syngeneic I-A+ antigen-presenting cells.
Matsuzaki et al. (1986)IL-2T-cellIn this situation, the persistently infected T-cell hybridomas produced IL-2 without being reexposed to virus.
Murakawa et al. (1985)IL 2T cellsSLE T cells failed to produce normal levels of IL 2 in vitro compared with normal control T cells.
Welte et al. (1987)IL-2T cellsThis IL-2 was not produced by Leu-11+ natural killer cells, which were found to be predominant in the circulation at this time, but by T11+, T3+, Ia antigen-bearing T cells.
Dadaglio et al. (1994)interleukin 2T cellsThe V beta 8 anergic T cells did not express interleukin 2 receptors (IL-2Rs) and failed to proliferate in response to exogenous IL-2 or IL-4, suggesting that this anergy was not a reversible process, at least by the use of these cytokines.
Tinubu et al. (1994)IL-2T cellsIL-2Rs are expressed by T cells activated in response to foreign histocompatibility Ags but not by normal cells.
Brown et al. (1991)interleukin 2T cellsHigh-affinity interleukin 2 receptors (IL-2Rs) are expressed by T cells activated in response to foreign histocompatibility antigens but not by normal resting T cells.
Maggi et al. (1988)IL 2T cellAlthough 21 out of 503 (4%) CD4+ T cell clones produced IL 4, but not IFN-gamma or IL 2, and 208 (41%) produced IL 2 and/or IFN-gamma, but not IL 4, a total number of 185 (37%) CD4+ clones showed the ability to produce IL 4 plus IL 2 and/or IFN-gamma.
Asao et al. (1994)IL-2T cellWe have investigated the role of JAK3 in interleukin 2 (IL-2)-induced signal transduction with a human T cell line, ED40515(-), lacking expression of the IL-2 receptor gamma chain and its sublines transfected with wild-type or mutant cDNAs of the IL-2 receptor gamma chain.
Chopra et al. (1989)IL-2T cellsPhorbol myristate acetate and calcium ionophore A23187-stimulated human T cells do not express high-affinity IL-2 receptors.
Oh-Hori et al. (1990)IL-2-dependentT-cellUsing this antiserum, we show that HTLV-I-positive T-cell lines, whether they are IL-2-dependent or not, scarcely express p56lck.
Trimble et al. (2000)interleukin 2T-cellAfter T-cell activation, CD3zeta-down-modulated cells express the activation marker CD69 but not the high-affinity interleukin 2 (IL-2) receptor alpha-chain CD25 and produce gamma interferon but not IL-2.
Waldmann et al. (1986)IL 2T cellsResting T cells do not express IL 2 receptors, but receptors are rapidly expressed on T cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen-specific T cell receptor complex.
Waldmann et al. (1986)IL 2T cellNormal resting T cells and most leukemic T cell populations do not express IL 2 receptors; however, the leukemic cells of all patients with HTLV-I-associated adult T cell leukemia examined expressed the Tac antigen.
Rothenberg and Ward (1996)IL-2T cellsHowever, in a conserved but poorly studied upstream region, we have now mapped several novel sites of DNase I hypersensitivity in vivo that constitutively distinguish IL-2 producer type T cells from cell types that cannot express IL-2.
Rossi et al. (1985)IL 2T cellsMoreover, B-CLL non-T cells (mainly B leukemic cells) produced no IL 2 themselves but played a much more efficient role in IL 2 production than did non-T cells from healthy donors.
Filion et al. (1995)IL-2T cellsIn response to GpIIb-IIIa, the GpIIb-IIIa-autoreactive T cells are neither able to proliferate nor produce IL-2 on their own, but do express IL-2 receptors alpha on their cell surface and produce IFN-gamma.
Tremisi and Bich-Thuy (1991)interleukin-2T cellsIn this study, using interleukin-2 and gamma interferon, we first induced the differentiation into plasma cells of primary chronic lymphoid leukemic B cells from patients whose T cells failed to produce interleukin-2.
Zaunders et al. (2006)interleukin-2T cellsThe majority of these initial vaccinia virus-specific CD4+ T cells were CD127+ and produced interleukin-2 (IL-2) but not CTLA-4 in response to restimulation in vitro.
Hassan et al. (1995)IL-2T cellsWith anti-CD2 alone, neonatal T cells proliferated slightly but produced no detectable IL-2, whereas adult T cells proliferated vigorously, with significant IL-2 production.
Swift et al. (1988)interleukin 2T cellsThis hybrid does not constitutively express detectable levels of interleukin 2 (IL 2) receptors but can be induced to express receptors by stimuli shown to activate T cells.
Jenkins et al. (1987)IL-2T-cellT cells stimulated in this manner failed to produce IL-2, but interleukin 3, interferon-gamma, and IL-2 receptors were partially induced and T-cell receptor beta mRNA was fully induced.
Burns and Littlefield (1993)IL-2T cellsAlthough anergic T cells responded normally to interleukin-2 (IL-2), these T cells did not produce IL-2 or IL-4 when peripheral blood mononuclear cells presented MBP or MBP peptides.
de la Rosa et al. (2004)IL-2TregWe demonstrate that Treg, which do not produce IL-2, compete for IL-2 secreted by responder T cells.
Picker et al. (1995)IL-2T cellsSimultaneous determination of IL-2 and gamma-IFN production among CD45ROhigh/CD4+ T cells showed distinct subsets that produce each of these cytokines alone (an average of 30% for IL-2 alone, 8% for gamma-IFN alone), both (16%), or neither (46%).
Waldmann (1986)IL-2T-cellBecause IL-2 receptors are present on the malignant T cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are treated with a monoclonal antibody that binds to the IL-2 receptor.
Teppler et al. (1993)IL-2T lymphocyteHuman immunodeficiency virus type 1 (HIV-1)-infected individuals lack IL-2 because of low CD4+ T lymphocyte numbers.
Morikawa et al. (1994)IL-2T cellsAt concentrations of 1.6 to 40 micrograms/ml, these drugs suppressed interleukin-2 (IL-2) production induced by mitogen-stimulated T cells, but not the expression of IL-2 receptor (CD25), in a dose-dependent manner.
Clark et al. (1984)TCGFT-cellNo differences in the organization of the TCGF gene in normal, leukemic, and human T-cell leukemia/lymphoma virus-infected cells was detected regardless of whether they produce TCGF or not.
Seigel et al. (1984)TCGF geneT-cellIn this clone of cells, which produces human T-cell leukemia virus, the TCGF gene was also located on chromosome 4 and was apparently not rearranged.
Welte et al. (1982)IL-2T cellThe purified IL-2 lacked detectable interferon (alpha and gamma), granulocyte-macrophage colony-stimulating factor, B cell growth factor, T cell-replacing factor, and thymocyte-differentiating activity and was free of any contaminating proteins as judged by silver staining in SDS-PAGE.
Waldmann and Tsudo (1988)IL-2T-cellBecause IL-2 receptors are present on the malignant T cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are being treated with either unmodified or toxin-conjugated forms of anti-Tac monoclonal antibody directed toward this growth factor receptor.
Waldmann (1987)IL-2T-cellBecause IL-2 receptors are present on the malignant T-cells but not on normal resting cells, clinical trials have been initiated in which patients with adult T-cell leukemia are being treated with either unmodified or toxin-conjugated forms of anti-Tac monoclonal antibody directed toward this growth factor receptor.
Depper et al. (1985)interleukin-2T lymphocytesResting human T lymphocytes do not express receptors for interleukin-2, but expression is rapidly induced by exposure to PHA.
Randazzo et al. (1984)IL-2T cellsT cells in the presence of antigen and monocytes and MP concentrations of greater than 10 micrograms ml-1 did not produce IL-2 and were incapable of expressing IL-2 receptors.
Fabricius and Stahn (1980)TCGFT-cellsThe continuously growing T-cells are unable to produce TCGF and depend strictly on external supply of the growth factor.
Yi-qun et al. (1997)IL-2T cellT cell anergy refers to a functional state in which the cells are alive but unable to produce IL-2 after appropriate triggering.
Palacios (1984)IL 2T cellsIt is concluded that: 1) both T cells lacking and T cells having receptors for IL 2 produce IL 2, but only IL 2 receptor-negative T cells appear to secrete IL 3; and 2) virtually all of the T cells that produce IFN-gamma after PHA stimulation express receptors for IL 2.
Burdach et al. (1987)IL 2T cellsIL 2 did not inhibit CFU-GM in the absence of T cells or in the presence of IL 2 receptor-negative T cells.
Chan et al. (1999)IL2T-cellsIn addition, these T-cells did not express IL2-receptors and expression of CD54 (ICAM-1) and CD58 (LFA-3) resembled that of resting T-cells.
Yamada et al. (1987)interleukin 2T cellsWe were unable to detect interleukin 2 receptors (IL 2R) on fresh LGL and T cells using flow cytometric analysis with anti-Tac monoclonal antibody or radiolabeled probes with [125I]anti-Tac.
Hauser (1992)IL-2T cellsT cells activated in this manner and subsequently cultured with IL-2 mediated contact sensitivity in vivo and produced IL-2 but no IL-4 upon restimulation in vitro.
Waldmann and Goldman (1989)IL-2T cellsTo exploit the fact that IL-2 receptors are present on abnormally activated T cells but no on normal resting T cells, clinical trials have been initiated involving patients with neoplastic or autoimmune disorders as well as those receiving organ allografts.
Narazaki et al. (2003)IL-2T-cellThe 3-D T-cell receptor (TCR):CD3 complex reconstituted in TCR-deficient Jurkat cells was capable of transmitting signals, evidenced by activation of the interleukin 2 (IL-2) gene following ligation with anti-CD3 antibody, yet the TCR-reconstituted cells failed to produce IL-2 in response to the target cells.
Bamford et al. (1994)IL-2T-cellLate-phase human T-cell lymphotropic virus I-associated adult T-cell leukemia cells express IL-2 receptors (IL-2R) but no longer produce IL-2.
Wotton et al. (1995)IL-2T cellsWhen restimulated, however, anergic T cells fail to up-regulate transcription of the IL-2 gene and in consequence do not produce IL-2.
LaSalle et al. (1992)IL-2T cellAlthough T cell presentation of peptide antigen resulted in a primary proliferative response, T cells that had been previously stimulated by T cells presenting antigen were completely unresponsive to antigen but not to interleukin 2 (IL-2).
Palacios and Sugawara (1982)IL-2T cellsThese results indicate that HC-A inhibits proliferation of T cells in AMLR by causing the IL-2 producer T cells to become unresponsive to IL-1 and unable to synthesize IL-2.
Inaba and Geiger (2006)IL-2T cellsThe suppressed T cells up-regulate high-affinity IL-2R but do not produce IL-2.
Jelinek et al. (1986)IL 2T cellWhen a two-step culture system was employed to determine the effect(s) of T cell influences during both initial activation and in propagating the response following activation, it was found that B cells activated by SA alone subsequently responded maximally to T sup but only minimally to IL 2 and not at all to IFN-gamma.
Umetsu et al. (1987)IL-2T cellsIn contrast, purified T cells exposed to soluble Leu-4 mAb do not exhibit a rise in intracellular [Ca2+]i, do not express receptors for IL-2, and do not proliferate upon addition of IL-2, indicating that the valency of anti-CD3 mAb is critical for the delivery of the first activation signal to the T cell.
Duc Dodon and Gazzolo (1987)IL2T cellsInfection of T cells with semipurified HTLV-I viral particles promoted colony formation, in the absence of IL2, of accessory cells or soluble factors.
Goebels et al. (1988)IL-2 mRNAT cellIn these cell lines, IL-2 mRNA was not detectable in RNA extracted from whole adult T cell leukemia cell populations because of dilution by other RNA species from the vast majority of cells that do not contain IL-2 mRNA.
Jones et al. (2009)interleukin-2T-cellHuman immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutations.
Umadome et al. (1988)IL-2T cellIn the present study, we describe a case of chronic T-lymphocytic leukemia (T-CLL) with monoclonal proliferation of human T-lymphotropic retrovirus (HTLV)-I or HTLV-II negative CD3(+)4(+)8(-) T cell expressing IL-2 receptors without stimulation.
Palacios (1984)interleukin 2T lymphocytesProduction of lymphokines by circulating human T lymphocytes that express or lack receptors for interleukin 2.
Ndhlovu et al. (2010)IL-2T cellsThus, the patient groups intended to subsequently receive IL-2 and not receive IL-2 did not differ from one another at baseline and, hence, show evidence the groups were well randomized (Table I).We observed that IL-17 responses were not induced by viral peptide pool stimulation of T cells in either CD4+ or CD8+ T cells, but were induced by TCR (anti-CD3/CD28) cross-linking in both groups by CD4+ T cells and did not differ between the two groups (Fig. 2).
Matsumura-Arioka et al. (2005)IL-2T cellsInterestingly, introduction of mutation in the elements increased background promoter activities in resting T cells in the absence of IL-2.
d'Hennezel et al. (2010)IL-2T cellsSimilarly, a recent study by Tang et al. showed that CD4+ Teff from islets of NOD mice were selectively impaired to produce IL-2, consistent with s report documenting the appearance of TCR hyporesponsive T cells coincident with the development of insulitis[10].
Mohagheghpour et al. (1985)IL 2T cellsOn the other hand, T cells of LL patients failed to express receptors for IL 2 or to produce IL 2 in response to M. leprae, whereas similarly treated T cells of BT patients both expressed IL 2 receptors and produced IL 2.
Mohagheghpour et al. (1985)IL 2T cellsThese results suggest that T cells of LL patients fail to respond to M. leprae despite an ability to produce IL 1 and that their failure to express receptors for IL 2 may explain both defective proliferation and the failure of exogenous IL 2 to reconstitute the response.
Habetswallner et al. (1988)IL-2T cellsFurthermore, IL-2 was not detected in the supernatant of T cells grown in the presence of PHA and IL-4.
Claësson and Röpke (1983)IL-2T cellIn the absence of IL-2,Tsc cells do not form colonies and T cell colony formation by Th cells is inhibited 50% by less than 5 x 10(-8)M HCS.
Wong et al. (1996)IL-2T cellIn snap-frozen biopsies, IL-2 was detected in none of 18 RA samples with significant T cell infiltrates.
Tanaka et al. (1999)interleukin-2T cellsReduction in interleukin-2-producing cells but not Th1 to Th2 shift in moderate and advanced stages of human immunodeficiency virus type-1-infection: direct analysis of intracellular cytokine concentrations in CD4+ CD8- T cells.