Viewing affirmative mentions of gene expression of IGHE (H. sapiens) in T cells

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Hemady et al. (1985)IgET cellThe addition of 10(-9)M of DM to eczema B+ T cell recombinations enriched for suppressor cells (depleted of Leu 3a+ helper T cells) resulted in a loss of suppressor-T cell activity and maximal augmentation of IgE synthesis.
Hemady et al. (1985)IgET cellsEnhancement of IgE synthesis was also noted when DM was added to eczema B+ T cell recombinations enriched for helper T cells (depleted of suppressor Leu 2a+ T cells).
Ricci et al. (1985)IgET cellsA small and variable increase of the spontaneous IgE synthesis was induced by soluble factor(s) produced by T cells from patients with severe atopy.
Geha (1985)IgET cellsIt is clear that T cells play a role in the regulation of IgE synthesis.
Strannegård and Strannegård (1984)IgET cellsThis enhancement was probably due to effects of cAMP on T cells since pretreatment of allogeneic MNC or T cells with dbcAMP abrogated their suppressive effect or resulted in enhancement of IgE synthesis in coculture experiments.
Carr et al. (1991)IgET-lymphocyteThe mechanisms of this rise are multifactorial, probably a combination of altered T-lymphocyte regulation of IgE synthesis and of production of specific IgE directed against microbial antigens.
Gordon (1992)IgET-lymphocyteAlthough available since 1910, its exact mechanisms of action is not known but may involve an increase in allergen-specific IgG antibodies, a decrease in IgE synthesis, and alteration in T-lymphocyte activity.
Hassner and Saxon (1983)IgET cellsInhibition of ongoing myeloma IgE synthesis in vitro by activated human T cells.
Hassner and Saxon (1983)IgET cellsThe ability of activated T cells to suppress ongoing IgE synthesis in vitro was assessed using U266--a human myeloma cell line spontaneously producing IgE.
Hassner and Saxon (1983)IgET cellsT cells were able to inhibit U266 IgE synthesis in the presence of 10 micrograms/ml of Con A by 41.8% (p less than 0.01).
Hassner and Saxon (1983)IgET cellsT cells preincubated with 10 or 50 micrograms/ml of Con A and washed extensively were still able to inhibit U266 IgE synthesis in the absence of Con A by 41 and 46% (p less than 0.05 and p less than 0.02, respectively).
Hassner and Saxon (1983)IgET cellsCulture supernatants of Con A-activated T cells were also able to suppress IgE synthesis by U266 (21%; p less than 0.01), which suggests that upon appropriate activation, T cells secrete material(s) with inhibitory properties for IgE synthesis.
Hassner and Saxon (1983)IgET cellsActivation of T cells by mixed lymphocyte culture using puromycin-treated lymphoblastoid cell lines as stimulators also generated T cells that had suppressive activity for IgE synthesis.
Hassner and Saxon (1983)IgET cellsT cells activated with Con A and subsequently incubated with IgE demonstrated a diminished ability to suppress IgE synthesis.
Chambers et al. (1992)IgET cellA total of 31 and 22 CD4+ T cell clones from the atopic and non-atopic donors, respectively, were characterized for the ability to help for IgE synthesis in vitro.
Chambers et al. (1992)IgET cellT cell clones generated with allergen AgE from the atopic donor were autoreactive and all induced IgE synthesis.
Chambers et al. (1992)IgET cellMost importantly, there was a higher frequency of clones able to support IgE synthesis between TT-specific T cell clones generated from the atopic versus the non-atopic donor.
Ferrazzi et al. (1993)IgET lymphocytesThe elevation of IgE may be related to a difference in IgE regulatory lymphokines produced by T lymphocytes.
Lanzavecchia and Parodi (1984)IgET cellsAllogeneic peripheral blood T cells did not provide any help, but rather suppressed the IgE production induced by the alloreactive clones.
Zaunders et al. (1985)IgET cellsSuppression of IgE synthesis in vitro by allogeneic T cells from atopic and non-atopic subjects.
Zaunders et al. (1985)IgET cellsThe role of T cells in the regulation of IgE synthesis by human PBMC was studied.
Zaunders et al. (1985)IgET cellsAutologous T cells from 10/26 atopic donors, whose B cells synthesised IgE, significantly suppressed this IgE synthesis.
Zaunders et al. (1985)IgET cellsThe addition of allogeneic T cells from atopic or non-atopic subjects to atopic B cells resulted in greater suppression of IgE synthesis than the addition of autologous T cells.
Buckley et al. (1981)IgET cellsThe marked augmentation of IgE synthesis by patients' B cells when separated from their own T cells indicates that patients' T cells have some regulatory capacity, but control T cells were more potent in this regard.
Ohta et al. (1980)IgET cellsNormal T cells suppressed in vitro production of IgE and IgE ab significantly more than did atopic T cells but no difference was found in IgG production.
Wright et al. (1990)IgET cellThe elevation of IgE may be related to a difference among the groups in T cell production of IgE regulatory lymphokines.
Okudaira et al. (1981)IgET cellsPeripheral blood lymphocytes (PBL) from atopic patients depleted of E-rosetting T cells developed IgE and IgE Ab in the absence of pokeweed mitogen (PWM), and it was not significantly affected by addition of T cells of of PWM. 1,000 R irradiation decreased more than 50% of the IgE and IgE Ab-producing capacity in 2 of 8 cases, but the remainder were not significantly affected.
Vercelli et al. (1989)IgET cellIgE synthesis requires T/B cell contact and involves interactions between B cell surface MHC Class II molecules and T cell surface receptors, as antibodies to both of these cell surface molecules inhibit IgE synthesis.
Vercelli et al. (1989)IgET cellFurthermore, alloreactive T cell clones which are unable to engage the B cell MHC Class II molecules fail to induce IgE synthesis in spite of their ability to secrete IL-4.
Umetsu et al. (1985)IgET cellDifferential requirements of B cells from normal and allergic subjects for the induction of IgE synthesis by an alloreactive T cell clone.
Umetsu et al. (1985)IgET cellsInduction of IgE synthesis in B cells from nonallergic individuals occurred only under conditions of cognate interaction, in which the B cells expressed the alloantigen recognized by the T cells.
Umetsu et al. (1985)IgET cellIn contrast, IgE synthesis in B cells from allergic donors occurred under conditions of cognate interaction with T cells as well as bystander conditions where the B cells did not express the alloantigen recognized by the T cell clones and where the T cell clones were stimulated by third-party monocytes bearing the relevant alloantigens.
Umetsu et al. (1985)IgET cellFurthermore, bystander stimulation of IgE synthesis in allergic donors occurred in the presence of tetanus toxoid (TT) antigen-specific T cell clones activated by the appropriate TT-pulsed monocytes.
Worm and Henz (1997)IgET lymphocytesAn important counteracting cytokine for IgE synthesis is interferon (IFN) gamma which is produced mainly by T lymphocytes.
Del Prete et al. (1986)IgET cellA total number of 119 (98 CD 4+ and 21 CD 8+) T cell clones were established from tonsil and peripheral blood of three nonallergic individuals and examined for their ability to induce in vitro IgE synthesis in normal B cells.
Del Prete et al. (1986)IgET cellThe in vitro IgE synthesis evoked by T cell clones was detectable between day 6 and 9 and peaked on day 12.
Del Prete et al. (1986)IgET cellsThe induction of IgE synthesis by cloned T cells did not reflect alloantigen recognition on target B cells, since T cell clones induced IgE synthesis in B cells from all randomly selected donors tested, including autologous B cells.
Del Prete et al. (1986)IgET cellVirtually all the T cell clones active on IgE synthesis induced the in vitro production of remarkable amounts of IgM and IgG as well.
Yanagihara et al. (1994)IgET cellAddition of rsFc epsilon RI alpha to cultures induced a dose-dependent inhibition of the T cell-dependent and independent synthesis of IgE.
Wheeler et al. (1996)IgET cellPeripheral blood based T cell-containing and T cell-depleted culture systems for human IgE synthesis: the role of T cells.
Wheeler et al. (1996)IgET cellBACKGROUND: Comparable T cell-containing and T cell-depleted culture systems for human IgE synthesis are currently not available.
Wheeler et al. (1996)IgET cellsReconstitution experiments were performed to investigate the role of T cells on IgE synthesis.
Wheeler et al. (1996)IgET cellAdding T cells back to the anti-CD40 stimulated T cell-depleted cultures resulted in a dose-dependent inhibition of IgE production.
Wheeler et al. (1996)IgET cellsIn the absence of anti-CD40 low numbers of T cells stimulated, while high numbers suppressed, IgE production: the optimal ratio of T cells to non-T cells for maximal IgE production was found to be 1:1.
Wheeler et al. (1996)IgET cellsAt this ratio, irradiated (non-replicating) T cells supported a much greater IgE synthesis than did non-irradiated T cells.
Wheeler et al. (1996)IgET cellCONCLUSION: The development of these systems provides directly comparable T cell-containing and T cell-depleted cultures for human IgE synthesis from peripheral blood, allowing further study of the role of T cells in IgE regulation.
Wheeler et al. (1996)IgET cellsThese systems will also be of use for determining whether potential modulators of IgE synthesis act on the T cells or on other cell types.
Leung and Geha (1987)IgET cellsThese results suggest that IgE synthesis in man is activated by T cells and isotype specific secretion of this immunoglobulin is modulated by IgE binding factors.
Leung et al. (1986)IgET cellTwo human alloreactive T cell clones were established from a one-way mixed lymphocyte culture involving two nonatopic donors, and were assessed for their capacity to induce IgE synthesis by B cells obtained from the original stimulator.
Leung et al. (1986)IgET cellHowever, one of the two clones, clone 2H6, induced IgE synthesis in the presence of supernatants from T cell lines derived from patients with the hyper-IgE syndrome (HIE), and enriched for T cells bearing receptors for IgE.
Di Fabrizio et al. (1991)IgET cellsHuman gamma delta T cells amplify IgE production by Epstein-Barr virus-activated B cells.
Di Fabrizio et al. (1991)IgET cellsThe classical "helper" subset of CD4+ alpha beta T cells, although potent inducers of other Ig isotypes, are not as efficient in augmenting IgE synthesis.
Di Fabrizio et al. (1991)IgET cellsIt will be important, for example, to determine whether gamma delta T cells, or products of these cells, directly regulate class switching or mediate the clonal expansion of IgE-expressing B cells.
Saxon et al. (1980)IgET cellsNormal human peripheral blood lymphocytes can be stimulated by PWM and T cells to produce IgE in vitro.
de Vries et al. (1991)IgET cellsInterleukin-4 induces IgE production specifically, but costimulatory signals provided by T cells are required.
Yang et al. (1988)IgET cellsWhile lectins failed to induce IgE synthesis, monoclonal anti-CD3 antibodies were very potent stimuli for the induction of human in vitro IgE synthesis, possibly due to the activation of T cells.
de Weck et al. (1985)IgET cellActivated, human T cells and T cell hybridomas produce IgE-binding factors, which may be detected by a sensitive in vitro test and which may apparently also become the endeavour of synthesis by molecular biological techniques.
de Weck et al. (1985)IgET cellAlthough the evidence available in rodents for the role of IgE-binding factors in modulating IgE synthesis has not yet been fully reproduced by us in man, the fact that classical IgE-enhancing procedures in rodents (e.g. radiotherapy, T cell suppression) also affect IgE production in man leads to believe that similar immunoregulation mechanisms apply to various mammalian species studied so far.
Romagnani et al. (1987)IgET cellThe addition to the cultures of mitogen-stimulated autologous unfractionated T cells inhibited in a dose-dependent fashion, the T cell clone induced IgE, but not IgG, synthesis.
Rossi et al. (1985)IgET-cellIn addition, several human T-cell lymphoma-leukaemia virus I-transformed T-cell lines were explored for their capacity to produce factor(s) able to suppress IgE synthesis in the U-266 cell line, and four out of 25 cell lines could be shown to do this in a constitutive manner.
Sherr et al. (1987)IgET cellsT cells from highly atopic individuals spontaneously secrete in vitro a factor that specifically induces IgE synthesis from normal human B cells.
Nutman et al. (1985)IgET cellFilarial parasite-specific T cell lines: induction of IgE synthesis.
Nutman et al. (1985)IgET cellsThese parasite-specific T cells can provide isotype-specific help for antigen-induced IgE production by B cells in vitro.
Nutman et al. (1985)IgET cellsAutologous T cells profoundly suppress IgE production in a concentration-dependent manner.
Ohta et al. (1983)IgET-cellEnhancement of IgE and IgG synthesis in the presence of pokeweed mitogen by T-cell irradiation.
Ohta et al. (1983)IgET-cellEnhancement was also dependent on the presence of PWM; T-cell irradiation did not enhance IgE synthesis in unstimulated cultures.
Ohta et al. (1983)IgET cellsThese observations suggest that radiosensitive T cells exert a suppressive activity that contributes to regulation of human IgE and IgG synthesis and that the suppressor function as well as the helper function can overcome allogeneic disparities.
Saryan et al. (1983)IgET cellsInduction of human IgE synthesis by a factor derived from T cells of patients with hyper-IgE states.
Saryan et al. (1983)IgET cellsIn contrast, supernatants of normal T cells failed to induce IgE synthesis.
Wheeler et al. (1995)IgET cellOur data therefore suggest that there are at least two mechanisms for CsA-induced potentiation of IgE synthesis, one T cell-dependent and the other T cell-independent.
Vercelli (1995)IgET cellsThe second signal is typically delivered upon engagement of CD40 on B cells by the CD40 ligand expressed on T cells, and results in switching and production of IgE.
Meki? and Smili? (2008)IgET cellImmunity effects of the therapy are basically, suppression of the allergen-specific IgE antibodies synthesis, stimulation of allergen-specific IgG antibodies synthesis, as well as suppression of antigen specific T cell response.
Kemeny (2000)IgET cellsThe investigations that made clear the importance of CD8 T cells for the regulation of IgE production were triggered by studies of castor bean allergy.
Thestrup-Pedersen et al. (1997)IgET-cellsBecause of the increased proliferation capacity of the aberrant T-cells, a cytokine imbalance occurs and in some patients this leads to the development of type I allergies due to a skewing of the humoral immune system towards IgE production.
Kimura et al. (1997)IgET lymphocytesBecause the level of mite-specific IgE antibody in the younger BA children is elevated (93.6 +/- 41.2 PRU/ml), the result also indicates that mite-specific peripheral T lymphocytes do not play a critical role in stimulating the mite-specific IgE synthesis.
Marshall (1992)IgET-cellThe production of IgE is a normal T-cell dependent antibody response.
Geha et al. (1981)IgET cellsIgE synthesis was suppressed by the addition of parental T cells to the culture.
Geha et al. (1981)IgET cellsElimination of the T8+ subset, but not of the T4+ subset, by complement-dependent lysis resulted in the loss of the capacity of parental T cells to suppress IgE synthesis.
Maggi et al. (1987)IgET cellSupernatants (SN) from 10 phytohemagglutinin (PHA)-stimulated human T cell clones (TCC), selected for their helper function on IgE synthesis, were found to provide IgE helper activity in atopic B cells showing low or undetectable spontaneous in vitro IgE synthesis.
Romagnani et al. (1987)IgET lymphocytesSeventy-eight clones established from tonsillar T lymphocytes of two nonallergic children were tested under different experimental conditions for their ability to induce in vitro IgE synthesis by B cells from allergic or nonallergic donors.
Romagnani et al. (1987)IgET cellUnder the same experimental conditions, virtually all of the T cell clones able to induce IgE synthesis in vitro by target B cells showed the ability to stimulate IgG and IgM production as well.
Romagnani et al. (1987)IgET cellThe successful induction of IgE synthesis by single T cell clones was apparently related to the lack of concomitant suppressor activity to which IgE-producing cells appeared to be exquisitely sensitive.
Pazdrak et al. (1992)IgET cellIgE production by B cell is T cell dependent.
Romagnani et al. (1989)IgET cellAnother T cell-derived lymphokine, IFN gamma, negatively regulates the IgE synthesis induced by IL-4.
Gauchat et al. (1990)IgET cellsHowever, IL-4 or cloned CD4+ T cells were able to induce germline epsilon transcripts without inducing IgE synthesis, for which both signals were required.
Lee et al. (1988)IgET cellsT cells play an important role in the regulation of IgE synthesis.
Romagnani et al. (1989)IgET cellAnother T cell-derived lymphokine, IFN-gamma negatively regulated the IgE synthesis induced by IL-4.
Heyd et al. (1988)IgET cellsThe cell populations required for IgE response (T cells, B cells, and antigen-presenting cells) may be reconstituted in advance of the regulatory elements that limit IgE production in healthy subjects.
Geha and Comunale (1983)IgET lymphocytesThe present results indicate that the synthesis of antigen-specific IgE in man is subject to regulation by idiotypic anti-idiotypic interactions that can involve both B and T lymphocytes.
Holen and Elsayed (1996)IgET cellOvomucoid and ovalbumin induced IgE synthesis by a small fraction of B cells (1%) present in the ovalbumin and ovomucoid specific T cell lines.
Hällgren et al. (1983)IgET-cellThe low IgE concentrations in uremia are suggested to reflect altered T-cell regulation of the IgE production.
Hemady et al. (1985)IgET cellsAbnormal regulation of in vitro IgE synthesis by T cells obtained from patients with atopic dermatitis.