Viewing affirmative mentions of gene expression of IFNG (H. sapiens) in T cells

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Palacios et al. (1983)IFN-gammaT lymphocyteThe cell producing IFN-gamma, both spontaneously and after UCHT1 antibody stimulation, is an OKT3+,4+,8-,HLA-DR-T lymphocyte as determined at the single cell level.
Alrawi et al. (2001)Gamma interferonT cellsBACKGROUND: Gamma interferon (IFN-gamma) is produced by activated natural killer and T cells under pathologic circumstances.
Akiba et al. (2001)IFN-gammaT cellSpecific cell-mediated immune responses, determined by T cell stimulation and IFN-gamma production, were evoked following stimulation with trichophytic antigens.
Kemp et al. (1997)IFN-gammaT cellsIt was found that IFN-gamma was produced in response to both PPD and Leishmania stimulant by T cells in the cultures.
Kemp et al. (1997)IFN-gammaT cellActivation of IFN-gamma producing natural killer (NK) cells was demonstrated only in some cultures, and only with concomitant T cell activation.
Baier et al. (1991)interferon gammaT lymphocytesIn order to evaluate further possible mechanisms of Ciamexone it was the aim of our investigation to study its influence on interferon gamma (IFN gamma) production in phytohaemogglutinin (PHA)-stimulated T lymphocytes of 15 tumour patients and 12 healthy reference subjects.
Novelli et al. (1997)interferon-gammaT cellsAntiblastic chemotherapy drugs up-modulate interferon-gamma receptor expression on human malignant T cells.
Novelli et al. (1997)IFN-gammaT cellsWe have previously shown that the contrasting ability of interferon-gamma (IFN-gamma) either to stimulate the proliferation of malignant T cells or to induce their apoptosis is determined by the low and high intensity of IFN-gamma receptor (IFN-gamma R) expression, respectively.
Novelli et al. (1997)IFN-gammaT cellHigh IFN-gamma R expression is a marker for the T cell stress that precedes apoptosis.
Novelli et al. (1997)IFN-gammaT-cellIn this paper, we show that a 12- to 24-h culture of three human malignant T-cell lines displaying distinct differentiation stages (ST4, PF382, and Jurkat) in medium supplemented with four chemotherapy drugs (etoposide, cisplatin, cytarabine, and daunomycin) up-modulates their IFN-gamma R expression followed by their apoptosis after 24-48 h later.
Livingston et al. (1994)interferon gammaT-cellCONCLUSIONS: Interferon gamma administration after injury stimulated monocyte HLA-DR antigen expression and density but failed to improve interferon gamma production, a T-cell-mediated function.
Enbergs (2006)interferon-gammaT-lymphocytesEffects of the homeopathic preparation Engystol on interferon-gamma production by human T-lymphocytes.
Enbergs (2006)interferon-gammaT-lymphocytesThe effects of the homeopathic preparation Engystol on interferon-gamma producing T-lymphocytes were studied in vitro.
Dolhain et al. (1993)interferon-gammaT cellsThe production of interferon-gamma (IFN-gamma) by anti-CD3-activated cloned human T cells was used as a model system.
Fuchs et al. (1989)interferon-gammaT-lymphocytesDiminished in vitro production of interferon-gamma by T-lymphocytes on stimulation with specific soluble antigens contrasts with increased levels of circulating interferon-gamma in patients.
Holmgren and Svennerholm (1992)IFN-gammaT cellsStudies of protective immune mechanisms have emphasized the importance of secretory IgA antibodies and mucosal memory for protection against noninvasive, enterotoxigenic infections such as cholera and ETEC diarrhea and also drawn attention to the possible protective role of IFN-gamma production by intestinal T cells in these secretory diarrheas.
Piper et al. (2007)interferon gammaT cellsThese HY-specific CD8+ T cells produced interferon gamma (IFNG) following peptide stimulation, demonstrating their functional capacity.
Melvin et al. (1995)IFN-gammaT cellsThe IFN-gamma gene was virtually completely methylated at all sites in thymocytes, neonatal T cells, and adult CD45RAhiCD45R0lo (antigenically naive) CD4 T cells, cell types that all have a low or undetectable capacity to express the IFN-gamma gene.
Melvin et al. (1995)IFN-gammaT cellsIn contrast, there was substantial hypomethylation in T-lineage cell types with relatively high capacities to express the IFN-gamma gene, including adult CD8 T cells and adult CD45RAloCD45R0hi (memory/effector) CD4 T cells.
Novelli et al. (1994)IFN-gammaT cellsEnvironmental signals influencing expression of the IFN-gamma receptor on human T cells control whether IFN-gamma promotes proliferation or apoptosis.
Novelli et al. (1994)IFN-gammaT cellsIFN-gamma R expression is subject to contrasting modulation on human T cells.
Novelli et al. (1994)IFN-gammaT cellsIFN-gamma R constitutive expression is low on three human malignant T cells (ST4, PF382, and Jurkat) growing in medium supplemented with serum.
Novelli et al. (1994)IFN-gammaT cellsBy contrast, when malignant T cells are cultured in medium without serum, IFN-gamma R expression dramatically increases and the cells undergo a slow apoptotic death.
Novelli et al. (1994)IFN-gammaT cellThis opposite ability of IFN-gamma to stimulate malignant T cell proliferation or death correlates with the intensity of IFN-gamma R cell expression, high expression being a marker for cell apoptosis.
Mizuno et al. (1986)Gamma-interferonT lymphocyteGamma-interferon production capacity and T lymphocyte subpopulation after allogeneic bone marrow transplantation.
Mizuno et al. (1986)IFN-gammaT cellThis failure of IFN-gamma production showed no correlation with stimulation index of mitogen blastogenesis or changes of T cell population.
Reichel et al. (1987)IFN-gammaT-lymphocyteFinally, we examined the effects of 1,25-(OH)2D3 on the constitutive IFN-gamma production by two human T-lymphocyte lines transformed by human T-lymphotropic virus type I.
Mohr et al. (2001)IFN-gammaT cellsCONCLUSIONS: These findings suggest that the production of the proinflammatory cytokine IFN-gamma by autoaggressive T cells in relapsing-remitting MS is related to depression and that treatment of depression may decrease IFN-gamma production.
Orlova et al. (1990)gamma interferonT-lymphocytes[The role of heterologous helper cells in the production of gamma interferon by T-lymphocytes of human blood and lymph].
Airenne et al. (2000)IFN-gammaT cellsGrowth of chlamydiae in different epithelial cell lines is restricted by interferon-gamma (IFN-gamma), a monocyte activator produced by T cells.
Sareneva et al. (1996)IFN-gammaT cellsInterferon-gamma (IFN-gamma) is a secretory glycoprotein produced by T cells in response to antigenic or mitogenic stimuli.
Murray (1988)interferon-gammaT cellsThis research and the identification of patients whose T cells fail to produce interferon-gamma properly has set the stage for evaluating the role of macrophage-activating immunotherapy using interferon-gamma in various human infectious diseases.
Mocchegiani and Malavolta (2004)IFN-gammaT-cellHowever, NKT cells bearing T-cell receptor (TCR) gammadelta also display an increased cytotoxicity and IFN-gamma production in very old age.
Gaspari et al. (1997)IFN-gammaT lymphocytesOBSERVATIONS: The T lymphocytes of the patient showed a significant (P < .05, unpaired Student t test) defect in IFN-gamma production (the basis for initiating IFN-gamma therapy).
Bahia-Oliveira et al. (1992)IFN-gammaT cellMost of the normal individuals from an endemic area failed to show significant proliferative responses to SWAP T cell Western blot assays or to antigen immobilized on nitrocellulose; they did show significant proliferative responses to whole soluble SWAP with positive IFN-gamma production.
Fuchs et al. (1989)IFN-gammaT lymphocytesHowever, direct and indirect measurement of endogenous interferon-gamma (IFN-gamma) brings some evidence that decreased in vitro production of IFN-gamma by T lymphocytes is associated with increased concentrations in vivo.
Rönnelid and Klareskog (1997)IFN-gammaT cellWhen using PBMC directly stimulated in the assay wells with T cell mitogens it was possible to measure production of human IFN-gamma at an earlier time point and with a higher sensitivity compared to conventional nitrocellulose plates.
Nakayama (1983)IFN-gammaT lymphocytesIFN-alpha was produced by B lymphocytes, and IFN-gamma was produced by T lymphocytes.
Nakayama (1983)IFN-gammaT-lymphocyteAn increase in the production of IFN-gamma resulted from the mixture of autologous macrophages in T-lymphocyte cultures.
Nakayama (1983)IFN-gammaT lymphocytesThe production of IFN-gamma by T lymphocytes was found to depend on prior, possibly cellular, immunity.
Yi et al. (2008)interferon-gammaT cellsAmelioration of human allograft arterial injury by atorvastatin or simvastatin correlates with reduction of interferon-gamma production by infiltrating T cells.
Yi et al. (2008)IFN-gammaT-cellCONCLUSIONS: Our results suggest that a benefit of statin administration in transplantation may include amelioration of GA primarily by inhibiting alloreactive T-cell accumulation and consequent IFN-gamma production and secondarily through suppression of the arterial response to IFN-gamma.
Kimura et al. (1999)IFN-gammaT lymphocytesIntracellular IFN-gamma production in both CD8 positive and negative T lymphocytes was assessed by flow cytometry.
Kimura et al. (1999)IFN-gammaT lymphocytesProduction of IFN-gamma in CD8+ T lymphocytes of patients with fulminant hepatitis was also elevated, furthermore significantly correlating with the prothrombin time (r=-0.64, p<0.01).
Yoshida (2001)IFN-gammaT-cellThe aim of the present study was therefore to evaluate the gamma/delta T-cell populations present in the peripheral blood and the IFN-gamma production of gamma/delta T-cells stimulated by PMA before and after anti-TB chemotherapy in patients in the initial treatment stage for primary active pulmonary TB.
Yoshida (2001)IFN-gammaT-cellsWe compared the population of gamma/delta T-cells and the production of IFN-gamma between normal healthy controls and TB patients.
Yoshida (2001)IFN-gammaT-cellsHowever, production of IFN-gamma in gamma/delta T-cells was dramatically suppressed prior to anti-TB chemotherapy in comparison with healthy control subjects, and further reduced following anti-TB chemotherapy.
Yoshida (2001)IFN-gammaT-cellsThe findings demonstrated a strong correlation between the production of IFN-gamma in gamma/delta T-cells and manifestation of primary active pulmonary TB, which was consistent with the hypothesized role for gamma/delta T-cells in the protective immune response to Mtb infection.
Hardy et al. (1987)IFN-gammaT cellBy using several T cell lines that differ in their inducible expression of IFN-gamma, we have now localized several additional structural domains within the human IFN-gamma gene that appear to be coordinately involved in regulating expression.
Weidanz et al. (2005)IFN-gammaT cellsPeripheral blood lymphocytes, isolated from both cohorts, were analyzed by enzyme-linked immunosorbent spot assays (ELISPOT) analyses and real-time reverse transcription-polymerase chain reaction (RT-PCR) to enumerate IFN-gamma producing T cells and IFN-gamma mRNA levels.
Weidanz et al. (2005)IFN-gammaT cellsLosartan also decreased IFN-gamma production (P < 0.001) in purified alloreactive T cells in vitro as did candesartan.
Di Fabio et al. (1994)IFN-gammaT cellsQuantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells.
Di Fabio et al. (1994)IFN-gammaT cellPeripheral blood mononuclear cells (PBMCs) from human volunteers were cultured with influenza virus-infected autologous cells; following 3 or 7 days of culture, T cell subsets were assessed for IFN-gamma production by IFN-gamma-specific ELISPOT and ELISA, while IFN-gamma mRNA expression was determined by reverse transcriptase-polymerase chain reaction (RT-PCR).
Di Fabio et al. (1994)IFN-gammaT cellStudies with purified T cell subsets showed that elevated IFN-gamma SFCs, IFN-gamma synthesis, and cytotoxic activity were associated with CD4-CD8+ T cells but not with the CD4+CD8- T cell subset.
Mizukoshi et al. (2008)IFN-gammaT cellRESULTS: HCV-specific T cell proliferation and IFN-gamma production were more common in nonviremic EIA-positive IDUs (16 [94%] of 17 IDUs) than in viremic EIA-positive IDUs (9 [45%] of 20 IDUs) (P= .003).
Loza et al. (2005)IFN-gammaT cellsThe linear model of maturation of IFN-gamma-producing cells from a proliferative pool of type 2 cytokine-producing T cells represents a fundamental shift in interpreting how changes in cytokine production by T cell populations are regulated.
Mohr and Genain (2004)IFN-gammaT-cellDepression and T-cell production of interferon-gamma (IFN-gamma), a lynchpin in MS pathogenesis, were assessed at baseline and posttreatment.
Mohr and Genain (2004)IFN-gammaT-cellRESULTS: Both depression and T-cell production of IFN-gamma were significantly reduced over the 16 weeks of treatment.
Akdis et al. (2004)IFN-gammaT cellsIn individuals with atopic allergic disease, activated allergen-specific T cells expressing high levels of IFN-gamma predominantly undergo apoptosis in the circulation, skewing the immune response to surviving T helper type 2 (Th2) cells.
Rasskazchikova et al. (1998)IFN-gammaT-lymphocytesIFN-gamma production by T-lymphocytes was not changed and essentially more high then in the comparative group.
Andersson et al. (1985)IFN-gammaT cellsSince human gamma interferon (Hu IFN-gamma) is synthesized by T cells and has a controlling role in regulation of Epstein-Barr virus (EBV) infection, we have studied the effects of CsA on EBV-induced cellular Hu IFN-gamma release.
Shimokata (1996)IFN-gammaT-cellAnalysis using monoclonal antibody and complement revealed that at least the OKT4+/OKT8- T-cell subset is responsible for the antigen-specific IFN-gamma production in pleural fluid T lymphocytes.
Trinchieri et al. (1984)gamma interferonT cellsA parallel production of gamma interferon (IFN-gamma) is induced by recombinant IL-2 (rIL-2), and NK cells appear to be the major producer cells, whereas T cells are unable to produce IFN-gamma under these experimental conditions.
Aguirre-Blanco et al. (2007)gamma interferonT-cellStrain-dependent variation in Mycobacterium bovis BCG-induced human T-cell activation and gamma interferon production in vitro.
Aguirre-Blanco et al. (2007)gamma interferonT-cellThree commonly used Mycobacterium bovis BCG vaccine strains elicited different magnitudes of T-cell activation and gamma interferon production in vitro in healthy BCG-vaccinated individuals.
Denys et al. (1997)IFN-gammaT-cellBACKGROUND AND OBJECTIVES: We previously found that interferon-gamma (IFN-gamma) antibodies in intravenous immunoglobulins (IVIG) can block not only IFN-gamma production and tumor necrosis factor-alpha secretion, but also T-cell proliferation.
Palermo et al. (2005)IFN-gammaT cellsMoreover, only vitiligo T cells were capable of efficient receptor down-regulation and IFN-gamma production in response to HLA-matched melanoma cells, suggesting that this difference in receptor affinity is physiologically relevant.
Toungouz et al. (1996)IFN-gammaT cellThe aim of the present work is to investigate the influence of IVIg on IFN-gamma production occurring during MLR and its subsequent impact on T cell proliferation and tumor necrosis factor (TNF)-alpha secretion.
Zevering et al. (1994)gamma-interferonT cellsT cells responsive to this peptide were CD450+ and produced gamma-interferon.
D'Ombrain et al. (2008)IFN-gammaT cellsThe expression of CD56 in malaria-responsive, IFN-gamma-expressing gammadelta T cells correlated with IFN-gamma responsiveness.
Koeffler et al. (1984)IFN-gammaT lymphocytesGamma-Interferon (IFN-gamma) is a lymphokine produced by T lymphocytes.
Buseyne et al. (2005)interferon- gammaT cellsThe frequency of HIV-specific interferon- gamma -producing CD8 T cells is associated with both age and level of antigenic stimulation in HIV-1-infected children.
Maruyama et al. (1995)gamma-interferonT cellsIt has also been demonstrated that gamma-interferon (IFN-gamma) which is released from infiltrated T cells can be detected in inflamed lesional sites.
Numata et al. (1991)IFN-gammaT-lymphocytesThese results suggest that CD4+ T-lymphocytes that produce IFN-gamma might play an important role in the antitumor response against cancer progression in human colorectal adenocarcinomas.
Bhayani and Falcoff (1985)IFN-gammaT-cellHowever, it was possible to induce IL-2 without concomitant production of IFN-gamma using some antibodies specific for other T-cell surface antigens, e.g., Tp 32-45, Tp 41, and Tp 100-120.
Cabral et al. (2006)Interferon gammaT lymphocytesInterferon gamma production by PAS-positive T lymphocytes of chagasic patients infiltrated into human hearts in the sites of lesions.
Mikovits et al. (1998)IFN-gamma geneT cellsThe ability of increased DNA methyltransferase activity to downregulate the expression of genes like the IFN-gamma gene may be one of the mechanisms for dysfunction of T cells in HIV-1-infected individuals.
Huang and Schwarz (2002)IFNg and receptorT cellsActivated T cells have been shown to produce cytokines such as IFNg and receptor activator of nuclear-factor- kappaB ligand, with direct effects on osteoclastogenesis.
Carvalho et al. (2001)IFN-gammaT cellsAlthough depletion of CD8+ T cells and natural killer cells did not affect IFN-gamma production, depletion of CD4+ T cells significantly decreased IFN-gamma production.
Rola-Pleszczynski et al. (1987)IFN-gammaT cellsLTB4 was also shown to enhance IFN-gamma production by T4+ T cells and to inhibit IFN-gamma production by T8+ T cells.
Chiang and Hill (1997)IFN-gammaT cellsThe increased number of T cells, expression of IFN-gamma, and enhanced antigen presentation in ectopic compared to eutopic endometrium support the concept that cellular immune activation is involved in endometriosis and its sequelae.
Lewis et al. (1986)IFN-gammaT cellsThese results suggest that reduced IFN-gamma mRNA levels in neonatal T cells is due to an intrinsic deficiency at the pretranslational level and indicate that the magnitude of IL-2 and IFN-gamma gene expression can be independently modulated pretranslationally.
van Baarle et al. (2001)IFN-gammaT cellsIn AIDS-NHL patients, EBV-specific T cells were not physically lost in the course of HIV-1 infection but showed progressive loss of their capability to produce IFN-gamma in response to EBV peptides.
van Baarle et al. (2001)IFN-gammaT-cellIn HIV-1-infected LTA individuals, in whom CD4(+) T-cell numbers were maintained, and progressors to AIDS-OI, IFN-gamma-producing EBV-specific T cells were stable and EBV load remained stable or decreased in the course of HIV infection, suggestive of immune control.
Wilson et al. (1986)IFN gammaT cellsAddition of IFN alpha, 10,000-50,000 U/ml of interleukin 2 or phorbol myristate acetate (PMA) to cord mononuclear cells or of adult monocytes or PMA to cord T cells increased IFN gamma production compared to cells stimulated with concanavalin A (ConA) alone.
Wilson et al. (1986)IFN gammaT cellsNevertheless, under optimal conditions (T cells + PMA + Con A), adult cells produced much more IFN gamma (1,360 +/- 261 U/ml by RIA) than cord cells (122 +/- 37 U/ml).
Shinada et al. (1986)interferon-gammaT-lymphocytesCollaboration between enriched T-lymphocytes and macrophages, both treated with glycyrrhizin, was needed for the enhancement of interferon-gamma production.
Brown et al. (1991)IFN-gammaT cellT cells infected with the HTLV (human T cell leukemia virus)-I and -II retroviruses often express the lymphokine interferon-gamma (IFN-gamma).