Viewing affirmative mentions of gene expression of HLA-E (H. sapiens) in T cells

Full-text article links are indicated by after the article reference.

Document Target Regulator Anatomy Sentence
Gattoni-Celli et al. (1993)MHCT cellsFurthermore, the regulatory role of MHC Class I antigens in the proliferation of T cells suggests that abnormalities in MHC Class I antigen expression may play a role in the disordered proliferation of malignant cells and in their metastatic potential by non-immunological mechanisms.
Pichler and Wyss-Coray (1994)MHCT cellsHuman T cells express major histocompatibility complex (MHC) class II antigens and adhesion molecules characteristic of antigen-presenting cells (APCs), and recent in vitro and in vivo evidence supports an antigen-presenting function for T cells.
Londei et al. (1984)MHCT cellsThese cells invariably express MHC class II molecules (HLA-D region in man and Ia in mouse) which are recognized by T cells of the helper/inducer subset in association with antigen fragments.
Fernandez et al. (1999)MHCT-cellIn several species, including humans, the MHC is also able to elicit T-cell-mediated immune responses to allogeneic MHC antigens (non-self MHC antigens expressed by another individual from the same species).
Lanier and Phillips (1996)MHCT cellsNatural killer (NK) and T cells express receptors for polymorphic major histocompatibility complex (MHC) class I molecules, and activation of these receptors results in inhibition of their effector cell function.
Heinemann et al. (1987)MHCT lymphocytesHowever in the two carcinomas expressing MHC Ag there was also a grade 2-3 infiltration with T lymphocytes.
Mandelboim et al. (1996)MHCT cellsClass II major histocompatibility complex (MHC)-restricted T cells that expressed a costimulatory natural killer (NK) cell receptor for class I MHC proteins were cloned.
Mishto et al. (2010)MHCT cellsProteasome degradation is the key step in the production of MHC class I-restricted epitopes and therefore its activity could be an important element in the activation and regulation of autoreactive CD8+ T cells in Multiple Sclerosis.
Wacnik et al. (2008)MHCT cellsWe report in this study that cannabinoids reduced the DC surface expression of MHC class II molecules as well as their capacity to stimulate T cells.
Peng et al. (2008)MHCT-cellThrough an antigen-screening approach using colorectal tumor-reactive T cells, we identified an HLA-DR11-restricted T-cell epitope encoded by KIAA0040 as well as MHC-unrestricted human galectin-3 (Gal-3) expressed by tumor cells.
van Houdt et al. (2008)MHCT-lymphocytesFavorable outcome in clinically stage II melanoma patients is associated with the presence of activated tumor infiltrating T-lymphocytes and preserved MHC class I antigen expression.
Wang et al. (2008)MHCT lymphocyteMeantime, the cellular immune function was also observed, including the T lymphocyte response determined by 3H-TdR, expression of MHC class I/II and B7 molecule detected by FACS, and interleukin 10 and 12 (IL-10, IL-12), interferon-gamma (IFN-gamma) tested by ELISA.
Carey et al. (2007)MHCT-cellsTo show that the HLA-A2 CTF is subsequently cleaved by PS1/gamma-secretase, we re-duced its activity in cell lines stably expressing HLA-A2 and in Jurkat T-cells expressing endogenous MHC I.
Stephens et al. (2007)MHCT cellsA comparison of the development and phenotype of FoxP3(+) T cells in relation to the expression of conventional MHC molecules facilitated the identification of several distinct lineages of naive and effector/memory populations of Foxp3(+) T cells.
Wrobel et al. (2007)MHCT-cellWe have characterized epithelial tumour cells of different origin with respect to cell surface expression of the known NKG2D ligands MHC class I-chain-related antigens (MIC) A/B and UL16-binding proteins (ULBP), and susceptibility to gammadelta T-cell killing.
Waithman et al. (2007)MHCT cellSteady state presentation resulted in deletional T cell tolerance despite these DCs expressing a relatively mature phenotype as measured by traditional markers such as the level of MHC class II and CD86 expression.
Andresen et al. (2007)MHCT cellsMolecular regulation of MHC class I chain-related protein A expression after HDAC-inhibitor treatment of Jurkat T cells.
Andresen et al. (2007)MHCT cellsIn this study, we characterize the molecular signal pathways that lead to MHC class I chain-related protein A (MICA) expression after histone deacetylase (HDAC)-inhibitor (HDAC-i) treatment of Jurkat T cells.
Dolan et al. (2006)MHCT lymphocytesTumor cells that constitutively express MHC class I molecules and are genetically modified to express MHC class II (MHC II) and costimulatory molecules are immunogenic and have therapeutic efficacy against established primary and metastatic cancers in syngeneic mice and activate tumor-specific human CD4+ T lymphocytes.
Godefroy et al. (2006)MHCT cellIdentification of two Melan-A CD4+ T cell epitopes presented by frequently expressed MHC class II alleles.
Appel et al. (2005)MHCT-cellUsing this compound, we show that human monocyte-derived dendritic cells generated in the presence of therapeutic concentrations of imatinib show a reduced expression of CD1a, MHC class I and II, and costimulatory molecules as well as decreased secretion of chemokines and cytokines resulting in an impaired capacity of dendritic cells to elicit primary T-cell responses.
Lafarge et al. (2005)MHCT cellsExpression of MHC class I receptors confers functional intraclonal heterogeneity to a reactive expansion of gammadelta T cells.
Lafarge et al. (2005)MHCT cellNK cell receptors for MHC class I molecules (MHC-NKR) can be expressed by T cell subsets.
Carr et al. (2005)MHCT cellThe killer cell Ig-like receptor (KIR) gene family encodes MHC class I receptors expressed by NK cells and several T cell subpopulations.
Jiang (2005)MHCT cellThe paradigm is based on the discovery of a subset CD8+ T cells with TCRs which specifically recognize a unique set of self-peptides presented by the MHC class Ib molecule Qa-1 differentially expressed on T cells as a function of the affinity/avidity of T cell activation.
Choi et al. (2005)MHCT cellsDespite numerous reports on MHC class II expression by T cells from a wide spectrum of mammalian species including humans, the biological relevance of this phenomenon has never been tested with appropriately designed animal models.
Schooten et al. (2005)MHCT cellsIn contrast to activated human T cells, activated mouse T cells fail to express MHC class II molecules (MHC-II) at their cell surface.
Sia and Weinem (2005)MHCT cellsTherefore, allelic variations in the coding sequences of TAP and LMP were suspected for a long time to be responsible for improper antigen processing, interruption of self-peptide presentation and reduced cell surface expression of MHC class I molecules resulting in the activation of autoreactive CD8(+) T cells.
Rajalingam et al. (2004)MHCT cellsThe killer cell Ig-like receptor (KIR) gene family encodes MHC class I-specific receptors, which regulate NK cell responses and are also expressed on subpopulations of T cells.
Wan et al. (2004)MHCT cellsCONCLUSION: Although HCC may escape from immune attack by weak immunogenicity or downregulated expression of MHC-1 molecules on the tumor cell surface, tumor infiltrating T cells can be activated via other costimulatory signal pathways to exert a limited antitumor effect on local microenvironment.
Parkhurst et al. (2004)MHCT cellFrom four of nine patients who expressed both HLA-DRbeta1*0401 and HLA-DRbeta1*0701, we raised five gp100-reactive CD4+ T cell populations that secreted TH1 type cytokines in response to exogenously loaded protein as well as target cells that endogenously expressed gp100 and MHC class II molecules, including transfectants and melanoma cells.
Bielekova et al. (2004)MHCT cellsTherefore, we focused on the characterization of high-avidity myelin-specific CD4+ T cells in a large cohort of MS patients and controls that was matched demographically and with respect to expression of MHC class II alleles.
Hayball et al. (2004)MHCT cellsCD4(+) T cells are activated upon recognition of peptide antigen in the context of MHC class II molecules, expressed by specialized APC.
Degauque et al. (2004)MHCT cellsIn several instances, CDR3-LD altered T cells exhibited MHC-restricted and tumor-specific IFNgamma or GM-CSF production.
Pajot et al. (2004)MHCT cellComparison of HLA-DR1-restricted T cell response induced in HLA-DR1 transgenic mice deficient for murine MHC class II and HLA-DR1 transgenic mice expressing endogenous murine MHC class II molecules.
Standeven et al. (2004)MHCT lymphocytesKiller cell Ig-like receptors (KIRs) are MHC class I-specific receptors expressed in NK and T lymphocytes.
Molinero et al. (2004)MHCT lymphocytesNF-kappa B regulates expression of the MHC class I-related chain A gene in activated T lymphocytes.
Otten et al. (2003)MHCT lymphocytesDeregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4+ T lymphocytes.
MarĂ­n et al. (2003)MHCT-cellDownregulation of MHC class Ia molecule expression is a widespread mechanism used by tumor cells to escape antitumor T-cell-mediated immune responses.
Reddy and Ferrara (2003)MHCT cellsAs a consequence expression of MHC antigens and adhesion molecules is increased, thus enhancing the recognition of host alloantigens by donor T cells.
Jones et al. (2003)MHCT cellsThis model suggests that any cell type that expresses MHC-peptide complexes, be they of self or foreign origin, should have the capacity to tolerize antigen-specific T cells when critical costimulatory interactions are interrupted.
Nguyen and Geiger (2003)MHCT cellsReceptor-modified T cells expressing chimeric MHC receptors have potential application in autoimmune and alloimmune diseases.
Ferrarini et al. (2002)MHCT-cellDown-regulation of expression of MHC alleles, as well as tumor-specific antigens, is observed frequently during tumor progression, resulting in an impairment of MHC-restricted, alphabeta-T-cell-mediated, tumor-specific immunity.
Pettersson and Forsberg (2002)MHCT cellsHowever, SEH bound to a high extent to murine MHC class II expressing cells and when presented by these cells SEH stimulated human T cells to proliferate.
Schell et al. (2002)MHCT lymphocytesFunctional MHC class I molecules are expressed on the cell surface in the absence of beta(2)-microglobulin (beta(2)m) light chain that can interact with CD8(+) T lymphocytes.
Adachi et al. (2002)MHCT cellsWhen the CD11c+ CD3- B220- cells in the PBMCs are cultured with GM-CSF, they show not only the potent ability to stimulate the proliferation of allogeneic T cells but also a higher expression of MHC class II, B7-1 and B7-2.
Haynes et al. (2002)MHCT cellOverall, this study has illustrated the ability of a chimeric scFv receptor capable of harnessing the signaling machinery of both TCR-zeta and CD28 to augment T cell immunity against tumors that have lost expression of both MHC/peptide and costimulatory ligands in vivo.
Choi et al. (2001)MHCT-cellsThe findings that human T-cells, unlike mouse T-cells, express MHC class II molecules on their surfaces and can play as antigen presenting cells suggesting possible peripheral T-T interaction network has not been intensively studied so far.
Dettmeyer et al. (2001)MHCT-lymphocytesImmunohistological investigations demonstrated an enhanced expression of MHC class II antigens, an increased number of leucocytes as well as T-lymphocytes.
Anderson et al. (2001)MHCT cellsThe mouse lectin-related Ly49 family and the human killer cell Ig-like receptor (KIR) family represent structurally distinct, yet functionally analogous, class I MHC receptors that are expressed on natural killer cells and some T cells.
Holler et al. (2001)MHCT cellsT cells are activated by binding of the T cell receptor (TCR) to a peptide-major histocompatibility complex (MHC) complex (pMHC) expressed on the surface of antigen presenting cells.
Soos et al. (2001)MHCT-cellCIITA may be a key target to modulate MHC class II expression, which could augment immunogenicity, Ag presentation, and CD4(+) T-cell activation in MG therapy.
Beineke et al. (2001)MHCT cellsMHC class II antigen, recognized by killer whale- and bovine-specific mAbs, was expressed on B and T cells.
Harding (2001)MHCT cellThe protocols utilize T hybridomas to detect expression of peptide-MHC complexes, since these cells provide the most convenient, consistent, and flexible T cell readout systems for these purposes.
Saifuddin et al. (2000)MHCT cellsBoth macrophages and activated CD4+ T cells can be productively infected by HIV-1, and both cell types express MHC class II molecules.
Mahboubi et al. (2000)MHCT lymphocytesAlthough IL-11 does not alter class I MHC complex molecule expression, pretreatment with 0.5 ng/ml IL-11 partially protects HUVECs against lysis by allospecific class I MHC-restricted cytolytic T lymphocytes or by anti-class I MHC Ab plus heterologous C.
Charreau et al. (2000)MHCT-cellDecreased MHC antigen expression dramatically reduced the ability of PAECs to further promote human T-cell proliferation.
Kaneko (2000)MHCT cellsThese three cytolytic autoreactive clones were shown to be capable of specifically lysing autologous activated T cells expressing class II MHC molecules, raising possibility that such autoreactive clones might play a role in negatively regulating T cell responses.
Burrows et al. (2000)MHCT cellThe production of synthetic MHC-peptide tetramers has revolutionized cellular immunology by revealing enormous CD8(+) T cell expansions specific for peptides from various pathogens.
Ody et al. (2000)MHCT-cellMHC class II and c-kit expression allows rapid enrichment of T-cell progenitors from total bone marrow cells.
Fontenot et al. (2000)MHCT cellThese CD4(+) T cell lines specifically responded to beryllium in culture in the presence of antigen-presenting cells that expressed class II MHC molecules HLA-DR, -DQ, and -DP.
Huard (2000)MHCT cellsExpression of inhibitory receptors for MHC class I molecules on T cells.
Pouly and Antel (1999)MHCT cellOLs, at least in vitro, express MHC class I molecules and are susceptible to CD8(+)T cell-mediated cytotoxicity.
Kieper and Jameson (1999)MHCT cellThis expansion required both T cell "space" and expression of normal levels of self class I MHC molecules.
Sedwick et al. (1999)MHCT cellWe have investigated the contribution of TCR, CD28, and LFA-1 signaling to T cell cytoskeletal polarization by assaying the response of an Ag-specific Th1 clone toward a panel of transfected APCs expressing MHC class II alone or in combination with ICAM-1 or B7-1.
Lang et al. (1999)MHCT cellsCONCLUSIONS: The absence of B7 protein or class II MHC antigen expression on human SCCHN cells is responsible for the failure of these tumors to induce proliferation of T cells in vitro.
McCoy et al. (1999)MHCT cellsThis enhanced response did not require the expression of MHC class II molecules on DC or the presence of CD4(+) T cells.
Pettit et al. (1999)MHCT cellUntransfected J82 cells expressed class I and II MHC antigens, a range of cell adhesion molecules, though did not induce T cell proliferation in a robust, allogeneic co-culture system.
Murphy et al. (1999)MHCT cellsHuman endothelial cells (EC) express MHC class II molecules in vivo and are likely to be involved in presentation of antigens to CD4(+) T cells.
Murata and Dalakas (1999)MHCT cellBecause the BB-1-positive fibers expressed MHC-class I antigen and bound to up-regulated counterreceptors CD28 and CTLA-4 on the autoinvasive CD8+ T cells only in PM, HIV-PM, and s-IBM, the BB-1 molecule in these diseases should have a functional role in antigen presentation and T cell differentiation.
Hwang et al. (1999)MHCT-cellIn addition, IL-2-stimulated T-cell proliferation and class I and class II MHC antigen expression on IFN-gamma-stimulated macrophages were strongly inhibited by FTY720.
Otten et al. (1998)MHCT lymphocyteThis relationship between the regulator gene, which behaves as a rate-limiting factor, and its target genes clarifies our understanding of the quantitative modulation of MHC class II expression, and thus of T lymphocyte activation.
Klein et al. (1998)MHCT-lymphocytesIn 38% (n = 16) of patients with elevated concentrations of cICAM-1 (> or = 337 ng/ml) and 41% (n = 7) of those with elevated serum levels of cVCAM-1 (> or = 1038 ng/ml), the myocardial biopsies showed increased lymphocytic infiltration between 7 and 22 T-lymphocytes/mm2 and an enhanced expression of the MHC antigens of class I/II as sign of an activated inflammatory process in the myocardium.
Yoong and Adams (1998)MHCT-cellThe absence of autologous tumour-specific cytolytic T-cell (CTL) activity may be due to the poor immunogenicity of colorectal tumour cells, which we found expressed only low levels of MHC I antigens and CD54 and failed to express MHC II antigens or the co-stimulatory molecules CD80, CD86 or CD106.
Sedgwick et al. (1998)MHCT cellsAn unusual clustering of activated microglia expressing strongly enhanced levels of CD11b/c and MHC class II was a feature of the GvHD-affected CNS, and despite the paucity of T lymphocytes present, activated microglial cell clusters were invariably intimately associated with these T cells.
Mannie et al. (1998)MHCT cellsT-APC presentation of antigen to responder T cells also resulted in reduced surface expression of class II MHC I-A glycoproteins on T-APC.
Manesse et al. (1998)MHCT lymphocytesTonsillar or mucosal epithelium is infiltrated by a large number of CD8+, WC1+ T lymphocytes and cells which express MHC class II molecules.
Hammond et al. (1998)MHCT lymphocytesWe demonstrated that pokeweed mitogen (PWM) stimulated PBMC generated large quantities of MHC class I and MHC class II expressing autologous lymphoblasts that were used initially to activate and expand antigen specific T lymphocytes and later to serve as a source of target cells in standard chromium release assays.
Horton et al. (1998)MHCT-cellIn vitro studies with control and thymectomized Xenopus splenocytes reveal that a non-T/non-B population and also two T-cell subsets all display natural cytotoxicity towards allogeneic thymus lymphoid tumour cells (which are deficient in MHC antigen expression).
Kalsow and Dwyer (1998)MHCT lymphocytesNumbers of MHC Class II antigen-expressing cells and T lymphocytes correlated with the extent of retinal histopathology.
Boismenu and Havran (1997)MHCT cellsIn general, recognition of these antigens by gamma delta T cells involves the antigen receptor but does not require antigen presenting cells to express MHC gene products or to have a functional antigen processing machinery.
Andersen (1997)MHCT-lymphocytesImmunohistochemically, strong expression of ICAM-1, vascular cellular adhesion molecule-1 and MHC class II antigens on tubular and endothelial cells along with interleukin-2-receptor bearing infiltrates of T-lymphocytes and significant presence of macrophages were highly correlated with acute rejection.
Housseau et al. (1997)MHCT-cellOnly the TM3 cell line, which expressed MHC-class II molecules upon IFN-gamma stimulation, was able to uptake, process, and present the human choriogonadotropin beta subunit to related T-cell hybridomas.
Maric et al. (1997)MHCT cellsBecause the TCR recognizes antigenic peptides presented by MHC molecules, the subset of T cells that exert effector function is determined by the class of MHC molecules expressed on a given tissue.
Woo et al. (1997)MHCT cellAntibodies recognizing MHC class I molecules expressed on the surface of T cells have been shown to inhibit T cell responses in vitro.
Thomas and Quinn (1996)MHCT cellsSynovial DC expressing high levels of MHC molecules and CD86 are strategically located to present arthritogenic Ag to T cells after transendothelial migration.
Li et al. (1996)MHCT cellsThe data presented by us suggest a model in which superantigens do not have to be involved in triggering the initial disease because autoreactive T cells elicited by antigen can, in the presence of superantigen, lyse cells that express MHC class II molecules, including activated T cells.
Young and Steinman (1996)MHCT cellDC express high levels of antigen presenting major histocompatibility complex (MHC) products (HLA-DP, DQ, DR; HLA-A, B, C) as well as several accessory molecules (e.g., B7-1, B7-2, LFA-3, ICAM-1, ICAM-3, CD40) that mediate T cell binding and costimulation.
Xie and Streilein (1996)MHCT cellsWe found that the functional and phenotypic features of these cells closely resembled those of LC cultured in single cell suspension: the cells strongly expressed B7-1 and B7-2, and displayed enhanced expression of class II MHC molecules; they readily activated naive autologous T cells.
Auchincloss and Sultan (1996)MHCT cellsFor many years the direct stimulation of T cells in response to donor MHC antigens expressed on donor antigen-presenting cells has been the focus of transplantation immunology.
Murray et al. (1995)MHCT cellsWe conclude that VSMCs express functional MHC class II molecules and stimulate pre-activated T cells.
Center et al. (1995)MHCT cellsIn addition to its chemoattractant activity, it is a growth factor for CD4+ T cells, inducing resting cells to enter G1, as evidenced by the expression of MHC II molecules and IL-2R.
Bettens et al. (1995)MHCT-cellsActivated T-cells expressing MHC class II surface antigens are able to present antigen and thus function as peptide-presenting cells (T-APCs).
Malinowski and Rapaport (1995)MHCT lymphocytesEffects of aging upon the expression of differentiation and class II MHC antigens on the surface of T lymphocytes from normal human subjects.
Koarada et al. (1995)MHCT cellWhen mixtures of transfectant APC lines TA beta z (that express A beta z/A alpha d MHC class II molecules) and hypothetical variant APC lines TA beta d (that express A beta d/A alpha d class II molecules) were cultured with and selected by autoreactive A beta z/A alpha d-restricted T cell clones, the percentage of TA beta d APC lines increased from less than 1% of the original APC mixtures to almost 100% after several cycles of selection.
Savage and Brooks (1995)MHCT lymphocytesHuman vascular endothelial cells expressing MHC class II molecules have previously been shown to stimulate the proliferation of allogeneic CD4+ human T lymphocytes.
Kanner et al. (1995)MHCT-lymphocytesLigation of major histocompatibility complex (MHC) class II antigens expressed on antigen-activated human CD4+ T-lymphocytes induces early signal transduction events including the activation of tyrosine kinases, the tyrosine phosphorylation of phospholipase-C gamma 1 and the mobilization of intracellular calcium.
Geng et al. (1995)MHCT cellsCell cycle analysis revealed that upon stimulation with Con A or anti-CD3, in spite of comparable surface expression of IL-2 receptors and class II MHC molecules, significantly fewer NT T cells entered the S and G2/M phases than CON T cells, indicating an arrest in the G0/G1 phase.
Melani et al. (1995)MHCT-cellsA retroviral vector, constructed by inserting IL-4 cDNA into the LXSN vector, was used to infect the human melanoma cell line Me14932, known to express the MHC class I HLA-A2 and the melanoma-associated antigen Melan-A/MART-1, recognized by HLA-A2-restricted T-cells.