Viewing affirmative mentions of gene expression of HLA-DRA (H. sapiens) in T cells

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Greenough et al. (1999)HLA-DRT cellsLTNPs had expansion of CD8 T cells with increased expression of HLA-DR.
Tabibzadeh (1991)HLA-DRT-cellsThe supernatant of the endometrial T-cells induced expression of HLA-DR molecules and morphological changes in cultures of HLA-DR-negative epithelial cells.
Tabibzadeh (1991)HLA-DRT-cellsThese findings are consistent with the hypothesis that endometrial T-cells are activated and suggest that the expression of HLA-DR molecules in glandular epithelium in vivo is mediated by the interferon-gamma secreted by the endometrial T-cells.
Deng et al. (1993)HLA-DRT cellsT cells and non-T cells from the peripheral blood of 10 patients with ITP and 10 Sex and age group matched healthy controls were investigated for HLA-DR expression by direct immunofluorescence.
Amoils et al. (1986)HLA-DRT-lymphocytesThe aberrant expression of HLA-DR on valvular fibroblasts could be important in triggering autoimmune destruction in that these cells could present self-antigens to sensitized T-lymphocytes which could initiate autoantibody production or direct destruction of local tissue.
Zehngebot et al. (1983)HLA-DRT cellsWe found that the proliferation of allogeneic T cells (measured by the 3H-TdR uptake) cultured with the DR-enriched and -depleted melanoma cell populations was directly related to the amount of the HLA-DR antigen expressed.
Kluin-Nelemans et al. (1984)HLA-DRT cellsHLA-DR expression was found on 6.7 +/- 0.7% of blood T lymphocytes from 34 patients with rheumatoid arthritis (RA) and 2.6 +/- 0.3% of T cells from normals.
Fong et al. (1991)HLA-DRT cellInduced HLA-DR expression on ocular nonimmune cells and T cell controlled responses also may participate.
Ditschkowski et al. (1999)HLA-DRT cellsData on the role of HLA-DR expression on T cells and soluble HLA-DR molecules are rare.
Ditschkowski et al. (1999)HLA-DRT cellsMETHODS: HLA-DR expression on monocytes and T cells was measured by flow cytometry.
Ditschkowski et al. (1999)HLA-DRT cellsRESULTS: HLA-DR expression on circulating T cells, calculated as mean fluorescence intensity in channels, was reduced at day 1 after admission in 20 patients with subsequent severe sepsis compared with 46 patients without sepsis.
Ihan and Cvenkel (2000)HLA-DRT lymphocytesThe expression of HLA-DR on T lymphocytes and epithelial cells was analysed by flow cytometry.
Girlanda et al. (2008)HLA-DRT-cellSimilarly, renal tubular stress, as indicated by HLA-DR expression, increased with monocyte but not T-cell infiltration.
Lee et al. (1996)HLA-DRT cellsA combination of perilobular and perivascular inflammation composed of B and T cells with epithelial expression of HLA-DR mimicking lymphocytic lobulitis was seen more frequently in lobular than ductal carcinoma.
Angel et al. (2007)HLA-DRT lymphocytesIn addition, a small subset of dermal T lymphocytes was found to express low-level HLA-DR suggesting an activated phenotype.
Niedecken et al. (1988)HLA-DRT cellCoexpression of HLA-DR and HLA-DQ was found especially often in cutaneous T cell lymphomas, skin tumors, and inflammatory dermatoses.
Alviggi et al. (1984)HLA DRT lymphocytesExpression of HLA DR antigens on T lymphocytes indicates that these cells are actively involved in an immune response.
Bottazzo et al. (1983)HLA-DRT lymphocytesThis involves the local aberrant expression of HLA-DR antigens by epithelial cells and their subsequent capacity to present autoantigens occurring on their surfaces to T lymphocytes.
Guerry et al. (1984)HLA-DRT cellsTo investigate the interaction of melanoma cells and autologous lymphocytes and its dependence on HLA-DR expression, we have established cell lines from biologically early (4 lines) and advanced disease (11 lines) and examined their capacity to stimulate blastogenesis of autologous T cells in vitro.
Guerry et al. (1984)HLA-DRT cellsMelanocytes from early disease expressed HLA-DR antigens and stimulated autologous T cells.
Dufresne et al. (1999)HLA-DRT lymphocytesGiven that HLA-DR surface marker is expressed on monocyte/macrophages and activated CD4+ T lymphocytes, the primary cellular reservoirs of the human immunodeficiency virus (HIV), the use of liposomes bearing surface-attached anti-HLA-DR could constitute a convenient strategy to more efficiently treat this debilitating retroviral disease.
Waldman et al. (1993)HLA DRT cellsWe now show that T cells thus activated can induce HLA DR expression on noninfected EC.
Waldman et al. (1993)HLA DRT cellsAgain, HLA DR expression was induced by supernatant from CMV-positive cocultures (only when cocultured T cells were isolated from CMV-seropositive donors), but not by supernatant from CMV-negative cocultures or from T cells cultured alone.
Fehr et al. (2004)HLA-DRT cellTwenty-seven healthy volunteers were analyzed for serum cytokines and acute phase proteins, HLA-DR and CD38 expression on T cells and superantigen-mediated T cell activation ex vivo before and after 14 days of statin treatment.
Holling et al. (2004)HLA-DRT-cellSubsequent analysis showed that the lack of human leukocyte antigen-DR (HLA-DR) expression correlated with hypermethylation of CIITA-PIII in leukemic T-cell lines and in primary T-cell acute lymphoblastic leukemia (T-ALL) and a T-cell prolymphocytic leukemia (T-PLL).
Holling et al. (2004)HLA-DRAT-cellTreatment of leukemic T-cell lines with a demethylation agent showed re-expression of CIITA-PIII and HLA-DRA.
de Boer et al. (1994)HLA-DRT cellsIn spite of the presence of a large amount of activated T cells in the epidermis, we found that HLA-DR expression on keratinocytes was not a major feature of psoriatic skin.
Greenberg et al. (1981)HLA-DRT lymphocyteComplement-mediated cytotoxicity testing demonstrated the presence of HLA-DR antigens and absence of a T lymphocyte antigen on the clonogenic CFUGM.
Becker et al. (1986)HLA-DRT-cellHuman peritoneal macrophages from healthy females have been investigated for their capability to produce interleukin-1 (IL-1), their expression of HLA-DR and -DQ, and for their antigen-presenting capacity in concanavalin A, tetanus toxoid (TT), and autologous T-cell proliferative responses.
Johansson et al. (1986)HLA-DRT lymphocytesThe HLA-DR expression was patchy in all and most pronounced in two candida biopsies which also contained large infiltrates of anti-Leu 3a reactive T lymphocytes.
Barker et al. (1988)HLA-DRT lymphocytesIn vivo studies revealed a spatial relationship between keratinocyte HLA-DR expression and activated T lymphocytes within the dermal inflammatory infiltrate.
Barker et al. (1988)HLA-DRT lymphocytesThese results suggest that, in vivo, gamma-interferon produced by activated T lymphocytes induces keratinocyte HLA-DR synthesis and expression.
Seymour et al. (1988)HLA-DRT cellsAt all stages the T cells displayed both HLA-DR and HLA-DQ antigens, but less than 10% had detectable IL-2 receptors.
Auböck et al. (1986)HLA-DRT-cellHLA-DR expression on keratinocytes was demonstrated in 38 dermatoses, including lymphocytic vasculitis, lupus erythematosus, morphea, vitiligo, lichen planus, cutaneous T-cell lymphoma, various infectious dermatoses, allergic contact dermatitis, granulomatous dermatoses, Sweet's syndrome, lichen sclerosus and erythema nodosum.
Andersson et al. (1988)HLA-DRT lymphocytesHLA-DR expression in the vascular lesion and circulating T lymphocytes of patients with giant cell arteritis.
Andersson et al. (1988)HLA-DRT cellHLA-DR was expressed on 28% (range 16-42%) of all T lymphocytes in the wall of the inflamed temporal artery, but only on average on 6% of peripheral blood T lymphocytes, indicating a high degree of local T cell activation in the inflammatory lesion.
Abuzakouk et al. (1996)HLA-DRT lymphocytesBACKGROUND: Activation of circulating T lymphocytes results in expression of HLA-DR, interleukin-2 receptor (IL-2R), transferrin receptor (TrR), and decreased amounts of surface CD3.
Abuzakouk et al. (1996)HLA-DRT lymphocytesRESULTS: All human IEL populations express HLA-DR and their density of expression is lower than on the small population of HLA-DR+ resting PB T lymphocytes (mean fluorescence intensity (MFI) 52.9, range 19.8-94.8 v 152.6 range, 49.1-320.3; p < 0.01).
Salomon et al. (1991)HLA-DRT lymphocytesThe identity and localization of cells found in transplantation-associated arteriosclerosis lesions from human cardiac allografts were evaluated, and their expression of class II major histocompatibility complex (human leukocyte antigen-DR [HLA-DR]), surface molecules required for recognition of foreign cells by CD4+ T lymphocytes, was noted.
Fugger et al. (1996)HLA-DRA1T cellA panel of HLA-DRB1*0401-restricted CD4+ mouse T cell hybridomas specific for bovine type II collagen were generated from transgenic mice expressing the human HLA-DRA1*0101/-DRB1*0401 and CD4 molecules.
Wong et al. (1995)HLA-DRT cellsFK506 (0.5 ng/ mL) reduced both the percentage of interleukin-2 receptor expressing T cells and the cell surface density of this receptor by 7.1% and 8.7% (P < .01), whereas it only reduced the proportion of HLA-DR expressing T cells by 6.8%.
Chiovato et al. (1994)HLA-DRT-cellIFN gamma, either recombinant or produced by T-cell clones, induced HLA-DR appearance in thyrocytes, whereas TSH or TSab stimulated TPO expression.
Salgado et al. (2002)HLA-DRT cellsInterleukin-dependent modulation of HLA-DR expression on CD4and CD8 activated T cells.
Salgado et al. (2002)HLA-DRT lymphocytesIn this paper, while studying the influence of some cytokines(IL-12, IL-2 and IL-4) on the expression of several markers [CD69,CD25, CD26, CD3, human leukocyte antigen (HLA-DR), CD45R0] in in vitro activated human T lymphocytes, we observed two groups of donors responding to phytohaemagglutinin (PHA) activation with high or low HLA-DRAg expression.
Salgado et al. (2002)HLA-DRT cellsIn 5 day cultures, IL-12 and IL-2 enhanced the CD8/CD4 ratio of activated T cells,which was responsible, in part, for the IL-dependent HLA-DR upregulation.IL-12 and IL-2 also upregulated the HLA-DR expression at the molecular level on CD8, and IL-12 downregulated it on CD4 cells.
Speiser et al. (2001)HLA-DRT cellsHuman CD8(+) T cells expressing HLA-DR and CD28 show telomerase activity and are distinct from cytolytic effector T cells.
Mezzetti et al. (1991)HLA-DRT cellsECs restored mitogen-induced DNA synthesis and DNA synthesis triggered by CD3 cross-linking in T cells, as did pulmonary macrophages, and this was unrelated to HLA-DR expression.
Dooper et al. (1991)HLA-DRT cellsWe have previously reported that during acute rejection of renal allografts T lymphocytosis and increased HLA-DR expression on tubular epithelial cells can be demonstrated in urinary sediments by incubating cytospin preparations with monoclonal antibodies against T cells and HLA-DR antigen in an indirect alkaline phosphatase technique.
Poulter et al. (1990)HLA-DRT-cellThese results show for the first time that a chronic T-cell-mediated immune response is present in the bronchial tissue of asymptomatic asthmatics, and that the HLA-DR expression promoted correlates with the hyperresponsive status.
Yilmaz et al. (2004)HLA-DRT cellDC clusters with a strong HLA-DR expression and frequent DC-T cell contacts were located particularly in the rupture-prone plaque regions and at complications.
Tabibzadeh (1990)HLA-DRT-cellsInterleukin-2 receptor was not expressed in human endometria; however, endometrial T-cells within lymphoid aggregates, some scattered in endometrial stroma and a few within epithelium, expressed HLA-DR, HLA-DP, HLA-DQ, and VLA-1.
Chantry et al. (1990)HLA-DRT-cellOur results indicate that GM-CSF is a major macrophage activating factor that is capable of inducing both the expression of HLA-DR and the cytokines involved in T-cell activation by macrophages; therefore, GM-CSF may be of importance in potentiating antigen presenting function.
Linardopoulos et al. (1992)HLA-DRT cellsIn the lesions of human autoimmune disease, such as the synovial membrane in rheumatoid arthritis, the T cells are activated as shown by a variety of phenotypic and functional changes including the expression of HLA-DR and the production of interleukin-6 (IL-6).
Linardopoulos et al. (1992)HLA-DRT cellsIt is shown that the formation of sheep red blood cell (SRBC) rosettes with resting T cells from human peripheral blood, which is equivalent to CD2/LFA-3 binding, leads to the de novo transcription of the HLA-DR and IL-6 genes and the expression of HLA-DR on the surface of the T cells.
Sabek et al. (2002)HLA-DRAT-cellExpression of the T-cell activation markers, granzyme B, perforin, and HLA-DRA, was quantified and correlated to the histopathologic changes in the renal biopsies.
Kelley et al. (1984)HLA-DRT cellThus, these data indicate that the expression of HLA-DR molecules that is vital for monocyte/macrophage and T cell interaction is stimulated by the lymphokine IFN-gamma, and that the effects of IFN-gamma are distinctive from IFN-alpha or -beta.
Speiser et al. (2001)HLA-DRT cellsThis demonstrates that telomerase-expressing and cytolytic CD8(+) T cells can be separated on the basis of the cell surface markers HLA-DR and CD56.
Tamiolakis and Venizelos (2006)HLA-DRT lymphocytesIn this study we used immunohistochemistry to analyse the expression of HLA-DR on epithelial cells of normal colonic mucosa, tubulovillous adenoma, and invasive carcinoma, as well as the magnitude of the stromal T lymphocytes at the relevant sites.
Beiske et al. (1987)HLA-DRT cellThe immunologic phenotype of PTC, as revealed on frozen tumor tissue sections, comprised the expression of CD5 (T1), CD4 (T4), and HLA-DR, but not CD8 (T8) and CD2 (T11) and suggested an affiliation to the T cell system.
Reitz et al. (1984)DR alpha mRNAT-cellsTreatment of these T-cells with 5-azacytidine resulted in the induction of DR surface antigen expression, the appearance of DR alpha mRNA, and the partial demethylation of the DR alpha DNA sequences.
Lehner and Jones (1984)HLA-DRT lymphocytesIndirect immunofluorescence studies suggest that T lymphocytes from peripheral blood of healthy subjects have a small proportion of cells expressing HLA-DR, beta chain determinants (1.4-3.8%).
Peakman et al. (1995)HLA-DRT cellsIn our first study, 157 patients in CDC groups II-IV were examined cross-sectionally for in vivo expression of the activation markers HLA-DR and CD25 on CD3, CD4 and CD8 T cells.
Cook et al. (1991)HLA DRT cellsAn additional finding of interest was a substantial decrease in the expression of HLA DR on CD4+ and non-T cells.
Wakefield et al. (1993)HLA-DRT cellIn contrast, the level of T cell HLA-DR expression rose significantly on the first day after operation (P < 0.05) in patients without sepsis to a level higher than in those who developed infection (P < 0.05).
Olsson et al. (1985)HLA-DRT lymphocyteHLA-DR expression, T lymphocyte phenotypes, OKM1 and OKT9 reactive cells in inflammatory myopathy.
Olsson et al. (1985)HLA-DRT cellsMany T lymphocytes of both phenotypes appeared in close contact with HLA-DR expressing non-T cells.
Meyer and Soergel (1999)HLA-DRT lymphocytesIncreased expression of HLA-DR and CD69 on CD4+ T lymphocytes was observed in the oldest age group.
Boomer et al. (2000)HLA-DRT lymphocytesRTF is expressed in vivo on the surface of individuals with B cell chronic lymphocytic leukemia and on activated T lymphocytes of HIV infected individuals as determined by their coexpression with CD38 and HLA-DR.
Kelley et al. (1984)HLA-DRT cellIt has been shown that gamma-interferon (IFN-gamma), a T cell product, can regulate macrophage HLA-DR expression.
Kudo et al. (2002)HLA-DRT cellsWe investigated signaling via HLA-DR molecules expressed on CD4+ T cells.
Moller et al. (1996)HLA-DRT cellsPHA, on the other hand, induced a higher expression of HLA-DR, an activation marker of T cells.
Ralfkiaer et al. (1984)HLA-DRT cellsThe T cells were predominantly T helper/inducer cells and in all patients the T cells expressed HLA-DR.
Pujol et al. (1993)HLA-DRT lymphocytesIn these populations, we determined the mean fluorescence channel after staining for CD14 (antigen expressed on monocytes), CD3 (antigen expressed on T lymphocytes), and HLA-DR (HLA class II expressed by monocytes and activated lymphocytes).
Kadota et al. (2000)HLA-DRT cellThe abnormal regulation of HLA-DR expression caused by impaired induction of CIITA may affect CD4+ T cell development in thymoma.
Alexander et al. (1995)HLA-DRT cellsBy flow cytometry analysis the CD4+ T cells in a panel of freshly digested human renal cell carcinoma primary and metastatic tumors expressed the activation markers CD69 and HLA-DR and manifested an increase in CD45RO and a reciprocal decrease in CD45RA expression as compared with peripheral blood CD4+ T cells.
Stimac et al. (1988)HLA-DRT-cellHLA-DR and other human class II histocompatibility genes are expressed by Epstein-Barr virus-transformed B-lymphocyte cell lines but not by most T-cell leukemia lines.
Erkeller-Yuksel et al. (1992)HLA-DRT cellsThe expression of the activation markers interleukin-2R and HLA-DR on T cells increases with age, as does the NK-associated expression of CD57 on CD8 cells.
Bestman-Smith et al. (2000)HLA-DRT lymphocytesAs the human HLA-DR determinant of the major histocompatibility complex class II is expressed on activated CD4+ T lymphocytes and antigen presenting cells such as monocyte/macrophages and dendritic cells, known as the cellular reservoirs of HIV-1, liposomes bearing anti-HLA-DR antibodies constitute an attractive approach to concentrate drugs in HIV-1 reservoirs and improve their therapeutic effect.
Moriya et al. (1987)HLA-DRT cellsMechanisms of HLA-DR antigen expression in phytohemagglutinin-activated T cells in man.
Hirabayashi et al. (1995)HLA-DRT cellsRESULTS: Supernatant of PCI-50 promoted expression of the following activation markers on NK and T cells: CD25 (interleukin-2R-alpha), HLA-DR (major histocompatibility complex class II), CD54 (ICAM-1), CD71 (transferrin receptor), and CD69 (activation-inducing molecule).
Cozzi et al. (1990)HLA-DRT-cellsIn a cell suspension of IL-2 activated T-cells, more than 80% of the cells with a blastic morphology were DAP IV-CD 26+; DAP IV-CD 26+ cells coexpressing Tac-CD 25, OKT 9-CD 71, HLA-DR positivity, relative to the total number of DAP IV-CD 26 positive cells, were 90.5%, 70.5% and 87% respectively.
Berdoz et al. (1987)HLA-DRT lymphocytesHLA-DR is expressed constitutively on B lymphocytes and on activated T lymphocytes.
Pincus et al. (1985)HLA-DRT cellsRNA hybridization studies, using a cloned HLA-DR alpha chain gene probe, indicate that the T cells actively synthesize HLA-DR antigens rather than passively adsorbing them.
Andrade et al. (1988)HLA-DRT cellsAntisera used included monoclonal antibodies LN-1 and LN-2 for B cells, LN-3 for cells expressing human leukocyte antigen-DR (HLA-DR) antigens, UCHL-1 for T cells, Leu-7 for natural killer (NK) cells, and T suppressor lymphocytes and the polyclonal antibody to S100 protein for dendritic cells.
Abdulkadir et al. (1995)HLA-DRAT lymphocytesThe class II major histocompatibility complex gene HLA-DRA is expressed in B cells, activated T lymphocytes, and in antigen-presenting cells.
Guse et al. (1999)HLA-DRT cellsThere is a causal relation between increased cADPR concentrations, sustained calcium signalling and activation of T cells, as shown by inhibition of TCR/CD3-stimulated calcium signalling, cell proliferation and expression of the early- and late-activation markers CD25 and HLA-DR by using cADPR antagonists.
Koning and Rust (1992)HLA-DRT cellsActivated human T cells, however, do express HLA-DR, -DP, and -DQ Ag and could consequently serve as APC for SE.
Peterfalvi et al. (2008)HLA-DRT cellsA high percentage of infiltrating T cells was CD8+ and expressed HLA-DR suggesting activation.
Tsuchiya et al. (1988)HLA-DRT lymphocytes2-dimensional flow cytometric analysis of peripheral blood T lymphocytes from patients with systemic lupus erythematosus: preferential expression of HLA-DR antigen on the surface of Leu 2a+ cells.
Grubeck-Loebenstein et al. (1986)HLA-DRT-cellsIn addition, lymphocytic infiltration of thyroid tissue, the amount of the various lymphocyte subsets (Leu 4+, Leu 3a+, and Leu 2a+ T-cells as well as B1+ B cells) in the thyroid gland, as well as the expression of the histocompatibility antigen HLA-DR on thyrocytes and intrathyroidal T-lymphocytes were examined.
Chan et al. (1994)HLA-DRT cellsOur results show in patients receiving allogeneic BMT: (1) T and NK cells were the predominant lymphocyte subsets in the early reconstitution stage while B cells were severely depleted; (2) absolute numbers of the major lymphocyte subsets normalised in 4-5 months; (3) an increased percentage of T cells that expressed the activation antigen HLA-DR and a reversed CD4:CD8 ratio were observed throughout the first 12 months after BMT; (4) patients with acute GVHD had significantly higher white cell count and NK cell percentage than those not complicated by acute GVHD.
Kon et al. (2001)HLA-DRT-cellsBy flow cytometry in peripheral blood, pre- and postinfusion assessment was made of: a) CD4 and CD8 counts and mean fluorescence; b) CD25, human leukocyte antigen-DR (HLA-DR), CD45RO and CD45RA expression on CD4+ T-cells; and c) interferon (IFN)-gamma, interleukin (IL)-4 and IL-5 expression in CD4+ T-cells.
Holland et al. (1991)HLA-DRT-lymphocytesEvidence suggests that thyrocyte HLA-DR expression is secondary to the production of cytokines by presensitized T-lymphocytes.
Yawalkar et al. (2000)HLA-DRT cellsAn increased percentage of the T cells expressed activation molecules like HLA-DR, CD25, CD26, CD69 as well as adhesion and co-stimulatory molecules like CD54, CD154 / 40 ligand.
Nakashiro (1991)HLA-DRT lymphocytesHLA-DR was expressed by most macrophages, macrophage foam cells and T lymphocytes.
Agostini et al. (1997)HLA-DRT cellsLung lymphocytes were CD45R0+/CD8+ T cells spontaneously expressing activation markers (CD69 and HLA-DR) and equipped with the receptorial subunits which bind IL-15, notably the beta and gamma chains of the IL-2 receptor (IL-2R) and the recently identified IL-15 binding-protein termed IL-15R alpha.