Viewing affirmative mentions of gene expression of HIVEP1 (H. sapiens) in T cells

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Unwalla et al. (2006)HIV-1T cellsPotent inhibition of HIV-1 gene expression and TAT-mediated apoptosis in human T cells by novel mono- and multitarget anti-TAT/Rev/Env ribozymes and a general purpose RNA-cleaving DNA-enzyme.
Nomura et al. (1991)HIV-EP1T cellsAs a new member of a HIV-EP1 family that is expressed at a high level in T cells, we have isolated cDNA clones of HIV-EP2 by cross-hybridization with HIV-EP1 cDNA.
Oakley et al. (2003)HIV geneT-cellsAltogether, a direct correlation exists between apoptosis and HIV gene expression in T-cells in response to both UV and IR but this is not the case in carcinoma cells.
Mannon and Coffman (1992)major histocompatibility complex proteinT cellsRejection can be prevented by interfering with the interaction of recipient T cells with alloantigens using interventions such as antibodies against major histocompatibility complex proteins or accessory adhesion molecules, peptide-binding antagonists, and genetic alteration of major histocompatibility complex protein expression.
Wang et al. (1998)anti-HIV-1 ribozyme geneT cellTaken together, these results indicate that the transfer of an anti-HIV-1 ribozyme gene into human T lymphocytes could have major impact on viral replication and T cell viability in the HIV-1-infected individual.
Jones et al. (2007)HIV-1 receptorT cellWe here demonstrate that optimization of HIV-1 receptor expression and the utilization of serum free medium compositions can increase susceptibility of reporter T cell lines to HIV-1 infection by up to two orders of magnitude.
Eckstein et al. (2001)HIV-1T cellsAlthough HIV-1 gene expression is detected in naive, resting T cells in vivo, such cells are resistant to productive infection in vitro.
Ensoli et al. (1989)HIV-1T cellsHuman herpes virus-6 increases HIV-1 expression in co-infected T cells via nuclear factors binding to the HIV-1 enhancer.
Ensoli et al. (1989)HIV-1 LTRT-cellsHuman Herpes virus-6 (HHV-6) can co-infect with HIV-1 human CD4+ T-cells, leading to accelerated cell death, and factors in HHV-6-infected cells stimulate HIV-1 LTR directed gene expression.
Stojanova et al. (2004)HIV-1T-lymphocytesIn this report, we show that ectopic expression of the nuclear phosphoprotein, c-Myc can inhibit HIV-1 gene expression and virus production in CD4+ T-lymphocytes.
Griffin et al. (1989)HIVT cellsWe now report that HIV gene expression in the monocyte lineage is regulated by NF-kappa B, the same transcription factor known to stimulate the HIV enhancer in activated T cells; however, control of NF-kappa B and HIV in monocytes differs from that observed in T cells.
Horvat and Wood (1989)HIVT cellsCotransfection of the HIV promoter with the HIV transactivator protein, tat, increases HIV promoter activity in both resting and activated primary human T cells only when the tat target sequences were present.
Goffinet et al. (2007)HIV geneT-cellsImportantly, transient trans-complementation by ex vivo nucleofection with the Tat-interacting protein Cyclin T1 of human origin markedly elevated HIV gene expression in primary rat T-cells.
Jaoko et al. (2008)HIV-1T-cellBoth vaccines, expressing HIV-1 subtype A gag p24/p17 and a string of CD8 T-cell epitopes (HIVA), were generally safe and well-tolerated.
Unwalla et al. (2006)HIV-1T cellsBoth Rzs and Dz showed not only potent inhibition of HIV-1 gene expression but also showed remarkable protection against HIV-1 TAT protein-mediated apoptosis in Jurkat T cells.
Schwartz et al. (1995)immunodeficiency virus type 1 HIV-1 Nef proteinT cellsWe have studied the fate of CD4 in CEM T cells expressing a human immunodeficiency virus type 1 HIV-1 Nef protein.
Tomaras and Haynes (2009)HIV-1T cellWe review recent data on HIV-1-specific antibody isotypes induced following HIV-1 transmission: to understand the effects of HIV-1 on B cell and T cell effector responses, to understand the timing of the rise and fall of different anti-HIV-1 antibodies and to understand how antibodies could contribute to protective immunity if they were either pre-existing or elicited immediately after HIV-1 transmission.
Guerbois et al. (2009)HIV-1T cellsAlthough a live attenuated HIV vaccine is not currently considered for safety reasons, a strategy inducing both T cells and neutralizing antibodies to native assembled HIV-1 particles expressed by a replicating virus might mimic the advantageous characteristics of live attenuated vaccine.
Dewhurst et al. (1988)HIVT lymphocytesHIV/neo-positive cell clones were maintained in continuous culture for over 5 months and showed the following characteristics: (i) expression of HIV antigens as detected by indirect immunofluorescence staining in 80-90% of cells; (ii) efficient production of HIV RNA and infectious progeny virus; (iii) minimal cytopathic effects (notably in cell morphology), in contrast to HIV-infected T lymphocytes.
Yeung et al. (2009)HIV-1T-cellsHere, we report the composition of small RNAs in HIV-1 productively infected MT4 T-cells.
Li et al. (1997)anti-HIV-1 immunoglobulinT cellsA panel of 14 human IgG monoclonal antibodies (MAbs) specific for envelope antigens of the human immunodeficiency virus type 1 (HIV-1), 2 high-titer human anti-HIV-1 immunoglobulin (HIVIG) preparations, and 15 combinations of MAbs or MAb/HIVIG were tested for their ability to neutralize infection of cultured human T cells (MT-2) with a chimeric simian immunodeficiency virus (SHIV-vpu+), which expressed HIV-1 IIIB envelope antigens.
Li et al. (1993)HIV-1T cellsWe conclude that cell division and cellular DNA synthesis are not required for efficient HIV-1 expression in T cells.
Leavitt et al. (1994)HIV-1T cellWe reported previously that human CD4+ T cell lines stably expressing a hairpin ribozyme targeted to the human immunodeficiency virus type 1 (HIV-1) U5 leader sequence were resistant to challenge with diverse HIV-1 viral clones and clinical isolates (Yamada et al., 1994).
Limón et al. (2002)HIV-1T-cellTo address these different findings, we analyzed the infectivity and nuclear localization phenotypes of two highly related T-cell-tropic strains, HIV-1(NL4-3) and a derivative of HIV-1(HXBc2) deficient for both Vpr and Nef.
Addo et al. (2003)HIV-1T-cellComprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.
Addo et al. (2003)HIV-1T-cellHIV-1-specific T-cell responses were detectable in all study subjects, with a median of 14 individual epitopic regions targeted per person (range, 2 to 42), and all 14 HIV-1 protein subunits were recognized.
Altfeld et al. (2003)HIV-1T-cellIn this study we assessed the impact of antigen variability on the characterization of HIV-1-specific T-cell responses by using an HIV-1 database to determine the sequence variability at each position in all expressed HIV-1 proteins and a comprehensive data set of CD8 T-cell responses to a reference strain of HIV-1 in infected persons.
Altfeld et al. (2003)HIV-1T-cellGamma interferon Elispot analysis of HIV-1 clade B-specific T-cell responses to 504 overlapping peptides spanning the entire expressed HIV-1 genome derived from 57 infected subjects demonstrated that the average amino acid variability within a peptide (entropy) was inversely correlated to the measured frequency at which the peptide was recognized (P = 6 x 10(-7)).
Goffinet et al. (2007)HIV geneT-cellsIn contrast, a profound impairment at the level of early HIV gene expression was disclosed at the single-cell level in primary rat T-cells and most other rat-derived cells.
Race et al. (1991)HIVT-cellsUsing a nondenaturing serological assay (immunofluorescence of live infected T-cells), we found that each of four infected individuals "seronegative" by the standard tests did possess antibody against native HIV proteins expressed on infected cells.
De Mareuil et al. (1995)HIV-1T-lymphocytesBoth parental viruses and all recombinants retrotranscribed their genomes with a similar kinetics and were able to complete HIV-1 DNA synthesis, HIV-1 LAV provirus present in preintegration complexes could be rescued by cocultivation with T-lymphocytes.
Matsuo et al. (1993)HIVT cellFurthermore, the present study demonstrates that there is no apparent correlation in the quantity of HIV-1 produced to either T cell, myelomonocytic cell, or megakaryocytic cell types.
Pomerantz et al. (1990)HIV-1T lymphocyteU1 and ACH-2 cells are subclones of HIV-1-infected monocyte/macrophage-like and T lymphocyte cell lines, respectively, which express the HIV-1 genome at very low levels.
Gupta et al. (1993)HIV-1T-cellsOur results indicate that the number of circulating CD4+ T-lymphocytes producing HIV-1 increased as the total number of CD4+ T-cells declined.
Williams et al. (2004)HIV geneT cellUsing multiple Jurkat T cell lines containing integrated but transcriptionally latent HIV proviruses (J-Lat cells), we now demonstrate that prostratin effectively activates HIV gene expression in these latently infected cells.
Shirazi et al. (1994)HIV-1T cellsRecently, we have shown that in acutely infected T cells interferons (IFNs) effectively inhibit the human immunodeficiency type 1 (HIV-1) proviral DNA synthesis during a single replication cycle.
Siekevitz et al. (1987)HIV-1 geneT cellThus, HIV-1 gene expression and replication appear to be regulated, via the HIV-1 LTR, by the same mitogenic signals that induce T cell activation.
Toossi et al. (2004)HIV-1T-cellsIn this study we sought to determine whether MTB-infected human primary mononuclear phagocytes-namely, alveolar macrophages (AMs) and their less mature blood precursors, monocytes-activate HIV-1 in a T-cell line stably transfected with an HIV-1 long terminal repeat (LTR) reporter construct (1G5 cells) and induce HIV-1 expression in T-cells from HIV-1-infected subjects.
Holl et al. (2010)HIV-1T lymphocytesWe found that HIV-1 replication and production in DCs were substantially enhanced by the coculture of DCs with primary CD4 T or nonpermissive B lymphocytes but not with primary activated CD8 T lymphocytes or human transformed CD4 T lymphocytes.
Lu et al. (2004)HIVT lymphocytesTransduction of CD4(+) T lymphocytes with this vector results in expression of the therapeutic antisense sequence and subsequent inhibition of productive HIV-1 replication.
Mäkitalo et al. (2004)HIVT-lymphocyte+i.o., exhibited the highest levels of HIV Env, Nef and Tat antibodies, high HIV Tat cytotoxic T-lymphocyte activity and T-lymphocyte proliferative responses to HIV Env.
Böhnlein et al. (1989)HIV-1T-cellAccelerated production of infectious HIV-1 virions appears to be closely linked to a heightened state of T-cell activation.
Chenciner et al. (1995)HIV-activatedT-cellThese results, as well as non-specific T-cell recruitment, suggest limits to the specificity of using HIV-activated toxic gene expression to kill HIV-infected cells.
Pise et al. (1992)HIV-1T cellHIV-1 antigen expression and cytopathicity in HL-60 cells infected with each of the three isolates was delayed by approximately 15 days as compared to those in the prototypic T cell line, H9.
Ying et al. (2010)HIV-1 geneT cellsBy inhibiting HIV-1 gene expression and virus production, histone deacetylase (HDAC) may contribute to the quiescence of HIV-1 within resting CD4+ T cells.
Dehbi et al. (1994)HIV-1T lymphocytesThe effect of v-src on HIV-1 gene expression occurred in the presence or in the absence of the tat viral trans-activator, in fibroblasts and in Jurkat T lymphocytes.
Schmidtmayerova et al. (1992)HIV1T-lymphocytesIn contrast with HIV1-PAR, infection of BDM with two laboratory strains adapted to T-cell lines, HIV1-LAV prototype and HIV1-NDK, a Zairian virus that is highly cytopathic for T-lymphocytes, resulted in a low production of HIV1 p24gag in culture fluid.
Liu et al. (2003)HIV-1T-cellsTo examine the role of alcohol in direct infection of T-cells, viral reverse transcripts and HIV-1 receptor expression were examined in infected peripheral blood lymphocytes (PBLs) pretreated with alcohol.
Miller et al. (2009)HIV-1T cellCells infected with a vector expressing the matrix (MA) subunit of the HIV-1 Gag protein were susceptible to lysis by CD8 T cell clones specific for the SL9 epitope found within MA.
Papsidero et al. (1990)T-cell lymphotropic virus type I core proteinT-cellImmunodetection of human T-cell lymphotropic virus type I core protein in biological samples by using a monoclonal antibody immunoassay.
Pontesilli et al. (1997)serum HIV-1 RNAT cellsViral load was measured both as serum HIV-1 RNA levels and frequency of circulating CD4+ T cells productively infected with HIV-1.
Siekevitz et al. (1987)HIV-1 LTRT cellActivation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I.
Orchard et al. (1990)immunodeficiency virus type 1 long terminal repeatT cellsA 7-base-pair mutation in the site B palindrome, which destroyed protein binding, resulted in increased expression from the human immunodeficiency virus type 1 long terminal repeat in T cells.
Niederman et al. (1993)HIV-1T-cellsThese studies suggest that, by inhibiting AP-1 activation, Nef may play a role in regulating HIV-1 gene expression in infected T-cells.
Goffinet et al. (2007)HIV-1T-cellsRESULTS: Levels of virus entry, HIV-1 cDNA synthesis, nuclear import, and integration into the host genome were shown to be remarkably similar in cell lines and, where technically accessible, in primary T-cells from both species.
Goffinet et al. (2007)HIV-1T-cellsCollectively, these results provide the basis for the advancement of this transgenic rat model through strategies aimed at boosting HIV-1 gene expression in primary rat CD4 T-cells, including human Cyclin T1 transgenesis.
Willerth et al. (2010)HIVT cellsA heterogeneous, clinically relevant population of HIV produced by CD4+ T cells taken from a patient enrolled in a HIV clinical trial [21] was then analyzed.
Nicholas and Martin (1994)immunodeficiency virus type 1T-lymphocyteIts predominant CD4+ T-lymphocyte tropism, its ability to activate human immunodeficiency virus type 1 (HIV-1) gene expression in vitro, and its upregulation of CD4 expression has led to speculation that HHV-6 may act as a positive cofactor in the progression of HIV infection to AIDS in individuals infected with both viruses.
Tong-Starksen et al. (1987)HIVT-cellBy acting directly on the HIV LTR, T-cell activation may play an important role in HIV gene expression and in the activation of latent HIV.
Stratov et al. (2004)HIVT cellViral vectors, such as canarypox, engineered to express HIV genes, have induced HIV-specific CD8 T cell responses in a minority of subjects in phase II trials and are proceeding to human efficacy trials.
Dumais et al. (2002)HIV-1T cellsSuch a combinatorial regulation may represent a mechanism that permits a fine regulation of HIV-1 expression by PGE(2) in human T cells.
Dickerson et al. (2010)HIVT cellUntreated HIV infection leads to a decrease in CD4+ T cell count, eventually resulting in the loss of cell-mediated immunity, an immunocompromised state and the onset of AIDS (Acquired Immunodeficiency Syndrome) [6].
Jordan et al. (2003)HIVT lymphocyteWe have used an HIV retroviral vector or a full-length HIV genome expressing green fluorescent protein to infect a T lymphocyte cell line in vitro and highly enrich for latently infected cells.
Yang and Engel (1993)HIV-1T cellHuman T cell transcription factor GATA-3 stimulates HIV-1 expression.
Markovitz et al. (1990)HIV-1T-cellWe report that the regulation of HIV-2 differs from that of HIV-1: a distinct T-cell activation pathway, triggering of the CD3 component of the T-cell receptor complex, stimulates HIV-2 but not HIV-1 gene expression.
Jones et al. (2008)HIV-1T-cellAs SupT1 cells and other T-cell lines are unable to produce sufficient quantities of DIS mutant HIV-1 viruses for analysis, WT and DIS mutant HIV-1 viruses were produced by either transfection of 293T cells or infection of PBMCs. 293T cells were used as a surrogate for virus production in SupT1 cells.
Petitjean et al. (2007)HIV-1T lymphocytesSpontaneous HIV-1-producing CD4+ T lymphocytes in patients
Petitjean et al. (2007)HIV-1T lymphocytesWe first demonstrated in an in vitro HIV-1 latent infection model that HIV-1 production was rescued from infected resting CD4+ T lymphocytes after polyclonal activation.
Petitjean et al. (2007)HIV-1T lymphocytesThis observation was extended by showing that addition of the HIV-1 integrase inhibitor L-731,988 in culture medium efficiently prevented HIV-1 production from stimulated CD4+ T lymphocytes.
Petitjean et al. (2007)HIV-1T cellsIn untreated patients, the de novo infection of resting CD4+ T cells is insured by the HIV-1 production from activated infected CD4+ T cells, which leads to the continual replenishing of the pool of infected resting CD4+ T lymphocytes harboring unintegrated HIV-1 DNA.
Petitjean et al. (2007)HIV-1T lymphocytesWhen HIV-1-Ag-SCs were undetectable, results were expressed as <1 HIV-1-Ag-SCs/107 resting CD4+ T lymphocytes according to the number of tested cells.
Jones et al. (2008)HIV-1T-cellIn contrast to the SupT1 cells, the other T-cell lines tested showed differing capacities to support the replication of DIS defective HIV-1 (Figure 2B–E).
Márquez et al. (2008)HIV-1 geneT cellUsing a Jurkat T cell line containing latent HIV proviruses, we found that prostratin and phorbol-13-stearate effectively activate HIV-1 gene expression in these latently infected cells, with phorbol-13-stearate being at least 10-fold more potent than prostratin, and its activity rapidly decreasing with a shortening of the acyl side chain.
Toschi et al. (2006)HIV-1 geneT-cellsTat, the transactivator of HIV-1 gene expression, is released by acutely HIV-1-infected T-cells and promotes adhesion, migration, and growth of inflammatory cytokine-activated endothelial and Kaposi's sarcoma cells.
Zhang et al. (2000)HIV-1T cellsMoreover, transfection of HIV-1 provirus containing mutations in NC zinc-finger domains dramatically decreases the enhancement activity in human T cells, in which HIV-1 LTR is stably integrated into the cellular genome.
Salahuddin et al. (2007)HIV-1T-cellsInitial in vitro studies of HIV-HHV co-infected T-cells showed that HHV-6 increased HIV-1 production and cell death [20].
Vandegraaff et al. (2001)HIVT cellsThe two diketo acid integrase inhibitors (L-708,906 and L-731,988) blocked the accumulation of integrated HIV-1 DNA in T cells following infection but did not alter levels of newly synthesized extrachromosomal HIV DNA.
Taher et al. (2000)HIV geneT-cellsUV radiation also activated HIV gene expression (< or = 9-fold) in 1G5 Jurkat T-cells stably transfected with a luciferase reporter gene under control of the HIV promoter.
Kishi et al. (1993)immunodeficiency virus type 1T cellPersistently human immunodeficiency virus type 1-infected T cell clone expressing only doubly spliced mRNA exhibits reduced cell surface CD4 expression.
Zhou et al. (1994)HIV-1T-lymphocytesThe T-lymphocytes expressing the anti-HIV-1 ribozymes showed resistance to HIV-1 replication.
Page et al. (1997)HIV-1T cellsWe have examined consequences of HIV-1 gene expression on T-cell activation in antigen-dependent T cells that have stably integrated copies of replication-defective proviral HIV-1.
Bollinger et al. (1993)HIV-1 geneCTLsFor each clone studied, upregulation of HIV-1 gene expression in chronically infected T cell lines resulted from the antigen-specific release by CTLs of tumor necrosis factor alpha (TNF-alpha).
Bollinger et al. (1993)HIV-1 geneCTLsCD4+ and CD8+ CTLs that released TNF-alpha on antigen stimulation were also shown to express a biologically active 26-kDa transmembrane form of TNF-alpha, which was sufficient to induce upregulation of HIV-1 gene expression in chronically infected T cells placed in direct contact with the CTLs.
Bollinger et al. (1993)HIV-1 geneCTLsSupernatants from antigen-activated, vaccine-induced CD4+ and CD8+ CTLs also caused upregulation of HIV-1 gene expression in chronically infected promonocytic cells.
Russo et al. (1999)HIV-1T lymphocyteIn order to investigate the effect of glucocorticoids in pathways that activate HIV-1 expression, we transfected promonocyte (U937) and T lymphocyte (CEM-T4) cell lineages with a plasmid containing the chloramphenicol acetyl transferase (CAT) reporter gene under the control of the HIV-1 LTR.
Favaro and Arrigo (1997)HIV-1T cellsThe effect of the human immunodeficiency type 1 (HIV-1) Rev protein on the splicing and cytoplasmic accumulation of HIV-1 RNAs was investigated in COS and T cells.
McCarthy et al. (1998)HIVT-cellsThe pattern of LTR activity in astrocytes suggests that host cell factors modulating HIV expression may differ from those dominant in T-cells or immortalized astroglia, and this could contribute to differences in the astrocyte's ability to support HIV replication.
Jones et al. (2008)HIV-1T-cellWhereas, a panel of human T-cell lines displayed a significantly reduced capacity to support the replication of DIS defective HIV-1 with up to a 100 000-fold decrease in infectivity compared to WT HIV-1.
Jones et al. (2008)HIV-1T-cellIn order to examine whether the observed RNA-mediated restriction of HIV-1 DIS mutants is limited to SupT1 cells or if it is a widespread phenomenon across other T-cell lines parallel infections were carried out using a panel of T-cell lines and PHA-stimulated PBMCs (Figure 2).
Jones et al. (2008)HIV-1T-cellIn comparison to primary PBMCs, all T-cell types tested demonstrated a reduced capacity to support the replication of DIS defective HIV-1 (from high to low replication capacity: A3.01, CEM-SS, CEM-T4, H9 and SupT1).
Jones et al. (2008)HIV-1T-cellUsing a panel of five DIS mutants, we have demonstrated that both the DIS stem-loop structure and the presence of a palindromic sequence are not required for viral replication in the natural target cells of HIV-1 and that laboratory T-cell lines display varying abilities to support the replication of DIS defective HIV-1.
Jones et al. (2008)HIV-1T-cellIn contrast, none of the DIS mutants tested were able to replicate in the laboratory adapted T-cell line SupT1, suggesting that the integrity of the entire native DIS stem-loop structure is absolutely required for HIV-1 replication in this T-cell line.
Petitjean et al. (2007)HIV-1T lymphocytesSpontaneously HIV-1-Ag-secreting CD4+ T lymphocytes were detected in 3/3 untreated patients (nos. 8, 11, 12) and in 2/4 sustained responders to HAART (nos. 15 and 21).
Saha et al. (1999)HIVT cellsOur data from this study show that differential expression of another anti-HIV factor(s) by selected CD4(+) T cells may be responsible for the protection of these cells against SI viruses.
von Eije et al. (2009)HIV-1T cellWe performed transient inhibition assays with either a luciferase reporter or HIV-1 molecular clone and also infected shRNA-expressing T cell lines with HIV-1 and monitored virus replication.