Viewing affirmative mentions of gene expression of CTLA4 (H. sapiens) in T cells

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Kawasaki et al. (2008)CTLA4T-cellCTLA4, which delivers inhibitory signals to T-cell activation, is expressed on the surface of activated T-cells and regulatory T-cells, and the lack of CTLA4 results in uncontrolled T-cell–mediated lymphoproliferative disease (6).
Chun et al. (2004)CTLA-4T cellsTo study expression of human CTLA-4 in peripheral T cells, we developed a new anti-peptide (anti-CTLA4pB) antibody.
Kaartinen et al. (2007)CTLA4T cellDuring the T cell activation two genetic variants in ICOS gene, IVS1+173T/C and c.1624C/T, affected expression of CTLA4 isoforms and ICOS, respectively.
Liu et al. (1998)CTLA-4T cellCTLA-4 is a cell surface molecule expressed on activated T cells that is suggested to deliver a negative signal for T cell activation.
Liu et al. (1998)CTLA-4 mRNAT cellsWe found that although CTLA-4 mRNA was readily detected in all patients and controls, only a very minor subset of T cells expressed detectable surface CTLA-4 molecules in both groups.
Liu et al. (1998)CTLA-4T cellsThe kinetics of CTLA-4 expression on T cells stimulated in vitro with PMA plus ionomycin were similar in normal controls and patients with SLE.
Liu et al. (1998)CTLA-4T cellsHowever, the induction of CTLA-4 expression on patients' T cells appeared to be weaker than that of normal individuals.
Zheng et al. (2010)CTLA-4T-cellsCytotoxic T-lymphocyte antigen 4 (CTLA-4), a CD28 homologue, is a glycoprotein expressed on activated T-cells that has a high binding affinity with the molecule B7, primarily expressed on APCs [5-8].
Schlotmann et al. (2000)CTLA-4T lymphocytesCD4 alphabeta T lymphocytes express high levels of the T lymphocyte antigen CTLA-4 (CD152) in acute malaria.
Schlotmann et al. (2000)CTLA-4T lymphocytesIn patients with malaria, CTLA-4 expression by CD4 alphabeta T lymphocytes was highly increased.
Mäurer et al. (2002)CTLA4T-cellFACS analysis of CTLA4 expression revealed a reduced up-regulation of CTLA4 from G/G donors upon T-cell activation, if compared with wild-type cells.
Magistrelli et al. (1999)CTLA-4T cellsA soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells.
Magistrelli et al. (1999)CTLA-4T cellsCTLA-4, expressed by activated T cells, transduces an inhibitory signal.
Magistrelli et al. (1999)CTLA-4 mRNAT cellsActivation of T cells with phorbol 12-myristate 13-acetate plus ionomycin or anti-CD3 plus anti-CD28 monoclonal antibodies induces a suppression of CTLA-4delTM mRNA expression associated with a preferential expression of the membrane CTLA-4 mRNA, showing that CTLA-4delTM mRNA expression is restricted to nonactivated T cells.
Magistrelli et al. (1999)CTLA-4T cellsThese results suggest that nonstimulated T cells may constitutively produce a soluble form of CTLA-4 which may have an important role in the regulation of immune homeostasis.
Xu et al. (2002)CTLA-4T cellsWe have explored the functional mechanisms of CTLA-4 by means of recombinant human CTLA-4 expressed on transfected Jurkat T cells.
Braun et al. (2003)CTLA-4T cellsTherefore, we measured PCT plasma levels and CTLA-4 expression by T cells in four groups of children from the Ashanti Region in Ghana: asymptomatic children with or without parasitaemia, children with uncomplicated P. falciparum malaria and children with severe disease.
Braun et al. (2003)CTLA-4T cellThe data from this study support the hypothesis that strong T cell activation as measured here by CTLA-4 expression is not just the by-product of a high parasite burden, but that it contributes to the pathogenesis of P. falciparum malaria.
Schott et al. (2007)CTLA4T lymphocytesBACKGROUND: CTLA4 is an inhibitory receptor expressed on a subset of T lymphocytes.
Carreno et al. (2000)CTLA-4T cellWe assessed the contributions of these two mechanisms using a panel of T cell lines expressing human CTLA-4 with mutations in the cytoplasmic region.
Carreno et al. (2000)CTLA-4T cellThus, CTLA-4 down-regulates T cell activation by two different mechanisms-delivery of a negative signal or B7 sequestration-that are operational depending on the levels of CTLA-4 surface expression.
Kouki et al. (2000)CTLA-4T cellCTLA-4, expressed on activated T cells, binds to B7 present on APCs and functions as a negative regulator of T cell activation.
Kavanagh et al. (2008)CTLA4T cellsCTLA4 is constitutively expressed on regulatory CD4(+) T cells (Tregs), but its role in these cells remains unclear.
Vendetti et al. (2002)CD152T lymphocytesIn addition, we found that the Ca(2+) ionophore ionomycin also up-regulates CD152, and that the combination of a cAMP analog or cAMP inducers with ionomycin further enhances the expression of CD152 in resting CD4(+) T lymphocytes.
Vendetti et al. (2002)CTLA-4 geneT cellThese findings demonstrate that at least two novel signal pathways regulate CTLA-4 gene expression and CD152 molecule up-regulation in human CD4(+) T lymphocytes, in the absence of full T cell activation.
Vandenborre et al. (1998)CTLA-4T lymphocytesHuman CTLA-4 is expressed in situ on T lymphocytes in germinal centers, in cutaneous graft-versus-host disease, and in Hodgkin's disease.
Vandenborre et al. (1998)CD152T cellsCytotoxic T-lymphocyte-associated antigen-4 (CTLA-4, CD152) is a molecule expressed on in vitro activated T cells.
Vandenborre et al. (1998)CTLA-4T cellsAs revealed in this study, CTLA-4 is expressed on thymocytes in thymic medulla, on a subset of CD4+ T lymphocytes in germinal centers of follicular hyperplasia, on T cells, mainly CD8+, infiltrating skin affected by graft-versus-host disease, and on T cells, mainly CD4+, infiltrating Hodgkin's disease lesions.
Vandenborre et al. (1998)CTLA-4T-cellInterestingly, no or at most scarce expression of CTLA-4 was found in granulomatous lymph nodes, T-cell-mediated inflammatory diseases, or non-Hodgkin's lymphomas, regardless of their expression of CD80 or CD86.
Maszyna et al. (2003)CD152T lymphocytesDiversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated individual T lymphocytes.
Maszyna et al. (2003)CD152T cellsIn this study, we use magnetofluorescent liposomes for the immunofluorescent detection of surface CD152-expressing CD4(+) T cells and show that, despite the fact that nearly all cells express intracellular CD152, only a fraction of 12% of activated T cells expresses surface CD152 at any given time point.
Maszyna et al. (2003)CD152T cellSurface expression of CD152 is independent of the proliferative history of an activated T cell.
Maszyna et al. (2003)CD152T cellsInstruction of T cells for surface expression of CD152 rather depends on the time elapsed since the onset of activation, with a maximum at 48 h, and requires less than 12 h of Ag exposure.
Wang et al. (2001)CTLA-4T cellsRegulation of surface and intracellular expression of CTLA-4 on human peripheral T cells.
Wang et al. (2001)CTLA-4T cellsIn order to analyze the expression and regulation of CTLA-4 on human peripheral T cells, CTLA-4 mRNA and protein expression were determined using analysis by reverse transcription-polymerase chain reaction (RT-PCR) and FACs, respectively.
Wang et al. (2001)CTLA-4T cellsIntracellular CTLA-4 was constitutively expressed in unstimulated CD4+ and CD8+ T cells.
Wang et al. (2001)CTLA-4T cellsGiven an inhibitory role of CTLA-4 and CD4+ CD25+ T cells in immune responses, the present findings suggest that IL-2-induced immunosuppression may result from its stimulatory effect of the CTLA-4 expression.
Scalapino and Daikh (2008)CTLA-4T cellsCTLA-4 expression is induced on the surface of T cells after they have received a costimulatory signal from antigen-presenting cells (APCs) via engagement of CD28 on the T-cell surface.
Kucharska et al. (2009)CTLA-4T cellsThe aim of the present study was to investigate surface expression of CTLA-4 on peripheral T cells in homozygotes AA and GG at position +49 of CTLA-4 gene in children with Hashimoto's thyroiditis and in healthy controls.
Kucharska et al. (2009)CTLA-4T cellsWe therefore conclude that decreased expression of CTLA-4 on T cells in children with Hashimoto's thyroiditis is not dependent on polymorphic changes at position +49 of CTLA-4 gene.
Su et al. (2007)CTLA-4T-cellCytotoxic T-lymphocyte antigen-4 (CTLA-4) is a molecule expressed mainly on activated T cells and is important in the down-regulation of T-cell activation.
Castan et al. (1997)CTLA-4T cellsCTLA-4, a coreceptor with sequence homology to CD28 is expressed on T cells after activation.
Lindsten et al. (1993)CTLA-4T cellsCharacterization of CTLA-4 structure and expression on human T cells.
Lindsten et al. (1993)CTLA-4T cellsCTLA-4 is an adhesion receptor expressed on activated T cells.
Lindsten et al. (1993)CTLA-4T cellsIn a recent study we found that CD28 and CTLA-4 were coexpressed at the mRNA level on activated T cells but that only CD28 was expressed on resting T cells.
Lindsten et al. (1993)CTLA-4T cellsHere we show that within the T cell population, CTLA-4 expression is restricted to the subset of T cells that also express cell surface CD28.
Lindsten et al. (1993)CTLA-4 mRNAT cellsCTLA-4 mRNA expression can be induced on quiescent T cells via phorbol ester-mediated activation of protein kinase C but not with calcium ionophore treatment alone.
Soylemezoglu et al. (2008)CTLA-4T cellsCytotoxic T lymphocyte-associated protein 4 (CTLA-4) is expressed on activated T cells, and, thus, it is critically involved in the immune response.
Robinson et al. (2004)CTLA-4T cellsCytotoxic T Lymphocyte-associated antigen 4 (CTLA-4) is an important costimultory receptor expressed on activated T cells.
Greve et al. (2008)CTLA-4T cellNo association of CT60 genotypes with T cell expression of ICOS and CTLA-4 after in vitro stimulation was detected.
Gibson et al. (2007)CTLA-4T cellsCTLA-4 expression, while inducible in most T cells, is expressed constitutively on T cells with a regulatory phenotype.
Gibson et al. (2007)CTLA-4T cellsThe mechanism controlling CTLA-4 expression in human T cells is poorly characterized, thus we sought to better understand the mechanism of activation of the CTLA-4 gene.
Zheng et al. (2008)CTLA-4T cellsAcquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.
Zheng et al. (2008)CTLA-4T cellsBy separating the expression of CTLA-4 and FoxP3, our data show that FoxP3 expression alone is insufficient to up-regulate CTLA-4; however, activation of CD4(+)CD25(-) T cells can induce both FoxP3 and CTLA-4 in a subpopulation of T cells that are capable of suppression.
Zheng et al. (2008)CTLA-4T cellsThese data suggest that the acquisition of suppressive behavior by activated CD4(+)CD25(-) T cells requires the expression of CTLA-4, a feature that appears to be facilitated by, but is not dependent on, expression of FoxP3.
Fong et al. (2009)CTLA4T cellsCTL-associated antigen 4 (CTLA4) is a costimulatory molecule expressed on activated T cells that delivers an inhibitory signal to these T cells.
Manzotti et al. (2002)CTLA-4T cellThe kinetics of CD80-CTLA-4 interactions revealed that CTLA-4 inhibition took place within the first 8 h of T cell stimulation, despite there being little measurable CTLA-4 expression on the majority T cells.
Thompson et al. (2006)CTLA-4T-cellT-cell expression of CTLA-4 indirectly facilitates tumor progression by restraining host antitumoral immunity.
Liu et al. (1999)CTLA-4T lymphocytesIncreased expression of down-regulatory CTLA-4 molecule on T lymphocytes from rheumatoid synovial compartment.
Liu et al. (1999)CTLA-4T cellsSince the CTLA-4 molecule expressed on activated T lymphocytes has recently been suggested to be an important negative regulator in autoimmune diseases, this study was undertaken to investigate the expression and function of CTLA-4 on synovial T cells from patients with rheumatoid arthritis.
Liu et al. (1999)CTLA-4T cellsOnly a small percentage of peripheral blood T cells from patients with rheumatoid arthritis had detectable surface CTLA-4 expression (mean +/- SD, 1. 89 +/- 1.92%).
Liu et al. (1999)CTLA-4T cellsWe thus concluded that CTLA-4 was up-regulated on synovial T cells from patients with RA, and the increased CTLA-4 expression might exert a down-regulation effect on tumour necrosis factor alpha and interleukin 1beta production.
Blansfield et al. (2005)CTLA-4T cellsCytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells and resting CD4CD25 T cells.
Matsubara et al. (2003)CTLA-4T cellsWe determined the intracellular expression of CTLA-4 in T cells by flow cytometry.
Matsubara et al. (2003)CTLA-4T cellsWe demonstrated that the intracellular expression of CTLA-4 is up-regulated in peripheral blood CD3+ T cells, CD4+ T cells and CD8+ T cells at the early part of the acute stage in KD.
Matsubara et al. (2003)CTLA-4T cellsHowever, the mean percentages of intracellular T cells expressing CTLA-4 in EBV-IM patients were about fourfold higher than those in T cells from patients with acute KD.
Jiang et al. (2006)CTLA-4T cellCytotoxic T lymphocyte associated antigen-4 (CTLA-4), expressed mainly in activated T cells, inhibits T cell activation and proliferation by combining B7 through competing CD28 and maintains immune homeostasis.
Jago et al. (2004)CTLA-4T cellDifferential expression of CTLA-4 among T cell subsets.
Jago et al. (2004)CTLA-4T cellAlthough some studies have investigated CTLA-4 expression on CD4(+) T cells, evidence is lacking regarding the kinetics of expression, and expression on T cell subpopulations.
Jago et al. (2004)CTLA-4T cellsOn naïve and CD4(+)CD25(-) T cells, CTLA-4 expression declined after four hours.
Genant et al. (2008)CTLA-4T cellEndogenous down-regulation of CD28-mediated T cell co-stimulation occurs through T cell expression of cytotoxic T lymphocyte antigen 4 (CTLA-4).
Yang et al. (2006)CD152T cellsRESULTS: Compared to the control groups, the positive rates of CD56+, CD57+, CD161+ cells in the livers of those with chronic hepatitis C sharply decreased (Probability value less than 0.01), and CD56+T cells had decreased mildly; CD28 from the CD56+T cells decreased mildly, but the expression of CD152 increased (P<0.05); the positive rates of CD83+CD1a+ cells had decreased mildly, and the positive rates of CD80+CD11c+ and the CD86+CD11c+ cells significantly decreased (P<0.01).
Favali et al. (2005)CTLA4T cellsNo alteration was detected on either TGF-beta production or the expression of CTLA44 or CD25 on CD4+ and CD8+ T cells.
Zhang et al. (2003)CTLA-4T cellTheir interactions with CD28/CTLA-4 receptors expressed on T cell surfaces are crucial for the proper regulation of T cell activity.
Wiendl et al. (2003)ICOST cellThis observation was paralleled by an augmented expression of the T cell activation markers CD25, ICOS, and CD69, thus showing B7-H1-mediated inhibition of T cell activation.
Trzonkowski et al. (2002)CD152T-cellThe aim of the study was to examine changes in CD4(+) and CD8(+) T-cell subpopulations, the expression of the inhibitory molecule, CD152 on T lymphocytes and the levels of interleukins (IL) 2, 6, 10, 12 and tumour necrosis factor alpha (TNF alpha) in primary glomerulonephritis chronic haemodialysis (HD) patients before and under rHuEpo treatment.
Holt and Thomas (1997)CTLA4T-cellAssociated GM-CSF-induced up-regulation of major histocompatability complex (MHC) class II and CTLA4 ligand expression by DC were also unaffected by dexamethasone phosphate (DX), reinforcing the view that the inhibitory effects of steroids on the T-cell activating functions of DC are restricted to steps upstream from presentation of processed antigen to the T-cell receptor (TCR).
Raué and Slifka (2007)CTLA-4T cellsPrevious studies have shown that T cells, which are genetically deficient in CTLA-4/CD152 expression, will proliferate uncontrollably, resulting in lethal autoimmune disease.
Raué and Slifka (2007)CTLA-4T cellsIn contrast to expectations, BrdU incorporation experiments demonstrated that CTLA-4 expression was associated with normal or even enhanced in vivo proliferation of virus-specific CD4+ and CD8+ T cells following acute lymphocytic choriomeningitis virus or vaccinia virus infection.
Ligers et al. (2001)CTLA-4T cellsCTLA-4, expressed mainly on activated T cells, helps maintain, through its inhibitory function, immune-system homeostasis.
Morton et al. (1996)CTLA-4T cellsCTLA-4 expressed on activated T cells binds to CD80 (B7-1) and CD86 (B7-2) molecules present on APC with high avidity and appears to deliver a negative regulatory signal to the T cell.
Hryniewicz et al. (2006)CTLA-4T cellsRegulatory T (T(reg)) cells are a subset of CD25(+)CD4(+) T cells that constitutively express high levels of cytotoxic T lymphocyte antigen-4 (CTLA-4) and suppress T-cell activation and effector functions.
Jonson et al. (2006)CTLA-4T cellsLower percentages of CD4+ T cells (P = 0.03) and CD4+ CD25high cells (P = 0.06) expressing intracellular CTLA-4 were detected in samples from children with CTLA-4 +49GG compared to children with the +49AA genotype.
Lazetic et al. (2002)CTLA-4BPT cellsIn addition, co-stimulation of purified human T cells was significantly suppressed when CTLA-4BP was cotransfected with either CD80 or CD28BP.
Handa et al. (2003)CTLA-4T-cellsCytotoxic T-lymphocyte antigen-4 (CTLA-4) is a negative regulator of T-cell activation expressed on activated T-cells.
Homann et al. (2006)CTLA-4T-cellLack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.
Homann et al. (2006)CTLA-4T cellsThus, lack of CTLA-4 expression by antigen-specific T cells can be compensated for by extrinsic factors in the presence of CTLA-4 expression by other cells.
Wang et al. (2002)CTLA-4T cellsAbnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence.
Wang et al. (2002)CTLA-4T cellsThe aberrant CTLA-4 expression is characterized by low surface and intracellular levels of CTLA-4 protein, impaired up-regulation of CTLA-4 in T cells in response to ConA stimulation and high levels of soluble CTLA-4 (sCTLA-4) in serum.
Pietrella et al. (2001)CTLA-4T cellsThe kinetics of cytotoxic T lymphocyte antigen 4 (CTLA-4) expression on T cells responding to Cryptococcus neoformans and its role in regulating the T-cell response were examined.