Viewing affirmative mentions of gene expression of CCR5 (H. sapiens) in T cells

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Zimmermann et al. (2010)CCR5T-cellLow expression of chemokine receptor CCR5 in human colorectal cancer correlates with lymphatic dissemination and reduced CD8+ T-cell infiltration.
Zimmermann et al. (2010)CCR5T cellsInfiltration of tumor margins with CD8(+) T cells in the context of CCR5 expression was analyzed by immunohistochemistry in additional 18 colorectal cancer specimens.
Zimmermann et al. (2010)CCR5T-cellIn addition, CCR5 expression positively correlated with CD8(+) T-cell infiltration in tumor margins (P=0.001).
Zimmermann et al. (2010)CCR5T-cellCONCLUSION: In summary, intermediate and strong CCR5 expression was significantly associated with nonmetastatic colorectal cancer and increased CD8(+) T-cell infiltration.
Pastore et al. (2003)CCR5T-cellWe have investigated the inhibitory mechanism of three N-terminally modified RANTES variants (AOP-, NNY-, and PSC-RANTES) with the MT-2 human T-cell line stably expressing either native or mutated CCR5.
Luis Abad et al. (2003)CCR5T cellsWhen expressed by retroviral transduction, some of these molecules significantly inhibited CCR5-dependent chemotaxis in the MCF-7 cell line and reduced CCR5 expression and HIV-1 infection in human T cells.
Desmetz et al. (2006)CCR5T cellFinally, we observed in healthy donors a correlation between the chemotactic response of peripheral blood CD8(+) T cell to CCL5 and their level of surface CCR5 expression.
Shioda et al. (2001)CCR5T cellsPeripheral blood CD4(+) T cells obtained from individuals heterozygous for this allele expressed very low levels of CCR5.
Follis et al. (1998)CCR5T-cellThat the TCLA virus can continue to utilize CCR5 despite the changes that occur upon adaptation and in the apparent absence of CCR5 expression in the FDA/H9 T-cell line suggests that the interaction between envelope protein and coreceptor may be mediated by multiple weak interactions along a diffuse surface.
Simmons et al. (1996)CCR5T-cellInfection of cat CCC/CD4 cells transiently expressing Lestr supported infection by T-cell line-adapted strains including LAI, whereas CCC/CD4 cells expressing CCR5 were sensitive to primary non-SI strains as well as to the molecularly cloned strains SF-162 and JR-CSF.
Amara et al. (2003)CCR5T lymphocytesUsing lentiviral vectors, we restored CCR5 expression in T lymphocytes and macrophages from individuals carrying the homozygous 32-bp deletion of the CCR5 gene (ccr5 Delta32/Delta32).
Schröder et al. (2007)CCR5T cellsPharmacologic antagonism of CCR5, a chemokine receptor expressed on macrophages and activated T cells, is an effective antiviral therapy in patients with macrophage-tropic HIV infection, but its efficacy in modulating inflammation and immunity is only just beginning to be investigated.
Mummidi et al. (2007)CCR5T cellsProduction of specific mRNA transcripts, usage of an alternate promoter, and octamer-binding transcription factors influence the surface expression levels of the HIV coreceptor CCR5 on primary T cells.
Mummidi et al. (2007)CCR5T cellsIn this study, we show that the increased cell surface expression of CCR5 on primary T cells is associated with selective enrichment of exon 1-containing transcripts.
Saba et al. (2010)CCR5T cellsWe found that virtually all T cells are of the effector memory phenotype with broad CC chemokine receptor 5 (CCR5) expression.
Kourtis et al. (2007)CCR5T cellsRESULTS: In uninfected women, 44%-78% of breast milk CD4(+) T cells expressed the C chemokine receptor 5 (CCR5), whereas 26%-73% of cells coexpressed CCR5 and CXC chemokine receptor 4 (CXCR4).
Kourtis et al. (2007)CCR5T cellsIn contrast, only 7%-20% of peripheral blood CD4(+) T cells expressed CCR5 and 1%-20% coexpressed CCR5 and CXCR4.
Kourtis et al. (2007)CCR5T cellsThe level of CCR5 expression in CD4(+) T cells in breast milk was higher than in blood.
Kourtis et al. (2007)CCR5T cellsCONCLUSIONS: A majority of CD4(+) T cells in breast milk express high levels of CCR5 and CXCR4.
Camargo et al. (2009)CCR5T lymphocyteCCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation.
Camargo et al. (2009)CCR5T cellsConversely, overexpression of CCR5 in human T cells results in enhanced IL-2 production.
Camargo et al. (2009)CCR5T cellsHere, we show that compared with CCR5(+/+), T cells from CCR5(-/-) mice secrete lower amounts of IL-2, and a similar phenotype is observed in humans who lack CCR5 expression (CCR5-Delta32/Delta32 homozygotes) as well as after Ab-mediated blockade of CCR5 in human T cells genetically intact for CCR5 expression.
Camargo et al. (2009)CCR5T cellHowever, the full impact of CCR5 expression on T cell responses remains unknown.
Camargo et al. (2009)CCR5T cellAccordingly, CCR5 expression also promoted IL-2-dependent events, including CD25 expression, STAT5 phosphorylation, and T cell proliferation.
Bendz et al. (2008)CCR5T cellThese results refute the hypothesis that mycHsp70 proteins require CCR5 expression and calcium signaling by APCs for enhanced antigen cross-presentation for T cell stimulation.
Yang et al. (2001)CCR5T cellsIL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4+ and CD8+ T cells.
Yang et al. (2001)CCR5T cellsLong-term (8-day) stimulation of PBMC with IL-2 resulted in high levels of CCR5 expression on T cells.
Yang et al. (2001)CCR5T cellsHowever, these TCR-triggered T cells expressed much higher levels of CCR5 when stimulated with IL-12.
Yang et al. (2001)CCR5T cellsThese results indicate that, in addition to IL-2, IL-12 plays an important role in the induction of CCR5 expression on T cells, particularly TCR-triggered T cells.
Grivel et al. (2001)CCR5T-cellFurthermore, we demonstrate that HHV-6 increases the production of the CCR5 ligand RANTES ('regulated upon activation, normal T-cell expressed and secreted'), the most potent HIV-inhibitory CC chemokine, and that exogenous RANTES mimics the effects of HHV-6 on HIV-1, providing a mechanism for the selective blockade of CCR5-tropic HIV-1.
Dubey et al. (2008)CCR5T cellTransfection of the T cell line CEM-CCR5 (which expresses CD4, CCR5 and CXCR4) with HIV-1 Nef or Vpu expression vectors, or treatment with recombinant soluble gp120 from CCR5- and CXCR4-tropic HIV-1, was carried out to determine their effects on co-receptor expression.
Sundrud et al. (2005)CCR5T cellsTranscription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells.
Sundrud et al. (2005)CCR5T cellsImportantly, decoding the mechanisms of GATA-1-mediated repression of CCR5 may offer an opportunity to develop novel approaches to inhibit CCR5 expression in T cells.
Isik et al. (2008)CCR5T cellCXCR4 and CCR5 are expressed on the surface of T lymphocytes and, during T cell activation, are both recruited to the immunological synapse (IS).
Inston et al. (2007)CCR5T-cellMATERIALS AND METHODS: Using a whole-blood red-cell lysis fluorescence-activated cell sorter, serial expressions of CXCR3 and CCR5 on T-cell subsets were analyzed in 19 human renal transplant recipients following transplant.
Inston et al. (2007)CCR5T cellsCONCLUSIONS: During allograft rejection, expression of CXCR3, but not CCR5, increases on peripheral CD4+ T cells prior to clinical evidence of allograft rejection and remains elevated for more than 2 weeks following transplantation.
Soares et al. (2006)CCR5T cellsHere we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion.
Odum et al. (1999)CCR5T-cellThese results were similar to those obtained from alloantigen specific CD4+ T-cell lines derived from CCR5 expressing individuals.
Turner et al. (2007)CCR5T cellsCXCR3 and CCR5 are chemokine receptor that are predominantly expressed on the surface of Th1 polarized T cells.
Turner et al. (2007)CCR5T cellIn a variety of human and experimental autoimmune diseases the enhanced expression of CXCR3 and CCR5 binding chemokine ligands is followed by the recruitment of CXCR3- and CCR5-positive T cells, indicating an important role for these chemokine receptors in T cell-mediated tissue damage.
Krauss-Etschmann et al. (2003)CCR5T cellsCalculations indicated that the majority of gastric T cells express CCR5; this finding is in contrast to the low percentage of CCR5(+) T cells in the peripheral circulation.
Anton et al. (2000)CCR5T lymphocytesThe percentage of mucosal CD4 T lymphocytes that expressed CCR5 and the per cell expression of CCR5 were both significantly increased compared with that in peripheral blood CD4 T lymphocytes.
Roy et al. (2005)CCR5T cellsInterestingly, even though CCR5 is expressed on far fewer T cells than is CXCR4, many patients in early- and late-stage HIV disease maintain high levels of CCR5-tropic (R5) viruses.
Moriuchi and Moriuchi (2003)CCR5T cellsExpression of CCR5, a major coreceptor for HIV, was enhanced on CD4+ T cells from patients with acute EBV infection.
Moriuchi and Moriuchi (2003)CCR5T cellsEBV effects on CCR5 expression on or susceptibility to R5-HIV-1 of CD4+ T cells did not require coinfection of the same cell with the two viruses, because CD4+ T cells from patients with acute EBV infection were not infected with EBV.
Moriuchi and Moriuchi (2001)CCR5T cellT cell activation can induce expression of CCR5, a major coreceptor for macrophage-tropic (R5) human immunodeficiency virus type 1 (HIV-1).
Moriuchi and Moriuchi (2001)CCR5T cellsThese results suggest that octamer transcription factors may play a critical role in the induction of CCR5 expression on, and thereby susceptibility to, R5 HIV-1 of T cells following antigenic stimulation.
Belmonte et al. (2001)CCR5T lymphocytesExpression of CCR5 on both CD4+ and CD8+ T lymphocytes was reduced after 7 days and remained low throughout the culture.
Kato et al. (1999)CCR5T-cellThese chimeric viruses were employed in virus infectivity assays using HOS-CD4 cells expressing either CCR5 or CXCR4, peripheral blood mononuclear cells, T-cell lines, or macrophages.
Goddard et al. (2001)CCR5T-cellAn in vitro model of T-cell alloactivation demonstrated a similar pattern of expression of functional CXCR3, CXCR4, and CCR5 on T cells.
Kopetzki et al. (2008)CCR5T-cellsOnly a small subset of CD4(+) T-cells express CCR5, while most CD4(+) T-cells express CXCR4 [23,24].
Kopetzki et al. (2008)CCR5T-cellsT-2635 protected CD4(+) T-cells from NL4-3-induced depletion, independent of the CCR5 expression.
Kopetzki et al. (2008)CCR5T-cellsExpression of CCR5 on the CD4(+) T-cell population of PBMC is limited to a small subset of cells, whereas CXCR4 is expressed on most of the CD4(+) T-cells [23,24].
Sáez-Cirión et al. (2006)CCR5T cellsReduced in vitro susceptibility to HIV-1 R5 of EU CD4 T cells bearing wild-type CCR5 has been linked to low CCR5 expression on the target cell surface and/or to increased secretion of natural CCR5 ligands – the ?
Hill et al. (1998)CCR5T cellsViral Env utilization of CCR5 expressed on 293-T cells does not always correlate with the cellular tropism of the virus, and one possible explanation is that Env-accessible interaction sites on CCR5 differ on different cell types.
Juffermans et al. (2000)CCR5T cellsThe effect of thalidomide on CXCR4 and CCR5 expression on CD4+ T cells was determined.
Juffermans et al. (2000)CCR5T cellsThalidomide may be beneficial in the treatment of intercurrent infections during HIV infection by reducing the up-regulation of CXCR4 and CCR5 expression on CD4+ T cells induced by bacterial and mycobacterial antigens, by a mechanism that involves inhibition of TNF-alpha.
Prakash et al. (2002)CCR5T lymphocytesThe level of cervical CCR5 expression per cell was shown to increase on both activated CD4(+) (CD69(+), P<0.05; HLA-DR(+), P<0.01) and CD8(+) (CD69(+), P<0.05; HLA-DR(+), P<0.05) T lymphocytes compared with COC use.
Prakash et al. (2002)CCR5T lymphocytesThese data show that with COC use, the expression of CCR5 on CD4(+) T lymphocytes is increased.
Bleul et al. (1997)CCR5T lymphocytesThe HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes.
Bleul et al. (1997)CCR5T cellCCR5 expression, however, showed only a gradual increase over 12 days of culture with interleukin 2, while T cell activation with phytohemagglutinin was ineffective.
Jin et al. (2008)CCR5T-cellTo analyse the protective effects of long-term expression of the CCR5Delta32 protein, recombinant lentiviral vectors were used to deliver the CCR5Delta32 gene into human cell lines and primary peripheral blood mononuclear cells that had been immortalized by human T-cell leukemia virus type 1.
Jin et al. (2008)CCR5T lymphocytesIt was shown that CD4(+) T lymphocytes expressing the lentivirus-encoded CCR5Delta32 gene were highly resistant to infection by a primary but not by a laboratory-adapted X4 strain, suggesting different infectivity requirements.
Vella et al. (1999)CCR5T-cellsEnhanced replication of M-tropic HIV-1 strains in Herpesvirus saimiri immortalised T-cells which express CCR5.
Vella et al. (1999)CCR5T-cellsPhenotypic analysis showed that HVS T-cells are CD4+-activated memory cells expressing both CXCR-4 and CCR5 co receptors.
Riddick et al. (2010)CCR5T cellsThe restricted expression of CCR5 mainly on memory CD4+ T cells, but broader expression of CXCR4 on both memory and naïve subsets, is thought in part to underlie the accelerated disease progression seen in individuals in whom CXCR4-using HIV-1 variants emerge late in the course of infection [13], [14], [15], [16].
Riddick et al. (2010)CCR5T cellsSooty mangabeys express very low levels of CCR5 on their CD4+ T cells, a mechanism by which replication might be regulated in vivo and restrict transmission and pathogenesis [17], [18].
Riddick et al. (2010)CCR5T cellsNotably, however, the proportion of CD4+ T cells depleted and/or infected at a given time in macaques and mangabeys may exceed the proportion of cells with detectable CCR5 expression, raising the possibility that other pathways in addition to CCR5 might be utilized [23], [24].
Riddick et al. (2010)CCR5T cells2 genotype acts as a determinant of CCR5 expression on CD8+ T cells.
Riddick et al. (2010)CCR5T cellsSooty mangabeys overall express very low levels of CCR5 on CD4+ T cells, which has been proposed as an evolutionary adaptive response to “protect” critical target cells and minimize pathogenesis [17], [18].
Riddick et al. (2010)CCR5T cellInterestingly, CXCR6 expression is regulated by T cell activation in a pattern that is tightly linked with CCR5 expression in response to some stimuli, but markedly different in response to others [59].
Juffermans et al. (2001)CCR5T cellsPatients with active tuberculosis have increased expression of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells.
Juffermans et al. (2001)CCR5T cellsExpression of human immunodeficiency virus (HIV) coreceptors CXCR4 and CCR5 was found to be elevated on CD4(+) T cells (1) in blood samples obtained from patients with tuberculosis and (2) in blood samples obtained from healthy subjects and stimulated with mycobacterial lipoarabinomannan in vitro.
Zhong et al. (2004)CCR5T cellsPriming of L. monocytogenes-specific CD8 T cells also occured independently of CCR5 expression.
Zaunders et al. (2003)CCR5T cellIncreased expression of Ki-67 and CCR5 ex vivo, as well as increased apoptosis, was seen in all T cell receptor beta-chain variable region (TCRBV) subfamilies studied.
Singer et al. (2001)CCR5T cellsSurprisingly, CCR5, CXCR4, and CD4 were found predominantly on microvilli and appeared to form homogeneous microclusters in all cell types examined, including macrophages and T cells.
Weissman et al. (2000)CCR5T cellsAdministration of IL-2 led to transient up-regulation of CCR5 on CD4+ T cells; up to 87% of CD4+ cells expressed CCR5 after a 5-day cycle, with return to baseline levels within 2 weeks.
Weissman et al. (2000)CCR5T cellsUnlike in vitro studies, CCR5 was coexpressed with CD45RA and CXCR4 on CD4+ T cells after IL-2 therapy.
Oswald-Richter et al. (2007)CCR5T cellIdentification of a CCR5-expressing T cell subset that is resistant to R5-tropic HIV infection.
Veazey et al. (2003)CCR5T cellsVaginal CD4+ T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection.
Veazey et al. (2003)CCR5T cellsIn mature female macaques, 54%-67% of the vaginal CD4(+) T cells expressed C chemokine receptor 5 (CCR5), whereas 84%-99% coexpressed CXC chemokine receptor 4.
Veazey et al. (2003)CCR5T cellsIn contrast, only 4.4%-14.8% of peripheral blood and 2.4%-13% of lymph-node CD4(+) T cells coexpressed CCR5.
Veazey et al. (2003)CCR5T cellsThis demonstrates that large numbers of CD4(+) T cells expressing high levels of CCR5 reside within the vagina and that these cells are preferentially targeted for elimination by SIV infection.
Cavarelli et al. (2008)CCR5T cellsIn neonates the memory CD4+ T cells, which express high levels of CCR5, are 6–7 times less represented than the naïve CD4+ cells [26].
Nabatov et al. (2007)CCR5T lymphocytesStatins disrupt CCR5 and RANTES expression levels in CD4(+) T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1.
Heredia et al. (2007)CCR5T cellsAt present, however, the role that CCR5 levels on primary CD4 T cells--which are markedly lower than in cell lines and vary only approximately fivefold among most donors--may play in virus replication levels or susceptibility to T-20 is not known.
Blanco et al. (2004)CCR5T cellsR5 HIV gp120-mediated cellular contacts induce the death of single CCR5-expressing CD4 T cells by a gp41-dependent mechanism.
Maier et al. (2000)CCR5T lymphocytesTo mimic physiologic conditions, highly purified primary Staphylococcus enterotoxin B (SEB)-reactive CD4 T lymphocytes were stimulated in the presence of autologous antigen-presenting cells and the kinetics of CCR5 and CXCR4 surface expression and HIV replication were studied.
Hladik et al. (2007)CCR5T cellsWithin 1 hr of surgical removal of the vaginal mucosa, before suction blistering or EDTA treatment, CCR5 was expressed by the majority of intraepithelial CD3+ T cells (83.6% in each of two donors; not shown) and CD1a+ LC (53.8%, 63.4%, and 73% in three donors; Figure S1A).
Hladik et al. (2007)CCR5T cellsAfter suction blistering, 71.6% (mean, range 49.7%–97.0%) of CD3+ T cells expressed CCR5 in cell suspensions generated by mechanical dispersion of epithelial sheets in three tissue donors (not shown).
Hladik et al. (2007)CCR5T cellsOf CD3+ T cells isolated from EDTA-separated sheets in three additional donors, 78.9% (mean, range 56.1%–95.1%) expressed CCR5, and 27.3% (mean, range 12.6%–54.4%) expressed CD4 (Figure S1B).
Hladik et al. (2007)CCR5T cellsThe majority (77%) of intraepithelial CD4+ T cells expressed CCR5, and LC commonly expressed CD4 (54%) and CCR5 (52%).
Hladik et al. (2007)CCR5T cellsOur findings were distinct from those previously reported, which failed to detect such high CCR5 expression on intraepithelial T cells and LC in the human vagina (Jameson et al., 2002; Rottman et al., 1997; Zhang et al., 1998).