Viewing affirmative mentions of localization of CD8A (H. sapiens) in T cells

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Chakraborty and Mukherji (1998)CD8T cellsUnfortunately, tumor antigen-specific, noncytolytic but type I cytokine-secreting CD8+ T cells have not received much investigative attention.
Larsson et al. (2001)CD8T cellsThe responding CD8(+) T cells secreted IL-2 and IFN-gamma, proliferated and developed into cytotoxic effectors.
Pal et al. (1997)CD8T lymphocytesCD8(+) T lymphocytes from individuals infected with human immunodeficiency virus-type 1 (HIV-1) secrete a soluble activity that suppresses infection by HIV-1.
Tsukada et al. (1991)sCD8T cellsWe evaluated the presence of soluble (s) CD4 and sCD8, released from activated T cells, in the sera of patients with multiple sclerosis (MS) and human T lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM) using an enzyme-linked immunosorbent assay (ELISA).
Rathmann et al. (2004)CD8T cellTo address the role of CD81 T cells we performed a pilot study by investigating CD8(+) T cell-mediated cytokine secretion after in vitro stimulation with 94 preproinsulin (PPI) peptides.
Geiben-Lynn et al. (2001)CD8T lymphocytesKinetic studies revealed that secreted suppressive activities of HIV-1-specific CTL and bulk CD8(+) T lymphocytes from all HIV-1-infected persons are significantly higher than that of supernatants from seronegative controls.
Maimone and Reder (1991)CD8T-lymphocyteCD8 is released in a soluble form upon T-lymphocyte activation.
Tomkinson et al. (1989)CD8T cellIn vitro, PHA or anti-CD3 mAb-mediated T cell activation led to release of CD8 into the culture supernatant.
Tomkinson et al. (1989)CD8T cellsThese data suggest that released CD8 may be of value in monitoring the involvement of CD8+ T cells in response to a pathologic event.
Schmitt et al. (2009)CD8T cellsAddition of different amounts of peptide (10-80 microg) to a mixed lymphocyte peptide culture (MLPC) resulted in the generation of interferon (IFN) gamma and granzyme B releasing CD8(+) CMV tetramer(+) T cells in a dose dependent manner.
Mayrhofer et al. (2009)CD8T cellsUnlike the whole-virus vaccine, the dVV-HA5 vaccine induced substantial amounts of gamma interferon-secreting CD8 T cells.
Lohman-Payne et al. (2009)CD8T lymphocyteWe investigated the kinetics of HIV-1-specific CD8(+) T lymphocyte secretion of interferon (IFN)-gamma in infants infected before 1 month of life compared with those infected between months 1 and 12 (late infection).
Dorn et al. (2008)CD8T-cellThis was evidenced by IFN-gamma secretion of an expanded MUC1-specific CD8(+) T-cell pool.
Khanna and Lefrançois (2008)CD8T cellHere, we provide a brief overview of studies examining CD8 T cell localization during the immune response to infection in the context of our current understanding of immune system structure.
Gahery et al. (2007)CD8T cellsThese cells are Nef-specific CD4(+) and CD4(+) CD8(+) T cells secreting IL-2/INF-gamma or IL-2 alone.
Hoelscher et al. (2006)CD8T cellsUnlike the recombinant H5HA vaccine, which is based on a traditional subunit vaccine approach, HAd-H5HA vaccine induced a three-fold to eight-fold increase in HA-518-epitope-specific interferon-gamma-secreting CD8 T cells (p=0.01).
Eshofonie et al. (2006)CD8T cellsThe sensitivity of the rVV-based ELISPOT assay was on average 1.25 interferon (IFN)-gamma spot forming cells (SFC) per 50 000 PBMCs specific for either infection, and 5 IFN-gamma-secreting CD8+ T cells/50 000 in the ICA.
Rice et al. (2004)CD8T cellsNevertheless, these findings indicate that DNA fusion vaccines can mobilize CD8(+) T cells against endogenous minor H Ags, even from a profoundly tolerized repertoire.
Raez et al. (2003)CD8T cellsImmunization significantly increased the frequencies of interferon-gamma secreting CD8 T cells in all but one patient in response to ex vivo challenge with NSCLC cells.
Hermann et al. (2002)CD8T cellsIndeed, we have detected parasite-specific CD8 T cells secreting interferon-gamma after coincubation with live T cruzi.
Gausling et al. (2001)CD8T cellRR-MS patients exhibited lower frequencies of IL-4 secreting CD4(-)CD8(-)V alpha 24J alpha Q T cell clones than patients with CP-MS and controls.
Gausling et al. (2001)CD8T cellsWe conclude that alterations in cytokine secretion patterns of CD4(-)CD8(-)V alpha 24J alpha Q T cells may influence the immune system and thus contribute to relapsing-remitting MS.
Coffey et al. (1997)CD8T lymphocytesC-C chemokines, secreted by CD8 T lymphocytes and other cells, are known to suppress HIV replication in lymphocytes.
Minai et al. (1996)CD8T cellOne of these CD8+ T cell clones, 13G2, secreted IFN-gamma at similar levels with calcium ionophore, A23187, as well as by Con A, but IL-10 production by A23187 was less than by Con A.
Deusch et al. (1991)CD8T cellsThese results are taken as evidence for a selective localization of V delta 1+ CD8+ gamma/delta T cells in the epithelium of the large intestine.
Smith et al. (2000)CD8T cellsHuman CD8(+) T cells specific for Mycobacterium tuberculosis secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia.
Tatsis et al. (2007)CD8T cellRecombinant adenovirus vectors and MVA vectors were used in prime boost vaccine regimens to address the impact of repeated immunizations on transgene product-specific CD8(+) T cell frequencies, phenotypes, function, and localization.
Zaharatos et al. (2004)CD8T-cellsIn light of these findings, alpha-defensins released into stimulated CD8+ T-cell supernatants are unlikely to be derived from the CD8+ T-cells themselves.
Zaharatos et al. (2004)CD8T-cellalpha-defensins released into stimulated CD8+ T-cell supernatants are likely derived from residual granulocytes within the irradiated allogeneic peripheral blood mononuclear cells used as feeders.
Hislop and Sabbah (2008)CD8T cellHere we discuss the CD8+ T cell response to these two gammaherpesviruses.
Demotte et al. (2008)CD8T cellWe observed that, when in this state, CTLs lose the colocalization of the T cell receptor (TCR) and CD8.
Streeck et al. (2008)CD8T cellDespite this variability, there was a similar pattern of changes in virus-specific CD8+ T cell functionality from early to chronic HIV-1 infection in the patients who did not receive antiretroviral treatment, as exemplified for patient Ac-177 (Figure 1B).
Riquelme et al. (2009)CD8T cellsMore significantly, it has been shown that TAICs are able to suppress proliferation of allogeneic CD4(+) and CD8(+) T cells after mitogenic stimulation.
Murdaca et al. (2009)CD8T-lymphocyteIn this study, we measured the levels of soluble HLA-G (sHLA-G) antigens in a cohort of HIV-infected patients before and during HAART. sHLA-G and sHLA-A, -B, -C levels were significantly elevated in HIV-infected subjects as compared with controls before antiretroviral treatment and significantly decreased after 36 months of HAART. sHLA-G levels were correlated with sHLA-A, -B, -C levels, the decrease of plasma HIV-RNA level, the increase of CD4+ T-lymphocyte number and the decrease of CD8+ T-lymphocyte number.
Drane et al. (2009)CD8T cellsAlthough still not completely understood, emerging data indicate that the generation of CD4(+) and CD8(+) T cells are important for the clearance of HCV.
Gong et al. (2008)CD8T cellThese artificial modified cells had the abilities of inducing CD8+ T cell activation, promoting CD8+ T cell proliferation, division, and long-term growth, inhibiting CD8+ T cell apoptosis, and enhancing CD8+ T cell secretion of IFN-gamma and perforin.
Cruz et al. (2006)CD8T-lymphocyteThe most attractive hypothesis to explain these results is the existence of a genetic trait associated with low CD8+ T-lymphocyte numbers localized in the HLA-A region.
Yen et al. (2000)CD8T cellsBoth the CD4+ and the CD8+ T cells of the elderly individuals secreted a significantly larger amount of IFN-gamma after activation.
Shen et al. (1998)CD8T cellBoth forms of the antigen, either secreted into the host cell cytoplasm or retained within bacterial cells, efficiently prime CD8 T cell responses.
Bar-Or et al. (2010)CD8T-cellThe effects of B-cell depletion on Th1/Th17 CD4 and CD8 T-cell responses in MS patients were assessed both ex vivo and in vivo, together with pharmacokinetic/pharmacodynamic studies as part of 2 rituximab clinical trials in relapsing-remitting MS.
Roato et al. (2010)CD8T cellsLocal CD8 T cells showed a regulatory phenotype, expressing CD25 and FoxP3, while CD4 T cells did not express activation markers.
Zou et al. (2009)CD8T-cellIFN-gamma overexpression correlated significantly with increased CD4 and CD8 T-cell accumulation.
Zou et al. (2009)CD8T cellsCONCLUSIONS: The imbalanced expression of proinflammatory and anti-inflammatory cytokines and increased accumulation of CD4, CD8 T cells, and KCs may contribute to immunopathogenesis in HBV-infected ACLF.
Bouquié et al. (2009)CD8T lymphocytesHLA multimers are now widely used to stain and sort CD8 T lymphocytes specific for epitopes from viral or tumoral antigens presented in an HLA class I context.
Rollman et al. (2008)CD8T cellsRelease of granzymes and perforin from the cytolytic granules of SIV-specific CD8 T cells is a critically important effector mechanism facilitating the elimination of SIV-infected cells.
Standley et al. (2007)CD8T-cellMoreover, vaccination with particles containing both ovalbumin (OVA) and CpG DNA induced a superior OVA-specific CD8 T-cell response in vivo, as measured by increased OVA-specific CD8 T-cell proliferation, secretion of the proinflammatory cytokine IFN-gamma, and the induction of OVA-specific cytotoxicity.
Choi et al. (2007)CD8T cellsVaccination with MIDGE/hNIS, MIDGE/hNIS-NLS and pcDNA3.1/hNIS produced a significant increase in the number of hNIS-associated IFN-gamma-secreting CD8(+) T cells, with MIDGE/hNIS having the strongest effect.
Li et al. (2005)CD8T cellWe first combined the use of an HLA-A*0201/peptide binding algorithm and T2 binding assays with the induction of specific CD8(+) T cell lines from normal donors by in vitro priming with high-affinity peptides, then IFN-gamma release and cytotoxicity assays were employed to identify the specific HLA-A*0201 CD8(+) T cell epitope using peptide-loaded T2 cells or the HCA587 protein(+) HCC cell line HepG2.
Jung et al. (2005)CD8T lymphocytesCONCLUSIONS: CD4 and CD8 T lymphocytes are stimulated by GBV-C to secrete antiretroviral factors, inhibiting R5- and X4-HIV strains.
D'Offizi et al. (2002)CD8T cellsIn this group, the frequencies of CD8 T cells releasing IFN-gamma after mitogen-induced or Gag-specific stimulation were highly increased after HAART discontinuation.
Papasavvas et al. (2000)CD8T cellIncreased T helper responses against HIV-1 p24 antigen (P=. 014) and interferon-gamma-secreting CD8 T cell responses against HIV-1 Env (P=.004) were present during interruption of therapy and after reinitiation of treatment.
Maric et al. (1997)CD8T cellsHere we analyzed the mechanism for selective recruitment of CD8 T cells into B7-1-transfected plasmacytoma J558.
Vaidya et al. (1997)CD8T lymphocytesWe showed previously that African trypanosomes express a protein called T lymphocyte triggering factor (TLTF), which triggers CD8(+) T lymphocytes to proliferate and to secrete IFN-gamma.
Bengsch et al. (2010)CD8T cellIn sum, these results suggest that T cell exhaustion contributes to the failure of about half of HCV-specific CD8+ T cell responses and that it is determined by a complex interplay of immunological (e.g.
Gervassi et al. (2004)CD8T cellThese CD8(+) T cell clones recognize chlamydial Ags processed via the conventional class Ia processing pathway, as assessed by treatment of infected APC with lactacystin and brefeldin A, suggesting that the Ags are translocated from the chlamydial inclusion into the host cell cytosol.
Lalvani et al. (1998)CD8T lymphocytesHuman cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis.
Arneth (2010)CD8T lymphocytesThe assay presented is able to differentiate between CD4+ and CD8+ T lymphocytes.
Bonehill et al. (2008)CD8T cellsIn correlation, we found a marked increase in cytolytic and IFN-gamma/tumor necrosis factor-alpha (TNF-alpha) secreting CD8(+) T cells.
Subklewe et al. (1999)CD8T lymphocytesPresentation of epstein-barr virus latency antigens to CD8(+), interferon-gamma-secreting, T lymphocytes.
Mikko et al. (2008)CD8T cellsCytokine secretion of stimulated CD4+ and CD8+ T cells was analysed.
Schellens et al. (2008)CD8T cellsKaplan-Meier survival analysis and Cox proportional hazard models showed that frequencies of cytokine-producing Gag-specific CD8+ T cells (IFN?
Rojas et al. (2003)CD8T cellsUsing microbead-enriched CD4(+) and CD8(+) T cell subsets, IFNgamma-secreting RV-specific CD8(+) but not CD4(+) T cells were detected in recently infected children.
Symons et al. (1990)sCD8T cellThere was an inverse relationship between the ability of SFMNC to release sCD8 and soluble interleukin-2 receptor, indicating that the CD8+ T cell population may play an important immunoregulatory role in RA.
Schirmer et al. (2002)CD8T cellsCD8+CD28- T cells have been reported to be effector cells, producing perforin, granzyme B, tumour necrosis factor-?
Klenerman and Kim (2007)CD8T cellsAntiviral CD8+ T cells typically secrete interferon (IFN)-gamma, and this has also been shown in T cells derived from the liver.
Balázs et al. (1994)CD8T cellActivation of T cells is apparently associated with the release of soluble CD8 (sCD8) and CD4 (sCD4) molecules from the corresponding T cell subset.
Baier et al. (1998)CD8T cellsFactors secreted by CD8(+) T cells have been described to suppress immunodeficiency virus replication.
Baier et al. (1998)CD8T cellsChemokines and IL-16 are secreted by CD8(+) T cells and inhibit HIV replication through different mechanisms.
Hong et al. (2009)CD8T cellThe majority of tetramer-binding cells localized in T cell zones and were CD8(+).
Hersperger et al. (2010)CD8T-cellNevertheless, to identify the potential contribution of perforin produced de novo, we examined the proportion of the HIV-specific CD8+ T-cell response that both degranulated (CD107a+) yet remained perforin+ after six hours of stimulation.
Hersperger et al. (2010)CD8T-cellsThe implications of this dichotomy are profound for our understanding of effective HIV-specific CD8+ T-cell responses: IL-2 producing CD8+ T-cells will presumably not have immediate cytolytic activity; conversely, perforin producing CD8+ T-cells may be inherently reliant upon production of IL-2 from cells in their surrounding environment for maintenance or modulation.
Walter and Santamaria (2005)CD8T cellsCD8(+) T cells can kill target cells directly, by recognizing peptide-MHC complexes on target cells, or indirectly, by secreting cytokines capable of signaling through death receptors expressed on the target cell surface.
Mercure and Wainberg (1994)CD8CTLCytotoxic CD8+ T lymphocytes (CTL) can kill HIV-infected cells and in addition, are able to secrete a soluble factor that inhibits HIV replication.
Garrison et al. (2007)CD8T cellOur aim was to measure the CD8+ T cell response against HERV.
Garrison et al. (2007)CD8T cellThis suggests that HLA presentation of HERV antigens on the surface of HIV-1-infected cells could prime a CD8+ T cell response against HERV.
Zhang et al. (2002)CD8T lymphocytesIt has been known since 1986 that CD8 T lymphocytes from certain HIV-1-infected individuals who are immunologically stable secrete a soluble factor, termed CAF, that suppresses HIV-1 replication.
Saksena et al. (2008)CD8T cellsThe non-cytolytic CD8+T cells from individuals infected with HIV suppress virus replication in CD4+ T cells in vitro by a non-cytolytic mechanism that involves interplay of several chemokines and an unidentified secreted soluble CD8 (+)-cell antiviral factor (CAF).
Villacres et al. (2001)CD8T cellsBoth interferon (IFN)-gamma secretion by CD8(+) T cells and the frequency of human leukocyte antigen (HLA)-tetramer-positive T cells in HLA-A*0201-positive HIV-infected subjects correlated with CMV-specific cytolysis.
Macatangay et al. (2010)CD8T cellsThe average post-vaccine percentage of CD8+ T cells secreting at least two immune mediators more than doubled after removal of Treg.
Lichterfeld et al. (2004)CD8T cellsThese results suggest that HIV-1-specific cytotoxicity of CD8(+) T cells is preferentially mediated by a subset of CD8(+) T cells secreting both interferon-gamma and TNF-alpha.
Lichterfeld et al. (2004)CD8T cellsThis subset of CD8(+) T cells also exhibited stronger intracellular perforin expression and more pronounced direct ex vivo HIV-1-specific cytoxicity than CD8(+) T cells secreting solely interferon-gamma following sorting of these subpopulations according to their cytokine profile.
Lichterfeld et al. (2004)CD8T cellsThese experiments revealed considerable intraindividual and interindividual differences among epitope-specific T-cell effector functions: while the frequency of HIV-1-specific CD8(+) T cells secreting interferon-gamma but no tumor necrosis factor-alpha (TNF-alpha) following antigenic stimulation was only weakly correlated to their cytotoxic activity (R = 0.05, P =.57), a subset of CD8(+) T cells secreting both inter-feron-gamma and TNF-alpha was substantially more strongly associated with cytotoxicity (R = 0.67, P <.001).
Rehr et al. (2008)CD8T cellsDuring ART, cytokine secretion by HIV-specific CD8(+) T cells was gradually restored, IL-7Ralpha and CD28 expression increased dramatically, and PD-1 levels declined.
Biddison et al. (1997)CD8T cellsTo address the potential role of soluble mediators secreted by CD8+ T cells in the pathogenesis of HAM/TSP, we have analyzed the capacity of a panel of nine HTLV-I-specific CD8+ CTL clones derived from three HAM/TSP patients to secrete cytokines, chemokines, and matrix metalloproteinases.
Rathmann et al. (2004)CD8T cellsPreproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes.
Watchmaker et al. (2008)CD8T cellsMoreover, memory CD8(+) T cells that release the DC-activating factor TNF-alpha before the release of cytotoxic granules induce DC expression of an endogenous granzyme B inhibitor PI-9 and protect DCs from CTL killing with similar efficacy as CD4(+) Th cells.
Bosque et al. (2005)CD8T cellThe physiological validity of these observations was corroborated by the demonstration of intracellular FasL and APO2L/TRAIL expression in CD4(+) and CD8(+) T cell blasts, which were secreted in their bioactive form into the supernatant upon PHA, CD3 or CD59 reactivation.
Cruz et al. (2006)CD8T-lymphocyteTherefore, a putative genetic marker of CD8+ T-lymphocyte numbers could be localized between D6S2222 and HLA-A.
Di Girolamo et al. (2008)CD8T cellsWe showed that T cells number was decreased in RLNs as compared to the controls with reduction in both CD4+ T cells and CD8+ T cells subsets and an inverted ratio (CD4+: CD8+).
Hermann et al. (2010)CD8T cellsThese KIR(+) T cells had an effector and effector/memory phenotype suggesting that KIR expression was consecutive to the antigenic stimulation; however, KIR was not preferentially found on parasite-specific CD8(+) T cells secreting interferon-gamma upon in vitro restimulation with live T. cruzi.
Bihl et al. (2009)CD8T-cellPatients with controlled Kaposi's sarcoma disease demonstrated undetectable Kaposi's sarcoma viremia together with KSHV-specific CD8 T cells secreting interferon-gamma and tumor necrosis factor-alpha, whereas progressors showed increasing viremia with weak or no T-cell responses.
Zhang et al. (2008)CD8T cellsThe frequency of IFN-gamma secreting spots of HBVcore18-27-specific CD8+ T cells of the CHB patients with their CD4+ CD25+ cells depleted was (112 +/- 33), significantly higher than that of the CHB patients whose CD4+ CD25+ cells in circulation were not depleted [(23 +/- 14), t =7.828, P<0.01)].
Klade et al. (2008)CD8T cellsIC41 has been shown to be safe and to induce HCV-specific interferon (IFN)-gamma-secreting CD4+ and CD8+ T cells in healthy volunteers.
Contini et al. (2007)CD8T cellsPatients' sera were able to induce transcription and secretion of FasL in CD8(+) T cells, followed by apoptosis in vitro; this apoptosis was inhibited by anti-HLA-I-specific monoclonal antibodies, suggesting that sHLA-I is responsible for cell death.
Gahery et al. (2007)CD8T cellsHLA-DR-restricted peptides identified in the Nef protein can induce HIV type 1-specific IL-2/IFN-gamma-secreting CD4+ and CD4+ /CD8+ T cells in humans after lipopeptide vaccination.
Zhang et al. (2007)CD8T cellsThe effector CD8(+ )T cells could release cytotoxic molecules of granzyme B and perforin after restimulation with natural HLA-A2(+)MAGE-A3(+) HCC cell lines in the samples tested.
Liu et al. (2006)CD8T cellsMETHODS: Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) secreted by CD3+ CD8(-)T cells were detected by flow cytometry in 35 patients with CAP/CPPS and 12 healthy volunteers, and significance of Th1/Th2 cells ratio in the etiology of CAP/CPPS was analyzed.
Miyamoto et al. (2005)CD8T cellsAd-hIL-10-infected CD4 and CD8 T cells secreted a large amount of hIL-10 for 3-4 days in culture in vitro.
Elkord et al. (2005)CD8T cellsThe expansion of IFN-gamma-secreting CD8+ T cells specific for three of the eight PSA-derived peptides (PSA-2(108-117), PSA-4(141-150) and PSA-6(146-154)) was detected in healthy individuals, but not in patients with PC.