Viewing affirmative mentions of localization of CD4 (H. sapiens) in T cells

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Fontenot et al. (2002)CD4T cellsTarget organ localization of memory CD4(+) T cells in patients with chronic beryllium disease.
Szeto et al. (2010)CD4T cellsMinocycline treatment resulted in significant changes in activation marker expression and inhibited proliferation and cytokine secretion of CD4+ T cells in response to activation.
Petersen et al. (1992)CD4T-cellsImmunocytochemistry localized CD4 to the surface of unstimulated T-cells.
Petitjean et al. (2007)CD4T lymphocytesSpontaneously HIV-1-Ag-secreting CD4+ T lymphocytes were detected in 3/3 untreated patients (nos. 8, 11, 12) and in 2/4 sustained responders to HAART (nos. 15 and 21).
Percherancier et al. (2003)CD4T-cellsHIV-1 entry into T-cells is not dependent on CD4 and CCR5 localization to sphingolipid-enriched, detergent-resistant, raft membrane domains.
Dieckmann et al. (2005)CD4T-cellFurthermore, we could demonstrate that CD4(+) T-cell clones stop secreting interferon-gamma (IFN-gamma), start to produce interleukin-10 and transforming growth factor-beta after coculture with preactivated CD4(+) CD25(+) T cells and become suppressive themselves.
Barcy and Corey (2001)CD4T cellWe have observed that infection of human B lymphoblastoid cells (B-LCL) by HSV resulted in a strong inhibition of their ability to induce CD4(+) T cell clone proliferation and cytokine secretion.
Rojas et al. (2003)CD4T cellsIn contrast, CMV-specific INFgamma-secreting CD4(+) T cells preferentially express L-selectin but not alpha4beta7.
Nielsen et al. (2010)CD4T cellsAlthough monocytes were prime producers of IL-10 in the early TG response, a few IL-10-secreting CD4(+) T cells, primarily with CD45RO(+) memory phenotype, were also detected.
Chen and Liu (2009)CD4T cellsDevelopment and function of IL-10 IFN-gamma-secreting CD4(+) T cells.
Chen and Liu (2009)CD4T cellsIL-10 IFN-gamma-secreting CD4(+) T cells were first found in the early 1990s.
Chen and Liu (2009)CD4T cellsIL-10 IFN-gamma-secreting CD4(+) T cells are activated in chronic infection and are responsible for prolonged infection.
Kaser and Blumberg (2008)CD4T cellsRECENT FINDINGS: CD4 T cells secreting interleukin-17 (T helper type 17) cells have emerged as a key effector population driving colitis in animal models previously associated with exaggerated T helper type 1 responses.
Jacobsen et al. (2008)CD4T-cellsThe most widely used biomarker in TB, which without a doubt is an important component of protective immunity, is IFNgamma secreted by antigen-specific CD4 T-cells.
Mathur et al. (2007)CD4T cellsIL-17-secreting CD4(+) T cells are critically involved in inflammatory immune responses.
Nylén et al. (2006)CD4T cellsRESULTS: In the volunteers monitored there was no significant difference in LST, IFNgamma production, or source of IFNgamma between those who developed a lesion and those who did not after LZ, with the exception that ulcer development was associated with an enhanced number of IFNgamma secreting CD4(+) CD45RA(-) (memory) T cells.
Aarli (2003)CD4T lymphocytesCytokines also have a key role in the pathogenesis of multiple sclerosis and most data suggest that this effect is mediated by myelin-specific CD4 T lymphocytes secreting Th type 1 cytokines.
Hacker-Foegen et al. (2003)CD4T cellsThese T cells are CD4 alpha/beta cells secreting a Th2-like cytokine profile, and responding of Dsg3 in a restriction to HLA-DRBI*0402 or 1401 alleles.
Hemmer et al. (2002)CD4T cellsExtensive studies in the animal model experimental autoimmune encephalomyelitis have suggested that multiple sclerosis is an autoimmune disorder mediated by myelin-specific CD4 T cells secreting T helper type 1 cytokines and tumor necrosis factor alpha.
Faltynek et al. (1992)CD4T lymphocytesIn mice recovering from high dose irradiation, rhuIL-7 treatment resulted in preferential expansion of CD8+ T lymphocytes and more rapid normalization of the CD4/CD8 ratios.
Garron et al. (2008)CD4T lymphocytesIn T lymphocytes, FAK and CD4 localise to the same signalling complexes after stimulation by either the human immunodeficiency virus (HIV) gp120 glycoprotein or an antigen, suggesting the concerted action of FAK and CD4 in these cells.
Gauduin (2006)CD4T cellsCentral to our optimized protocol is the addition of cross-linked costimulatory anti-CD28 and anti-CD49d Mabs, a modification that results in up to 3-fold enhancement of the frequency of cytokine-secreting CD4(+) T cells following superantigen or antigen-specific stimulation.
Meyaard et al. (1994)CD4T-cellChanges in cytokine secretion patterns of CD4+ T-cell clones in human immunodeficiency virus infection.
Pawelec et al. (1989)CD4T cellIt is shown here that eight alloreactive CD4+ T cell clones (TCC) secreted significant amounts of TNF-alpha after stimulation with either specific alloantigen or 12-O-tetradecanoylphorbol 13-acetate together with the calcium ionophore ionomycin (up to 50 ng/ml/24 h/10(6) cells) whereas CD8+ TCC failed to do so (max. 2 ng/ml/24 h/10(6) cells).
Brenchley et al. (2008)CD4T-cellTaken together, these data suggest mechanisms for mucosal CD4 T-cell depletion and interventions that might circumvent global depletion of mucosal CD4 T cells.
Renault et al. (2010)CD4T lymphocyteAlternatively, dedicated flow cytometers (e.g., FACSCount; Becton Dickinson Immunocytometry, San Jose, California) are used for the single purpose of CD4+ T lymphocyte enumeration.
Veazey and Lackner (2006)CD4T cellsFor example, detection of increased percentages of “activated” CD4+ T cells in a tissue that has undergone massive CD4+ T cell depletion could be interpreted either as an immune response to the infection or as a selective loss of “resting” CD4+ T cells.
Stickler et al. (2003)CD4T-cellWe developed an assay to determine the location of immunodominant CD4(+) T-cell epitopes in any protein.
Chen et al. (2008)CD4T cells[In vitro proliferation of CD4(+)CD25(+) T cells from PBMCs of the chronic myelocytic leukemia patients and their inhibitory effect on CD4(+)CD25(-) T cells].
Radfar et al. (2009)CD4T cellsSoluble factors secreted from activated CD4(+) T cells, likely acting on the tumor and its microenvironment, were responsible for the observed effect.
Herbeck et al. (2008)CD4T cellBecause clinical AIDS endpoints could not be used (due to antiretroviral therapies and prophylaxis), three prognostic markers of disease progression were used as proxies for HIV-1 virulence: plasma viral RNA load and CD4+ T cell count at “set point” (between ?
Höllsberg (1997)CD4T cellsInstead this hypothesis suggests that the presence of IFN-gamma-secreting HTLV-I-infected CD4 T cells and their recognition by virally specific CD8 T cells in the CNS induce microglia to secrete cytokines, such as TNF-alpha, which may be toxic for the myelin.
Merkenschlager et al. (1990)CD4T cellAs previously observed for conventional alloresponses, saturating concentrations of CD4 antibodies were required (and sufficient) for substantial blocking of T cell responses to transfected HLA-DQ and -DR products, and antibodies to a wide range of CD4 epitopes were inhibitory.
Castelli et al. (2008)CD4T-cellImmunoprevalence of the CD4+ T-cell response to HIV Tat and Vpr proteins is provided by clustered and disperse epitopes, respectively.
Gómez et al. (2009)CD4T cellsA better anti-proliferative function of CD4+CD25+ T cells was found in patients than in controls (p=0.009), whereas higher TNFalpha secretion was found in patients (p=0.028).
Corrigan and Kay (1992)CD4T-lymphocytesIncreasing evidence is accumulating that activated CD4 T-lymphocytes participate in the inflammatory reaction observed in the asthmatic bronchial mucosa, by secreting lymphokines which attract and activate eosinophils and mast cells.
Vukmanovic-Stejic et al. (2008)CD4T cellThe kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo.
Riquelme et al. (2009)CD4T cellsMore significantly, it has been shown that TAICs are able to suppress proliferation of allogeneic CD4(+) and CD8(+) T cells after mitogenic stimulation.
Mehandru et al. (2006)CD4T cellThe consequences of persistent CD4+ T cell depletion in the GI tract are unknown at this point.
Mehandru et al. (2006)CD4T cellsIt is noteworthy that, while none of the patients examined by flow cytometry showed “normalization” of CD4+ T cell percentage in the GI tract, 30% of the studied patients did show “normalization” of absolute numbers of CD4+ T cells within the GI LP.
Gao et al. (2008)CD4T-lymphocyteBoth Cox-2 expression and the number of CD4+ TIL and CD4+ infiltrating T-lymphocyte were detected by immunohistochemistry, and data were analyzed closely with patients' clinical figures so as to investigate the correlation between the 3 elements.
Murdaca et al. (2009)CD4T-lymphocyteIn this study, we measured the levels of soluble HLA-G (sHLA-G) antigens in a cohort of HIV-infected patients before and during HAART. sHLA-G and sHLA-A, -B, -C levels were significantly elevated in HIV-infected subjects as compared with controls before antiretroviral treatment and significantly decreased after 36 months of HAART. sHLA-G levels were correlated with sHLA-A, -B, -C levels, the decrease of plasma HIV-RNA level, the increase of CD4+ T-lymphocyte number and the decrease of CD8+ T-lymphocyte number.
Jacobson et al. (2009)CD4T cellSecond, we selected our cases and controls based on more than one factor (i.e., the groups differed based on both CD8+ T cell activation and absolute CD4+ T cell counts).
Gidon-Jeangirard et al. (1999)CD4T lymphocyteAnnexin V delays apoptosis while exerting an external constraint preventing the release of CD4+ and PrPc+ membrane particles in a human T lymphocyte model.
Jana et al. (2010)CD4T cellsNevertheless, a population of CD4+CD25+CD127low/- T cells does not exhibit enhanced suppressor function compared to CD4+CD25high T cells in our hands (Glisic S, unpublished) as well as in studies of Miyara et al [7].
Jana et al. (2010)CD4T cellsCD4+CD25low T cells proliferate more than CD4+CD25- T cells
Jana et al. (2010)CD4T cellsDifferential suppression of CD4+CD25- and CD4+CD25low responders by the same Tregs could be due to an unequal inhibition of IL-2 transcript in the two responder T cells.
Andrieu and Lu (2004)CD4T cellsAt PDN onset, these three patients had a HVL and 256, 337 and 361 CD4 T cells/?
Andrieu and Lu (2004)CD4T cellsThe evolution of the CD4 T cell counts of the 11 patients who were under ziduvidine when starting PDN had the same profile: their CD4 T cells started from lower values (329 ± 35 cells/?
Pereyra et al. (2009)CD4T cellAbsolute CD4(+) T cell decrease was more common among individuals with detectable viremia (P = .04).
Jolly and Sattentau (2007)CD4T cellHere, we review findings that shed light on CD4+ T cell secretion in health and disease.
Portevin et al. (2009)CD4T cellsCorrelating with their proliferation status described above, CD25 surface expression is rapidly acquired by some CD4+ T cells when PBMCs are cultured with IL-2 alone, however this is markedly delayed when 3a-G1 is present.
Portevin et al. (2009)CD4T cellGiven the fact that 3a-G1 inhibits CD4+ T cell proliferation without affecting NK cell one within PBMCs, we checked whether this activity could not be broadened to all T cells.
Sirven et al. (2009)CD4T cellIn vitro human CD4+ T cell response to the vaccinia protective antigens B5R and A33R.
Ramduth et al. (2009)CD4T cellCONCLUSIONS/SIGNIFICANCE: These data indicate that in chronic untreated clade C HIV-1 infection, IFN-gamma-secreting Gag-specific CD4+ T cell responses are immunodominant, directed at multiple distinct epitopes, and associated with viral control.
Rojas et al. (2003)CD4T cellsUsing microbead-enriched CD4(+) and CD8(+) T cell subsets, IFNgamma-secreting RV-specific CD8(+) but not CD4(+) T cells were detected in recently infected children.
Ovsyannikova et al. (2003)CD4T cellsThe median frequency of CD4(+) T cells secreting IL-4 in response to measles virus was 0.03% in seronegative subjects and 0.09% in highly seropositive subjects (P = 0.005).
Drane et al. (2009)CD4T cellsAlthough still not completely understood, emerging data indicate that the generation of CD4(+) and CD8(+) T cells are important for the clearance of HCV.
Graham et al. (1993)CD4T-cellThe localization of this major CD4 T-cell epitope may permit the construction of chimeric viruses utilizing the natural picornavirus T-cell response to augment production of antibody specific for inserted sequences.
Durham (1993)CD4T lymphocytesNovel therapeutic approaches might include a broad strategy directed against T lymphocytes, including the use of immunosuppressive agents or anti CD4 antibodies or more precise targeting of IL-4 and/or IL-5.
Kuwata et al. (2009)CD4T cellDespite intensive study, the mechanisms of CD4+ T cell depletion in human immunodeficiency virus (HIV) infection remain elusive.
Kavousanaki et al. (2010)CD4T cellsMature plasmacytoid DCs from RA patients with low disease activity, but not those from healthy controls, expressed high levels of indoleamine 2,3-dioxygenase and promoted the differentiation of allogeneic naive CD4+CD25- T cells into interleukin-10-secreting Treg cells, or Tr1 cells, that showed poor proliferation in vitro.
Kavousanaki et al. (2010)CD4T cellsProliferation of and cytokine release by naive CD4+CD25- T cells were measured in cocultures of these cells with DCs from patients with RA and healthy controls.
Hioe et al. (2001)CD4T cellsInhibition of human immunodeficiency virus type 1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120.
Sellier et al. (2010)CD4T cellThe initiation of antiviral therapy 4 hours after infection prevented CD4+ T cell depletion in lung tissues (Figure 5).
Sellier et al. (2010)CD4T cellThe initiation of antiviral therapy 4 hours after infection prevented CD4+ T cell depletion in rectal mucosae (Figure 4).
Sellier et al. (2010)CD4T-cellTincati et al. evaluated the kinetics of CD4+ T-cell decrease and ART-mediated immune reconstitution in the gastrointestinal tract of nine patients during the acute phase of HIV infection, by performing rectosigmoid colonic biopsies before and after six months of ART [23].
Mikko et al. (2008)CD4T cellsCytokine secretion of stimulated CD4+ and CD8+ T cells was analysed.
Tamma et al. (1997)CD4XLT cellsCD4+ T cells expressing dn-ras secreted significantly reduced levels of TNF-alpha in response to CD4XL.
Gahery et al. (2007)CD4T cellsThese cells are Nef-specific CD4(+) and CD4(+) CD8(+) T cells secreting IL-2/INF-gamma or IL-2 alone.
Diedrich et al. (2010)CD4T cellThese monkeys had significant sustained CD4 T cell depletion in the periphery as has been reported for cynomolgus macaques infected with SHIV89.6 [27], yet did not experience reactivation by seven months post-SHIV infection (unpublished data).
Jenei et al. (2009)CD4T-cellWe investigated spatial organization of Interleukin-2R alpha and -15R alpha (IL-2R alpha and IL-15R alpha) on a human CD4+leukaemia T-cell line, Kit225 FT7.10 by using transmission electron microscopy (TEM).
Arneth (2010)CD4T lymphocytesThe assay presented is able to differentiate between CD4+ and CD8+ T lymphocytes.
Aucher et al. (2010)CD4T cellsAs the anti-CD4 mAb we used (clone RPA-T4) is conformational, our results also imply that the CD4 is exposed in a correct conformation to the extracellular milieu on the surface of the CD8+ T cells. 3.2.
Aucher et al. (2010)CD4T cellsThese results strongly suggest that CD4, once captured by CD8+ T cells is virologically functional and can induce syncytia formation with MOLT-4 cells. 3.5.
Aucher et al. (2010)CD4T cellsIn the case of CD4, it is however unclear if the fact that CD4 is sometimes found on CD8+ T cells can be due to trogocytosis solely as de novo CD4 expression has also been occasionally documented on activated CTL [13–20].
Aucher et al. (2010)CD4T cellsAt this stage, however, it remains unclear, whether our inability to detect infection in CD8+ T cells was due to technical limitations or if CD4 capture by CD8+ T cells never leads them to become susceptible to a productive HIV infection.
Reding et al. (2000)CD4T cellsSensitization of CD4+ T cells to coagulation factor VIII: response in congenital and acquired hemophilia patients and in healthy subjects.
Yen et al. (2000)CD4T cellsBoth the CD4+ and the CD8+ T cells of the elderly individuals secreted a significantly larger amount of IFN-gamma after activation.
Homann et al. (2009)CD4T cellOn day 4, 8, and 12 p.i., cell culture supernatant was analyzed by p24 ELISA to quantify HIV-1 production and CD4+ T cell depletion was determined by flow cytometry.
Homann et al. (2009)CD4T lymphocyte12–39 variants, the two mutants that displayed defects in CD4+ T lymphocyte depletion in the above analyses.
Homann et al. (2009)CD4T lymphocytenef HIV-1 in HLAC from a large number of donors demonstrated that Nef elevates the efficacy of both HIV spread and CD4+ T lymphocyte depletion.
Homann et al. (2009)CD4T lymphocyteA panel of isogenic Nef mutant viruses consistently revealed a partial segregation of Nef activities: while a large number of molecular determinants in Nef was required for optimal HIV-1 spread in HLAC, two distinct protein interaction surfaces were identified that specifically govern Nef-mediated enhancement of CD4+ T lymphocyte depletion which preferentially occurs in bystander cells.
Homann et al. (2009)CD4T lymphocyteHowever, the cytotoxicity of CCR5 tropic Env proteins is relatively reduced, explaining why CD4+ T lymphocyte depletion is generally mild and can only be slightly enhanced by Nef in HLAC infections with R5-tropic strains [9,62].
Woodfolk (2007)CD4T lymphocytesThe allergic response in human beings is engineered by CD4(+) T lymphocytes, which secrete T(H)2 cytokines in response to activation by allergen-derived peptides.
Fondere et al. (2004)CD4T lymphocytesHuman immunodeficiency virus type 1 (HIV-1) antigen secretion by latently infected resting CD4+ T lymphocytes from HIV-1-infected individuals.
Lee et al. (2009)CD4T cellWe investigated the potential translocation of microbial products in idiopathic CD4 lymphocytopenia (ICL), a rare disorder characterized by low CD4 T cell counts in the absence of HIV infection.
Monti et al. (2008)CD4T-cellsFollowing the same protocol as for CFSE staining, 1 × 105 FACS-sorted CD4+CD25high T-cells were first stained with SNARF (Molecular Probes) and were subsequently mixed with an equal number of CFSE+CD4+CD25?
Monti et al. (2008)CD4T-cellsTo reduce this risk, we FACS-sorted both CD4+CD25bright T-cells (falling in the top 1–2% of CD25+ cells) and CD4+CD25?
Palmer et al. (2002)CD4T cellsNo statistically significant differences in the frequencies of cytokine-secreting, HIV-1-specific CD4(+) T cells between the donor groups were found, despite differences in viral load and treatment status.
Conti-Fine et al. (2008)CD4T cellsCytokines are involved in the growth and differentiation of CD4(+) T cells, and are secreted by activated CD4(+) T cells as effectors of their functions: differentiated CD4(+) T cells are classified into subtypes based on the cytokines they synthesize and secrete.
Conti-Fine et al. (2008)CD4T cellIn this chapter, we will review studies on the effects on the development of acquired MG symptoms of several cytokines secreted by activated CD4(+) T cells or influencing the activation of particular CD4(+) T cell subsets.
Huard et al. (1996)CD4T cellIn addition, we show that LAG-3/class II molecule interaction leads to the down-regulation of CD4+ Ag-specific T cell clone proliferation and cytokine secretion.
Yan and Liu (2009)CD4+CD25T cellFoxp3+ T cell population may serve as the main replenishment for CD4+CD25+Foxp3+ iTreg population that could rapidly be recruited to the Treg pool upon CD25 regaining, in order to combat the more aggressive expansion of autoreactive T cells and B cells during disease flare.
Kingsley et al. (2009)CD4T cellsTo determine the proliferative responses of both CD4+ and CD8+T cells after 7 days of allostimulation, CFSE labelled cells were surface stained with antibodies to CD4 (APC-CY7) (BDBiosciences) and CD8 (APC) (BD Biosciences) at a 1?
Stickler et al. (2003)CD4T-cellThis method identifies functional CD4(+) T-cell epitopes in any protein without pre-selection for HLA class II, suggests whether a donor population is pre-exposed to a protein of interest, and does not require sensitized donors for in vitro testing.
Kulkarni et al. (2008)CD4T cellA low, moderate and high CCL3L1-CCR5 GRG status was associated with a step-wise increase in susceptibility to depletion of CD4+ T cells during HIV-1 infection, as well as impaired CD4+ T cell recovery during HAART [20], [23].
Palendira et al. (2002)CD4T cellsOn subsequent exposure to aerosol BCG rapid expansion of gamma interferon-secreting alpha(4)beta(1)(+) CD4(+) T cells occurred to the same extent in all immunized mice, regardless of the route of immunization.