Viewing affirmative mentions of positive regulation of IL2 (H. sapiens) in T cells

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Meuer et al. (1982)IL 2T cellMitogen stimulation led to secretion of equivalent amounts of IL 2 from both the major T cell subsets; in contrast, after allogeneic activation, IL 2 was produced predominantly from the T4+ subset.
Gazzolo and Duc Dodon (1987)IL-2T-cellIndeed, binding of viral particles to these cells induces IL-2 production and IL-2 receptor expression, and triggers T-cell proliferation.
Bonnard et al. (1979)TCGFT cellsThese experiments suggested specific absorption of TCGF by activated T cells, and led us to develop a model of ligand-activated TCGF-induced proliferation of T cells: Ligands induce production of TCGF by T-producer cells and deliver a first signal to the T-responder cells.
Landsverk et al. (2002)IL-2T-cellExtracts of stimulated human T cells elicit chromatin binding of transcriptional activators of the interleukin-2 (IL-2) gene, anchoring and activity of a chromatin-remodeling complex and hyperacetylation of the IL-2 promoter in purified exogenous resting T-cell nuclei.
Solbach et al. (1982)Il-2T cellIn order to release Il-2, the OKT4 positive T cell requires a stimulus, such as allogeneic cells or the lectin phytohaemagglutinin A (PHA).
Arya et al. (1984)cell growth factorT cellActivated T lymphocytes require T cell growth factor (TCGF) for proliferation.
Toossi et al. (1986)IL-2T cellSuppression by adherent cells was operative in one group of patients; adherent cell depletion increased their T cell production of IL-2 7.2-fold.
Waldmann (1986)IL-2T cellsAntigen or mitogen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2) as well as the expression of specific cell surface receptors for this lymphokine.
Duc Dodon and Gazzolo (1987)IL2T cellsThe results also suggest that viral attachment to T cells possibly supplies an accessory function triggering autocrine secretion of IL2 by these cells.
Weiss et al. (1984)IL 2T cellsThe role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.
Reem et al. (1985)IL-2T cellsThese results document that IL-2 acts as a hormone that induces the activation of thymocytes and T cells, as evidenced by the de novo induction of biologically active, high-affinity IL-2 receptors.
Manger et al. (1986)interleukin 2T cellDifferent T cell lines, which can be induced to secrete interleukin 2 (IL-2) in vitro, were used to dissect the effect of cyclosporin A (CsA).
Manger et al. (1986)IL-2T cellAnother T cell line, HUT 78, also produces IL-2 in response to a rise in [Ca++]i and PMA; however, in HUT 78, PMA alone induces low levels of IL-2 production that is not blocked by CsA.
Roosnek et al. (1985)interleukin 2T cellsThe requirements for lectin-induced interleukin 2 (IL2) production by human T cells have been investigated.
Jantscheff et al. (1999)IL-2T-cellTogether with increases in serum interleukin-2 (IL-2), modifications of the V-beta T cell receptor repertoire and induction of intratumoral T-cell infiltration were observed.
Westendorp et al. (1994)IL-2 promoterT cellsTransient expression of HIV-1 Tat induced a five- to eightfold increase in IL-2 promoter activity in Jurkat T cells stimulated with phytohemagglutinin and phorbol myristate acetate.
Westendorp et al. (1994)IL-2T cellsIL-2 secretion was increased more than twofold in both Jurkat T cells and primary T cells stimulated by extracellular HIV-1 Tat protein.
Westendorp et al. (1994)IL-2T cellsThe observed increase in IL-2 levels might facilitate virus spread from or to T cells.
Scarisbrick et al. (2006)IL2T cellsIn human Jurkat T cells we demonstrate differential regulation of select kallikreins by CD3 receptor, Concanavilin A (Con A), interleukin 2 (IL2), and lipopolysaccharide (LPS)-mediated activation and by exposure to steroid hormones, dexamethasone, norgestrel, androstan and estradiol.
Nordmann et al. (1989)interleukin 2T-cellThe kinetics of interleukin 2 mRNA accumulation in the leukemic T-cell line Jurkat, which can be induced with phytohemagglutinin and phorbol 12-myristate 13-acetate to produce large amounts of interleukin 2, was analyzed by a modified DNA-excess solution hybridization assay using a 5'-32P-labeled oligodeoxyribonucleotide 30 bases long as probe.
Kumagai et al. (1988)IL-2T cellsThus, we have demonstrated that Ca2+ mobilization is required for rendering T cells competent to express functional IL-2 receptors, to produce IL-2 in response to subsequent incubation with PDB, and that sustained activation of protein kinase C seems necessary for IL-2 production and subsequent progression of competent T cells to DNA synthesis.
Gillis and Watson (1980)IL-2T cellTo isolate a stable tumor cell line capable of producing human interleukin 2 (IL-2; formerly referred to as T cell growth factor), 16 human T and B leukemia cell lines were screened for constitutive and mitogen-stimulated IL-2 production.
Morikawa et al. (1994)IL-2T cellsAt concentrations of 1.6 to 40 micrograms/ml, these drugs suppressed interleukin-2 (IL-2) production induced by mitogen-stimulated T cells, but not the expression of IL-2 receptor (CD25), in a dose-dependent manner.
Matsui et al. (1992)IL-2T-cellThese results suggest that cocaine augments proliferation of human T-lymphocytes when the cells are activated through the T-cell receptor complex by increasing cytosolic Ca2+ mobilization and subsequent IL-2 production.
Blue et al. (1986)interleukin 2T cellThe earliest stage (day 0-2) was characterized by the induction of the interleukin 2 (IL2) and transferrin receptors, the T cell lineage specific Ta1 antigen, and increased reactivity with anti-T8 antibody.
Müller-Quernheim et al. (1986)interleukin 2T lymphocytesCompartmentalized activation of the interleukin 2 gene by lung T lymphocytes in active pulmonary sarcoidosis.
DiSanto et al. (1990)IL-2T cellThis patient's immunological defect appears to be attributable to a selective deficiency in T cell production of IL-2, which may reflect a subtle abnormality in the IL-2 gene locus or a defect in a regulatory factor necessary for IL-2 transcription.
Holán et al. (1994)IL-2T cellIn two additional T cell lines tested, MOLT-16 and H-9, DC did not enhance mitogen-stimulated IL-2 production, but suppressed it when applied at 1 mA for more than 10 min.
Waldmann (1990)IL-2T cellsAntigen-induced activation of resting T cells induces the synthesis of IL-2 as well as the expression of specific cell surface high-affinity receptors for this lymphokine.
Hou et al. (1995)IL-2T cellFollowing T cell activation, the genes encoding IL-2 and the various chains of its receptor are transcriptionally induced.
Corley (1982)IL2T cellsThe antigenic requirements for stimulating the production of interleukin 2 (IL2) and the growth of IL2 producing T cells was evaluated using antigen-(Keyhole limpet hemocyanin) specific F1 T helper cell lines.
Nomura et al. (2003)IL-2T lymphocytesThus muscarinic receptors positively modulate cell growth in human T lymphocytes by the autocrine mechanism through enhancing expression of both IL-2 and the receptors.
Krönke et al. (1984)TCGFT-cellThese studies were performed with a cloned human leukemic T-cell line (Jurkat, subclone 32), which can be induced with phytohemagglutinin and phorbol 12-myristate 13-acetate to produce large amounts of TCGF.
Gmünder et al. (1990)IL-2 mRNAT cellAs in cultures of splenic T cells, GSH depletion had no substantial effect on the induction of IL-2 mRNA and TCGF production in several mitogenically stimulated T cell clones.
Ruscetti (1983-1984)T-cell growth factorT-cellWhile it is clear that a source of T-cell growth factor (TCGF) is an absolute requirement for the growth of T cells in liquid culture, less is known of the factors influencing T-cell colony formation.
Cereseto et al. (1999)IL-2T-cellsThese results suggest that, during the transformation process, the HTLV-I-infected T-cells become less sensitive to cell death signals through the acquisition of constitutive activation of the IL-2 receptor pathway.
Kabouridis and Tsoukas (1990)IL2T cellsThe Ca++ ionophore ionomycin, under conditions that cause significant intracellular Ca++ influx cannot by itself mediate upregulation of IL2 receptor expression in T cells.
Cooley et al. (1989)IL2T cellsIncreasing the potency of the stimulus increased the amount of IL2 and IFN produced by PBMC from both normal volunteers and from marrow transplant recipients, but for each stimulus the amount of IL2 produced by marrow transplant recipient PBMC remained 10-100-fold lower than that produced by normal PBMC, suggesting an underlying defect in IL2 production by marrow transplant recipient T cells, not due to accessory cell or CD2 defects.
Reeves et al. (1985)cell growth factorT cellsT cell growth factor required for optimal induction of T cell growth factor receptor expression in phytohemagglutinin-stimulated T cells.
Blomhoff (2004)IL-2T-cellsIn contrast, the proliferation of T-cells was enhanced by physiological levels of retinoic acid, and the effect was due to induction of IL-2 (interleukin 2).
Blomhoff (2004)IL-2T-cellsThe 'non-death-receptor'-mediated apoptosis of normal T-cells induced by prolonged (but single) stimulation of the cells was also prevented by retinoid acid, and also this effect was mediated via enhanced production of IL-2.
Blomhoff (2004)IL-2T-cellsThe induction of IL-2 was at the transcriptional level, and all the effects of vitamin A on both B-and T-cells were mediated via the nuclear retinoic acid receptors (RARs), and not retinoid X receptors (RXRs).
June et al. (1989)IL-2 geneT cellsCostimulation of T cells with CD3 MoAb and either CD28 MoAb or PMA, but not calcium ionophore, induced a 50-100-fold increased in IL-2 gene expression and secretion.
Kees (1988)IL-2T-cellCell line PER-117 provides a model to investigate the requirements for induction of IL-2 receptors in a cell expressing the first T-cell-specific marker and may help to elucidate the role of IL-2 during thymic differentiation and in the uncontrolled proliferation of T-cell leukemias.
Creemers et al. (1986)IL-2T-cellAfter 48 hr of stimulation, expression of the IL-2 receptor on both T-cell subsets was significantly increased in lymphadenopathy patients as compared to values in heterosexual age-matched controls; this difference was less after 72 hr of stimulation.
Zunich and Kirkpatrick (1988)interleukin-2T-cellStudies done 24 hr after infusions revealed increases in interleukin-2 production in one patient, but when pre- and posttreatment values were compared there were no significant changes in numbers of circulating T cells of any phenotype or in T-cell responses to mitogens or antigens.
Hünig et al. (1983)IL2T cellIt was found that with increasing T cell purification, first the ability is lost to produce sufficient levels of endogenous IL2, whereas induction of IL2 responsiveness can still take place.
Waldmann and Tsudo (1988)IL-2T cellsAntigen-induced activation of resting T cells induces the synthesis of interleukin-2 (IL-2), as well as the expression of specific cell surface receptors for this lymphokine.
Wieder et al. (1990)interleukin-2T-cellsTranscriptional activation of interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and the protooncogene H-ras was accomplished by signaling highly purified normal human resting T-lymphocytes (T-cells) with diC8, a physiologic regulator of protein kinase C, and the calcium ionophore, ionomycin.
Wieder et al. (1990)IL-2T-cellsTo amplify very low levels of IL-2 mRNA, sequential reverse transcription and polymerase chain reaction (RT-PCR) of T cell mRNA were used to demonstrate the capacity of the calcium signal (ionomycin) to promote low-level IL-2 transcription in normal human T-cells without additional signals.
Konaka et al. (1981)IL2T cellsThe data are consistent with the hypothesis that a differentiated subset of T cells in any mixed population is responsible for IL2 production.
Ferguson et al. (2001)IL-2 geneT-cellShortly after T-cell stimulation, transcription of the IL-2 gene is upregulated.
Waldmann (1987)interleukin-2T-cellsAntigen-induced activation of resting T-cells induces the synthesis of interleukin-2 (IL-2), as well as the expression of specific cell surface receptors for this lymphokine.
Waldmann (1987)interleukin-2T-cellsAntigen-induced activation of resting T-cells induces the synthesis of interleukin-2 (IL-2), as well as the expression of specific cell surface receptors for this lymphokine.
Teodorczyk-Injeyan et al. (2008)IL-2T lymphocytesIt is therefore unlikely that the observed increments in SPA-induced production of IL-2 ensued from in vivo (systemic) pre-activation of circulating peripheral blood T lymphocytes.
Teodorczyk-Injeyan et al. (2008)IL-2T lymphocytesSuch improved interaction has been shown to be mediated by another cytokine, interleukin 15 (IL-15) resulting in increased IL-2 production by T lymphocytes, such as observed in our study.
Teodorczyk-Injeyan et al. (2008)IL-2T lymphocytesThis could improve DC interaction with T lymphocytes and increase IL-2 production.
Trifiletti et al. (1989)interleukin 2T cellsSince in other experimental systems the activation of T cells by CD2/LFA-3 interactions has resulted in increased secretion of interleukin 2 (IL2), we were interested in studying the role of IL2 in PBMC cultures stimulated with PWM and autologous E.
Venuta et al. (1983)IL-2T-cellA recently developed monoclonal antibody, Pan T2, binds to normal T cells, renders T cells responsive to IL-2, and induces the release of IL-2, which in turn provides the second signal for T-cell proliferation.
Depper et al. (1985)IL-2T lymphocytesActivators of protein kinase C and 5-azacytidine induce IL-2 receptor expression on human T lymphocytes.
Wu and Yang (1991)interleukin 2T cellsEnhancement of interleukin 2 production in human and Gibbon T cells after in vitro treatment with lithium.
Safwat (2000)Il2T-cellData from animal experiments have shown that low-dose TBI could enhance the immune response through (1) augmenting the proliferative reactive response of the T cells to mitogenic stimulation; (2) altering cytokine release, particularly the activation of interferon gamma and Il2 production; (3) increasing the expression of Il2 receptors on the T-cell surface; (4) facilitating signal transduction in T lymphocytes; (5) increasing splenic catecholamine content and lowering the serum corticosterone level; and (6) eliminating a particularly radiosensitive subset of the suppressor T cells.
Attallah et al. (1987)IL-2T cellsOur results indicated that NK cells from patients with IDDM can respond to IL-2 with enhanced cytotoxicity, and, because activation of resting T cells by mitogenic stimuli depends on the production of IL-2 as well as the appearance of a receptor for IL-2, our finding of low levels of in vitro IL-2 production by PBMC from patients with IDDM may explain the depressed NK activity and the observed poor response to T-cell mitogens.
Tsuchida and Sakane (1988)IL-2T cellIntracellular activation signal requirements for the induction of IL-2 responsiveness in resting T cell subsets in humans.
Ford et al. (1988)IL-2T cellsOur studies now show that an intrinsic T cell abnormality exists when HD patients' T cells are stimulated with agonistic MAb that can optimally activate and stimulate IL-2 production in normal control T cells.
Satoh et al. (2002)IL-2T-cellsInvolvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4(+)25(+) HTLV-1-infected T-cells in human carriers of both HTLV-1 and S. stercoralis.
Gramatzki et al. (1985)IL-2T lymphocytesCertain cell lines were found to significantly enhance IL-2 production by phytohemagglutinin-stimulated T lymphocytes, and the mechanisms involved in mediating such an enhancement have been studied.
Lipkowitz et al. (1984)IL 2T lymphocytesThe first phase requires mitogen (or antigen) to induce expression of IL 2 receptors and production of IL 2 by the T lymphocytes.
Kumagai et al. (1987)IL-2 mRNAT cellsThe level of IL-2 mRNA accumulation and resultant IL-2 secretion is one of the limiting factors for proliferation of T cells exposed to the drugs for less than 3 hr, but not for longer exposures.
Larsen (1990)IL-2T-cellExposure of T cells to both agents for different times resulted in IL-2 production, IL-2R expression, and proliferation in proportion to the duration of incubation with at least 4 h required for maximal T-cell activation.
Larsen (1990)IL-2T-cellIn contrast T cells incubated with ionomycin were induced to produce IL-2 and express IL-2Rs upon brief exposure to PDBu with a 2-h incubation period being sufficient for maximal T-cell activation.
Skerka et al. (1995)interleukin 2T cellActivation of the interleukin 2 (IL-2) gene after antigen recognition is a critical event for T cell proliferation and effector function.
Skerka et al. (1995)IL-2 promoterT lymphocytesPrior studies have identified several transcription factors that contribute to the activity of the IL-2 promoter in stimulated T lymphocytes.
Skerka et al. (1995)IL-2 promoterT cellsIn Jurkat T cells, the ZIP site serves as an activator for IL-2 gene expression, and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity.
June et al. (1989)IL-2T lymphocytesEvidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.
June et al. (1989)IL-2T cellPrior results indicated that stimulation of T cells by anti-CD28 mAb plus PMA could induce IL-2 expression and T cell proliferation that was entirely resistant to cyclosporine.
June et al. (1989)IL-2T cellsThe addition of anti-CD28 to T cells stimulated with PMA plus calcium ionophore induced a 5- to 100-fold increase in IL-2 gene expression and secretion that was resistant to cyclosporine.
Schmidt et al. (1985)IL 2T cellIn contrast to T cell clones, the induction of IL 2 receptor expression after T11 activation was possible only for some NK clones such as JT10 and JT3, but not for CNK5.
Krönke et al. (1985)IL-2T cellsHowever, mitogenic stimuli activate IL-2 receptor gene expression in normal T cells, whereas these stimuli paradoxically inhibit IL-2 receptor gene transcription in HTLV-I-infected leukemic T cells.
Agata et al. (1992)IL-2T cellThese results suggest that the increased IL-2 production after food antigen stimulation is due to increased T cell activity in food sensitive atopic dermatitis.
Zubler and Miescher (1990)interleukin-2T lymphocytesIn very active systemic lupus erythematosus (SLE), the serum levels of interleukin-2 (IL-2) are increased, indicating activation of T lymphocytes in the organism.
Wustrow (1989)IL-2T cellThe IL-2 secretion is dose dependent after stimulation with the mitogens phytohaemagglutinin A (PHA), phorbolester (PMA) or the monoclonal T cell antibody OKT3.
Hori et al. (1986)interleukin-2T-cellWe studied cell proliferation and interleukin-2 (IL-2) receptor upregulation mediated by exogenous IL-2 in leukemic cells from adult T-cell leukemia (ATL) patients to characterize some aspects of abnormal IL-2 receptor expression in ATL.
Lillehoj and Shevach (1985)IL-2T cellWe have studied the mechanism by which cyclosporin A (CsA), dexamethasone (DEX), and ouabain (OUA) inhibit T cell proliferation by measuring the effects of these agents on 1) interleukin-2 (IL-2) production, 2) acquisition of IL-2 responsiveness, 3) the induction of IL-2 receptor expression, and 4) the specific interaction of IL-2 with its receptor.
Nelson et al. (1991)IL-2T lymphocytesSeven patients also had elevated IL-2 receptor expression on peripheral T lymphocytes (P less than 0.05).
Kanamori et al. (1989)IL-2T cellsThe results indicate that the constitutive up-regulation of the IL-2 receptor in HTLV-1-infected T cells may be ascribed to not only the transcriptional but also post-transcriptional regulation.
Reipert and Moore (1990)IL-2T cellsWhen sorting fresh blood lymphocytes for Leu 19+ and Leu 19- before IL-2 activation, enrichment of gamma/delta T cells could be demonstrated in both subpopulations after 20 days of culture.
Becker et al. (1995)IL-2T cellsAnergy is a mechanism of T-lymphocyte tolerance induced by antigen-receptor stimulation in the absence of costimulation, whereby T cells exhibit a defect in antigen-induced transcription of the interleukin 2 (IL-2) gene.