Viewing negative mentions of positive regulation of IL2 (H. sapiens) in T cells

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Tsang et al. (1986)IL-2T cellHowever, no augmentation of IL-2 production was observed when cultures of HUT-78 cells, a human leukemic T cell line, were treated with ISO.
Holán et al. (1994)IL-2T cellIn two additional T cell lines tested, MOLT-16 and H-9, DC did not enhance mitogen-stimulated IL-2 production, but suppressed it when applied at 1 mA for more than 10 min.
Bensussan et al. (1984)IL-2T-cellWe find that Te-Ti triggering of suppressor clones (T8AC6, T8AC7 or T8RW) does not result in IL-2 production or T-cell proliferation and in contrast to inducer clones, also leads to a transient IL-2 unresponsive state.
Larsen (1990)IL-2T cellsSequential stimulation with PDBu and ionomycin failed to induce IL-2 production, IL-2R expression, and consequently proliferation of the T cells, indicating that T-cell activation requires simultaneous activation of protein kinase C (PKC) and elevation of cytosolic calcium.
Meuer and Meyer zum Büschenfelde (1986)IL 2T lymphocytesIn contrast, presensitized T lymphocytes do not require IL 1 for IL 2 production.
Matsuzaki et al. (1986)IL-2T-cellThis process was not a consequence of nonspecific IL-2 gene activation, which occurs in cells persistently infected with reovirus, because reovirus infection did not activate IL-2 secretion in T-cell hybridomas with other antigenic specificities.
Welte et al. (1987)IL-2T cellsThe IL-2 production could be enhanced by coculture with host PBMC frozen before transplant but not by stimulation with mitogenic amounts of OKT3 antibody, thus suggesting an in vivo activation of donor T cells or their precursors by host tissue.
Hara and Fu (1985)IL-2T cellsTPA induced a low level of IL-2 receptor expression in monocyte-depleted T cells, without inducing IL-2 secretion.
Abramson et al. (1983)IL2T cellsIn addition, the data suggest that Ia+ sonicates alone may suffice for induction of IL2 responsiveness, but not for endogenous IL2 production and subsequent proliferation by primed T cells.
Holán and Minowada (1993)IL-2T cellThe production of IL-2 in T cell line H9 was not enhanced by any of the cytokines used.
Zatz et al. (1984)T-cell growth factorT-cellIncubation of lymphocytes with thymosin alone failed to induce any production of T-cell growth factor.
Lombardi et al. (1994)IL-2T cellDespite their high levels of B7 expression, the T cell clones, were unable to induce proliferation or IL-2 secretion by DR-restricted, antigen-specific T cells.
Tsubata et al. (2005)interleukin 2T-cellPDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line.
Podtschaske et al. (2007)IL-2T-cellThe stimulation of a human cytomegalovirus (CMV) specific T-cell line with CMV peptide-pulsed autologous APC also induced IL-2 expression but did not show two seperated populations.
Wotton et al. (1995)IL-2 geneT cellsWhen restimulated, however, anergic T cells fail to up-regulate transcription of the IL-2 gene and in consequence do not produce IL-2.
Boussiotis et al. (1993)IL-2T cellsBB-1 appears to be a molecule distinct from B7 by its expression on B7- cells and its capacity to induce T cells to proliferate without significant accumulation of IL-2.
Becker et al. (1993)IL-2T cellWe observed that a CD4+ T cell clone and an autologous melanoma cell line form conjugates with each other that leads to an increase of [Ca++]i in the T cell clone; however, this interaction failed to induce IL-2 production or proliferation of the T cell clone.
Penttila et al. (1990)IL-2T lymphocytesGluten fraction 111 induced expression of IL-2 receptors on T lymphocytes from coeliac but not from normal subjects (P = 0.0005), whereas soyabean hydrolysate did not induce IL-2 receptor expression.
Maeda (1992)IL-2T cellFurthermore, these IL-2 dependent T cell lines often begin to proliferate in the absence of IL-2 and to not respond to IL-2, despite IL-2 receptors on their cell surface, thus mimicking ATL cells in vivo.
Venkataraman (1992)IL-2-secretingT cellsElimination of CD8+ T cells (putative suppressor cells) from MNCs has also resulted in the production of increased amounts of IL-2 by fresh cells, and again, freezing did not further enhance the IL-2-secreting activities of MNCs, that are devoid of CD8+ T cells.
Gmünder et al. (1990)IL-2T cellModerate intracellular GSH levels, however, are apparently not inhibitory for IL-2 production, since intracellular GSH depletion by cysteine starvation or by graded concentrations of DL-buthionine sulfoximine (BSO) had virtually no effect on IL-2-specific mRNA expression and the production of T cell growth factor (TCGF).
Shimizu et al. (1988)IL-2T cellFurthermore, surfactant had either no effect or enhanced (depending upon the concentration of IL-2 used) the response of exogenous recombinant IL-2 on IL-2-dependent T cell line, In vitro addition of recombinant IL-2 corrected the suppressive effect of surfactant on the AMLR.
Baxevanis et al. (1990)IL-2T cellsIncubation of T cells with ProT alpha, in the absence of PHA or alloantigen, failed to induce any production of IL-2.
Schafer et al. (2003)IL-2T cellsElevation of IL-2 production from Jurkat T cells was observed as early as 6 h poststimulation and correlated with an increase in IL-2 promoter activity that was dependent upon the proximal but not the distal AP-1 binding site.
Or et al. (1992)IL-2T cellsThe production of IL-2 and IL-4 by competent T cells could not be enhanced by the noncorresponding lymphokine.
Lindauer et al. (1996)IL-2T lymphocytesWe conclude that endogenous IL-2 secretion by the colorectal carcinoma cell line SW480 does not result in the activation of MHC restricted specific T lymphocytes but predominantly induces lymphokine-activated killer cells.
Liston et al. (2007)IL-2T cellsWe find that IL-2 is not required for Aire-dependent thymic clonal deletion of high-avidity diabetogenic clones, but is essential for thymic formation of islet-specific Foxp3-expressing CD4 T cells.
Ebert et al. (1987)IL 2T cellThus the inhibition of T cell proliferation is likely to be due primarily to a mechanism independent of IL 2.
Hurez et al. (2003)IL-2T cellThus, there is intrinsic variability in clonal T cell populations that restricts IL-2 commitment, and prolonged engagement with mature DCs is necessary, but not sufficient, for IL-2 gene transcription.
Höllsberg et al. (1996)IL-2T cellsHowever, Ag stimulation failed to induce IL-2 mRNA transcription and IL-2 secretion, although immediate early tyrosine phosphorylation was normal and anti-CD3 cross-linking induced identical levels of CD40L expression in anergized and non-anergized CD8 T cells.
Kosaka et al. (1990)interleukin 2T cellIts ability to promote T cell proliferation without stimulating interleukin 2- or 4-dependent autocrine mechanism.
Lobo-Yeo et al. (1990)IL2T lymphocytesThese results indicate that the high levels of IL2R positive T lymphocytes characteristic of autoimmune chronic active hepatitis are not due to a deficiency of soluble IL2 receptors.
Boulougouris et al. (1999)IL-2T cellMoreover T cell proliferation was unaffected by the addition of blocking Abs to both IL-2 and the IL-2 receptor, demonstrating that this form of costimulation by CD28 was independent of IL-2.
Junger et al. (1997)IL-2 mRNAT-cellHTS alone does not result in IL-2 mRNA transcription, IL-2 expression, or T-cell proliferation.
Carlin et al. (2005)IL-2T cellsThus, distinct organizations of CD3 at the T-cell IS correlate with different cytokine profiles; the mature IS formed by resting T cells correlates with their production of both IFN-gamma and IL-2, whereas the immature IS formed by anergic T cells seems able to facilitate IFN-gamma but not IL-2 production.
Noma et al. (1990)IL-2T-cellsIn in-vitro studies, antigen presenting cells (adherent cells) from the patient pretreated with 5, 50 and 500 ng/ml doses of Ketotifen for 12 h failed to present OVA or Df antigen to T-cells for induction of IL-2 responsiveness.
Kawano et al. (1992)IL2T cellsSince normal CD4+45RA+ T cells did not show antigen-induced IL2 responsiveness even after pretreatment with the CD45RA antibody, it is unlikely that the CD45RA antibody stimulates CD4+45RA+ T cells to become responsive to IL2 after antigenic challenge.
Inaba et al. (1983)IL-2T cellT cell growth was not required for IL-2-mediated helper factor release, since irradiated and untreated responders produced similar levels of factor and did so within 3 h of the addition of IL-2.
Niwano et al. (1989)interleukin-2T-lymphocyteSuppression of T-lymphocyte blastogenesis by ovine trophoblast protein-1 and human interferon-alpha may be independent of interleukin-2 production.
Mohagheghpour et al. (1985)IL 2T cellsOn the other hand, T cells of LL patients failed to express receptors for IL 2 or to produce IL 2 in response to M. leprae, whereas similarly treated T cells of BT patients both expressed IL 2 receptors and produced IL 2.
Brkic et al. (1985)IL-2T cellThese findings suggest that impaired T cell functions seen in some (but not all) marrow recipients are probably not due to IL-1 but to IL-2 deficiency or to the mechanism that causes IL-2 deficiency.
Yoshida et al. (2001)IL-2T cellIL-2 independent transformation of a unique human T cell line, TY8-3, and its subclones by HTLV-I and -II.
Payvandi et al. (2005)IL-2T cellsImmunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT.
Evans et al. (1992)IL-2T-cellFrom these data we conclude that, in human T-cells, RB phosphorylation is not directly associated with T-cell receptor-mediated events, but requires the interaction of IL-2 and new gene transcription following IL-2 stimulation.
Swift et al. (1988)interleukin 2T cellsThis hybrid does not constitutively express detectable levels of interleukin 2 (IL 2) receptors but can be induced to express receptors by stimuli shown to activate T cells.
Hader et al. (1991)IL-2T cellsUnlike normal IL-2 secretion, which was higher after removal of CD8+ T cells, the pattern and degree of IL-2 secretion by cells from fibromyalgia patients were not changed following removal of CD8+ T cells.
Hain et al. (1990)Il-2T cellsThis stimulatory activity was found in the high molecular weight range (approximately 150 kDa) and could not be attributed to the action of immunoglobulins or known cytokines such as Il-2 or interleukin-1 (Il-1), suggesting the activity of a material that modulates the Il-2-dependent growth of T cells.
Huang et al. (1986)IL 2T cellsFurthermore, a normalization of IL 2 secretion took place in the presence of either SLE serum or normal serum, and the addition of fresh autologous T cells to 3-day-cultured SLE T cells did not cause suppression of IL 2 secretion.
Tinubu et al. (1994)IL-2T cellsIL-2Rs are expressed by T cells activated in response to foreign histocompatibility Ags but not by normal cells.
D'Souza and Lefrançois (2003)IL-2T cellIL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
Carlin et al. (2005)interleukin 2T cellsHowever, intercellular communication between anergic human T cells and agonist peptide-loaded APCs was not a null event, since it triggered secretion of T-cell interferon gamma (IFN-gamma) but not, for example, interleukin 2 (IL-2).
Johnson et al. (1998)IL-2T cellsThese data suggest that adult vascular EC costimulate production of IL-2 and IFN-gamma but not IL-4 by mature T cells, that EC costimulation is not increased in inflamed tissues, and that different EC optimally costimulate particular T cells.
Nanda et al. (1994)IL-2T cellAlthough Th0 cells are also known to synthesize cytokines of both the Th1- and Th2-type T cells, the suppressor T cells described in this report are different from Th0 cells in that they produce (i) neither IL-2 nor IL-4 molecules and (ii) stimulation via their CD3-TCR system seems independent of both IL-2 and IL-4, the typical autocrine molecules for T cell proliferation.
Alderson et al. (1990)IL-2CTLIn contrast to its effects on CTL generation, the induction of LAK cells by IL-7 was virtually independent of IL-2.
Villemain et al. (1989)interleukin-2T cellsNo increase in the number of T cells showing activation markers, such as human leukocyte antigens and interleukin-2 receptors, was noted.
Kreisberg et al. (2006)IL-2T cellsInfection of memory CD4 T cells also requires endogenous soluble factors, but not IL-2 or -15.
French and Plate (1985)IL 2CTLThe activation of pre-CTL and IL 2-producing cells by the recognition of determinants on the H-2Db antigen was not sufficient for the generation of effector CTL, as demonstrated in the H-2Dd-anti-H-2Db response.
Cayeux et al. (1989)IL-2T cellsAllogeneic mixed lymphocyte reactions during a second round of ontogeny: normal accessory cells did not restore defective interleukin-2 (IL-2) synthesis in T cells but induced responsiveness to exogeneous IL-2.
Fournel et al. (1996)IL-2T cellsHuman T cells require IL-2 but not G1/S transition to acquire susceptibility to Fas-mediated apoptosis.
Viret et al. (1995)IL-2T cellT cell activation by antigens on human melanoma cells--co-stimulation by B7-1 is neither sufficient nor necessary to stimulate IL-2 secretion by melanoma-specific T cell clones in vitro.
Nguyen et al. (2004)IL-2T cellsCholesterol-loaded peripheral T cells were completely unresponsive to alphaCD3/alphaCD28 stimulation, demonstrating no increase in IL-2, GM1 expression or cell size.
Proust et al. (1991)IL 2T lymphocytesResting T lymphocytes were induced to express IL 2R under experimental conditions in which IL 2 production was not induced or was prevented.
Mohagheghpour et al. (1995)IL-2T cellsPhorbol ester (PMA), a direct activator of PKC, provoked LHRH production and cell surface expression of CD69 and IL-2R molecules by T cells, but not IL-2 synthesis.
Chien et al. (2004)IL-2T cellsOur findings suggested that the stimulation of PLD activity and its mRNA expression by LPS might be required for IL-2 R expression and a sustained PKC dependent pHi elevation but not for the secretion of IL-2 or IL-4 in human T cells.
Palacios and Sugawara (1982)IL-2T cellsThe addition of interleukin-1 (IL-1) to HC-A-treated cultures did not restore or increase the synthesis of IL-2, whereas IL-1 added to non HC-A treated cultures significantly enhanced the synthesis of IL-2, Finally, IL-2 but not IL-1 could overcome the abrogatory effect of hydrocortisone on proliferation of T cells induced by AMLR.
Goeken et al. (1986)IL-2T cellsThey do not secrete IL-1 nor stimulate secretion of IL-2 by T cells.
Geppert and Lipsky (1987)IL 2T cellA variety of other immobilized Mab directed at T cell surface proteins including class I major histocompatibility complex encoded gene products, CD2, CD5, 4F2, and Tp44, did not induce proliferation even in the presence of IL 2.
Brouard et al. (2005)IL2T cellsThe cytokine transcriptional patterns of sorted T cells with altered TCR usage show no accumulation of cytokine transcripts (IL10, IL2, IL13, IFN-gamma), suggesting a state of hyporesponsiveness in these patients.
Yi-qun et al. (1997)IL-2T cellT cell anergy refers to a functional state in which the cells are alive but unable to produce IL-2 after appropriate triggering.
O'Hehir et al. (1991)lymphokineT cellsRestimulation of anergic T cells with an antigenic challenge failed to induce lymphokine production, with the exception of allergen-reactive T cells that secreted IFN-gamma.
Mehrotra et al. (1993)IL-2T cellsIL-12 augmentation of proliferation and cytotoxicity of CD8+ T cells was not inhibited by a mAb to the p55 subunit of the IL-2 receptor (alpha-Tac) at a concentration sufficient to block the activity of exogenously added IL-2, indicating that the activity of IL-12 did not require IL-2.
Gerosa et al. (1986)Interleukin-2T-cellInterleukin-2 production in response to phytohemagglutinin is not necessarily dependent upon the T3-mediated pathway of T-cell activation.
Roussel et al. (1995)lymphokineT cellThese results show that lung adenocarcinoma TIL populations had little lymphokine gene activation despite the presence of several T cell subsets expressing different adhesion/activation markers.
Vandenabeele et al. (1990)IL-2T-cellIL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression.
Dunne et al. (2001)IL-2T cellsBoth cytokines stimulated cytotoxicity by NK and CD56(+) T cells against K562 targets, but not the production of IFN-gamma, TNF-alpha, IL-2, or IL-4.
Schwab et al. (1985)IL 2T cellsThese T cells, however, are not induced to express IL 2 receptors or secrete IL 2.
Jaalouk et al. (2006)IL-2T-cellsSince cytotoxic CD8+ T-cells do not significantly induce IL-2 promoter as compared to CD4+ T-cells, we propose that the SINIL-2pr system would be especially useful in applications such as negative selection of alloreactive CD4+ T-cells when the disparity between donor and recipient is at the MHC Class II locus and for preferential enrichment of antigen-specific CD4+ T-cells which have been shown to confer an advantage in several immunotherapy applications.
Saloga et al. (1993)IL-2T-cellIn the present manuscript we provide evidence that soluble monoclonal antibodies (mAbs) to CD3 or the T-cell receptor (TCR), similar to the phorbol esters, can induce IL-2 production and cell proliferation in competent but not resting T cells.
Lorré et al. (1990)IL 2T cellsIn contrast, preincubation with rIL 4 did not enhance IL 2 responsiveness and rIL 2 but not rIL 4 up-regulated IL 2R expression on anti-CD2-stimulated T cells.
Spits et al. (1987)IL-2T cellThe T cell growth-promoting effect of IL-4 on preactivated T cells was not inhibited by monoclonal antibodies against IL-2 or the IL-2 receptor, indicating that the IL-4 activity is independent from IL-2 or the IL-2 receptor.
Chou et al. (1995)IL-2 mRNAT cellsT cells infected with ORF-1 and ORF-2 deletion mutants expressed no detectable IL-2 mRNA.