Viewing affirmative mentions of positive regulation of IFNG (H. sapiens) in T cells

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Croll et al. (1986)IFN-gammaT-cellLow-density lymphocytes prepared by Percoll fractionation of human peripheral blood mononuclear leucocytes were found to produce large amounts of interferon-gamma (IFN-gamma) in response to different T-cell mitogens in the absence of macrophages, whilst higher density lymphocytes were strongly dependent on the presence of macrophages for significant IFN-gamma production.
Kemp et al. (1997)IFN-gammaT cellActivation of IFN-gamma producing natural killer (NK) cells was demonstrated only in some cultures, and only with concomitant T cell activation.
Tennenberg and Weller (1996)IFN-gammaT cellIn the absence of HAMVEC, LPS-induced T cell activation for IFN-gamma secretion was only minimally demonstrated in the presence of monocytes.
Fuchs et al. (1989)interferon-gammaT-lymphocytesDiminished in vitro production of interferon-gamma by T-lymphocytes on stimulation with specific soluble antigens contrasts with increased levels of circulating interferon-gamma in patients.
Novelli et al. (1994)IFN-gammaT cellsBy contrast, when malignant T cells are cultured in medium without serum, IFN-gamma R expression dramatically increases and the cells undergo a slow apoptotic death.
Meng et al. (2006)IFN-gammaT lymphocytesCONCLUSION: It is feasible to detect significantly increased IFN-gamma secreting T lymphocytes after allogeneic PBMNCs stimulation based on the CKSA technique at single cell level and these cells can be efficiently enriched and expanded for further research.
Nakayama (1983)IFN-gammaT-lymphocyteAn increase in the production of IFN-gamma resulted from the mixture of autologous macrophages in T-lymphocyte cultures.
Kimura et al. (1999)IFN-gammaT lymphocytesProduction of IFN-gamma in CD8+ T lymphocytes of patients with fulminant hepatitis was also elevated, furthermore significantly correlating with the prothrombin time (r=-0.64, p<0.01).
Hardy et al. (1987)IFN-gammaT cellBy using several T cell lines that differ in their inducible expression of IFN-gamma, we have now localized several additional structural domains within the human IFN-gamma gene that appear to be coordinately involved in regulating expression.
Sloand et al. (2002)IFN-gammaT cellsOf 70 patients with severe AA, 36 (51%) demonstrated increased IFN-gamma in circulating T cells.
Mishra et al. (2003)interferon-gammaT cellOn the other hand, we observed that interferon-gamma (IFN-gamma) was significantly elevated in T cell mitogen, PHA, stimulated PBMCs culture supernatant of lead exposed individuals.
Aguirre-Blanco et al. (2007)gamma interferonT-cellStrain-dependent variation in Mycobacterium bovis BCG-induced human T-cell activation and gamma interferon production in vitro.
Toungouz et al. (1996)IFN-gammaT cellDuring mixed lymphocyte reaction (MLR), which constitutes an in vitro model of allograft rejection and GVHD, T cell recognition of HLA differences induces IFN-gamma release.
D'Ombrain et al. (2008)IFN-gammaT cellsParasite-induced early IFN-gamma was predominantly derived from gammadelta T cells (68% of which expressed the natural killer marker CD56) and alphabeta T cells, whereas natural killer cells and other cells made only minor contributions.
Bhayani and Falcoff (1985)IFN-gammaT-cellMonoclonal antibodies specific for human T-cell-differentiation antigens were used to investigate the mechanism of induction of interferon-gamma (IFN-gamma) and interleukin 2 (IL-2).
Wilson et al. (1986)IFN gammaT cellsAddition of IFN alpha, 10,000-50,000 U/ml of interleukin 2 or phorbol myristate acetate (PMA) to cord mononuclear cells or of adult monocytes or PMA to cord T cells increased IFN gamma production compared to cells stimulated with concanavalin A (ConA) alone.
Shinada et al. (1986)interferon-gammaT-lymphocytesCollaboration between enriched T-lymphocytes and macrophages, both treated with glycyrrhizin, was needed for the enhancement of interferon-gamma production.
Jiang et al. (2007)interferon-gammaT-cellAll three synthetic analogues induce antigen specific T-cell proliferation and interferon-gamma (IFN-gamma) production in ex vivo experiments with a totally synthetic liposomal vaccine system.
Csomor et al. (2007)IFN-gammaT cellAs IFN-gamma levels were increased in supernatants of MDC-T cell co-cultures, our data suggest that C1q-induced DC maturation generates a Th1-type response.
Atayar et al. (2006)IFNgammaT cellOn the other hand, IFNgamma transcripts were elevated in NLPHL and PTGC T cell subsets as compared to tonsillar T cell subsets.
Pellet et al. (2006)IFN-gammaT cellsWe observed a significant increase of IL-2 and IFN-gamma production by CD4 T cells and an increase of IFN-gamma production by CD8 T cells compared to control patients.
Tortorella et al. (2006)IFN-gammaT cellsDespite a higher IL-12 production, phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC), as well as CD4(+) or CD8(+) T cells from elderly donors released interferon (IFN)-gamma amounts similar to those observed in young controls, and underwent only a slight increase in IFN-gamma production after IL-12 costimulation.
Norris et al. (2006)IFN-gammaT cellsThese animals develop a prolonged colonization state characterized by a persistent influx of CD8+ T cells and neutrophils, and local increases in IL-8, IFN-gamma, and TNF-alpha.
Haddeland et al. (2005)IFN-gammaT cellsCompared with the FH(-) group, the FH(+) group showed a significantly lower capacity for generation of CCR4(+) T cells (mean percentage of total T cells: FH(+), 2.42%versus FH(-), 5.74%; P < 0.01), whereas induction of CXCR3 and IFN-gamma did not differ significantly between the two groups.
Gannagé et al. (2005)IFN-gammaT cellsCML-specific tetramer(+) CD8 T cells had a predominantly memory phenotype, an intermediate perforin content, and low intracellular IFN-gamma accumulation in the presence of the relevant peptide.
Hodge et al. (2005)IFNgammaT cellsThere was a significant increase in IFNgamma, IL-2, IL-4, TGFbeta, and TNFalpha production by CD8 T cells and IFNgamma and TNFalpha production by CD4 T cells in BAL from transplant patients compared with controls.
Karni et al. (2004)IFN-gammaT cellsCyclophosphamide modulates CD4+ T cells into a T helper type 2 phenotype and reverses increased IFN-gamma production of CD8+ T cells in secondary progressive multiple sclerosis.
Companjen et al. (2004)IFN-gammaT cellPsoriasis is a T cell-mediated inflammatory skin disease characterized by an elevated IFN-gamma and IL-12p70 expression in skin lesions.
Kubsch et al. (2003)IFN-gammaT cellsIn contrast, both treatments induced a down-regulation of p27Kip1 and acomplete inhibition of the antigen-specific regulatory function as demonstrated by high proliferation and enhanced IFN-gamma production of co-cultured T cells.
Hoffman et al. (2003)interferon-gammaT cellsTo determine the effect of IL-12 supplementation, rhesus macaques were vaccinated with a recombinant MV expressing IL-12; these macaques had increased interferon-gamma production by CD4(+) T cells, decreased production of IL-4, and lower levels of MV-specific immunoglobulin G4 and neutralizing antibody.
Attarbaschi et al. (2003)IFN-gammaT cellsSix months later, a decreased, but still elevated IFN-gamma expression within the CD8+ T cell subset, and an increased percentage of IL-2-expressing CD4+ and CD8+ T cells, reaching values shown for controls, were noted.
BenMohamed et al. (2002)IFN-gammaT cellsMoreover, the mucosal route resulted in the preferential induction of IFN-gamma producing T cells and of IgG2a antibody production, as compared to the dominant IL-4 and IgG1 responses obtained by the s.c. route, thus bringing a distinct advantage in the field of many infectious diseases and allergy.
Monzavi-Karbassi et al. (2001)IFN-gammaT lymphocytesSurprisingly, T lymphocytes from peptide-immunized animals were activated in vitro by sLex, also triggering IFN-gamma production in a MHC-dependent manner.
Bellón et al. (1999)IFN-gammaT cellThe cross-linking of the CD94/NKG2 heterodimer in one of these CD8 alphabeta CD94+NKG2A- T cell clones (K14B06) was able to: 1) increase the intracellular concentration of Ca2+, 2) induce the up-regulation of CD25 Ag expression and the secretion of IFN-gamma, and 3) trigger redirected cytotoxicity in a TCR-independent manner.
Foreman et al. (1999)IFN-gammaT-cellsAfter stimulation by the transfected tumor cells, T-cells produced a Th-1 type cytokine production profile with increased IL-2 and IFN-gamma levels.
Bartholomé et al. (1999)IFN-gammaT cellsAs a consequence, DC differentiated in the presence of IFN-beta induced less IFN-gamma secretion by alloreactive T cells.
Bartholomé et al. (1999)IFN-gammaT cellsAs a consequence, DC differentiated in the presence of IFN-beta induced significantly less IFN-gamma secretion by alloreactive T cells, whereas they were more efficient than control DC in eliciting IL-5 secretion.
Krampera et al. (1999)IFN-gammaT cellsThe results showed a progressive increase of circulating Th(c)1-type, interferon-gamma (IFN-gamma)- and/or IL-2-producing T cells along with ageing and, conversely, a stable number, although higher than in cord blood samples, of CD4+/IL-4+ T cells in the post-natal groups.
Contreras et al. (1998)IFN-gammaT-cellSeven of nine T-cell clones exhibited a Th0-like cytokine profile, producing high levels of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) upon stimulation with specific peptides and mitogens.
Ferry et al. (1997)interferon-gammaT cellsIn activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h.
Schwaighofer et al. (1996)IFN-gammaT cellsThe analyses showed that an increase in IFN-gamma and neopterin serum levels was a specific feature of cyclophosphamide administration and was not observed after other cytostatic drugs or total body irradiation, and that an increase in IFN-gamma, neopterin, beta2-microglobulin, and IFN-alpha release depends on the presence of T cells in the graft.
Boirivant et al. (1996)IFN-gammaT cellsGiven that IFN-gamma secretion is significantly increased in LP T cells in which apoptosis is inhibited, this feature of LP T cells may represent a mechanism of regulating detrimental immune responses in the mucosal environment.
De Gast et al. (1995)IFN-gammaT cellImproved T cell activation was noted, as indicated by an increase in IFN-gamma, IL-6, IL-8, and IL-10, in addition to high TNF-alpha increases.
Wilkes and Weissler (1994)interferon-gammaT-cellThe inability of DC to stimulate IgG synthesis was observed despite a potent induction of T-cell proliferation and interferon-gamma (IFN-gamma) production.
Robinson et al. (1994)interferon-gammaT-cellEvidence for a Th1-like bronchoalveolar T-cell subset and predominance of interferon-gamma gene activation in pulmonary tuberculosis.
Dumont and Kastner (1994)interferon-gammaT cellTransforming growth factor beta 1 inhibits interleukin-1-induced but enhances ionomycin-induced interferon-gamma production in a T cell lymphoma: comparison with the effects of rapamycin.
Mages et al. (1993)interferon-gammaT cellsFew known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).
Carozzi et al. (1993)IFN-gammaPTLsThere was also an increased release of IFN-gamma and IL-1 from PTLs and PM phi s (cytokines that stimulate the collagen synthesis) and a decreased release of PGE2 (cytokines which inhibit the collagen synthesis).
Lai et al. (1991)IFN-gammaT-cellBlockade of IL-2R or IL-4R both resulted in a reduction of interferon-gamma (IFN-gamma) production, indicating that both endogenously generated IL-2 and IL-4 are important mediators of IFN-gamma induction in PBL cultures stimulated with T-cell mitogens.
Tocci et al. (1989)IFN-gammaT cellFK506, a neutral macrolide with immunosuppressive properties, was shown to selectively and rapidly inhibit the accumulation of IL-2 mRNA, as well as the mRNAs of other early (E) phase T cell activation genes such as IL-3, IL-4, GM-CSF, TNF alpha, IFN-gamma, and c-myc in activated human peripheral blood T cells.
Platsoucas et al. (1986)IFN-gammaT-cellStaphylococcal enterotoxin A (SEA), a protein isolated from culture supernatants of Staphylococcus aureus, is a potent T-cell mitogen and an inducer of interferon-gamma (IFN-gamma).
Schober et al. (1984)gamma-interferonT lymphocytesThe production of gamma-interferon (IFN gamma) in human peripheral blood T lymphocytes was induced by stimulation with PHA.
Losana et al. (2002)IFN-gammaT cellsRequirement for both IL-12 and IFN-gamma signaling pathways in optimal IFN-gamma production by human T cells.
Losana et al. (2002)IFN-gammaT cellModerate production of IFN-gamma was partially enhanced only in IFN-gamma R1(-/-) T cell clones generated in the presence of IL-12, but was almost completely abolished when IL-12R beta 1(-/-) and IFN-gamma R1(-/-) T cell clones were generated in the presence of anti-IFN-gamma R1 or anti-IL-12 mAb, respectively.
Iho et al. (1999)IFN-gammaT cellsOligodeoxynucleotides containing palindrome sequences with internal 5'-CpG-3' act directly on human NK and activated T cells to induce IFN-gamma production in vitro.
Mayer et al. (2002)IFN-gammaT cellsDepletion of either CD4+ T cells, CD8+ T cells or CD16+/CD56+ T cells by immunomagnetic separation demonstrated that TT-specific IFN-gamma secretion is mediated exclusively by CD4+ T cells.
Faroudi et al. (2003)IFN-gammaT cellsRemarkably, under these conditions, T cells were eventually activated to IFN-gamma production and the amount of IFN-gamma produced was directly related to the total signaling time despite the repeated interruptions.
Svedersky et al. (1985)IFN-gammaT cellThese results suggest that rIL 2, in addition to being a T cell growth factor, may exhibit other activities through induction of LT and IFN-gamma.
Le et al. (1986)IFN-gammaT cellsAddition of autologous or allogeneic tonsillar DC to cultures of purified T cells caused up to a fifteen-fold increase in phytohemagglutinin (PHA)-induced IFN-gamma production and up to a seven-fold augmentation of IFN-gamma induction by interleukin 2 (IL 2).
Le et al. (1986)IFN-gammaT cellsMarked enhancement of IFN-gamma production by T cells was seen in the presence of as little as 0.3% thymic DC.
Xu et al. (2009)interferon-gammaT cellsDC vaccination-induced interferon-gamma production is positively correlated with the number of antigen-specific T cells generated.
Wang et al. (2001)IFN-gammaT cellsIn this study, we demonstrate that human Vgamma2Vdelta2 T cells produce IFN-gamma and TNF-alpha as early as 2 h after Ag exposure, and that they produce these cytokines in a dose- and time- dependent manner in response to stimulation with a live bacterial product, iso-butylamine (IBA), but not to dead bacteria or LPS. gammadelta T cells began, ceased, and then resumed IFN-gamma and TNF-alpha generation in an on/off/on cycling pattern, both in vitro and in vivo, depending on the presence or absence of IBA.
de Pater-Huijsen et al. (2002)interferon-gammaT cellsProducts from human mast cell line cells enhance the production of interferon-gamma by CD8+ and CD4+ T cells.
de Pater-Huijsen et al. (2002)IFN-gammaT-cellThe enhancement of IFN-gamma production was induced both in polyclonal CD4+ and CD8+ T cells and in CD4+ and CD8+ T-cell clones.
Nishi et al. (1998)interferon gammaT lymphocytesLysophosphatidylcholine enhances cytokine-induced interferon gamma expression in human T lymphocytes.
Nishi et al. (1998)IFN-gammaT lymphocytesEnhanced expression of IFN-gamma in T lymphocytes by lyso-PC may play a crucial role in atherogenesis.
Nishimura et al. (1998)IFN-gammaT-cellsWe observed the following: 1) TCR antagonism for T-cell clones reactive to non-self or autoantigenic peptides, 2) partial activation (agonism) without cell proliferation, including production of lymphokines and increases in cell size, and in expression levels of several cell surface proteins or survival time in the absence of antigenic stimulus, 3) augmentation in cell proliferation and production of interferon-gamma (IFN-gamma) and granulocyte monocyte colony stimulating factor (GM-CSF), 4) augmentation of interleukin (IL)-12 production by antigen presenting cell (APC) and the subsequent augmented production of IFN-gamma by T-cells.
Redchenko et al. (2006)IFN-gammaT-cellFurthermore, antigen-presenting cells (APCs), infected with a viral vector expressing 5T4, were able to stimulate IFN-gamma production by the peptide-specific T-cell clones.
Nakamura et al. (1996)IFN-gammaT cellsBoth the degree of spontaneous proliferation and the production of TNF-alpha, IFN-gamma, and GM-CSF by EC-adherent T cells of HAM patients were significantly increased, compared to anti-HTLV-I seronegative controls.
Wang et al. (2008)IFN-gammaT cellIn Jurkat T cells and primary human CD4+ T cells, Prox1 expression decreases quickly upon T cell activation, concurrent with a dramatic increase in IFN-gamma expression.
Miyagawa et al. (2001)IFN-gammaT cellsThus, although pamidronate induced cell clustering, proliferation, and IFN-gamma production of gammadelta T cells in the culture of PBMC, it failed to induce any of these activities in the culture of purified primary gammadelta T cells.
Blay et al. (1992)IFN gammaT cellsThe ability of BA to elicit IFN gamma from human T cells was inhibited in the presence of anti-Tac, suggesting that BA also induces IL-2 secretion and that IL-2 is involved in BA-mediated IFN gamma secretion.
Vannucchi et al. (2001)IFN-gammaT lymphocytesCMV-specific T lymphocytes were identified following induction of interferon gamma (IFN-gamma) secretion prompted by peptide exposure.
Castes et al. (1988)IFN-gammaT cellsOur results help explain the anergy of T cells from DCL patients to leishmanial antigen, which could lead to a defective production of IFN-gamma and possibly contribute to their incapacity to kill the Leishmania parasite.
Horváth et al. (1999)IFNgammaT lymphocytesThese results suggest, that inhibition of IFNgamma gene expression by histamine is a direct effect of histamine on H2 receptor of T lymphocytes; however, the superinduction of IFNgamma by cimetidine requires the presence of other (probably primarily B) cell subsets.
Wilkinson and Morris (1984)IFN-gammaT-lymphocyteIFN-gamma production induced by phytohemagglutinin (PHA) in both fresh peripheral blood mononuclear leukocytes ( PBML ) and T-lymphocyte lines was augmented by 5- to 10-fold when cultured with SRBCs.
Ince et al. (2004)IFN-gammaT cellsWe investigated whether inhibitory natural killer cell receptor (iNKR) expression contributes to impaired antigen-specific cytotoxicity and interferon-gamma (IFN-gamma) production by CD8 T cells during chronic infection. iNKR immunoglobulin-like transcript-2 (ILT2/CD85j) is expressed on 40-55% of cytomegalovirus (CMV)-, Epstein-Barr virus (EBV)- and human immunodeficiency virus (HIV)-specific CD8 T cells in both healthy and HIV-infected donors.
Oyaizu et al. (1996)interferon-gammaT cellsWe have recently demonstrated that the cross-linking of CD4 molecules (CD4XL) results in death of normal peripheral T cells through apoptosis and imbalanced cytokine secretion (ie, induction of tumor necrosis factor-alpha [TNF-alpha] and interferon-gamma [IFN-gamma] in the absence of interleukin-2 [IL-2] or IL-4 secretion).
Lolli et al. (1994)interferon gammaT cellsHIV antigen-reactive T cells detected by antigen-induced interferon gamma secretion.
Yoshimoto et al. (1985)Interferon-gammaT cellsInterferon-gamma (IFN-gamma) induction was detected during the course of activation of alloantigen-primed T cells into the cytotoxic state.
Kloosterboer et al. (2004)IFN-gammaT cellsAML193-DR(+) cells induced IL-2 and IFN-gamma secretion with slower kinetics and lower levels in UCB T cells than in AB T cells.
Cello et al. (1996)IFN-gammaT cellAnalysis of the peptide-induced IFN-gamma production and proliferative response showed that the cross-reactive T cell epitopes are localized mainly in capsid protein VP2 and VP3 and to a lesser extent in VP1.
Gitelson et al. (2001)IFN-gammaT-cellsWe showed that ALVAC-encoded B7.1 or B7.2 was continuously expressed on the infected, and subsequently irradiated, leukemia cells, and only cells with ALVAC-mediated expression of costimulatory molecules (but not unmodified leukemia cells or those infected with the ALVAC-parental vector) induced significant proliferation and IFN-gamma production by alloreactive T-cells.
Bhayani and Falcoff (1985)interferon-gammaT-cellT-cell surface antigens defined by monoclonal antibodies, involved in the induction of human interferon-gamma and interleukin 2.
Yan et al. (2007)IFN-gammaT cellThe HLA-A2.1/66Pa peptide complex in vitro stimulated the in vivo-primed T cells as shown by increased T cell proliferation, higher secretion of the T cell cytokine interferon-gamma (IFN-gamma), increased production of intracellular IFN-gamma in CD8+ T cells, and higher T cell-mediated cytotoxicities of CML66L+ human tumor cells.
Agnholt and Kaltoft (2001)IFN-gammaT cellT cell cultures from patients with Crohn's disease produced significantly higher levels of IFN-gamma (<0.001) and TNF-alpha (P=0.04) than T cell cultures from healthy controls.
Grabstein et al. (1986)IFN-gammaT cellsThe later accumulations of IFN-gamma and IL 2R mRNA and the resulting expression of the corresponding proteins may therefore be dependent on the earlier production of IL 2 and its subsequent interaction with the IL 2R on the surface of such activated T cells.