Viewing affirmative mentions of positive regulation of CEL (H. sapiens) in T cells

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Weyand and Goronzy (1990)cellT cellPolymorphic determinants encoded by the third hvr are shared among disease-associated haplotypes and may function to mediate the interaction of alloreactive T cell receptor molecules with the HLA complex.
Hermann et al. (2010)cellT cellsKiller cell immunoglobulin-like receptor expression induction on neonatal CD8(+) T cells in vitro and following congenital infection with Trypanosoma cruzi.
Muramoto et al. (2010)cellT cellsE6201 also suppressed T cell receptor-stimulated IL-17 production from human T cells.
Uno et al. (2009)cellT cellLXRalpha and LXRbeta inhibited beta-catenin transactivation of T cell factor-mediated transcription in a ligand-dependent manner.
Sela et al. (2008)cellT cellThus, hCDR1 down-regulates Akt phosphorylation, which leads to up-regulated expression of T cell Egr-2 and Egr-3, resulting in the inhibition of IFN-gamma secretion that is required for the maintenance of SLE.
Chatterjee and Tainsky (2008)cellT-cellIn cases in which tumor antigens are overexpressed in cancer, mimotopes can overcome tolerance by activating T-cell receptors (TCRs) that originally had low avidity for their respective tumor antigens.
Wu and Ashwell (2008)cellT cellNEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.
Ranuncolo et al. (2008)cellT-cellSpecifically, BCL6 is required for formation of germinal centers in response to T-cell dependent antigen activation.
Olsnes et al. (2008)cellT cellIn vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22.
Shitashige et al. (2008)cellT-cellBACKGROUND & AIMS: The function of beta-catenin as a transcriptional coactivator of T-cell factor-4 (TCF-4) is crucial for colorectal carcinogenesis.
Wilkins and Sansom (2008)cellT-cellAfter Apc loss, there is deregulation of the Wnt signaling pathway and transactivation of T-cell factor/leukemia enhancing factor target genes such as C-Myc.
Czyzyk et al. (2008)cellT cellWe found that stimulation of the T cell receptor complex leads to the rapid development of a physical association between Ras and Imp.
Shinnakasu et al. (2008)cellT cellsThe differentiation of naive CD4 T cells into Th2 cells requires the T cell receptor-mediated activation of the ERK MAPK cascade.
Caruso et al. (2007)cellT-cellA functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells.
Sakata-Sogawa and Tokunaga (2007)cellT cellT cell receptors (TCR) are activated by a specific antigen and interact with other signaling molecules, such as kinases and adaptors.
Agnholt et al. (2007)cellT-cellOPN increased CD69 and CD25 expression and enhanced T-cell IFN-gamma and TNF-alpha production in a dose-dependent fashion with higher levels in CD than in healthy controls (HC), but induced a concomitant higher IL-10 production in HC than CD.
Frisancho-Kiss et al. (2007)cellT cellWe show that TLR4 and IFN-gamma levels are significantly elevated and regulatory T cell (Treg) populations significantly reduced in the heart of males following CVB3 infection, whereas females have significantly increased T cell Ig mucin (Tim)-3, IL-4 and Treg.
Toualbi et al. (2007)cellT-cellThe stabilized beta-catenin is able to translocate to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. beta-Catenin may cross-talk with many signalling cascades to activate target genes.
Tobo et al. (2007)cellT cellGPR4-expressing cells also showed a calcineurin-dependent nuclear factor of activated T cell (NFAT) promoter activation at pH 7.4, and this activity was further increased by pH below 7.2 in association with inositol phosphate production.
Maksumova et al. (2007)cellT cellExpression of PTPalpha and PTPalpha-Y789F in T cells revealed that the mutant had a reduced ability to decrease Fyn and Cbp phosphorylation, to regulate the kinase activity of Fyn, and to restore T cell receptor-induced signaling events when compared with PTPalpha.
Gorelik et al. (2007)cellT cellImpaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus.
Chang et al. (2007)cellT-cellAlternatively spliced T-cell receptor transcripts are up-regulated in response to disruption of either splicing elements or reading frame.
Seki et al. (2006)cellT-cellThe oncogenic beta-catenin/T-cell factor (TCF) signal is a common trigger inducing expressions of various cancer-related genes and is activated in various types of human malignancy.
Kiyici et al. (2006)cellT cellRESULTS: The CD4/CD8 ratio was significantly decreased and expression of T cell receptor-gammadelta was increased in the infected group.
Wittmann et al. (2006)cellT cellsCalcineurin antagonists are known as potent immunosuppressants working particularly on T cells by virtue of their capacity to block nuclear factor of activated T cell (NFAT) activation and translocation to the nucleus.
Obermeier et al. (2006)cellT-cellIL-15, a T-cell growth factor, has been shown to be increased in inflammatory bowel disease (IBD).
La Motte-Mohs et al. (2005)cellT-cellStimulation of the in vitro-differentiated T cells by TCR engagement induced the expression of T-cell activation markers and costimulatory receptors.
Ip et al. (2005)cellT cellElevation of plasma soluble T cell costimulatory molecules CTLA-4, CD28 and CD80 in children with allergic asthma.
McNulty et al. (2005)cellT cellsStudies to evaluate the tissue microenvironment showed that in OPC+ persons, the adhesion molecule for T cells to enter mucosa, mucosal addressin cell adhesion molecule, is significantly increased, whereas E-cadherin, which allows T cells to migrate through mucosa, is significantly decreased compared to OPC- persons.
Zeyda et al. (2005)cellT cellIn this study, we evaluated the impact of the active leflunomide metabolite teriflunomide on T cell integrin activation, evolution of the IS, and antigen-specific formation of stable T cell/APC conjugates.
Ahmed et al. (2005)cellT-cellDistinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors.
Roy et al. (2005)cellT cellWe investigated the intracellular mechanism by which morphine controls CD4+ T cell differentiation and demonstrate that morphine treatment in vitro 1) increases anti CD3/CD28 Ab-induced CD4+ T cell IL-4 protein synthesis, IL-4 mRNA, and GATA-3 mRNA accumulation through a pertussis toxin-sensitive receptor; 2) results in a dose-dependent increase in anti-CD3/CD28 Ab-induced CD4+ T cell cytoplasmic cAMP concentration; and 3) increases the forskolin-stimulated cytoplasmic cAMP level through a pertussis toxin-sensitive receptor.
Peng et al. (2005)cellT-cellIn the presence of IL-10 neutralizing antibodies, DC IL-12p70 production and T-cell IFNgamma were increased in vitro.
Haraguchi et al. (2004)cellT-cellHuman Valpha24+ natural killer T (NKT) cells have an invariant T-cell receptor-alpha chain and are activated in a CD1d-restricted manner.
Breuckmann et al. (2004)cellT cellOur results suggest that UVA1 irradiation exerts its positive effects by a modulation of endothelial regulation/transformation beside the proposed induction of T cell apoptosis and collagenases.
Sawyer et al. (2004)cellT cellsThis study identifies HLA-DP as a regulatory component in the activation of T cell receptors on Be-specific CD4+ T cells from CBD patients resulting in proliferation and proinflammatory cytokine production.
Diaz-Mitoma et al. (2004)cellT cellThe following gene families were also selectively upregulated by influenza antigens: complement ligands and receptors, T cell activation genes, growth factors, genes related to antigen processing and inflammatory responses.
Spertini et al. (2004)cellT-cellWe conclude that down-regulation of membrane-associated tyrosine phosphatase activity by CD45 extracytoplasmic domain multimerization led, in an epitope-specific fashion, to unopposed tyrosine kinase activity and to the activation of the T-cell receptor/CD3 complex signalling cascade, resulting in TNF-alpha gene expression.
Uno et al. (2003)cellT cellA series of immune responses leading to the induction of T cell IL-12/IL-18 responsiveness in patients with relatively large tumor burdens.
Wada et al. (2003)cellT cellIn vitro expression studies indicated that mutant protein encoded by the second-site mutation was expressed and functional, since it was able to bind to cellular partners and mediate T cell receptor/CD3 downregulation.
Swingler et al. (2003)cellT-lymphocyteThis activity requires the upregulation of B-cell receptors involved in the alternative pathway of T-lymphocyte stimulation.
Ito et al. (2003)cellT cellOverexpression of wild-type SAP-1, but not that of a catalytically inactive mutant of SAP-1, inhibited both the basal and the T cell antigen receptor (TCR)-stimulated activity of Lck in human Jurkat T cell lines.
Chen et al. (2003)cellT-cellIn conclusion, it is conceivable that up-regulation of T-cell IL-13 production in children with active nephrotic relapse was associated with suppression of monocyte CD14 expression, down-regulating pro-inflammatory cytokine production, and could account for the increased susceptibility to bacterial sepsis seen in nephrotic children in active relapse.
Yung and Mo (2003)cellT cellAging is associated with increased human T cell CC chemokine receptor gene expression.
Hawcroft et al. (2002)cellT-cellIndomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells.
Borovsky et al. (2002)cellT cellTriggering of the T cell receptor (TCR) leads to the production of intracellular intermediates with half-life of a few minutes.
Suzuki et al. (2002)cellT cellsThese results suggest that the increased number of gammadelta T cells in diffuse lung diseases likely plays a role in immunosurveillance and contributes to the activation of antigen-specific alphabeta T cell.
Ostensen and Villiger (2002)cellT cellIn what way the induction of T cell tolerance to fetal antigens or maternal-fetal HLA disparity modulates disease activity of RA has not been studied.
Marshall and Born (2002)cellT-cellHowever, some observations indicate a delayed enhancing effect on sleep which could be related to the induction of secondary, perhaps T-cell-related factors.
Sanjuán et al. (2001)cellT cellAfter examining induction of the T cell activation marker CD69 in cells expressing a constitutively active form of the enzyme, we present evidence of the negative regulation that DGKalpha exerts on diacylglycerol-derived cell responses.
Letamendia et al. (2001)cellT-cellThese factors elicit their biological effects through distinct pathways in which TGF-beta and Wnt signaling induce activation of the transcriptional regulators Smads and lymphoid enhancer binding factor/T-cell-specific factor (LEF/TCF), respectively.
Rider et al. (2001)cellT cellThe estrogen dependent increases in SLE T cell CD40L mRNA and cell surface protein were blocked by the estrogen receptor antagonist ICI 182,780.
O'Mahony et al. (2000)cellT-cellThis requirement for kinase-proficient IKKalpha to activate IKKbeta in heterodimeric IKK signalsomes is also observed with other NF-kappaB inducers, including tumor necrosis factor alpha, human T-cell leukemia virus type 1 Tax, Cot, and MEKK1.
Kokura et al. (2000)cellT lymphocytesThe overall objective of this study was to determine whether T lymphocytes can modulate the increased neutrophil adherence and upregulation of endothelial cell adhesion molecules in human umbilical vein endothelial cells (HUVECs) exposed to anoxia/reoxygenation (A/R).
Katagiri et al. (2000)cellT cellsFurthermore, a dominant negative form of Rap1 (Rap1N17) inhibited T-cell receptor-mediated LFA-1 activation in Jurkat T cells and LFA-1/ICAM-1-dependent cell aggregation upon differentiation of HL-60 cells into macrophages, suggesting that Rap1 is critically involved in physiological processes.
Heuss et al. (2000)cellT-cellSome mechanisms require the release of granzymes and T-cell restricted intracellular antigen (TIA-1) which induce cell death by apoptosis.
Yamada et al. (2000)cellT-cellThe mutational inactivation of a tumor suppressor gene, adenomatous polyposis coli (APC), results in the accumulation of cytoplasmic beta-catenin protein and the activation of T-cell factor (TCF)/lymphoid enhancer factor transcriptional factors.
Alcover and Alarcón (2000)cellT-cellT-cell activation by antigen, anti-TCR-CD3 antibodies, or pharmacological activators of protein kinase C, results in increased TCR-CD3 internalization, followed by the downmodulation of TCR-CD3 surface levels.
Markoti? et al. (1999)cellT cellThe increased expression of both early and late T cell activation antigens, e.g.
Little et al. (1999)cellT-cellThere was no significant difference in the immunoglobulin G levels to the antigen in the 2 groups, but the levels of T-cell antigen-binding molecules against the para-aminobenzoic acid conjugated to human serum albumin were elevated significantly in subjects sensitive to toluene.
Kim et al. (1999)cellT cellThe transcription factors Ets-1 and AML1 (the alphaBl subunit of PEBP2/CBF) play critical roles in hematopoiesis and leukemogenesis, and cooperate in the transactivation of the T cell receptor (TCR) beta chain enhancer.
Langland et al. (1999)cellT-cellNFAT transcription factors play a central role in initiating T-cell activation through the induction of immediate-early T-cell specific genes including interleukin-2 (IL-2).
Zurier et al. (1999)cellT cellHuman peripheral blood T lymphocyte proliferation after activation of the T cell receptor: effects of unsaturated fatty acids.
Johnson et al. (1998)cellT cellEC activation by pretreatment with tumor necrosis factor alpha (TNF-alpha) does not increase T cell costimulation despite large increases in EC cell adhesion molecule expression.
Ariail et al. (1998)cellT-cellNovel adjuvants for induction of T-cell and antibody responses to encephalitogenic and regulatory determinants in Lewis rats.
O'Rourke et al. (1998)cellT cellHowever, the Ras/MAPK pathway alone is not sufficient for activating T cell LFA-1, as inhibition of both downstream MAPK/extracellular regulated kinase kinase (MEK) activity and phosphatidylinositol 3-kinase activity is required for complete inhibition of adhesion.
De et al. (1998)cellT cellAddition of 10% B cells [either unstimulated or pokeweed mitogen (PWM)-stimulated] to autologous T cells only moderately augmented T cell IL-13 levels.
De et al. (1998)cellT cellMphi culture supernates were equally effective in augmenting T cell IL-13 levels, suggesting both that cell-to-cell contact is not critical for Mphi augmentation of T cell IL-13 levels, and that Mphi secreted factors are pivotal.
De et al. (1998)cellT cellFinally, experiments with exogenous addition of recombinant monokines, as well as neutralization experiments with different cytokine antibodies, suggested IL-1beta as a primary cytokine involved in the augmentation of T cell IL-13 levels by accessory cells.
Tugores et al. (1997)cellT-cellA tandem array of Sp-1 sites and a reverse initiator element are both required for synergistic transcriptional activation of the T-cell-specific MAL gene.
Winoto (1997)cellT-cellStimulation of the T-cell receptor complex in resting T cells leads to activation.
Cui et al. (1997)cellT cellThe activation-induced expression of the immediate-early gene, Nur77, and the T cell death genes, CD95 (Fas) and CD95 ligand (FasL), were inhibited.
Callea et al. (1997)cellT-cellIn this investigation we identified a group consisting of 52% of the children who showed the immature B phenotype, while the remaining 48%, similarly to adult ITP displayed an increase of T-cell antigens.
Marengère et al. (1997)cellT cellWe demonstrate that following CD28 ligation, a CD28-associated tyrosine kinase activity is increased in parallel to activation of the T cell-specific tyrosine kinase Itk (Itk/Emt), while Lck and Fyn kinase activities are not increased.
Contasta et al. (1996)cellT cellMoreover in M+ it seems also important to solve the problem of the switch from B to macrophage cells as immune cells which present antigens, and the possible involvement of c-Ki-ras gene mutations in the impairment of T cell receptor activation (TCR).
Hernández-Munain et al. (1996)cellT cellDevelopmental activation of VDJ recombination at the T cell receptor (TCR) delta locus is controlled by an intronic transcriptional enhancer (E delta).
Taub et al. (1996)cellT cellExamination of chemokine-treated APCs revealed that the T cell costimulatory molecule B7-1 was induced by various beta chemokines.
Chastagner et al. (1996)cellT cellTransfection of T cell clone 8.2 with human IL-2R alpha genes restores their capacity to proliferate in response to IL-2.
Quelle et al. (1996)cellT-cellThe membrane-proximal region of 96 amino acids is necessary and sufficient for mitogenesis as well as Jak2 activation, induction of c-fos, c-myc, cis, the T-cell receptor gamma locus (TCR-gamma), and c-pim-1.
Gigliotti et al. (1996)cellT cellOverexpression of select T cell receptor V beta gene families within CD4+ and CD8+ T cell subsets of myasthenia gravis patients: a role for superantigen(s)?
Redmon et al. (1996)cellT cellFK506 (tacrolimus) is an immunosuppressive drug which interrupts Ca2+-calmodulin-calcineurin signaling pathways in T lymphocytes, thereby blocking antigen activation of T cell early activation genes.
Casamayor-Palleja et al. (1995)cellT cellA subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex.
Israel et al. (1995)cellT-cellTransactivation of human T-cell leukemia virus type 1 by herpes simplex virus type 1.
Li et al. (1995)cellT cellThese data suggest that a second signal, possibly through the T cell antigen receptor since activation of the T cell receptor-associated kinase fyn was also seen, is required for epithelial cell-driven T cell proliferation.
Hettmann and Cohen (1995)cellT cellOur studies provide an explanation for a previous observation that TCRG mRNA levels, but not mRNA levels for T cell receptor alpha and -beta, are increased by ionomycin treatment.
Van Gool et al. (1994)cellT cellsInteraction of CD28/CTLA-4 on T cells with B7 on antigen-presenting cells constitutes an important costimulatory signal for T cells and is responsible for cyclosporin A-resistant interleukin 2 (IL-2) gene expression and potentially also for prevention of anergy induction after T cell receptor triggering.
Ziegler et al. (1994)cellT cellCD69 is a rapidly induced T cell activation Ag that is also expressed in an inducible fashion on cells of most, if not all, hematopoietic lineages.
Roth (1994)cellT cellWe conclude that IL-2 promotes CD45RA+ cells to express the memory phenotype and is a mediator of CD45RO expression after stimulation of the T cell receptor/CD3 complex.
Johnson and McMurray (1994)cellT-cellLymphoproliferative responses to M. tuberculosis and induction of the T-cell cytokine IL-2 were predictably high in the cells of PPD-sensitized donors, low in normal naive individuals, and variable among TB patients.
Kotani et al. (1994)cellT-cellThe induction of apoptosis in these cells by adding an anti-Fas antibody and the expression of activated T-cell surface antigens, CD25 and CD26, were also studied.
Zhao et al. (1994)cellT cellFlow cytometry detected an increase in the level of donor-specific anti-T cell antibodies in both valve and skin allograft recipients but not in isografted animals.
Ward et al. (1994)cellT cellStimulation of the T cell antigen receptor/CD3 complex is followed by phospholipase C activation, phosphoinositol lipid metabolism and ultimately by a rapid rise in both myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and myo-inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4] as well as cytosolic free calcium concentration.
Watts et al. (1994)cellT cellSimilar analysis of 32P-labeled Jurkat cells stimulated with anti-T cell receptor antibodies reveals Tyr-492 and Tyr-493 as the principal sites of T cell antigen receptor-induced tyrosine phosphorylation, with additional phosphorylation at the Tyr-292, but not the Tyr-126 autophosphorylation site.
Zhou et al. (1994)cellT cellsThe 4-1BB antigen has been recently demonstrated to be a 30 kDa inducible T-cell antigen and is expressed on the cell surface of activated splenic T cells and thymocytes.
Katzav et al. (1994)cellT cellStimulation of the T cell antigen receptor (TCR) leads to tyrosine phosphorylation of a number of cellular proteins, including the vav proto-oncogene product.
Goodbourn (1994)cellT-cellAssembly of the activated T-cell transcription factor, NF-AT, from two different types of subunit is sensitive to immunosuppressive drugs and is a striking example of gene regulation by convergent intracellular signals.
Dupuis et al. (1993)cellT cellMoreover, when the release of granule-associated proteins was triggered by stimulation of the T cell receptor complex, calreticulin was released along with granzymes A and D.
Maes et al. (1993)cellT-cellSignificantly increased expression of T-cell activation markers (interleukin-2 and HLA-DR) in depression: further evidence for an inflammatory process during that illness.