Viewing affirmative mentions of binding of Mhc (D. melanogaster) in T cells

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Casal et al. (2005)MHCT cellsT cells scan the surface of antigen-presenting cells (APCs) or target cells for specific peptides bound to MHC molecules.
Sano et al. (2000)MHCT cellsThe possibility is discussed that graft rejection in normal eyes is not mediated by T cells that recognize MHC alloantigens via the direct pathway, but via T cells that recognize donor alloantigens presented by recipient MHC molecules (indirect pathway).
Detours and Perelson (1999)MHCT cellFurther, we demonstrate that highly alloreactive pre- and post-selection repertoires can be obtained without assuming germline bias of T cell receptors toward recognition of allele-specific MHC residues.
Britschgi et al. (2003)MHCT-cellAdditionally, we focus on certain conditions of non-covalent drug presentation by antigen presenting cells and on the molecular recognition of MHC/peptide/drug complexes by specific T-cell receptors.
Reche and Reinherz (2007)MHCT-cellIdentification of peptides that can bind to major histocompatibility complex (MHC) molecules is important for anticipation of T-cell epitopes and for the design of epitope-based vaccines.
Speck and Pierce (1982)MHCT cellsPrimary B cells manifest a much less stringent requisite for MHC recognition by T cells, and under conditions in which secondary B cells fail to be stimulated, primary B cells are stimulated to secrete IgM antibody.
Lu (1994)MHCT-cellIn contrast, the T-cell recognizes a hidden antigenic determinant, together with portions of the MHC on the presenting cell.
Ivanciuc and Braun (2007)MHCT-cellMajor histocompatibility complex (MHC) molecules bind short peptides resulting from intracellular processing of foreign and self proteins, and present them on the cell surface for recognition by T-cell receptors.
Prammer et al. (1995)MHCT-cellComputer design of T-cell agonist or antagonist glycopeptides: the effect of sugar identity and anomeric configuration on MHC binding.
Prammer et al. (1995)MHCT cellRecently, we prepared glycopeptide analogues of major T helper cell epitopic peptides corresponding to rabies virus proteins, and experimentally characterized their ability to bind to MHC class II proteins and stimulate T cell clones to rabies virus.
Forsdyke (1991)MHCT cellsThere is unwarranted satisfaction with the view that MHC polymorphism evolved because there was a selective advantage in having a variety of MHC proteins to bind a variety of peptide subsets for presentation to T cells.
Whitton and Oldstone (1989)MHCT cellSince class I MHC glycoproteins may function by "screening and selecting" degraded proteins, we wished to determine whether very short peptides made within a cell were detected and bound by MHC, and presented for T cell perusal.
Marrack et al. (1988)MHCT cellsThis process is usually thought to involve positive selection of T cells bearing receptors with high and low affinity for MHC on thymus epithelium, and subsequent deletion of high affinity cells by interaction with bone marrow-derived cells.
Lan et al. (2002)MHCT cellT cell can only recognize specific antigenic peptide-MHC complex on antigen-presenting cell.
Janeway et al. (1985)MHCT cellsMajor histocompatibility complex (MHC)-restricted T cells, which we have analyzed in detail, appear to recognize antigen only on the surface of cells bearing the appropriate MHC gene product.
Tong et al. (2007)MHCT-cellT-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for cellular immunity.
Chao et al. (2005)MHCT cellIn order to survive thymic selection, a T cell with low affinity for all self peptides expressed in the thymus must have high affinity for major histocompatibility complex (MHC), which makes it highly cross-reactive.
Givan et al. (2004)MHCT cellAfter stimulation of a T cell by the binding of its receptor to its cognate antigen in the context of a major histocompatibility complex (MHC) molecule on an antigen-presenting cell, the T cell will begin to proliferate and synthesize cytokines.
Krensky and Clayberger (1993)MHCT-lymphocyteAs recently as 10 years ago it was generally believed that recognition of major histocompatibility complex (MHC) molecules by T lymphocytes was direct and represented the "simplest" kind of T-lymphocyte interaction.
Werdelin et al. (1988)MHCT lymphocytesSome of the antigen fragments bind to MHC class II molecules and are transported to the surface of the antigen-presenting cell where the actual presentation to T lymphocytes occurs.
Germain (1995)MHCT cellTo elicit suitable T cell responses vaccines must, therefore, contain proteins or peptides derived from the organism against which protection is desired, the pathogen-derived peptides must be capable of interacting with the allelic forms of the MHC molecules expressed in the vaccinated individuals, and the vaccine components must be delivered in a manner that ensures they are made available for binding to the MHC molecules on appropriate antigen-presenting cells.
Romagnoli et al. (1991)MHCT cellWe find that Ni alters a T cell response to a peptide and show that Ni interacts with this peptide to alter its antigenicity rather than its ability to bind to MHC molecules.
Kane et al. (1989)MHCT-cellPeptide binding to class II MHC proteins, and T-cell recognition of these complexes at the functional level has been demonstrated.
Fineschi and Miller (1997)MHCT cellsT cells are activated by fragments of antigenic proteins bound to major histocompatibility complex (MHC) molecules and displayed on the cell surface.
Landry (1997)MHCT cellsAlthough selectivity at the levels of peptide binding to major histocompatibility complex (MHC) class II and recognition by T cells may partially account for immunodominance patterns, it is clear that differential antigen processing also exerts a strong effect.
Ziegler et al. (2009)MHCT cellsThe dual requirement for T cells to recognize a particular major histocompatibility complex (MHC) antigen presenting a foreign peptide and to lack strong reactivity with a complex of the same molecule when bound to a self-peptide, is attained by thymic positive and negative selection processes, the molecular details of which are currently only partially understood.
Crowley et al. (2000)MHCT cellsA population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule.
Forsdyke (1996)MHCT-cellThe domains of polymorphic major histocompatibility complex (MHC) proteins which interact with peptides and T-cell receptors are considered to have been under positive evolutionary selection pressure.
Adorini and Nagy (1990)MHCT-cellIn addition, it is possible to modulate T-cell activation by interfering with the binding of antigenic peptides to MHC class II molecules.
Garcia et al. (1997)pMHCT cellsAlloreactive T cells have alphabeta TCRs that can recognize both self- and foreign peptide-MHC (pMHC) complexes, implying that the TCR has significant complementarity with different pMHC.
Bui et al. (2005)MHCT cellPrediction of which peptides can bind major histocompatibility complex (MHC) molecules is commonly used to assist in the identification of T cell epitopes.
McCarthy and Singer (1986)MHCT cellsThe role of MHC class I alloantigens in the regulation of class II allospecific responses illustrates that T cells recognizing class I and class II MHC antigens in mixed leukocyte cultures interact in a complex and nonreciprocal manner to influence the final effector T cell repertoire elicited by this complex immunogenic challenge.
Blackman et al. (1986)MHCT cellThe T cell repertoire may be biased in favor of MHC recognition.
Blackman et al. (1986)MHCT cellThe receptors of two T cell hybridomas that recognize class I and class II major histocompatibility complex (MHC) molecules, respectively, have been compared.
Blackman et al. (1986)MHCT cellMoreover, the finding that in two independent examples hybrid receptor molecules created randomly by in vitro cell fusion recognize MHC supports the theory that the T cell repertoire has an intrinsic affinity for MHC.
Schueler-Furman et al. (2001)MHCT cellsAntigenic peptides bind to major histocompatibility complex (MHC) molecules as a prerequisite for their presentation to T cells.
Hugo et al. (1993)MHCT-cellDuring development in the thymus, thymocytes bearing alpha beta T-cell receptors are selected to mature if the receptors they bear are able to interact in some way with major histocompatibility complex (MHC) proteins expressed on thymic stromal cells.
Udaka et al. (1995)MHCT cellsMajor histocompatibility complex (MHC) class I molecules are cell-surface glycoproteins that bind peptides and present them to T cells.
Wu et al. (2006)MHCT-cellCONCLUSION: These data show that carbamazepine and certain stable carbamazepine metabolites stimulate T cells rapidly via a direct interaction with MHC and specific T-cell receptors.
Peters et al. (2005)MHCT cellTools that use various methods for prediction of MHC binding will also be provided, along with tools predicting proteasomal processing and TAP transport of T cell epitopes.
von Greyerz et al. (1998)MHC-peptideT cellIn fact, activated T cell clones can recognize drugs associated with the MHC-peptide complex in a non-covalent way.
Parham and Ohta (1996)MHCT cellIn principle, the function of major histocompatibility complex (MHC) molecules is simple: to bind a peptide and engage a T cell.
Marrack et al. (2008)MHCT cellThe ligands for alpha beta T cell receptors (alphabetaTCRs) are usually major histocompatibility complex (MHC) proteins bound to peptides.
Reay et al. (1994)MHCT cellUse of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103).
Reay et al. (1994)MHCT cellSubstitution with all naturally occurring L-amino acids at each of 11 residues of the IEk-restricted month cytochrome c (93-103) epitope has allowed us to analyze the requirements for MHC binding and T cell recognition to a level of definition not previously possible.
Reay et al. (1994)MHCT cellInterestingly, changing residues involved in MHC binding can ablate T cell recognition without altering MHC association.
Reay et al. (1994)MHCT cellAdditionally, residue identity at two positions that do not appear critical for MHC binding, nor to be involved in specific T cell contact, nonetheless dramatically affect T cell responses.
Thomson and Donn (2002)MHCT-cellMHC-, cytokine- and T-cell-related genes have all been positively associated with JIA.
De Vries et al. (2003)MHCT cellsTo induce an effective immune response, these cells should not only express high levels of MHC and costimulatory molecules but also migrate into the lymph nodes to interact with na´ve T cells.
Cochran et al. (2001)MHCT cellsT cells are activated via engagement of their cell-surface receptors with molecules of the major histocompatibility complex (MHC) displayed on another cell surface.
Detours and Perelson (2000)MHCT cellsAlthough 1-24% of T cells are alloreactive, i.e., respond to MHC molecules encoded by a foreign haplotype, it is generally believed that T cells cannot recognize foreign peptides binding foreign MHC molecules.
Marrack et al. (1988)MHCT cellsDuring development in the thymus, T cells are deleted if their receptors are able to recognize self major histocompatibility complex (MHC) proteins.
Marrack et al. (1988)MHCT cellsIn addition, development in the thymus picks out T cells to mature if their receptors will be restricted for antigen recognition in association with self MHC alleles expressed on thymus epithelial cells.
Zepp et al. (1987)MHCT lymphocytesThe second experiment was designed to determine which Ia-positive thymic compartment participates in conferring tolerance to MHC antigens in maturing T lymphocytes.
Elliott et al. (1987)MHCT cellWhen we investigated the hypothesis that amphipathic alpha helical peptides digested from foreign antigen bind to class II major histocompatability complex (MHC) molecules' binding site (desetope) for foreign antigen to be presented to T cell receptors, we found such an extended amphipathic helix in Ii.
Overath and Aebischer (1999)MHCT cellsThis transition from a resting to an activated state is mediated by the interaction with specific T cells that recognize pathogen-derived peptides complexed to major histocompatibility complex (MHC) molecules at the surface of host cells.
Knapp et al. (2010)MHCT cellHowever, the molecular nature of the interaction between peptide and MHC and how it influences T cell responsiveness is not fully understood.
Carl et al. (2005)MHCT cellThe model also explains the experimentally observed breakdown of major histocompatibility complex (MHC) class specificity in peptides associated with the MHC II proteins of activated autoimmune B cells, and sheds light on the selection of particular T cell epitopes in autoimmunity.
Accolla et al. (1991)MHCT cellsAntigenic peptides become associated with major histocompatibility complex (MHC) class I and class II surface antigens, are then presented to T cells and thereby elicit an antigen-specific cellular or humoral immune response.
Braciale and Braciale (1991)MHCT cellsT cells recognize nonnative processed fragments of antigens presented in association with major histocompatibility complex (MHC) class I or class II molecules.
Adorini et al. (1989)MHCT cellsT cells recognize foreign proteins as peptides bound to self molecules encoded by the major histocompatibility complex (MHC).
Renoux et al. (1988)MHCT-cellThe induction of T-cell responses involves the recognition of extrinsic antigens in association with antigens of the major histocompatibility complex (MHC).
Wraith et al. (1989)MHCT cellsA peptide analog of the encephalitogenic epitope is shown to be "heteroclitic" for MHC binding and activation of encephalitogenic T cells in vitro.
Flomenberg (1989)MHCT-cellT-cell clones recognizing MHC products.
Britschgi et al. (2003)MHCT-cellThis led us to an other new concept: the pharmacological interaction of drugs with immunological receptors, namely the MHC and T-cell receptors.
Obst et al. (2000)MHCT cellBy analyzing T cell responses against foreign major histocompatibility complex (MHC) molecules loaded with peptide libraries and defined self- and viral peptides, we demonstrate a profound influence of self-MHC molecules on the repertoire of alloreactive T cells: the closer the foreign MHC molecule is related to the T cell's MHC, the higher is the proportion of peptide-specific, alloreactive ("allorestricted") T cells versus T cells recognizing the foreign MHC molecule without regard to the peptide in the groove.
Speck and Pierce (1982)MHCT cellsImmune, or secondary B cells require syngeneic-like MHC recognition by collaborating T cells, and in its absence fail to be stimulated.
Schild et al. (1990)MHCT cellsMHC molecules can also bind endogenous self peptides, to which T cells are tolerant.
Moudgil and Sercarz (2005)MHCT-cellFurthermore, this residual T-cell repertoire, largely directed against cryptic determinants, will contain some T cells with sufficient affinity for MHC and antigen that enables them to respond under inflammatory conditions, thus facilitating presentation of previously cryptic determinants.
Uracz et al. (1985)MHCT-cellThus, the serologically detectable I-J epitopes are found to be associated with inducible T-cell receptors recognizing self class II MHC antigens.
Reche et al. (2002)MHCT-cellTherefore, a position specific scoring matrix (PSSM) or profile derived from a set of peptides known to bind to a specific MHC molecule would be a suitable predictor of whether other peptides might bind, thus anticipating possible T-cell epitopes within a protein.
Kast and Melief (1991)MHCT-cellThis leads to the conclusion that this 10-mer peptide is optimal for MHC binding and T-cell recognition.
Kast and Melief (1991)MHCT-cellAreas of the peptide primarily involved in binding to MHC or in T-cell recognition are delineated.
Araneo (1986)self-MHCT cellThird, several lines of evidence have established that T cell recognition of self-MHC molecules is a modifiable phenotype; conferred by a receptor having both variable and constant regions and not encoded by genes in the MHC.
Mannie (1991)MHCT cellsThese T cells experience positive thymic selection and eventually dominate a repertoire of mature T cells predisposed to exhibit non-efficacious binding to "self" MHC ligands.
Mannie (1991)MHCT cellsBy this mechanism, the mature T cell repertoire is selected so that clonotypic T cells are predisposed to bind the very sites on MHC glycoproteins responsible for antigen presentation without risk of autoimmunity.
Schneck et al. (2001)MHC-IgT cellsMHC-Ig dimers display stable binding properties when they interact with antigen-specific T cells thus allowing their use in the staining of antigen-specific T cells by flow cytometry.
Mottez et al. (1995)MHC-peptideT cellsCells expressing these fusion proteins are recognized by T cells specific for the particular MHC-peptide complex.
Allison et al. (1984)MHCT cellThe recent report by Marrack et al. (1983b) that the receptors of two independent T cell hybridomas with the same antigen and MHC specificities expressed the same clonotypic determinant and yielded identical peptide maps (Kappler et al. 1983) provides strong evidence that the heterodimer is responsible for both antigen and MHC recognition.
Rath et al. (1992)MHCT cellNormal T cells and T cell clones preferentially recognize MHC class II molecules that have been associated with Ii, suggesting that thymic selection may be influenced by MHC conformation independently of specific peptide binding.
Huseby et al. (2005)MHCT cellT cells bearing alphabeta T cell receptors (TCRs) recognize antigens in the form of peptides bound to class I or class II major histocompatibility proteins (MHC).
Apostolopoulos et al. (2008)MHCT cellMajor histocompatibility complex (MHC) molecules bind and present short antigenic peptide fragments on the surface of antigen presenting cells (APCs) to T cell receptors.
Apostolopoulos et al. (2008)MHCT cellsRecognition of peptide-MHC complexes by T cells initiates a cascade of signals in T cells and activated cells either destroy or help to destroy the APC.
Apostolopoulos et al. (2008)MHCT cellIn the design of molecular vaccines for the treatment of diseases, an understanding of the three-dimensional structure of MHC, its interaction with peptide ligands, and its interaction with the T cell receptor are important prerequisites, all of which are discussed herein.
Nolte-'t Hoen et al. (2004)MHCT cellsWe found that anergic CD4(+) T cells had a reduced capacity to bind MHC class II-peptide multimers compared to their non-anergic counterparts.
Martin (1996)MHCT cellsThese observations suggested the hypothesis that donor T cells prevent rejection mediated by host effectors that recognize donor MHC class I alloantigens but do not prevent rejection mediated by host effectors that recognize donor class II alloantigens.
Kyburz and Speiser (1995)MHCT lymphocytesIn the thymus maturing T lymphocytes are positively selected for efficient interaction with self-MHC molecules.
Murali-Krishna et al. (1999)MHCT cellsIn addition, memory CD8 T cells, unlike na´ve cells, divided without MHC-T cell receptor interactions.
Cui et al. (2006)MHCT-cellMajor histocompatibility complex (MHC)-binding peptides are essential for antigen recognition by T-cell receptors and are being explored for vaccine design.
Lovitch and Unanue (2005)MHCT cellsThe relative plasticity of peptide binding to class II major histocompatibility complex (MHC) molecules permits formation of multiple conformational isomers by the same peptide and MHC molecule; such conformers are specifically recognized by distinct subsets of T cells.
Singer and Hodes (1982)MHCT cellThe present study has examined the possibility of TNP-Ficoll-responsive B cells recognize the MHC determinants expressed by the accessory cells with which they interact for the generation of T cell-independent responses to "high" concentrations (10(-2) micrograms/ml) of TNP-Ficoll.
Nihira et al. (1996)MHCT cellsPeptides binding to a particular class II major histocompatibility complex (MHC) molecule can inhibit the activation of T cells by other peptides binding to the same molecule, a phenomenon termed class II MHC blockade.
Gebe and Kwok (2007)MHCT cellsRecombinant MHC multimers have been produced where MHC-binding peptide antigens are either covalently or noncovalently bound to the MHC, with the latter having the advantage of the ability to use a single recombinant MHC to investigate multiple MHC-binding peptides and their interacting T cells.
Altuvia et al. (1994)MHCT-cellTwo groups of peptides are assigned to each MHC type: (1) peptides that bind to that MHC molecule to elicit a T-cell response, and (2) peptides that were shown experimentally either not to bind to or not to elicit a T-cell proliferative response in association with that MHC molecule.
Knapp et al. (2010)MHCT cellThese mutant peptides differ in MHC binding affinity, CD4+ T cell priming, and alter the severity of peptide-induced experimental allergic encephalomyelitis.
Wu et al. (2006)MHCT cellsT cells were stimulated by carbamazepine (metabolites) bound directly to MHC in the absence of processing.
Reich et al. (1997)MHCT-cellT cells initiate many immune responses through the interaction of their T-cell antigen receptors (TCR) with antigenic peptides bound to major histocompatibility complex (MHC) molecules.