Viewing negative mentions of localization of IL2 (H. sapiens)

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Lamb et al. (1983)IL-2The clones that functioned as helper cells in the production of specific antibody failed to release detectable amounts of IL-2.
Ythier et al. (1985)IL2In fact, there was no measurable interleukin 2 (IL2) secretion and no significant increase in IL2 susceptibility following incubation with either PHA or anti-T11(2) plus anti-T11(3).
Bergmann et al. (1991)interleukin 2Since recombinant interleukin 2 is not secreted by bacteria, but is instead obtained from bacterial lysates, we have analysed several different recombinant interleukin 2 molecules as well as the naturally synthesized cytokine by phase separation in Triton X-114.
Skerka et al. (1995)IL-2In unstimulated cells which do not secrete IL-2, only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element.
Arima et al. (1987)IL 2Group 2 (seven patients): Cells of this group did not secrete IL 2 when cultured in mitogen-free medium, but the cells showed response to exogeneously added recombinant IL 2 and proliferated in culture.
Arima et al. (1987)IL 2Group 4 (three patients): Cells of this group did not secrete IL 2 in mitogen-free medium.
Walker et al. (1986)IL 2Addition of exogenous IL 2 did not release cells arrested in the G1a phase.
Danzer et al. (1994)IL-2Among more than 100 random MLC experiments, we observed one cytokine pattern similar to the cytokine release detected in a control MLC of HLA-identical siblings, which showed marginal or no secretion of IL-2, sIL-2R, IFN-gamma, TNF-alpha, and IL-6.
Huland et al. (1997)IL-2Thus, patients who could not tolerate high-dose systemic IL-2 were able to tolerate inhalation IL-2 therapy.
Huland et al. (1999)IL-2Response of patients treated with inhalation of interleukin-2 (IL-2), which can be offered to those not suitable for systemic therapy, was compared to risk factors.
Nieto et al. (1990)IL-2Nevertheless, IL-2 is not secreted by these activated cells.
Schwartzentruber et al. (1988)IL-2Two patients were subsequently retreated with IL-2 without complication.
Kaufmann et al. (1984)IL 2We have found that a pharmacologic level of CsA (10 ng/ml) blocks antigen- and lectin-driven interleukin 2 (IL 2) secretion without affecting cell proliferation.
Tavel et al. (2010)IL-2METHODOLOGY: Participants not on continuous ART with > or = 300 CD4(+) cells/mm(3) were randomized to: no treatment; IL-2 for 5 consecutive days every 8 weeks for 3 cycles; or the same IL-2 regimen with 10 days of ART administered around each IL-2 cycle.
Zicari et al. (1995)IL-2Tissues did not release IL-2.
Elkahwaji et al. (1999)IL-2Hepatic CYPs and monooxygenase activities were not significantly decreased in 5 patients receiving daily doses of 3 or 6 10(6) IL-2 units/m2, compared to 7 patients who did not receive IL-2.
Matsushita et al. (1994)IL-2 mRNANorthern blot analysis did not show any IL-2 mRNA.
Liu et al. (1991)IL-2The L3T4+ cells secreted IL-2 and had characteristics of T helper cells, while the 38+ cells did not secrete IL-2 and appeared to be T cytotoxic-suppressor cells.
Giovarelli et al. (1988)IL-2lfIn seven further cases (25.9%), small quantities of IL-2lf (0.2-1.7 U) were detected, while only in four (14.8%) no release was found.
Mingari et al. (1991)IL-2In addition, following stimulation with phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (or PHA alone) all clones released interferon-gamma and tumour necrosis factor-alpha, but not IL-2.
Marrack et al. (1983)interleukin 2It was found that subclones of the hybridoma that no longer secreted interleukin 2 in response to Ag/H-2, even though they continued to secrete interleukin 2 in response to concanavalin A, also no longer bound specifically to Ag-pulsed monolayers of the appropriate H-2 type.
Charley et al. (1985)porcine IL2A neutralizing polyclonal anti-human IL2 antiserum was also unable to neutralize porcine IL2.
Resta et al. (1994)IL-2CD73 transfectants of Jurkat mutants defective in the TCR, in p56lck, or in the tyrosine phosphatase CD45 did not secrete IL-2 in response to CD73 mAb + PMA, suggesting a role for the CD3/TCR-signaling complex in CD73-mediated signal transduction.
Podtschaske et al. (2007)IL-2The isolated IL-2 secreting cells had a 25-fold greater IL-2 mRNA-content than the cells not secreting IL-2 (Fig. 2), indicating that the expression of IL-2 in the activated Th cells is regulated upstream of transcription.
Anderson and Teuber (2010)IL-2However, immunomodulatory effects are present, including an inhibition of cellular proliferation despite no decrease in IL-4 or IL-2.
Bagnasco et al. (1988)IL-2Finally, 44% of intrathyroid clones were neither cytolytic nor able to release IL-2 and gamma-interferon.
Grabbe et al. (1994)IL-2IL-8 was secreted at a high level throughout the culture, whereas no spontaneous secretion of IL-2, IL-3, IL-4, and IL-7 was measured at all.
Sturmh÷fel et al. (1995)IL-2Signaling through the zeta-chain was required, as cells transfected with a chimera containing only a 22 amino-acid long, truncated zeta-chain did not secrete IL-2 constitutively.
Del Prete (1992)IL-2Human type 1 helper (Th1), but not type 2 helper (Th2), cells produce interleukin-2 (IL-2), gamma-interferon (IFN-gamma), and tumor necrosis factor-beta, whereas Th2, but not Th1, cells secrete IL-4 and IL-5, but not IL-2 or IFN-gamma.
Van Reijsen et al. (1994)IL-2Upon stimulation with allergen or anti-CD3+ phorbol myristate acetate (PMA) IL-4 was released with or without IL-5, while no (or extremely low concentrations of) IL-2 and interferon-gamma (IFN-gamma) were detectable.
Swain et al. (1990)IL-2Those cells that do survive continue to secrete IL-4 and IL-5 but not IL-2.
Lollini et al. (1997)IL-2IL-15 is typically produced by normal cells that do not release IL-2, but little information is currently available on human tumors.
Pantaleo et al. (1988)IL-2All of the five clones selected for detailed analysis did not express CD4, CD8, and CD28 antigens and did not release IL-2, whereas they displayed cytolytic activity against NK-sensitive, NK-resistant, and fresh tumor target cells.
Swain et al. (1990)IL-2Our studies show that the presence of IL-4 during the response of naive Th cells causes precursors to develop into a population comprised largely of "Th2-like" effectors that secrete IL-4 and IL-5, but little IL-2 or IFN-gamma.
Nagy et al. (2009)IL-2Na´ve PBMCs, which did not respond to IL-2, did not display binding to either probe, thus verifying that constitutive NF?
Lauritzsen and Bogen (1991)IL2Six of the clones are of the Th1 type as they secrete IL2 and IFN gamma, but not IL4.
Tsubata et al. (2005)IL-2C did not grow in the absence of IL-2, and were close to cell death approximately 2 days after IL-2 withdrawal.
Moiola et al. (1994)IL-2They secreted IL-2, not IL-4, suggesting that they comprised T helper type 1 cells.
Shimizu et al. (1980)TCGF-ETCGF-E is neither synthesized or secreted by this lymphoma cell line unless stimulated by Con A.
Del Prete et al. (1991)IL-2In contrast, most TES-specific TCC secreted IL-4 and IL-5 but not, or limited amounts of, IL-2 and IFN-gamma.
Del Prete et al. (1991)IL-2PPD-specific TCC that failed to secrete IL-4 and IL-5, and TES-specific TCC that failed to secrete IL-2 and IFN-gamma, were found to lack transcripts for IL-4 and IL-5, or for IL-2 and IFN-gamma, respectively.
Manigold et al. (2010)IL-2Remarkably, Gn(465-473)-specific cells readily secreted IFN-gamma, granzyme B and TNF-alpha but not IL-2 upon stimulation and showed a 'revertant' CD45RA(+)CD27(-)CD28(-)CCR7(-)CD127(-) effector memory phenotype, thereby resembling a phenotype seen in other latent virus infections.
Del Prete et al. (1991)IL-2Under both these experimental conditions, the great majority of PPD-specific TCC secreted IL-2 and IFN-gamma but not, or limited amounts of, IL-4 and IL-5.
Maus et al. (2004)IL-2The T(CM) were capable of 20-40 mean population doublings in vitro, and the expanded cells produced IFN-gamma, IL-2, and TNF-alpha in response to Ag, and a subset of cells also secreted IL-4 with PMA/ionomycin treatment.
Spits et al. (1990)IL-2All clones were able to secrete IL-2, IFN-gamma, and GM-CSF but not IL-4 after activation.
Karpus et al. (1992)IL-2CD4+ Ts do not proliferate or secrete IFN-gamma, IL-2, or IL-4 in response to myelin basic protein, nor do CD4+ Ts proliferate or secrete IL-2 when co-cultured with irradiated EAE effector cells.
Vekemans et al. (2000)IL-2Cells of such newborns occasionally released gamma interferon (IFN-gamma) and no interleukin-2 (IL-2) and IL-4 upon specific stimulation, while their mothers responded by the production of IFN-gamma, IL-2, and IL-4.
Kawakami et al. (1995)IL-2Furthermore, both TU/BAL and KN/LN represented a profile of Th1-like cells: they secreted IL-2 and IFN-gamma, but not IL-4, IL-5 and IL-6, when stimulated with PHA in the presence or absence of 12-O-tetradecanoylphorbol-13-acetate.
Szigeti et al. (1986)lymphokineThe lymphokine-producing clones, which were Thy-1+, Ly-1+ and Ly-2-, did not secrete MIF and LIF constitutively.
Klarnet et al. (1989)IL-2Therefore, the role of IL-1 in the activation of CD8+ CTL that do not secrete IL-2 after activation was assessed.
Anderson et al. (1989)interleukin-2Myeloma cells neither proliferated nor secreted Ig in response to G/M-CSF, G-CSF, M-CSF, interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), or interleukin-4 (IL-4).
Zanussi et al. (1996)IL-2In contrast, CD8+ cells from progressors are unable to secrete IL-2 and IL-10.
de Carli et al. (1993)IL-2When compared to TCC derived from the PB of both patients and controls, RO TCC showed remarkably high proportions of both CD8+ and CD4+ clones with a Th1-like cytokine profile, as documented by their ability to secrete IL-2, IFN-gamma, and tumor necrosis factor-alpha (TNF-alpha), but not IL-4 or IL-5.
Tang et al. (2006)IL-2They secrete type 1 cytokines but not IL-2.
Hayball and Lake (2000)IL-2However, these cells did not secrete IL-2, IL-3, IL-4 or IFN-gamma, nor did they proliferate.
Wagner et al. (1998)IL-2HKB-1 produced high amounts of interleukin (IL)-6 as detected in culture supernatant whereas no secretion of IL-1 beta, IL-2, IL-4, IL-10, IL-12 or interferon (IFN)-gamma was detected.
Anderson et al. (1989)IL-2Although they neither proliferated nor secreted Ig in vitro to G/M-CSF, G-CSF, M-CSF, IL-1, IL-1B, IL-2, or IL-4, proliferation without Ig secretion (Stimulation Index greater than or equal to 3.0) was induced to IL-6 in 6 of 10 patients (pts); to IL-3 (2 pts) and to IL-5 (2 pts).
Sahoo et al. (2009)IL-2Immunization with F6 intensely upregulated both Th1 (IFN-gamma, TNF-alpha, IL-1 beta, IL-2, IL-6, IgG1, IgG2a and lymphoproliferation) and Th2 (IgG2b and IL-10) responses and NO release.