Viewing negative mentions of regulation of IL2 (H. sapiens) in lymphocytes

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Borysiewicz et al. (1985)IL-2lymphocytesSimilarly, IL-2 release was not affected by Herpes simplex virus infection of such cultures, although lymphocytes infected with Sendai or respiratory syncytial viruses produced considerably less IL-2.
Podevin et al. (2001)IL2lymphocyteIn addition to mixed lymphocyte reaction (MLR) inhibition, chenodeoxycholate (CDC) inhibit ConA-induced IL2 production without any effect on IL2 R expression.
Sidell and Ramsdell (1988)IL-2PBLIn contrast to these effects on thymocytes, peripheral blood lymphocyte (PBL) proliferative responses were unaffected by RA treatment and, correspondingly, RA affected neither IL-2 receptor expression on PBL blasts nor the growth of these cells.
Maxwell et al. (1993)IL-2lymphocyteSince IL-2 production and lymphocyte proliferation in response to Con A were normal in the patient group and were not altered by treatment, the reduction in TNF levels seemed not to be a general inhibitory effect.
Yamamoto et al. (1986)IL2 mRNAlymphocytesAddition of alpha-methylornithine and methylglyoxal bis (guanyl hydrazone), which inhibit polyamine synthesis, did not affect the induction of IL2 mRNA in the lymphocytes stimulated with PHA and TPA, indicating that polyamine synthesis is not necessary for IL2 mRNA induction.
Fujimoto et al. (1986)IL 2lymphocyteCCA at 50 micrograms/ml, which was not toxic to cells, blocked AMLR, IL 1 production and immunoglobulin production (IgM and IgG) significantly, while CCA at the same dose did not affect IL 2 production and lymphocyte mitogenic responses to Staphylococcus aureus Cowan I(SAC) and pokeweed mitogen(PWM).
Keicho et al. (1993)interleukin-2lymphocytesEM had a suppressive effect on the proliferative response of human lymphocytes stimulated with mitogens and antigens, while EM had no effect on concanavalin A (Con A)-induced interleukin-2 (IL-2) production or IL-2R alpha (CD25) expression.
Kozenitzky et al. (1992)IL-2lymphocytesFollowing treatment IL-2 production, free IL-2 receptor (IL-2R), the ability of lymphocytes to induce a local graft-versus-host reaction (GVHR) and the ability of separated CD4 cells to induce help were tested. 8-Methoxypsoralen alone did not significantly affect either cell proliferation or IL-2 production or functional activity.
Dupont (1987)interleukin 2lymphocytesDespite its significant antiproliferative action, 6-mercaptopurine does not affect interleukin 2 production nor Ia antigen induction on lymphocytes after stimulation with phytohemagglutinin.
Szamel et al. (1997)IL-2lymphocytesThe expression of high affinity IL-2 receptors was completely inhibited by cholera toxin, while IL-2 synthesis and secretion were not influenced in BMA 031-stimulated human lymphocytes.
Tovar et al. (2002)interleukin-2lymphocytesBiochemical deficiency of pyridoxine does not affect interleukin-2 production of lymphocytes from patients with Sjögren's syndrome.
Sharom et al. (1990)IL-2lymphocytesInterleukin-2 (IL-2) production by ganglioside- and glycophorin-treated lymphocytes was unchanged.
Kumar and Satchidanandam (2000)interleukin-2lymphocytesThe responses of these lymphocytes to interleukin-2 or to concanavalin A were, however, unaffected.
Nachbaur et al. (1997)interleukin-2lymphocyteReduced interleukin-2 (IL-2) protein levels in culture supernatants of IVIG-supplemented mixed lymphocyte reactions (MLR) but unchanged IL-2 mRNA levels strongly argue in favour of a post-transcriptional interference of IVIG with cytokines and/or cytokine production.
Chang (1995)IL-2lymphocyteNo amiprilose HCl mediated changes in lymphocyte IL-1 beta or IL-2 receptor expression were observed.
Karlsson et al. (1991)IL-2lymphocytesIn activated lymphocytes the expression of soluble IL-2 receptors was unaffected by FK506 incubated up to 72 h.
Sfikakis et al. (1998)IL-2 mRNAlymphocytesIn contrast, 2-CdA (0.1 microgram/ml) at concentrations that inhibit by 80-90% the PHA-induced proliferative responses of lymphocytes did not affect IL-2 mRNA accumulation.
Albers et al. (2003)IL2lymphocyteOther aspects of immune function, ie DTH responses, NK cell activity, lymphocyte proliferation and production of TNF-alpha, IL1-beta, IL6, IFN-gamma, IL2, IL4, and PGE(2), were not affected.
Yoshino et al. (1992)IL-2lymphocyteThe TIL preparation, which was usually contaminated with 5 to 10% tumor cells, did not exhibit any response in autologous mixed lymphocyte-tumor culture even in the presence of interleukin 2 (IL-2) in all five cases tested.
Allegretta et al. (1986)IL-2-dependentlymphocyteThe failure of the antibodies to neutralize the biological activity of recombinant interleukin-2 (IL-2) in lymphocyte proliferation assays and to bind to the native lymphokine suggests that they may not affect IL-2-dependent cellular immune functions in vivo.
Slauson et al. (1984)IL-2lymphocyteSerotonin thus produced an inhibition of lectin-stimulated lymphocyte proliferation via a mechanism independent of IL-2 production, and caused a decrease in the expression and distribution of IL-2 receptors on the surface of responder cells.
Barcellini et al. (1992)IL-2lymphocyteResults from the ex vivo study showed that treatment with tiaprofenic acid had no significant effects on the immune parameters investigated, i.e. unstimulated and mitogen-induced proliferation and IL-2 production, spontaneous and stimulated Ig synthesis, lymphocyte subpopulations, serum Ig and complement levels.
Haga et al. (1996)IL-2PBLExpression of CD56 antigen and IL-2 receptor alpha chain was unchanged in bilirubin-treated PBL following IL-2 stimulation as compared to bilirubin free control.
Pozsonyi et al. (1992)interleukin-2lymphocyteHowever there was no significant alteration neither in the response of lymphocyte nor in the production of interleukin-2 using of Pokeweed mitogen.
Lalmanach-Girard et al. (1992)IL-2lymphocytesFurthermore, IL-2 production and IL-2 receptor expression by activated lymphocytes were markedly decreased in the presence of STPM proteins compared to the native membrane but remained unaffected in the presence of STPM lipids.
DaMert and Sohnle (1979)lymphokinelymphocytesChloramphenicol had little effect on the production of the lymphokine leukocyte migration inhibition factor by lymphocytes stimulated either by candida antigen or by concanavalin A, whereas puromycin at a concentration of 5 microgram/ml significantly suppressed this response.
Asano et al. (1994)IL-2lymphocytesL-MTP-PE did not affect the expression of these cytokines in lymphocytes, nor did L-MTP-PE upregulate IL-2 expression in lymphocytes.
Gutiérrez et al. (1991)IL-2lymphocyteThe phenotypic profile of lymphocyte populations and the production of IL-2 were not altered in TOS subjects.
Zbróg et al. (1991)IL-2lymphocytesNext, in the presence of opioid receptor agonists directions of changes in the mitogen-induced proliferative response may not follow the alterations of IL-2 and Trf receptor expression on both uremic and normal lymphocytes.
Matsumoto et al. (1993)interleukin-2lymphocytesIR-1116 suppressed the antibody production by human B lymphocytes activated with pokeweed mitogen or Epstein-Barr virus, but did not affect the interleukin-2 production by human lymphocytes stimulated with phytohemagglutinin.
Canaan et al. (1998)IL-2lymphocytesProduction of interleukin (IL)-1beta, IL-2, IL-6, and tumour necrosis factor (TNF)-beta by stimulated lymphocytes after cyropreservation was not significantly different from those responses before storage, with one exception: IL-6 production was negligible after 24 weeks' frozen storage when thawed cells were cocultured with pokeweed mitogen.
Zbróg et al. (1991)IL-2lymphocytesHowever, metenkephalin inhibited mitogen-induced proliferation and surface Trf receptor expression on uremic lymphocytes without affecting IL-2 receptor expression on PHA-stimulated cells.
Matsukawa et al. (1992)IL-2lymphocyteNonetheless, famotidine did not have mitogenic function itself to lymphocyte and did not affect IL-2 production.
Thomson et al. (1983)lymphokinelymphocyteWhereas Cs A (0-13) caused almost total suppression of the mitogenic responses of lymph node cells to PHA and antigen, OVA-induced migration inhibition and production of the lymphokine inducing macrophage procoagulant activity (MPCA), Cs A (0-4) augmented these responses to OVA, but did not affect lymphocyte transformation or lymphokine production in response to mitogen.
Pedersen et al. (1990)IL-2lymphocytesFurthermore isoprinosine did not influence the ability of interleukin 2 (IL-2) to stimulate the proliferation of lymphocytes or the natural killer (NK) cell activity either unstimulated or stimulated in vitro with alpha interferon (IFN-alpha), IL-2, or indomethacin.
Fagiolo et al. (1990)IL-2lymphocyteFinally, lymphocyte responsiveness to PHA tended to increase, while no effect on lymphocyte ability to produce IL-2 following mitogen stimulation was observed.
Starkie et al. (2001)IL-2lymphocytesBLK attenuated (P < 0.05) the elevation in the concentration of lymphocytes producing cytokines during exercise; however, BLK did not affect the amount of IL-2 and IFN-gamma produced.
Rall et al. (1996)IL-2lymphocyteTraining did not induce changes in PBMC subsets, interleukin (IL)-1 beta, tumor necrosis factor-alpha (TNF), IL-6, IL-2, or PGE2 production, lymphocyte proliferation, or DTH response in any of the training groups, compared with control subjects.
Kohut et al. (2003)IL-2lymphocyteThe addition of the same supplement, DHEA or androstenedione alone to lymphocyte cultures in vitro did not alter lymphocyte proliferation, IL-2, IL-10, or IFN-gamma, but did increase IL-4.
Kowalczyk et al. (1986)lymphokinelymphocyteThe lymphocyte response to PHA in vitro was diminished but PHA-induced lymphokine production was not altered.
Di Renzo et al. (2003)IL-2lymphocytesIL-2 and TNF-alpha production was not significantly different among lymphocytes from the four samples.