Viewing affirmative mentions of negative regulation of IL2 (H. sapiens)

Full-text article links are indicated by after the article reference.

Document Target Regulator Anatomy Sentence
Horst and Flad (1987)interleukin 2Corticosteroid-interleukin 2 interactions: inhibition of binding of interleukin 2 to interleukin 2 receptors.
Moreau et al. (1995)IL-2Characterization of a monoclonal antibody directed against the NH2 terminal area of interleukin-2 (IL-2) and inhibiting specifically the binding of IL-2 to IL-2 receptor beta chain (IL-2R beta).
Ghoneum et al. (1987)Interleukin-2Interleukin-2 and lymphotoxin production were decreased by 64% and 38%, respectively.
Elfenbein et al. (1984)interleukin-2There appear to be defects in both interleukin-2 production and interleukin-2 responsiveness in this system early after marrow transplant.
Katsiari and Tsokos (2006)interleukin-2Transcriptional repression of interleukin-2 in human systemic lupus erythematosus.
Petrov and Lijnen (2000)IL-2The normal expression of IL-2 receptors was preserved while the IL-2 production was blocked in the presence of nifedipine or mibefradil.
Melder and Jain (1992)IL-2The increased rigidity of these cells was maintained throughout 96 h of IL-2 deprivation, although significant relaxation of rigidity was observed between 48 and 96 h.
Konrad et al. (1990)IL-2The median serum IL-2 levels are 430-fold lower than levels in the i.p. fluid and decrease with a median half-life of 6.3 h.
Warrington (1988)IL-2At high cell densities, IL-2 production was decreased in SLE but remained enhanced in RA.
Vetto et al. (1987)interleukin-2Reduction of toxicity of interleukin-2 and lymphokine-activated killer cells in humans by the administration of corticosteroids.
Lomnitzer et al. (1984)interleukin-2Suppression of interleukin-2 production by human concanavalin A-induced suppressor cells.
Lomnitzer et al. (1984)IL-2These results show that Con A-treated MN cells suppressed or prevented [3H]thymidine incorporation by actively inhibiting IL-2 production.
McElhaney et al. (1990)interleukin 2Age-related decline in interleukin 2 production in response to influenza vaccine.
McElhaney et al. (1990)IL2This study provides evidence that defective IL2 production may also occur in response to physiologic antigenic stimulation and may be one explanation for the reduced efficacy of influenza vaccination in elderly persons.
Wang et al. (1984)IL-2Actinomycin D and puromycin inhibited the appearance of IL-2 receptors as well as the production of IL-2.
Marijani et al. (2007)IL-2The bioactivity of ciclosporin MDI formulations was evaluated by determining the ciclosporin-mediated inhibition of interleukin-2 (IL-2) release from human Jurkat cells stimulated with phorbol 12-myristate 13-acetate (PMA).
Pahlavani and Richardson (1996)IL-2The expression of IL-2 has been found to decrease with age in humans and rodents.
Pahlavani and Richardson (1996)IL-2The decline in IL-2 production has been shown to parallel the age-related decrease in immunologic function.
Prochazka et al. (1987)IL-2These data collectively suggest that, in addition to impaired IL-2 production, there is an endogenous defect in IL-2 responsiveness.
Hoon et al. (1986)IL-2When the IL-2 receptors were blocked with anti-Tac (anti-IL-2 receptor) antibodies, the inhibitory effect of IL-2 was significantly reduced.
Hoon et al. (1986)IL-2Similarly antibody to IL-2 blocked the inhibitory effect of IL-2.
Charley et al. (1985)IL2Preculture of porcine PBL or addition of indomethacin enhanced IL2 production, suggesting the existence of a prostaglandin-mediated inhibition of IL2 production in fresh PBL cultures.
Toossi et al. (1986)interleukin 2Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis.
Olejniczak and Kasprzak (2008)IL-2Decreased IL-2 production is often observed in the more advanced clinical stages of human tumors, which provides rational for inclusion of recombinant IL-2 in the immunotherapy for some tumors.
Kenney et al. (1986)IL-2Those test systems detect covalent and non-covalent aggregates, degradation products, and inappropriately oxidized forms of human interleukin-2 all of which contribute to an overall loss of IL-2 biological activity.
Sasagawa et al. (2006)IL-2E. purpurea extracted in a solvent mixture of 95:5 ethanol/water dose-dependently inhibited IL-2 production.
Sasagawa et al. (2006)IL-2Lower concentrations from 6.25 to 25 microg/mL significantly decreased IL-2 production but not cell viability.
Sasagawa et al. (2006)IL-2Alkylamides at concentrations found in a 50 microg/mL extract decreased IL-2 production by approximately 50%.
Pinkston et al. (1987)IL 2 geneIn this regard, sarcoidosis represents a "model" human disorder to test in vivo the known in vitro action of corticosteroids on suppressing the activated IL 2 gene.
Ades et al. (1986)IL-2Using human IL-2 or recombinant IL-2, we have found that monosaccharides inhibit IL-2 enhanced functional activity in a concentration-dependent fashion; that increased expression of endogenous monosaccharide binding receptors on effector cells occurs after treatment with IL-2; and that greater quantities of monosaccharide were required to obtain equivalent inhibition of IL-2 enhanced NK activity.
DeBruyne et al. (1995)IL-2Therefore, nonresponsiveness to the allograft appeared to be due to a deficit in IL-2 production.
Kusugami et al. (1989)interleukin 2However, cultures of Crohn's disease- and ulcerative colitis-derived cells contain significantly decreased interleukin 2 activity, suggesting that in vivo the availability of interleukin 2 may be limited, perhaps resulting in impaired cytotoxic function.
Kusugami et al. (1989)interleukin 2In ulcerative colitis, a loss of interleukin 2-responsive cells, a hyporesponsiveness to interleukin 2, or both might be present.
Cadée et al. (2002)rhIL-2The protein release profiles both the non-degradable and degradable dextran-based hydrogels showed that with increasing crosslink density of the gel, the release of rhIL-2 decreases.
Li and Weir (1990)IL-2This inhibition is likely mediated through a reduction in both IL-2 production and IL-2 responsiveness.
Johansson and Möller (1990)IL-2The fungal metabolite FK506 was discovered because it shared an important property, the ability to inhibit production of IL-2, with another well-known immunosuppressive fungal metabolite, CsA.
Viganó et al. (1992)IL-2In addition, danazol could significantly inhibit both IL-2- and INF alpha-activated cytotoxicity at the concentration of 10(-5) M.
Borradori et al. (1987)IL2A number of studies have demonstrated that in patients with primary and secondary immunodeficiency disease, including patients with human immunodeficiency virus infections, decreased immune response was associated with impaired production of, or abnormal reaction to, IL2.
Toossi et al. (1989)IL-2Upon addition in low ratios to Leu 11-depleted cells, Leu 11-enriched fractions increased antigen-induced IL-2 production three-fold (P less than 0.05), whereas at higher ratios IL-2 production was suppressed P less than 0.01.
Kermani-Arab et al. (1985)IL-2This study suggests that CsA acts by inhibiting IL-2 production (via blockade of IL-2 gene expression) rather than by preventing the expression of the IL-2 receptor.
Modiano et al. (1988)IL2Reducing the Ca++ levels from the normal 200 microM to 10 microM in PHA-stimulated cultures partially inhibited IL2 receptor expression, IL2 production, and subsequent proliferation.
Nakashima et al. (1986)IL-2Protein synthesis and IL-2 receptor expression were also inhibited at 4 and 5 days post infection.
Lacaille and Paradis (1993)Interleukin-2Interleukin-2 production was decreased 35% to 60% by ursodeoxycholic acid and its conjugates.
Lindqvist et al. (1987)IL-2A significant positive correlation between blockage of induced cell aggregation by antibody 60.3 and reduction in IL-2 release was observed.
Yoshimura and Kahan (1985)IL-2Dialysis patients did not display inhibited IL-2 production.
Yoshimura and Kahan (1985)IL-2Serial posttransplant studies in individual patients confirmed no inhibition of IL-2 generation pretransplant (1.94 +/- 0.07 U/ml) followed by a high degree of inhibition thereafter, namely 0.87 U/ml (55.0% inhibition) at 1 week, 1.15 U/ml (40.6% inhibition) at 2 weeks, 0.42 U/ml (78.2% inhibition) at 3 weeks, and 0.99 U/ml (48.7% inhibition) at 4 weeks.
Chandy et al. (1984)interleukin-2This suggests that the deficient AMLR in IDDM may be in part due to a deficiency in the production of interleukin-2.
Kruger et al. (1984)IL2These data show that CVI patients are a heterogeneous group but have in common a decreased in vitro production of IL2 resulting in a proliferative defect which is correctable at least in part, in vitro, in the majority by the addition of purified IL2.
Gerez et al. (1995)IL-2 geneOnce its transcription has been induced, therefore, expression of the IL-2 gene is down-regulated extensively at the level of precursor RNA processing.
Calder et al. (1987)IL-2The expression of IL-2 receptors and production of IL-2 were reduced.
Freedman et al. (1992)IL-2In serum-free cultures, ChTX and high [K+]e induced a specific dose-dependent decrease in IL-2 production.
Freedman et al. (1992)IL-2The IC50 for ChTX-inhibition of IL-2 elaboration and IL-2 mRNA were both 1 nM.
Freedman et al. (1992)IL-2Similarly, high [K+]e inhibited proliferation with an IC50 of 38.9 +/- 1.1 mM (n = 13), decreased IL-2 elaboration with an IC50 of 21.3 +/- 1.2 mM (n = 6), and decreased IL-2 mRNA steady-state levels with an IC50 of 18 mM.
Pelassy et al. (1991)interleukin-2Concomitantly, in serinol-treated Jurkat cells, interleukin-2 production was markedly inhibited.
Freed et al. (1987)interleukin 2Concentrations of 100 microM to 200 microM H2O2 inhibited interleukin 2 production by 45% to 57%.
Kaplan (1986)IL-2In experiments designed to test the effect of ethanol on various aspects of proliferation, it was demonstrated that ethanol did not inhibit interleukin 2 (IL-2) production or the acquisition of IL-2 receptors.
Kaplan (1986)IL-2This mechanism appears to be unique among immunosuppressive agents thus far studied; cyclosporin A and corticosteroids inhibit IL-2 production and are required at the initiation of activation for maximal effect.
Carrillo-Vico et al. (2005)IL-2Finally, we made the real significance of the membrane melatonin receptors in this process clear, so prostaglandin E(2)-induced inhibition on IL-2 production increased when we blocked the membrane receptors using luzindole.
Nordmann et al. (1989)interleukin 2Cyclosporin A was used as a valuable tool to gain more insight into the quantitative aspects of interleukin 2 production, on the basis of the assumption that transcription of the interleukin 2 gene is completely inhibited shortly after administration of cyclosporin A.
Hirooka et al. (1990)interleukin-2Impaired production of interleukin-2(IL2) in patients with Graves' disease by newly developed IL2 radioimmunoassay.
Hirooka et al. (1990)interleukin-2However, the improvement of decreased interleukin-2 production in methimazole-treated patients with Graves' disease was observed (38.2 +/- 28.1 U/ml, 48.0 +/- 35.6 U/ml, respectively).
Horst and Flad (1987)IL-2This suppression was in full accordance with an inhibition of the IL-2 binding capacity, whereby the high affinity binding sites were reduced by 85%, while the low affinity sites were less affected.
Wilkinson and Euhus (2003)IL-2IL-2 levels declined thereafter.
Chiao et al. (1986)interleukin 2Suppression was accompanied by drastically reduced production of interleukin 2 and lymphokines, which regulate differentiation of myeloid leukemia cells, and suppression was reversed by addition of exogenous interleukin 2.
Weir et al. (1991)IL-2Although 5-LO potently inhibited IL-2 production, it had no effect on IL-2 responsiveness or IL-2 receptor acquisition.
Fernandez et al. (1995)IL-2No inhibitory effect on the IL-2 production by thalidomide could be detected at any of the drug concentrations tested (5-30 micrograms/mL), whereas 10 to 100 ng/mL of cyclosporine inhibited the IL-2 production by 95 to 100%.
Weir (1991)IL-2There was some additive inhibition of IL-2 receptor expression at the higher concentrations of verapamil and cyclosporine that were tested.
Xu et al. (1995)IL-2The results presented here demonstrate that destabilizing the C-terminus alpha helix through introduction of Pro residues in either positions 125 or 127 reduced the biological activity of IL-2 by a factor of 10 that was correlated with a decreased ability to bind the receptor.
Olive et al. (1986)IL2They fell into two groups: one with strong to moderate inhibition of IL2, the other without any detectable functional activity in in vitro assays.
Ketzinel et al. (1991)IL-2 geneThe distinct nature of suppressor cells is supported by the absence of down-regulation of IL-2 gene expression in a helper cell line, MLA-144; yet, in these cells, negative control can be expressed when active suppressor cells are introduced.
Blue et al. (1986)IL2The second stage (day 3-4) of in vitro culture was distinguished by loss of T6, maximal activation (both in cell size and nuclear morphology) and maximal expression of both transferrin and IL2 receptors.
Paul and Baumann (1989)IL-2Impaired IL-2 production could conceivably contribute to the pathogenesis of PV by limiting the ability of IL-2-dependent cells to regulate hematopoiesis.
Jira et al. (1987)IL-2These data suggest that, in addition to impaired IL-2 production, there is an endogenous defect in IL-2 responsiveness.
Borzy (1987)IL-2In addition, production of IL-2 was significantly decreased in the AIDS group (P less than 0.01) and the PGL group (P less than 0.005) with median values of IL-2 produced being 0.1 and 1.0 U/ml, respectively, compared to 9.9 U/ml for control.
Heslan et al. (1991)IL-2Immunoadsorption experiments gave definite proof since the complete removal of IL-2 from concentrated supernatants did not affect the VPF activity.
Modiano et al. (1991)IL2 geneThis effect was due partially to a 50% decrease in IL2 gene expression.
Modiano et al. (1991)IL2However, when PKC inhibitors were added after IL2 gene transcription had already proceeded for 3-4 h, the IL2 in the culture supernatants was still reduced by 30-80%, and intracellular IL2 was increased by up to 50%.
Roffman et al. (1984)IL-2The induction of IL-2 receptors by the oxidized cells was not inhibited by subsequent reduction with borohydride, since the cells could still be stimulated with IL-2.
Roffman et al. (1984)IL-2The conditioned medium derived from the borohydride-reduced cells cannot support the growth of the IL-2-dependent line, indicating that borohydride inhibits the oxidation-induced IL-2 production.
Bettens et al. (1984)IL 2Endogenous IL 2 production was blocked in situ by pharmacologic concentration of DEX (100 to 1000 nM), resulting in an 80 to 90% reduction of thymidine uptake.
Dornand et al. (1987)IL 2Unlike the expression of IL 2 receptors, IL 2 production and IL 2-dependent proliferation were not inhibited by the low drug concentrations which indeed prevent blastogenesis.
Lissoni et al. (1989)IL-2This preliminary study confirms in vivo the reduced IL-2 production in metastatic solid neoplasms, previously documented in vitro.
Slauson et al. (1984)IL-2A marked decrease in IL-2 receptors and a change in their distribution on responder cells was seen when treated cultures were examined with the anti-Tac monoclonal antibody.
Pruett and Lackey (1987)IL-2Thus, even complete inhibition of IL-2 by human serum could not account for the rapid cytotoxicity caused by human serum.
Holán et al. (1994)IL-2These results show that pretreatment of cells with DC can enhance or suppress IL-2 production depending on the intensity of DC and the type of IL-2 producing cell clones.
Plitnick et al. (2001)IL-2In summary, these studies demonstrate a novel effect of LTA on the immune response through direct binding to IL-2 and inhibition of IL-2 function.
Wu et al. (1982)TCGFAdherent cells impair TCGF production.
Marcos et al. (2008)interleukin-2A decrease in serum levels of interleukin-2 (IL-2) is usually found in alcoholic cirrhotics.
Trzonkowski et al. (2001)interleukin 2Luteal phase of the menstrual cycle in young healthy women is associated with decline in interleukin 2 levels.
Parker et al. (1984)IL2The ability of gangliosides to inhibit IL2 activity is directly related to the complexity of their carbohydrate portion, and related ceramide derivatives at similar concentrations do not inhibit IL2 activity.
Chatenoud et al. (1986)IL-2IL-2 activity was significantly decreased in patients as compared to normal controls (mean +/- SEM, 0.28 +/- 0.09 unit per ml) in hemodialyzed patients versus 1.02 +/- 0.16 units per ml in normal controls).
Rezai et al. (1990)IL-2Both secreted IL-2 and messenger RNA coding for IL-2 were inhibited by histamine.