Viewing negative mentions of negative regulation of IL2 (H. sapiens)

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Borysiewicz et al. (1985)IL-2In early measles infection (up to 48 h) there was no suppression of IL-2 production: in fact measles infected cells spontaneously released low levels of IL-2 in the absence of lectin.
Chandy et al. (1984)Interleukin-2Interleukin-2 production was diminished in the patient but not in the healthy twin.
Zier et al. (1984)IL-2IL-2 synthesis by 6 non-insulin-dependent diabetic subjects (NIDDM) was not decreased (mean +/- SEM, 1.20 +/- 0.04 U/ml).
Bloemena et al. (1988)IL-2However, expression of the biologically active, high-affinity IL-2 receptors was not diminished.
Goebel et al. (2000)IL-2In immunoblots of IL-2R beta- and gamma-chain-immunoprecipitates the tyrosine phosphorylation of both chains by IL-2, but not by IL-15, was attenuated in the presence of Daclizumab.
Freed et al. (1991)IL-2The polar maleimides N-hydroxymaleimide (NHM) and 4-maleimidosalicylic acid (M84) did not suppress IL-2 production significantly, even though NHM reacted with more cellular thiols (12%) than did NPM (8%).
Ishiyama et al. (1993)IL-2Cyclosporin A (CyA) suppressed in vitro IL-2 production in one patient, but not in the other.
Hassan et al. (1997)IL-2The influence of CsA in reducing but not blocking IL-2 synthesis is discussed.
Armant et al. (1995)IL-2The IL-2 protective effect was mediated through the p75 beta chain of the IL-2R, as neutralizing monoclonal antibody (mAb) to the p75 beta chain but not to the p55 alpha chain completely abolished the IL-2 anti-apoptotic activity.
Riesbeck (1999)IL-2Bleomycin, carboplatin, doxorubicin, novobiocin or etoposide, which were included for comparison, did not interfere with IL-2 expression.
Najjam et al. (1998)IL-2Overall our data suggest that the binding of human IL-2 to heparin and heparan sulfate does not interfere with IL-2/IL-2 receptor interactions.
Kuroiwa et al. (1994)IL-2Depressed IL-2 production in active UC was not reversed by the addition of anti-CD3 monoclonal antibody plus phorbol myristate acetate (PMA), but was largely reversed by adding calcium ionophore plus PMA.
Stopeck et al. (1998)IL-2IL-2 secretion by tumor cells persisted for at least 30 days post-transfection and was unaffected by freeze thawing or irradiation to 8000 rads.
Smith et al. (1983)IL 2The neutralization of cellular proliferation was specific for IL 2-reactive cells, coincided with an inhibition of IL 2 receptor binding, could be completely overcome by affinity-purified IL 2 and was species-specific; human and murine IL 2 were neutralized, whereas rat IL 2 activity remained unaffected.
Mekori et al. (1989)IL-2Reserpine also interfered with the mitogen-induced IL-2 production by these cells, but the IL-2 receptor expression, as measured by immunofluorescence, was unaffected.
Fleischmann et al. (1989)interleukin-2No loss of recombinant interleukin-2 activity occurred during heating in serum-free media.
Liu et al. (2006)IL-2IL-2 was significantly decreased by morphine and fentanyl but not by tramadol in vitro.
Gelfand et al. (1986)IL2In parallel the drug prevents the lectin-induced increase in concentration of [Ca2+]i and interleukin 2 (IL2) secretion; IL2 receptor expression is unaffected.
Bernsen et al. (1999)IL-2The main differences are systemic therapy and surgical removal of the primary tumour in case of human cancer patients, whereas these treatment modalities are not used in IL-2 treated veterinary cancer cases.
Klingemann et al. (1993)IL-2Starting values for LTC-IC in patient marrow samples were markedly reduced to approximately 7% of normal values, but as in normal cultures, did not decrease further in culture with or without IL-2.
Baroja and Ceuppens (1987)IL-2No decline of IL-2 concentrations beyond 18-24 h of culture was observed, indicating that anti-Tac effectively blocked IL-2 consumption.
Seymour et al. (1985)IL-2There appeared to be no relationship between IL-2 production and BRA and the severity of the disease as assessed by loss of attachment.
Fernandez et al. (1995)IL-2No inhibitory effect on the IL-2 production by thalidomide could be detected at any of the drug concentrations tested (5-30 micrograms/mL), whereas 10 to 100 ng/mL of cyclosporine inhibited the IL-2 production by 95 to 100%.
Mochizuki et al. (1997)IL-2UV-5 cells were not suppressed in IL-2 medium.
Dornand et al. (1986)IL 2Our data revealed that at concentrations lower than 0.2 microM, IL 2 accumulation was not reduced in ouabain-treated cultures, even when cell proliferation was completely inhibited (0.1-0.2 microM ouabain).
Nokta and Pollard (1989)IL-2The differential effect of IL-2 was independent of IL-2 receptor expression.
Hall et al. (1991)HrIL-2However, HrIL-2 nephrotoxicity in vitro was unaffected by addition of dexamethasone to cultures and LLC-PK.1 cells were found to be resistant to the anti-proliferative effects of TNF-a.
Lewis et al. (1993)IL-2These concentrations are below those at which IL-2 mRNA synthesis was shown to be unaffected.
Redondo et al. (1987)IL-2Although levamisole did not replace IL-2 and had no effect at saturating IL-2 concentrations, it reduced by 2- to 4-fold the dose of IL-2 required to give 50% of the maximal DNA synthesis, the optimal concentration of levamisole being between 1 to 3 X 10(-4) M.
Geiselhart et al. (1997)IL-2The effect of p-BQ appeared to be specific for IL-2 production, since de novo induction of the IL-2 receptor alpha-chain (CD25) and ICAM-1 (CD54) and upregulation of LFA-1 alpha/beta (CD11a and CD18) were unaffected.
Belosevic and Nacy (1990)IL-2In this cooperative interaction of cytokines, IL-2 can be replaced with any of several mAb directed against the beta chain of the IL-2 receptor, but not by antibodies to a number of other cell receptors or antigens.
Szamel et al. (1993)IL-2While interleukin-2 (IL-2) synthesis and cellular proliferation were completely inhibited by 200 ng/ml CsA in BMA 030- or BMA 031-stimulated cells, expression of high-affinity IL-2 receptors was not influenced by the immunosuppressive drug.
Cohen and Munro (1984)TCGFThey do not impede either the function or production of TCGF in the secondary culture but we are unable to detect a non-specific suppressor factor made by these cells.
Attal et al. (1995)IL-2We conclude that, in ALL, early allogeneic BMT after the BFM induction regimen is an effective consolidation treatment and that IL-2 does not decrease the high relapse rate observed after autologous BMT.
Shah et al. (1991)IL-2Our results suggested that the secretion of inhibitory factors could not explain the IL-2 defect.
Müller et al. (1993)IL-2Although the expression of high affinity IL-2 receptors (IL-2R) (p75) was unaffected, exogenously added IL-2 failed to restore proliferation.
Jonasch et al. (2008)IL-2Disease progressors who had not yet received IL-2 began IL-2 treatment, and progressors who had already received IL-2 came off study.
Müller-Steinhardt et al. (2009)IL-2Notably, 3/11 and 2/11 individuals had unaffected IL-2 and IL-4 mRNA expression after 4h incubation with SRL, respectively.
Gately et al. (1991)IL-2This effect of IL-12 was independent of IL-2 because it was not blocked by antibodies to either IL-2 or IL-2R.
Mapara et al. (1993)IL-2-dependentOne informative BCLL, however, with a similar pattern of APO-1-antigen expression, did not show SAC plus IL-2-dependent bcl-2 down-regulation.
Mårlind et al. (2008)F16-IL2The administration of doxorubicin either before (8 days, 24 h, or 2 h) or simultaneously with the injection of F16-IL2 did not decrease the accumulation of immunocytokine in the tumor as measured by quantitative biodistribution analysis.
Kretowski et al. (1999)IL-2In the previous studies increased, decreased and unchanged IL-2 levels in patients with recent onset of insulin-dependent diabetes mellitus (IDDM) were found.
Bessler et al. (2005)IL-2Atorvastatin did not affect IL-1beta, but suppressed IL-1ra, IL-2 and IFNgamma production.
Anderson and Teuber (2010)IL-2However, immunomodulatory effects are present, including an inhibition of cellular proliferation despite no decrease in IL-4 or IL-2.
McDermott et al. (1998)IL-2The coadministration of s(CHO) IL-1R produced no apparent reduction in IL-2 clinical toxicity manifested by either the ability to administer more IL-2 than anticipated or a reduction in the toxicity associated with a given amount of IL-2.
Gorse and Kopp (1987)interleukin-2Vincristine and vinblastine treatment of the cells did not reduce interferon or interleukin-2 yields.
Koulova et al. (2005)IL-2The combination of recombinant IL-2 and GM-CSF administered in the designed schedule and doses was not effective in patients with metastatic RCC and may even interfere with the therapeutic potential of moderate-dose IL-2 and increase its adverse events.
Mazzoccoli et al. (1997)IL-2In the group of younger subjects a clear circadian rhythm was validated for the time-qualified changes of all the factors studied, with the exception of CD16, FT4 and IL-2.
11365363IL-2In one Italian study, all groups receiving IL-2 combined with antiviral therapy had CD4+ cell increases from 96% to 129%; the group not receiving IL-2 had only an 8% increase in CD4+ cells.
Buter et al. (1993)IL-2In a phase I/II study the safety, immunostimulatory and antitumor effects of a combined OKT3/interleukin 2 (IL-2) treatment was studied in 15 cancer patients who failed IL-2 treatment.
Hamada et al. (1989)IL 2Endogenous production of IL 2 in PHA response was not reduced by ISS, but the expression of the IL 2 receptor in the PHA response was significantly suppressed by ISS.
Jin and Yu (1995)IL-2The basic level of serum TNF was low and was not increased or even decreased after IL-2 in these patients.
Schellens et al. (2008)IL-2producing (Fig. 3A), nor of single IL-2 producing (Fig. 3B) nor of double IFN?
Faist et al. (1987)IL-2Removal of adherent cells (C-AC) did not reverse the suppression of IL-2 production. gamma-interferon levels were depressed in parallel with IL-2 levels but did not increase with C + INDO.
Arankalle et al. (2010)IL2As against differential cytokine levels and viral load observed in a male and pregnant female fatal H5N1 case [21], except for higher down-regulation of IL1B/IL2, the pregnant woman (S3) in our series was similar to others.
Karanth et al. (1992)IL-2The combination of 3.75 or 15 microM DA plus IL-2 failed to alter the IL-2 suppressed LH release, whereas the addition of 0.187 microM DA to IL-2 blocked its suppressive influence, and 60 microM DA added to Il-2 produced an additive inhibitory effect.
Shenoy et al. (2001)IL-2Hence, altered Fas pathway signaling with or without defective IL-2 responses should be considered in the etiology of hematologic autoimmunity.
Roncarolo et al. (1988)IL-2These results confirm the presence in IDDM patients of an imbalanced cellular immune response and demonstrate that the IL-2 deficiency is already present at the diagnosis and is not correlated with insulin administration.
McGeachy et al. (2009)IL-2T(H)-17 cells failed to downregulate IL-2 and also failed to maintain IL-17 production or upregulate expression of the IL-7 receptor alpha-chain.
Narayan et al. (2002)IL-2Its immunosuppressive effect was further demonstrated by inhibition of interleukin-9 (IL-9), IL-10 but failed to influence IL-2, IL-15 and interferon-y (IFN-gamma) in PPD stimulated human PBMCs.
Touw et al. (1986)IL 2In addition, they support the notion that T-ALL and T-NHL cells have not lost dependence on IL 2 and IL 2 receptor activation for in vitro growth.
Inoue et al. (1994)IL-2IL-2 production and IFN-gamma concentrations were not reduced in these patients.
Gong et al. (2010)IL-2While at the same time ELISA assay showed no significant difference of IL-2, TNF-alpha, IFN-gamma concentrations between SEA and targeted SEA groups.
Smith and Popmihajlov (2008)IL-2In contrast, we found no evidence that FOXP3(+) cells actively suppress IL-2 expression, thereby failing to support the notion that such cells regulate potential effector cells.
Stauber et al. (2006)IL-2The quaternary structure is consistent with a stepwise assembly from IL-2/IL-2R alpha to IL-2/IL-2R alpha/IL-2R beta to IL-2/IL-2R alpha/IL-2R beta/gamma(c).
Rothermel et al. (1983)lymphokineThis lymphokine effect was completely abolished by monoclonal antibody against human gamma-interferon, but not by antisera against human alpha- or beta-interferons.
Ting et al. (1987)IL-2We further found that the helper defect was not due to impaired IL-2 production, because the endogenous production of IL-2 AsGM1-depleted responders was not reduced.
Alroy et al. (1995)IL-2VDR DNA-binding mutants were unable to either bind to this element in vitro or repress in vivo; the VDR DNA-binding domain alone, however, bound the element but also could not repress IL-2 expression.
Mirabet et al. (1999)interleukin-2These receptors are functional since interleukin-2 production in these cells is reduced by NECA but not by R-PIA or CGS21680.
Oddera et al. (1998)IL-2Salmeterol (10(-7) M) or dexamethasone (10(-9) M) induced a similar, statistically significant, downregulation of GM-CSF release (p < 0.05, each comparison) and induced a slight, not significant, decrease in the production of IFN-gamma, TNF-alpha, IL-1 beta and IL-2 (p > 0.05 each comparison).
Schandené et al. (1994)IL-2The inhibition of IL-5 production by rIL-10 was not due to IL-2 deprivation because it was not modified by the addition of exogenous rIL-2.
Sad and Mosmann (1995)IL-2The defect in IL-2 synthesis could not be reversed by subsequent stimulation with potent antigen-presenting cells in the presence of IL-2 and anti-IL-4, or with anti-CD3 plus anti-CD28 antibodies.
Dembek et al. (2010)IL-2This observation indicates that IL-2 expression represents neither an essential marker of nonprogressive HIV-1 infection nor a distinctive feature of CD45RA+ IFN-?
Beilin et al. (1998)IL-2Production of IL-2 was suppressed in the hypothermia but not in the normothermia group at 24 h.
Kammula and Serrano (2008)IL-2This procedure was identical to the 6 day sensitization except that an additional peptide exposure was performed on day 6, IL-2 (90 IU/ml) was added on day 7, and the cultures assayed for reactivity on day 10.
Wick et al. (2000)IL-2There were no significant posttraumatic alterations in numbers of CD3(+) cells stained for intracellular IL-2 or IL-4, except for a minor decrease in IL-2(+) cells during the first week after trauma.
Eichhorn et al. (1993)interleukin 2In addition, interleukin 2 (IL-2), IL-2R, and c-myc gene expression are also unaffected.
Mi et al. (2000)IL-2Conversely, stimulation of IL-2 production by ionomycin, with or without PMA, was unaffected by the CE cells.
Rout et al. (2010)IL-2and IL-2 production in the absence of IL-13 was only seen after PMA/Ca but not C1R.d/?
Kilciler et al. (2008)IL-2According to our results, neither IL-2 levels nor IL-2/IL-4 ratios
Lagrelius et al. (2006)IL-2The multiplex analysis detected representative cytokine profiles for the majority of the cytokines on day 7 by identifying peak levels or good correlation with peak levels, with the exception of IL-2 and TNF-alpha in PHA and CMV cultures and IL-10 in PHA cultures.
Radons et al. (2002)IL-2Replacement of these aa with alanyl residues did not reconstitute NF-kappaB activation, IL-2 production, or JNK activation but partly restored IL-2 promoter activation.
van den Akker et al. (2006)IL-2Ex vivo, GC-induced up-regulation of GC-induced leucine zipper mRNA via transactivation did not significantly differ in GR-9beta homozygotes, whereas the down-regulation of IL-2 expression via transrepression was decreased.
Matera and Mori (2000)IL-2-inducedIL-2-induced synthesis of IFN-gamma was increased by physiological concentrations of PRL but was unaffected or inhibited by high concentrations.
Salo et al. (1997)IL-2Decreased IFN gamma (p < 0.001) and IL-4 concentrations (p < 0.01) were found in the presence of thiopentone, but IL-2 production was unaffected.
Summers et al. (1999)IL-2This inhibitory effect could be reversed by neutralizing transforming growth factor beta (TGFbeta) and interleukin-2 (IL-2), but not by IL-12, in the SF.
Commes et al. (1989)interleukin-2No defect in the production of BCGFs, interleukin-2, and interferon-gamma was found in patients with active (N = 14) or stable (N = 10) MM, compared with healthy donors (N = 13).
Ramsdell et al. (1994)IL-2We were unable to detect IL-2 or IL-4 production in response to CD40L, and Ab-blocking studies indicate that the mechanism of activation appears to involve IL-1 but is independent of IL-2, IL-4, and IL-7.
Frank et al. (1992)lymphokineDespite abnormalities in phosphorylation induced by the mutations, lymphokine production in these transfectants was unaffected.
Navarro-Zorraquino et al. (2001)IL-2On 1PO, all variables decreased except IgE, IL-1, IL-2, IL-4, IL-6, CIC, and CD19.
Bose and Gerton (2010)IL-2were both significantly decreased when RNAi was used to target Rad21, but the inducibility of a control locus, IL-2, was unaffected.