Viewing affirmative mentions of gene expression of IL2 (H. sapiens)

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McElhaney et al. (1990)interleukin 2helper T cellsSeveral studies have presented evidence to show that immune dysfunction in aged mice and humans may be due to a defect in the production of interleukin 2 (IL2) by helper T cells (TH).
Russell et al. (1998)IL-2helper T lymphocyteEvaluation of X-radiation and UV-B radiation for elimination of 3H-thymidine incorporation into responder cells in the IL-2 producing helper T lymphocyte precursor assay.
DeBruyne et al. (1995)IL-2HTLLimiting dilution analysis for IL-2-producing HTL was utilized, with cadaver donor splenocytes as a source of donor alloantigens.
Winandy et al. (1998)IL-2helper T lymphocyteImproved IL-2 detection for determination of helper T lymphocyte precursor frequency in limiting dilution assay.
Moretti et al. (1992)IL-2helper T cellsA method for assessing the size of the pool containing allospecific helper T cells capable of producing IL-2 could be applied in the selection of better donors for marrow transplantation.
Salmon et al. (1988)Interleukin-2helper T-cellInterleukin-2 production and response by helper T-cell subsets in man.
Russell (2002)interleukin 2helper T lymphocyteAlloreactivity and the predictive value of anti-recipient specific interleukin 2 producing helper T lymphocyte precursor frequencies for alloreactivity after bone marrow transplantation.
Russell (2002)Interleukin 2helper T lymphocyteInterleukin 2 (IL-2) producing helper T lymphocyte precursor (HTLp) frequencies determined by limiting dilution analysis (LDA) in the graft-versus-host direction were explored.
Jeras et al. (2000)IL-2helper T cellBy calculating frequencies of IL-2 producing helper T cell precursors (HTLp) and amounts of IL-2 produced in each experiment, we were able to confirm that HLA-DR molecules are the most potent alloantigens.
Miller et al. (1986)IL 2helper T cellsAlloantigen stimulation leads, within 48 to 72 hr, to the expression of IL 2 receptors (IL 2R) on the surface of most of the helper T cells with specificity for the stimulating antigens.
Miller et al. (1986)IL 2helper T cellsThe IL 2R-bearing cells, separated by flow cytometry from 3-day human or mouse mixed lymphocyte cultures, were found by limiting dilution methods to be enriched 10- to 20-fold (compared to IL 2R- cells) for antigen-specific helper T cells detected by IL 2 production.
Petersen et al. (2005)IL-2helper T lymphocyteIn the present study, the use of limiting dilution analysis of interleukin-2 (IL-2) producing helper T lymphocyte frequencies (HTL assay) as a way to quantify alloreactivity following HCT was investigated.
Jooss et al. (1988)IL-2HTLA limiting dilution (LD) culture system was developed to estimate the frequency of IL-2 producing alloantigen-reactive human helper T lymphocytes (HTL).
Dráber (1982)IL2helper T cellsIL1 induces IL2 production by helper T cells and IL2, in turn, initiates proliferation of the sensitive T cells with IL2 receptors.
Mannie (1996)interleukin 2T-helper cellsFirst, activation of myelin basic protein-specific T-helper cells elicits a single episode of interleukin 2 production followed by a 7-10 day refractory phase during which antigenic restimulation elicits proliferation but without interleukin 2 production or reexpression of encephalitogenic activity.
Kubota et al. (2002)interleukin-2helper T lymphocytesThese effects have largely been attributed to the enhancing effects of cimetidine on the host's antitumour cell-mediated immune response, such as inhibition of suppressor T lymphocyte activity, stimulation of natural killer cell activity and increase of interleukin-2 production from helper T lymphocytes.
Salomon and Halioua (1990)interleukin-2helper T lymphocytesCyclosporin is a potent immunosuppressive agent with a selective and reversible inhibitory effect on helper T lymphocytes functions mainly interleukin-2 production.
Petersen et al. (2002)IL-2helper T lymphocyteLimiting dilution analysis has been used in the context of allogeneic bone marrow transplantation to determine anti-recipient interleukin-2 (IL-2) producing helper T lymphocyte precursor (HTLp) frequencies, which in several studies have been predictive of graft-versus-host disease (GVHD).
Sakurai et al. (1992)interleukin 2helper T cellsCells from both fresh and the established cell line, named KB-1 showed identical surface markers of helper T cells, expressed the interleukin 2 (IL-2) receptor and had an identical defective HTLV-I provirus genome with deletions of the gag and env genes involving pX gene exon 2.
Heeg et al. (1988)interleukin-2helper T cellsHigh-dose irradiated splenic stimulator cells show no endogenous interleukin-2 production but stimulate clonally developing helper T cells to produce interleukin-2.
Heeg et al. (1988)IL-2helper T lymphocytesThe effect of various physical or chemical treatments of splenic stimulator cells on their endogenous, mitogen-inducible IL-2 production and on their ability to induce IL-2 production in clonally developing helper T lymphocytes was investigated.
Li et al. (1992)IL-2helper T cellsFrom these results, it may be suggested that the reduction of IL-2 production in the patients with obstructive jaundice is an important reason for the suppression of T lymphocyte proliferative response, not merely a reflection of the decrease of helper T cells.
Kradin et al. (1989)IL-2helper T cellsWe hypothesize that this may reflect diminished IL-2 production by antigen-specific helper T cells and that other lymphokines may promote these immediate hypersensitivity responses.
Jenkins et al. (1987)IL-2helper T-cellExposure of normal interleukin 2 (IL-2)-producing helper T-cell clones to antigen and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide-treated antigen-presenting cells results in proliferative unresponsiveness to subsequent stimulation with antigen and normal antigen-presenting cells.
Subtil et al. (1994)interleukin 2helper T lymphocytesThe cytokine interleukin 2 (IL2) is produced by activated helper T lymphocytes and modulates the growth and activity of cells expressing high-affinity surface IL2 receptors that transduce its signaling.
Van Hoffen et al. (2000)IL-2helper T lymphocytesWe investigated whether the reduced CTL frequency and the incidence of rejection episodes coincided with a change in the frequency of either IL-2- or IL-4-producing helper T lymphocytes (HTL).
Wood et al. (1984)IL-2helper T-cellThe percentage of circulating helper T-lymphocytes, the principal source of IL-2, was also reduced, although this did not always correlate with IL-2 production, which remained depressed after recovery of the helper T-cell population.
Vose (1987)IL-2Helper T cellsHelper T cells can be induced to proliferate upon exposure to cells of the autologous tumour and to secrete detectable levels of interleukin 2 (IL-2).
Russell and Vindelov (1998)IL-2helper T cellOptimization and comparison of the MTT assay and the 3H-TdR assay for the detection of IL-2 in helper T cell precursor assays.
Yang et al. (1989)IL-2T-helper cellsThese findings suggest that unsaturated fatty acids inhibit in vitro T-D PFC responses by selectively interfering with early stages of the antibody response, particularly those events leading to IL-2 production by T-helper cells.
Adams et al. (1992)IL-2HTLThese cultures were tested for IL-2 production as an index of HTL stimulation.
Miller et al. (2007)IL-2TH1The most promising prognostic indicators to date are decreased production of the IL-12, elevated IL-10, soluble IL-2 receptor-a (sIL-2Ra), and IL-18 levels, IL-18 promoter polymorphisms, the IL-6:IL-10 ratio, and the degree of TH1 suppression as measured by diminished IL-2 and IFN-gamma.
Uemura (1993)IL-2helper T cellOn the other hand, CsA suppressed IL-2 receptor expression and proliferation of helper T cell clone.
Greenberg and Cheever (1984)IL-2helper T cellsSince this cytolytic subpopulation lacked helper T cells, the limited activity observed presumably reflected a requirement for an IL-2-producing cell.
Burton et al. (1990)IL-2helper T cellsThe association of ICAM-1 with the IL-2 receptor may facilitate the paracrine IL-2-mediated stimulation of T cells expressing IL-2 receptors by augmenting homotypic T-T-cell interaction, by receptor-directed focusing of IL-2 release by helper T cells, and by focusing IL-2 receptors of the physically linked cells to the site of lymphocyte function-associated antigen 1-ICAM-1-IL-2 receptor interaction.
Clerici et al. (1989)interleukin-2T-helper cellHere we demonstrate that interleukin-2 production is often retained even when proliferative activity is absent, and that it can be used to monitor T-helper cell responses by HIV-seropositive donors.
Miller et al. (1991)interleukin-2helper T-cellThere was a decrease in PHA stimulated: PBL blastogenesis (p = 0.002), T-cell expression (p = 0.018), helper T-cell expression (p less than 0.001), interleukin-2 receptor expression (p less than 0.001), interleukin-2 production (p = 0.035) and gamma-interferon production (p less than 0.001).
Yasukawa et al. (1990)IL-2helper T cellsThese results suggest that stimulation of human PBMC with rotavirus results in the production of lymphokines, such as IL-2 and IFN-gamma, by rotavirus-reactive helper T cells and that these lymphokines augment NK activity and generate other forms of non-specific cytotoxic human lymphocyte activity.
Hu et al. (1988)IL 2helper T cellsThe concerted action of both anti-GT2 + T11(1) mAb and exogenous recombinant IL2 is required to induce cloned helper T cells to produce IL 2 and interferon-gamma to significantly increase IL2 receptors (IL2R) and finally to divide by an autocrine mechanism, whereas each signal alone has no effect.
Robinson et al. (1994)interleukin-2helper T-cellMycobacterium-specific human helper T-cell clones produce a Th1 pattern of cytokines in vitro: interferon-gamma (IFN-gamma) and interleukin-2 (IL-2), but little or no IL-4 or IL-5.
Pinchuk et al. (2008)T-cell growth factorT-helper cellBoth molecules support suppressive functions of CMFs in the regulation of activated CD4(+) T-helper cell proliferative responses; blocking this interaction reverses the suppressive effect of CMFs on T-cell proliferation and leads to increased production of the major T-cell growth factor, interleukin (IL)-2.
Taguchi (1994)IL-2T-helper cellThe main secretory source of IL-2 is the T-helper cell.
Yahata et al. (1994)IL-2helper T-cellsThese results indicated that suppressor T cells exhibit suppressive effects not only by inhibiting IL-2 synthesis but by inhibiting the direct effects of helper T-cells.
Durie et al. (1990)IL-2T-helper cellsT-helper cells expressed more interleukin (IL-2) receptor (Tac) than T-suppressor/cytotoxic cells.
Kaye et al. (1984)interleukin 2helper T cellGrowth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.
Thies et al. (2001)interleukin-2helper T lymphocytesNone of the treatments affected the production of interleukin-2 or interferon-gamma by PBMC and none of the treatments affected the number or proportion of T or B lymphocytes, helper or cytotoxic T lymphocytes or memory helper T lymphocytes in the circulation.
Mukherji et al. (1990)IL-2helper T-cellThe other type of CD4+ T-cell clone exhibits the phenotype of the helper T-cell clone (CD3+, CD4+, CD8-, WT31+) but suppresses the cytotoxic response of the autologous PBL in co-culture in the presence of the autologous tumor cells and exogenous IL-2.
Adams et al. (1994)IL-2HTLWe have previously demonstrated that allogeneic HUVEC stimulate IL-2 production by CD8+ helper T lymphocytes (HTL), but not CD4+ HTL, in the absence of accessory Mo.
Adams et al. (1994)IL-2HTLThe CD4+ HTL production of IL-2 increased with increasing numbers of Mo.
Adams et al. (1994)IL-2HTLThese data suggest that Mo promote IL-2 production by presenting HUVEC-derived alloantigens via MHC class II molecules to CD4+ HTL, rather than by providing cytokines that promote more efficient IL-2 production by CD8+ HTL, or by inducing MHC class II expression on the HUVEC.
Jenkins et al. (1987)interleukin 2helper T-lymphocyteMolecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.
Mori et al. (1999)IL-2helper T cellsTranscriptional control of the IL-5 gene by human helper T cells: IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis.
Miller et al. (1986)lymphokinehelper T cellsEven when IL 2 is supplied, and lymphokine production measured by assay of a second factor, IL 3, the large majority of individual activated helper T cells remain dependent on further antigenic exposure for their continued maturation into lymphokine-secreting effectors.
de Groen (1989)lymphokinehelper T cellsIts predominant immunologic effect is inhibition of lymphokine production and secretion by helper T cells.
Shoker et al. (1995)interleukin-2T-helper cellsThe absence of T cell immunity to alloantigens suggests that sustained activation of T-helper cells with subsequent interleukin-2 production is not necessary to maintain alloreactive B cell function.
Jänicke and Dröge (1985)IL-2helper T cellsThis indicated that the inhibitory effect was not (exclusively) expressed at the level of the IL-2-producing helper T cells.
Kristensson et al. (1992)lymphokineT-helper cellsHuman CD4+ T cells expressing CD45RA acquire the lymphokine gene expression of CD45RO+ T-helper cells after activation in vitro.
Lutz et al. (1981)TCGFhelper T lymphocytesOther published reports indicate that M phi may promote cytolytic activity indirectly, amplifying TCGF production by helper T lymphocytes.
Young et al. (1996)interleukin-2helper T lymphocyteEnumeration of human alloreactive helper T lymphocyte precursor frequencies by limiting dilution analysis of interleukin-2 production.
Monson et al. (1988)Interleukin-2helper T-lymphocyteAfter 7 days of TPN, augmented lymphocyte blastogenesis and production of the helper T-lymphocyte lymphokine Interleukin-2 were observed.
Young et al. (1996)interleukin-2helper T lymphocyteWe describe a limiting dilution assay for the enumeration of alloreactive interleukin-2 (IL-2) producing helper T lymphocyte precursors (HTLp).
Beshgetoor et al. (2004)IL-2helper T-cellsNo statistical difference was noted between athletes and non-athletes in the percentages of antigen-responding CD4 + helper T-cells producing IL-2 (2.4 % and 2.3 %, respectively).
Mori et al. (2000)IL-2helper T cellsRESULTS: Dexamethasone, FK506, and cyclosporin A suppressed the production of IL-2, IL-4, and IL-5 by human helper T cells, which shows a similar concentration-response relationship in each case.
Syto et al. (1998)interleukin 2helper T cellHuman interleukin 10 (huIL-10) is a cytokine that regulates the synthesis of type 1 helper T cell derived cytokines such as gamma-interferon, interleukin 2, and tumor necrosis factor alpha.
Jeong et al. (2010)IL-2helper T-cellsIL-10 has the inhibitory properties of inflammatory cytokines like interferon gamma, IL-2, and IL-3, which are produced by macrophages and helper T-cells (14).
Schena et al. (1989)IL-2helper T cellsThese findings suggest that the increased production of IL-2 in patients with IgAN may be responsible for the increased activity of helper T cells.
Corley et al. (1986)Lymphokinehelper T cellsLymphokine production is associated with, but not limited to, helper T cells, and usually follows antigenic or mitogenic stimulation.
Hauser and Saurat (1991)lymphokinehelper T cellsThe patient's immune deviation is consistent with a transient imbalance of lymphokine production in helper T cells.
Young et al. (1997)interleukin-2-producinghelper T lymphocyteAnalysis of donor-specific helper T lymphocyte precursor frequencies revealed a significant decrease of interleukin-2-producing cells 3 months after transfusion in the total patient population.
Gerez et al. (1991)IL-2helper T cellsOur findings demonstrate a selective impairment of IL-2 gene expression in Down syndrome, rather than a general deficiency in helper T cells.
Kanzawa et al. (2003)lymphokinehelper T cellsIL-4 IL-4 is a multifunctional lymphokine produced by helper T cells
Ting et al. (1986)interleukin 2helper T-cellsMacrophages were needed to produce CCDF and to activate the Lyt 1+ helper T-cells to produce interleukin 2.
Roelen et al. (1995)IL-2-producinghelper T cellSimilarly, comparable frequencies of IL-2-producing helper T cell precursors directed against NIM HLA class II antigens and NIP HLA class II antigens were found.
Baier et al. (1995)interleukin-2T-helper cellsFurthermore, such recombinant immunotargeted HIV-1 peptide antigens demonstrated improved immunogenicity over equivalent nonimmunotargeted control antigens, as shown by their ability to stimulate interleukin-2 production by CD4+ T-helper cells from human donors exposed to HIV-1 antigens.
Young et al. (1998)interleukin-2helper T-lymphocytesHLA-DRB1 amino acid disparity is the major stimulus of interleukin-2 production by alloreactive helper T-lymphocytes.
Young et al. (1998)IL-2helper T-lymphocyteThe generation of interleukin-2 (IL-2)-mediated helper activity is a central step in the immune response induced by allogeneic histocompatibility antigens, and IL-2-producing helper T-lymphocyte precursor (HTLp) frequencies have been proposed as a measure of alloreactivity in transplant recipients.
Müller-Quernheim et al. (1989)interleukin-2helper T-cellsCurrent concepts of the immunopathogenesis of sarcoidosis favor a central role of activated, interleukin-2 (IL-2) producing helper T-cells at sites of inflammation.
Schuler (1993)Interleukin-2helper T-cellsThese T-cells produce Interleukin-2 and Interferon-gamma, and, thus, constitute so-called type 1 helper T-cells (Th 1).
Lin et al. (1988)IL-2helper T cellsThe transient remission associated with measles infection is probably related to the effect of the virus on the helper T cells, resulting in a decrease in specific OKT4 helper T cells and normalization of the OKT4/OKT8 ratio, suppression of IL-2 and gamma-interferon production, and platelet-associated IgG production.
Frey (1993)lymphokineT-helper cellsGlucocorticoids inhibit preferentially the activities of monocytes and T-helper cells as well as lymphokine production.