Viewing affirmative mentions of positive regulation of IL2 (H. sapiens) in plasma

Full-text article links are indicated by after the article reference.

Document Target Regulator Anatomy Sentence
Baker et al. (1989)IL-2plasmaMean plasma biopterins were normal (1.2 +/- 0.5 ng/ml) before therapy; in contrast, biopterins increased significantly to 3.4 +/- 1.9 ng/ml and 3.9 +/- 1.9 ng/ml during IL-2 and IL-2 + LAK treatment each, respectively.
Clerici et al. (1997)IL-2plasmaPentoxifylline also potentiated antigen-stimulated IL-2 production and proliferation in 8 of 9 patients and induced significant but transient decreases in plasma viremia in 7 of 9 patients.
Allegra et al. (1998)IL-2plasmaThese observations suggest that some of the alterations in thyroid hormone levels seen in NTI are associated with elevated plasma concentrations of IL-2.
Radke et al. (1996)IL-2plasmaCompared with patients with benign gynaecological disorders, ascites and/or plasma of patients with ovarian cancer showed significantly higher levels of IL-6, IL-8, IL-10, TNF-alpha, and sIL-2R.
Bocci et al. (1993)interleukin-2plasmaOur data show that when albumin is present, the plasma concentrations of interleukin-2 versus time is increased and swelling at the injection sites is reduced.
Gardner et al. (1989)interleukin-2plasmaTriggering of T-lymphocytes via either T3-Ti or T11 surface structures opens a voltage-insensitive plasma membrane calcium-permeable channel: requirement for interleukin-2 gene function.
Durrant et al. (1994)interleukin 2plasmaProliferative leukocyte responses to the targeted tumor antigen gp72 were observed in these patients and plasma interleukin 2 levels were increased following immunization.
Szamel et al. (1995)IL-2plasmaThey implicate that elevated incorporation of polyunsaturated fatty acids into plasma membrane phospholipids might contribute to sustained activation of protein kinase C-beta, and establish a link between activation of protein kinase C-beta and induction of IL-2 synthesis in human lymphocytes.
Sei et al. (1996)IL-2 mRNAplasmaReduction of plasma viremia was associated with an increase in IL-2 mRNA levels in LN.
Meydani et al. (1990)IL-2plasmaIn the vitamin E-supplemented group 1) alpha-tocopherol content was significantly higher (p less than 0.0001) in plasma and PBMCs, 2) cumulative diameter and number of positive antigen responses in DTH response were elevated (p less than 0.05), 3) IL-2 production and mitogenic response to optimal doses of concanavalin A were increased (p less than 0.05), and 4) PGE2 synthesis by PBMCs (p less than 0.005) and plasma lipid peroxides (p less than 0.001) were reduced.
Korting et al. (1993)IL-2plasmaUsing an interleukin-2 (IL-2)-dependent cell line it could be demonstrated that the addition of patients' plasma to cultured cells markedly depressed mitogen-induced IL-2 synthesis.
Alpsoy et al. (1998)IL-2PlasmaPlasma levels of IL-2 and sIL-2R were increased in BD over controls, but the differences were not statistically significant. sIL-2R levels in patients with active disease were significantly higher than in either patients with inactive disease (p < 0.001) or the control group (p < 0.05).
Michie et al. (1988)interleukin-2plasmaThe responses observed were quantitatively similar to those that occurred after endotoxin administration in healthy subjects (n = 13), but differed in the following manner: 1) the onset of fever and endocrine changes occurred after a longer latent interval (180-240 minutes vs. 60-90 minutes after endotoxin), 2) peak responses after the administration of interleukin-2 also occurred later, 3) no increased circulating tumor necrosis factor was detected after administration of interleukin-2 (peak plasma concentration was greater than 35 pg/ml vs. 270 +/- 70 pg/ml after endotoxin administration), and 4) administration of interleukin-2 but not of endotoxin was associated with increased circulating concentrations of gamma interferon (peak plasma concentration 1.7 +/- 0.2 NIH U/ml vs. less than 0.1 NIH U/ml after endotoxin administration).
Schiphorst et al. (1999)IL-2plasmaIn one patient plasma clearance of IL-2 was enhanced to 760 ml/min after continuous i.v. infusion of 4 and 6 million IU IL-2/24 hours, as compared to a clearance of 310 ml/min at a dose of 2 million IU IL-2/24 hours.
Rosenzweig et al. (1990)IL-2plasmaIL-2 induced plasma lipoprotein changes may be due in part to the induction of interferon gamma.
Hall et al. (2006)IL2plasmaAssuming a plasma volume of 3 l in a 70 kg patient, a single FFP unit would increase the plasma anti-DT389IL2 IgG, anti-DT388IL3 IgG, and anti-DT388GMCSF IgG by 0.13 microg/ml, 0.17 microg/ml, and 0.19 microg/ml, respectively.
Hodge et al. (2005)IL-2LDPIn cell cultures exposed to poststorage LDP, T-cells showed reduced expression of CD69, CD25 (IL-2Ralpha), CD122 (IL-2Rbeta) and CD132 (IL-2Rtau) and production of TNF-alpha and IL-2 but there was no significant alteration for IFN-tau or IL-4.
Simpson et al. (1991)interleukin 2plasmaPrevious studies of renal transplant recipients have demonstrated that allograft rejection is accompanied by an increase in plasma and urinary levels of interleukin 2 and its soluble receptor before the development of clinical symptoms.
Wester et al. (1998)interleukin-2plasmaThe human plasma protein alpha1-microglobulin (alpha1m) was found to inhibit the antigen-induced interleukin-2 (IL-2) production of two different mouse T-helper cell hybridomas.
Finck-Seelen et al. (1996)IL-2plasmaDuring IL-2 infusion mean plasma lactate levels increased from 2.3 to 3.2 mmol.l-1 and all patients had lactate concentrations above 2.0 mmol.l-1 at the end of therapy.
Tyler et al. (1986)IL-2plasmaPost-DST+A plasma also enhanced the response to suboptimal IL-2 doses.
Wu (1990)IL-2plasmaIL-2 responsiveness was enhanced by plasma from both normal and patients.
Muñoz et al. (2005)IL-2plasmaRESULTS: After supplementation, a significant increase in IL-2 production was found only in subjects with normal-low plasma Cp.
Gupta et al. (1991)IL-2plasmaBoth antibodies depolarized plasma membranes, increased cell volume, induced IL-2 production and the expression of IL-2 receptors (CD25 antigen) and induced DNA synthesis.
Young et al. (1992)interleukin-2plasmaAllograft arteriopathy after heart transplantation seems predicted by early elevation of plasma soluble interleukin-2 receptor levels, and patients with this difficulty generally have elevated levels during long-term follow-up.
Young et al. (1991)interleukin-2plasmaLate morbidity and mortality after heart transplantation seem predicted by early elevation of plasma soluble interleukin-2 receptor levels.
de Gruijl et al. (1999)IL-2plasmaT-helper (Th) cell-dependent IL-2 production and plasma IgG responses to virus-like particles consisting of the human papillomavirus type 16 (HPV-16) major capsid protein L1 (L1-VLP) were determined in patients with cytological evidence of cervical intraepithelial neoplasia (CIN) participating in a non-intervention prospective cohort study.
Cohen and Pollack (2005)IL-2plasmaSpontaneous and interleukin-2 (IL-2)-induced NCA, in vitro IL-2 and IL-12 secretion, and levels of plasma cortisol and urinary catecholamines were tested in daughters.
Brynskov and Tvede (1990)IL-2plasmaIncreased concentrations of plasma IL-2 and serum sIL-2R were seen in 66% and 81% of the patients, respectively.
Antón et al. (2008)IL-2plasmaWe show that MAL is required in T cells for efficient expression of Lck at the plasma membrane and activation of IL-2 transcription.
Morteau et al. (2010)IL-2plasmaThe addition of IL-2 to cells rested in medium did not increase the discrimination of the assay between the different groups suggesting that the effects seen with plasma are due to drug-induced IL-2 blockade (data not shown).
Ramachandran et al. (1996)PEG-IL-2plasmaVirologic monitoring by polymerase chain reaction quantitation of proviral DNA and plasma RNA and p24 antigen assays showed no evidence of increased HIV activation during PEG-IL-2 or thymosin alpha 1 therapy.
De Luca et al. (2000)IL-2plasmaPatients with late-stage HIV infection (CD4+ cells <50/microl) showed a higher production of MIP-1alpha and RANTES and lower plasma levels of IL-2 compared with HIV-positive patients at the intermediate stage (CD4+ cells >150/microl).
Sano et al. (1988)IL-2plasmaIn the case of 2-hr iv infusion, rIL-2 was rapidly cleared from the plasma, with a half life of about 30 min, while in the case of 24-hr continuous infusion, more than 1 U/ml serum IL-2 activity was maintained for 14 days in group B3.
Donati et al. (1991)IL-2plasmaSince soluble IL-2 receptor has been reported to down-regulate lymphocyte responses, the elevation in plasma levels of soluble IL-2 receptor in hemodialysis patients may be a pathogenetic factor in the progressive development of impaired immunity associated with end-stage renal disease.
Amicosante et al. (2003)IL-2plasmaNo differences were observed in levels of IL-2, IL-7, or interferon-alpha in plasma.
Antón et al. (2008)IL-2plasmaWe show that MAL is required in T cells for efficient expression of Lck at the plasma membrane and activation of IL-2 transcription.
Arankalle et al. (2010)IL2plasmaThe disease severity correlated with increased plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10.
Arankalle et al. (2010)IL2plasmaWe identified higher plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10 as markers of severity.
Craddock et al. (2007)IL-2plasmaLower numbers of CD4+ cells and hence IL-2 production have also been reported in schizophrenia [15], although Muller et al describe increased CD4+ cell number [16], in addition to altered plasma and serum levels of other cytokines such as IL-6 [17].
Mocchegiani et al. (1999)IL-2plasmaThey showed reduced active thymulin, decreased NK activity and IL-2 production, increased soluble IL-2 receptor (sIL-2R) and augmented alpha2-macroglobulin in the circulation, whereas plasma zinc levels were within the normal range for age.
Shephard et al. (1994)IL-2PlasmaPlasma levels of interleukin-1 increase but interleukin-2 (IL-2) levels generally fall.
Vogler et al. (2004)IL-2PlasmaPlasma markers of immune activation all increased significantly in IL-2 recipients.
Antón et al. (2008)IL-2plasmaAlthough partial correction of the latter defects was possible by forced expression of Lck at the plasma membrane, their complete correction, formation of transport vesicles, partitioning of Lck, and restoration of signaling pathways, which are required for IL-2 transcription up-regulation, were achieved by exogenous expression of MAL.
Antón et al. (2008)IL-2plasmaProbably as a consequence of the depletion of Lck at the plasma membrane, polarized assembly of TCR and Lck to the IS and activation of the signaling pathways leading to IL-2 gene transcription were both impaired.
Chibowska et al. (2001)IL-2plasmaCONCLUSIONS: We concluded that elevated plasma levels of IL-2 and sIL-2R are markers of internal organ involvement in scleroderma.
Heinz et al. (2003)IL-2plasmaThe stress-associated increase in IL-2 concentrations approached statistical significance and correlated negatively with luteinizing hormone plasma levels.
Ostrowski et al. (2006)IL-2plasmaIn addition, plasma levels of the following inflammatory markers were also investigated: soluble tumour necrosis factor receptor (sTNFr)-II, TNF-alpha, interleukins (IL)-10, IL-6, IL-4, IL-2 and interferon (IFN)-gamma.
Moldofsky et al. (1989)interleukin 2-likeplasmaSleep deprivation led to enhanced nocturnal plasma interleukin 1-like and interleukin 2-like activities.
Fong et al. (1994)IL-2PlasmaPlasma IL-1 and IL-2 levels were higher in Group 1 [IL-1 alpha: 408 pg/ml (SEM: 107), IL-2: 4.20 ng/ml (SEM: 1.5)] than in Group 2 [IL-1 alpha 150 pg/ml (SEM: 15), IL-2: 2.58 ng/ml (SEM: 0.7)] or Group 3 [IL-1 alpha: 140 pg/ml (SEM: 11), IL-2: 1.93 ng/ml (SEM: 0.3)] (p < 0.01, p < 0.009 respectively).
Castell et al. (1997)IL-2plasmaThe plasma levels of IL-1 alpha were unaffected by the exercise, while that of IL-2 was increased 16 h after exercise.
Simpson et al. (1991)interleukin 2plasmaAfter measuring interleukin 2 and interleukin 2 receptor levels in the plasma, bile, and urine of liver transplant recipients, we found that rejection is preceded by elevation of plasma and biliary levels of both substances, that cyclosporine toxicity did not affect either of these levels, and that urinary levels of the substances are unaffected in either condition.
Beq et al. (2004)IL-2plasmaIL-7 and Flt-3L plasma levels are increased during highly active antiretroviral therapy-associated IL-2 therapy.
Klausner et al. (1991)interleukin-2-inducedplasmaPretreatment with the hydroxyl radical scavenger dimethylthiourea, 1 gm/kg, intravenously, (n = 6) prevented the interleukin-2-induced increase in mean pulmonary artery pressure, lung lymph flow, lymph/plasma protein ration, lymph protein clearance, and thromboxane B2 levels in plasma and lung lymph.
Moldawer et al. (1992)interleukin-2plasmaElevated plasma levels of tumor necrosis factor-alpha, interleukin-2, and interferon-gamma have rarely been detected in patients or experimental animals with cancer, although interleukin-6 levels appear to correlate with tumor progression in animal models.
Sylvan and Hekkström (1989)IL-2plasmaPeripheral T lymphocytes from asymptomatic HBsAg carriers and hepatitis B (HB) immune (naturally acquired or vaccine induced) donors were induced into interleukin-2 (IL-2) secretion by plasma-derived HBsAg and the translational products of the S- and pre-S2+S gene of HB virus (HBV) in vitro.
Niwa et al. (2000)IL-2plasmaThe protease inhibitors PMSF, aprotinin and leupeptin produced a dose-dependent increase in measurable levels of IL-2 and IL-10 in plasma.
Fletcher et al. (2009)IL-2plasmaMedian plasma levels of IL-2 and IFN?
Yagmur et al. (2005)IL-2PlasmaPlasma levels of interleukin (IL)-1, IL-2, IL-6, IL-8 and TNF-alpha were measured.
Xie et al. (2006)IL-2plasmaMoreover, levels of plasma endotoxin, TNF-alpha, IL-6 and IL-8 in the treatment group after treatment decreased significantly, while IL-2 level increased (P < 0.01), and showed a significant difference (P < 0.01) as compared with those in the control group.
Kurum et al. (2007)IL-2plasmaIn ischemic patients on standard treatment, plasma IL-2 levels were elevated after treatment (P=0.047).
Niwa et al. (2000)IL-2plasmaThe plasma levels of IFN-gamma, IL-2, and IL-5 were significantly elevated, but the serum levels of these cytokines were not significantly changed.
Gao et al. (2003)IL-2plasmaTreatment of Ganopoly for 12 weeks resulted in a significant (P < 0.05) increase in the mean plasma concentrations of interleukin (IL-2), IL-6, and interferon (IFN)-gamma, whereas the levels of IL-1 and tumor necrosis factor (TNF-alpha) were significantly (P < 0.05) decreased.
Renzi et al. (1997)IL-2plasmaThe cytokines interferon gamma (T-helper (TH) type-1 cytokine) and IL-4 (TH-2) were measured in plasma and in vitro after stimulation with IL-2 or with the house-dust mite (Dermatophagoides farinae) antigen.
Craddock and Thomas (2006)IL-2plasmaA review of the literature reveals several cytokines, including IL-1beta, IL-2, IL-6 and IFN, have been shown to be elevated in plasma of working-age adults with depression and dysthymia.
Patil et al. (2010)interleukin-2plasmaThe enriched CD4+ T cells in the interface of density medium and plasma yielded approximately 98% purity; subsequently stimulated with phytohemagglutinin (0.5 ug/ml) and interleukin-2 (10-20 U/ml) before infection with virus stocks.
Guo et al. (2007)IL-2plasmaThe pretreatment plasma levels of both IFN-gamma and IL-2 were significantly increased and those of IL-4, IL-10, and TGF-beta1 significantly decreased, compared with those of the normal controls (P < 0.01), indicating a Th1-dominant cytokine profile typically found in ITP.
Koch et al. (2007)IL-2plasmaSerum concentrations of IL-1beta, TNF-alpha, IL-2 and IL-4 were increased but as we adjusted the level of significance at p = 0.0045, most cytokine plasma levels failed to reach statistical significance.
Vigano et al. (1997)interleukin-2plasmaPediatric long-term resistant hosts were characterized by higher production of interleukin-2 and interferon-gamma and lower production of interleukin-10, normal concentration of IgE, HIV isolates with a non-syncytium-inducing phenotype, and lower plasma viremia.
Aubouy et al. (2002)IL-2PlasmaPlasma IL-2 levels were low at diagnosis although cells retained their ability to produce IL-2, which was found more frequently in plasma after cure.
Sandstead et al. (2008)interleukin-2plasmaThe zinc and micronutrients treatment increased the lymphocyte ratios of CD4(+) to CD8(+) and of CD4(+)CD45RA(+) to CD4(+)CD45RO(+), increased the ex vivo generation of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), decreased the generation of interleukin-10 (IL-10), and increased plasma interleukin-1 receptor antagonist (sIL-1ra) and soluble tumor necrosis factor receptor 1 (sTNF-R1).
Elsässer-Beile et al. (1994)IL-2plasmaIncreased plasma concentrations for type I and II tumor necrosis factor receptors and IL-2 receptors in cancer patients.
Ríos-Olivares et al. (2006)IL-2plasmaTNF-alpha, IL-6, IFN-gamma, IL-2, IL-4, IL-10, IL-12 cytokines and not IL-1beta were significantly increased in plasma from HCV-positive "speedball" users compared with healthy controls.
Rodrigue-Gervais et al. (2010)IL-2plasmaThe result is decreased CD8(+) T cell polyfunctional capacities (production of IFN-gamma, IL-2, TNF-alpha, and CD107a mobilization) that is confined to HCV specificities and that relates to the extent to which HCV inhibits DC responses in infected subjects, despite comparable plasma viral load, helper T cell environments, and inhibitory programmed death 1 receptor/ligand signals.
Narin et al. (1995)IL-2plasmaAccording to our results, the evidences of increased cellular immune response in ARF are increased percentages CD4+ and CD25+ cells, CD4/CD8 ratio, and increased plasma concentrations of IL-1 alpha and IL-2.
Tekgül et al. (1999)IL-2plasmaCerebrospinal fluid and plasma TNF-alpha and IL-2 levels were nondetectable in two patients who had a stationary course of disease and were markedly elevated in patient 3, who displayed a rapidly progressive course.
Kato et al. (2000)IL-2plasmaIn conclusion, we found that major abdominal surgery induces characteristic changes in plasma soluble IL-2 receptor levels.
Tricou et al. (2010)IL-2plasmaSubsequently, a luminex-based Bio-Plex system (Bio-Rad Laboratories, Hercules, CA) was used according to the manufacturer's instructions to measure simultaneous plasma levels of IL-2, IL-4, IL-6, IL-8, IL-10, granulocyte macrophage colony stimulating factor (GM-CSF), INF- ?
Shingu and Nobunaga (1994)IL-2plasmaIn Wegener's granulomatosis, TNF-alpha, IL-1 beta and IL-2 receptor positive infiltrating cells were observed in the kidneys of these patients, and in these patients, plasma levels of TNF-alpha and soluble IL-2 receptor were markedly increased.
Haslett et al. (1999)IL-2plasmaWe observed increased levels of plasma soluble IL-2 receptor, soluble CD8 antigen, and IL-12 (p < 0.01 for all parameters), as well as increased cutaneous delayed-type hypersensitivity reactions to recall antigens (p < 0.01) in thalidomide-treated patients.