Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in lymphocytes

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Gerber et al. (1989)IL2lymphocytesThe shape of the survival curve and the radiosensitivity was shown to depend upon the ability of lymphocytes to produce IL2: the survival curve for lymphocytes that were the most competent producers of IL2 is the closest to linearity; the lymphocytes that were poor producers show biphasic survival curves.
Bödeker et al. (1981)lymphokine interleukin-2lymphocytesHuman spleen cells or peripheral blood lymphocytes (PBL) were stimulated with the T-cell mitogens concanavalin A or phytohemagglutinin to produce the lymphokine interleukin-2 (IL-2).
Azogui et al. (1983)IL 2lymphocytesIrradiation of patients' lymphocytes in vitro with low dose gamma-rays partially restored the IL 2 production after 6 mo of evolution.
Morgano et al. (1990)IL2lymphocyteDecreased lymphocyte blastogenesis, IL2 production and NK activity following nifedipine administration to healthy humans.
Mossalayi et al. (1986)IL2PBLThe same dose of Imuthiol also stimulated IL2 production by human PBL.
Duchateau et al. (1985)interleukin 2lymphocyteIn vitro influence of thymopentin on proliferative responses and phytohemagglutinin-induced interleukin 2 production in normal human lymphocyte cultures.
Andersson and Sander (1989)IL-2lymphocytesA new intracytoplasmic immunofluorescence staining technique to detect and quantify human interleukin-2 (IL-2)-producing lymphocytes is described.
Cossarizza et al. (1989)IL-2lymphocytesExtremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects.
Cossarizza et al. (1989)interleukin-2lymphocytesThe effects of the exposure of mitogen-stimulated human lymphocytes from aged subjects to low-frequency pulsed electromagnetic fields (PEMFs) were studied by measuring the production of interleukin-2 (IL-2) and the expression of IL-2 receptor.
Silveira-Lacerda et al. (2010)IL-2lymphocytesFor the first time, we show that, at low concentration (10-100 microg L(-1)), the cis-[RuCl(2)(NH(3))(4)]Cl compound induces peripheral blood lymphocytes proliferation and also stimulates them to IL-2 production.
Nishimura et al. (1996)IL-2lymphocytesTo clarify whether seronegative, HTLV-I related neurological disease may exist, we have developed a method that measures the production of interleukin-2 (IL-2) from HTLV-I synthetic peptide-stimulated peripheral blood lymphocytes (PBL) of HTLV-I infected persons.
Kalashnikova and Pukhal'ski? (1993)interleukin-2lymphocytes[The effect of low doses of dexamethasone on interleukin-2 production by human peripheral blood lymphocytes].
Bygbjerg et al. (1987)interleukin 2lymphocytesEffect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes.
Bygbjerg et al. (1987)IL-2lymphocytesEffect of pyrimethamine, an antimalarial antifolate, and of mefloquine, chloroquine, and quinine, which belong to the quinoline group of antimalarials, on proliferation and interleukin 2 (IL-2) production of human lymphocytes was studied in vitro.
Bygbjerg et al. (1987)IL-2lymphocytesPyrimethamine at concentrations above therapeutic levels suppressed the lymphocytes' proliferation, but not their IL-2 production.
Bygbjerg et al. (1987)IL-2lymphocyteThe IL-2 production was suppressed at concentrations twice as high as those required to suppress lymphocyte proliferation.
Grote et al. (1987)IL-2lymphocyteThis degree of lymphocyte purity was important since phagocytes were inhibitory to 12-O-tetradecanoylphorbol 13-acetate/calcium ionophore (TPA/A23187)-induced IL-2 production when their concentration exceeded 15% of the total cells.
Hersey et al. (1981)IL2lymphocytesIL2 was produced from blood lymphocytes cultured for 24 h with phytohaemagglutinin (PHA) and purified by membrane chromatography to exclude PHA.
Harel-Bellan et al. (1983)interleukin 2lymphocytesImproved culture conditions for quantitative evaluation of interleukin 2 production by frozen human lymphocytes.
Harel-Bellan et al. (1983)interleukin 2lymphocytesSeveral culture parameters were studied in order to establish methods for optimal and reproducible production of interleukin 2 (IL2) by thawed lymphocytes.
Wang et al. (1984)Interleukin 2PBLOur previous findings on the expression of Interleukin 2 (IL-2) receptors have shown that under the influence of certain drugs, it was possible to dissociate IL-2 production from the appearance of IL-2 receptors on human peripheral blood lymphocytes (PBL).
Russell et al. (2001)IL-2lymphocyteThe extent and impact of these aspects for IL-2 production and HTLp frequency determination were studied by autologous and allogeneic mixed lymphocyte reactions with healthy volunteers and HTLp determinations from bone marrow transplantation donor/recipient pairs.
Su et al. (1991)IL-2lymphocyteThe results indicated that both IL-2 production of PBMC and lymphocyte proliferation increased (P less than 0.01).
Lyte (1988)Interleukin-2lymphocytesInterleukin-2 (IL-2) production was examined in mitogen stimulated human lymphocytes.
Lyte (1988)IL-2lymphocyteThe use of whole blood culture, while not permitting a precise in vitro dissection of the cellular mechanisms governing IL-2 production, may more accurately reflect the mechanisms governing in vivo lymphocyte activation.
Arya et al. (1984)TCGF mRNAlymphocytesDexamethasone, a synthetic glucocorticoid, strongly inhibits the synthesis of TCGF mRNA in human normal peripheral blood lymphocytes stimulated in culture with phytohemagglutinin.
Vie and Miller (1986)interleukin 2lymphocytesWe present here a culture method for the estimation, in human blood, of the number of lymphocytes that can respond to mitogen by producing interleukin 2 (IL 2).
Fagnani et al. (1984)interleukin 2lymphocytesHuman interleukin 2, produced by phytohemagglutinin-stimulated peripheral blood lymphocytes cultured in the absence of serum, has been purified to apparent homogeneity with a two-step combination of affinity chromatography with Cibacron blue-Sepharose and gel filtration.
Domingo et al. (1985)interleukin-2lymphocyteHuman pregnancy serum inhibits proliferation of T8-depleted cells and their interleukin-2 synthesis in mixed lymphocyte cultures.
Domingo et al. (1985)IL-2lymphocyteA possible mechanism to explain the inhibition of mixed lymphocyte cultures by pregnancy serum could therefore be decrease of cellular proliferation of the T8-depleted subpopulation with a decrease in IL-2 synthesis, implying an inhibition of cytotoxic effector cells.
Smith and Pruett (1989)IL-2lymphocytesCircadian variations of human lymphocytes are not responsible for contradictory or variable results in studies of IL-2 production.
Smith and Pruett (1989)IL-2lymphocytesOne possible contributing factor to these results could be the existence of circadian variations in the capacity of lymphocytes to produce IL-2 in culture.
Waldmann (1986)interleukin-2lymphocytesThe structure, function, and expression of interleukin-2 receptors on normal and malignant lymphocytes.
Froelich et al. (1988)interleukin-2lymphocytesPhytohemagglutinin induced proliferation by aged lymphocytes: reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion.
Tohmatsu et al. (1993)interleukin-2PBLIn two autologous human tumor systems, using the tumor cells engineered to produce interleukin-2 by gene transduction techniques, we have examined whether or not such genetically altered cells are capable of inducing a tumor specific cytolytic T cell (CTL) response, in vitro, in co-culture with the respective autologous peripheral blood lymphocytes (PBL).
Tohmatsu et al. (1993)IL-2PBLWe found that in neither system did co-cultures of the IL-2 producing tumor cells and the autologous PBL generate much cytolytic effector cell activity directed against the respective tumor cells, although these co-cultures did lead to the generation of substantial levels of natural killer (NK) cell activity when measured against the prototype NK sensitive target K562 line.
Blumberg et al. (1987)IL-2lymphocytesThe cytotoxic activity, absolute number of T4 lymphocytes, and interleukin-2 (IL-2) production decreased, whereas the relative number of Ia+ lymphocytes increased with the extent of infection with the human immunodeficiency virus (HIV).
Kermani-Arab et al. (1985)interleukin 2lymphocytesMediation of the antiproliferative effect of cyclosporine on human lymphocytes by blockade of interleukin 2 biosynthesis.
Borysiewicz et al. (1985)IL-2lymphocytesSimilarly, IL-2 release was not affected by Herpes simplex virus infection of such cultures, although lymphocytes infected with Sendai or respiratory syncytial viruses produced considerably less IL-2.
Saito et al. (1988)Interleukin-2lymphocytesInterleukin-2 production by human fetal lymphocytes.
Saito et al. (1988)interleukin-2LymphocytesLymphocytes from the 16-week-old fetus produced appreciable amounts of interleukin-2 (IL-2).
Voss et al. (1989)interleukin-2lymphocyteExpression of the low-affinity interleukin-2 (IL-2) receptor molecule (TAC) has been associated with lymphocyte activation, in vitro and in vivo [Greene WC (1987) Clin Res 35:439].
Itoyama et al. (1988)IL-2PBLSince IL-2 receptor positive cells increased in HAM, this spontaneous PBL proliferation is probably a response to IL-2 through the expression of IL-2 receptors.
Baroja and Ceuppens (1987)interleukin-2lymphocytesMore exact quantification of interleukin-2 production by addition of anti-Tac monoclonal antibody to cultures of stimulated lymphocytes.
Baroja and Ceuppens (1987)IL-2lymphocyteWe conclude that addition of anti-Tac to lymphocyte cultures enables more exact quantification of in vitro IL-2 production, presumably by blocking IL-2 consumption.
Yoshimura and Kahan (1985)IL-2lymphocytesPeripheral blood lymphocytes (PBL) from CsA-Pred treated recipients displayed 40.6% inhibition (1.14 +/- 0.06 U/ml, n = 117, P less than 0.001) of IL-2 production compared with normal individuals (1.93 +/- 0.04 U/ml, n = 164).
Yoshimura and Kahan (1985)IL-2lymphocytesCsA did not inhibit the expression of the IL-2 receptor: 4.15 +/- 11.2% and 63.1 +/- 10.3 of normal lymphocytes and 36.7 +/- 9.8% and 60.4 +/- 12.2% of CsA-treated patient lymphocytes expressed anti-IL-2 receptors after 24 or 48 hr of PHA stimulation, respectively.
Kruger et al. (1984)interleukin-2lymphocytesWe studied the ability of phytohemagglutinin (PHA) and two anti-T-cell monoclonal antibodies, OKT3 and Pan T2, to induce interleukin-2 (IL2) production and proliferation in peripheral blood lymphocytes (PBL) from 14 patients with combined varied immunodeficiency (CVI).
Kruger et al. (1984)IL2PBLThe median values of endogenous IL2 produced by mitogen-stimulated PBL was significantly lower in patients than controls irrespective of the mitogen used.
Bagasra et al. (1993)interleukin-2lymphocytesThere was a decreased ability of lymphocytes, obtained after alcohol consumption, to produce interleukin-2 and soluble immune response suppressor activity after stimulation with concanavalin A.
Bartz et al. (1995)interleukin 2lymphocytesOne CsA analog with antiviral activity costimulated the phytohemagglutinin-induced production of interleukin 2 by human lymphocytes.
Freed et al. (1987)interleukin 2lymphocyteA 50 microM concentration of H2O2 completely blocked the generation of cytotoxic T cells in the mixed lymphocyte culture but did not inhibit the production of interleukin 2.
Galanis et al. (2004)IL-2lymphocytesLaboratory analysis of tumor samples revealed the presence of IL-2 plasmid DNA in six of eight patients posttreatment, increased IL-2 expression in tumor cells in four of eight patients posttreatment, and increased tumor infiltration by CD8-positive lymphocytes in five of eight patients posttreatment.
Skibber et al. (1987)IL-2PBLExpansion of peripheral blood lymphocytes (PBL) in recombinant or naturally produced IL-2, mitogens, and feeder cells results in a progressive expansion of cell number but a decline in lytic activity with time.
Ulmer and Flad (1982)Il-2lymphocytesT-lymphocytes from fractions 6 and 7 and in most experiments also from fraction 5 (low-density lymphocytes containing between 20% and 50% Fcmu receptor bearing cells, but still 0.2% up to 30% monocytes) could be stimulated by PHA for the production of Il-2 also without additional monocytes.
Lopez et al. (1991)interleukin-2lymphocytesThymic hormones have been shown to exhibit immunorestorative effects in vivo and in vitro, and to enhance the expression of high affinity interleukin-2 (IL-2) receptors on normal human lymphocytes stimulated with phytohemagglutinin.
Carrillo-Vico et al. (2005)IL-2lymphocytesMelatonin exerted these effects by a receptor-mediated action mechanism because both IL-2 and IL-2 receptor expressions significantly decreased when lymphocytes were incubated in the presence of the specific membrane and/or nuclear melatonin receptor antagonists, luzindole, and/or CGP 55644, respectively.
Hu et al. (1990)IL-2lymphocytes[Effects of polyactin A on in vitro IL-2 production and responsiveness of human lymphocytes].
Hu et al. (1990)IL-2lymphocytesThe effects of a novel antitumor antibiotic polyactin A (PA) on in vitro IL-2 production and IL-2 responsiveness of human lymphocytes were investigated.
Hu et al. (1990)IL-2lymphocytesThe results show that PA in a concentration range from 0.01 to 100 micrograms/ml obviously augmented in vitro IL-2 production, IL-2 receptor expression and responsiveness to IL-2 of human lymphocytes in the presence of PHA, and that these enhancing effects of PA were dose-dependent.
Hu et al. (1990)IL-2lymphocytesThe possible application of PA to the treatment of immune disorders involving deficiency of IL-2 production and/or IL-2 responsiveness of lymphocytes is also considered.
Hirooka et al. (1990)interleukin-2lymphocytesKinetics of interleukin-2 production in seven normal lymphocytes revealed that in both PHA- and Con A-stimulations, the peak levels of interleukin-2 were seen at the end of 72 hours (113.9 +/- 54.4 U/ml, 111.6 +/- 37.3 U/ml, respectively) and then declined.
Bagasra et al. (1989)interleukin 2lymphocytesThere was also decreased ability of lymphocytes to produce interleukin 2 and soluble immune response suppressor activity after stimulation with concanavalin A, the former, possibly both, for over 4 days after alcohol ingestion.
Cox et al. (1987)interleukin-2lymphocytesThe observed decrease in lymphocyte proliferation hyporesponsiveness to interleukin-2 correlated with the ability of 8-methoxypsoralen to induce a dose-dependent decrease in interleukin-2 receptor expression on phytohemagglutinin-stimulated lymphocytes.
Seymour et al. (1985)Interleukin-2lymphocytesInterleukin-2 production and bone-resorption activity in vitro by unstimulated lymphocytes extracted from chronically-inflamed human periodontal tissues.
Cox et al. (1988)interleukin-2lymphocyteAt the optimal concentration of PHA, 8-MOP (140 microM) caused a delay in lymphocyte proliferation, interleukin-2 (IL-2) production/accumulation and IL-2 receptor expression.
Cox et al. (1988)IL-2lymphocyteAddition of exogenous IL-2 to cultures stimulated with an optimal concentration of PHA did not overcome the delay of lymphocyte proliferation and IL-2 receptor expression.
Cox et al. (1988)IL-2lymphocyteAt the suboptimal concentration of PHA, 8-MOP (140 microM) caused a sustained inhibition of lymphocyte proliferation, IL-2 production/accumulation and IL-2 receptor expression.
Cox et al. (1988)IL-2lymphocyteAddition of exogenous IL-2 under these conditions restored the magnitude of lymphocyte proliferation and IL-2 receptor expression.
Cox et al. (1988)IL-2lymphocyteHowever, the responses displayed the delayed lymphocyte proliferation and IL-2 receptor expression typical of cells incubated with 8-MOP and an optimal concentration of PHA.
Borron et al. (1996)IL-2lymphocyteSurfactant associated protein-A inhibits human lymphocyte proliferation and IL-2 production.
Chen et al. (1994)interleukin-2lymphocytesGlutathione increases interleukin-2 production in human lymphocytes.
Chen et al. (1994)IL-2lymphocytesThe present study investigated the effects of GSH on interleukin-2 (IL-2) production from normal human peripheral blood lymphocytes (PBL).
Chen et al. (1994)IL-2PBLIL-2 production from PBL was markedly increased at the presence of exogenous GSH (0.5-8 mmol/l) or 2-ME (12.5-50 mumol/l) which corresponded to 1.57-2.82 nmol/10(6) cells and 1.41 - 1.80 nmol/10(6) cells of intracellular concentrations of GSH, respectively.
Tsang et al. (1985)IL-2lymphocyteIn the presence of ISO, ConA-induced lymphocyte proliferation, NK activity, neutrophil chemotaxis, and IL-2 production were restored to normal or near normal levels in 50 of the 55 (90.0%), 35 of the 41 (85.3%), 44 of the 52 (84.6%), and 25 of the 35 (71.4%) aging humans, respectively.
Yang et al. (1994)interleukin-2lymphocyteLymphocytes were incubated with a suboptimal dose of Con A or PHA in the presence or absence of varying doses of triptolide to assess the effect of triptolide on lymphocyte proliferation, interleukin-2 (IL-2) production and IL-2 receptor expression.
Fraher et al. (1995)IL-2lymphocytesThis inhibitory effect was seen despite the fact that cultured lymphocytes continued to express the IL-2 receptor and other activation markers.
Rosenberg et al. (1984)interleukin-2lymphocytesThe gene for interleukin-2 was isolated from the Jurkat cell line and from normal peripheral blood lymphocytes and, when inserted in Escherichia coli, was expressed at high concentrations.
Labalette-Houache et al. (1991)interleukin-2lymphocytesEnumeration of interleukin-2 (IL-2) producing cells by their cytoplasmic immunofluorescence showed that enlarged lymphocytes were the main IL-2 producing cells.
Ahmed et al. (1990)interleukin 2lymphocytesProduction of interleukin 2 and expression of interleukin 2 receptors by pony peripheral blood lymphocytes after stimulation with a soluble fraction of Trypanosoma evansi.