Viewing negative mentions of gene expression of IL2 (H. sapiens) in lymphocytes

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Blumberg et al. (1987)IL-2lymphocytesCytotoxic activity correlated positively with the number of T4 lymphocytes (r = .56, P less than .001) and the amount of IL-2 produced (r = .47, P less than .01) but not with interferon production.
Sidell and Ramsdell (1988)IL-2PBLIn contrast to these effects on thymocytes, peripheral blood lymphocyte (PBL) proliferative responses were unaffected by RA treatment and, correspondingly, RA affected neither IL-2 receptor expression on PBL blasts nor the growth of these cells.
Salmeron et al. (1992)IL-2TILUncultured TIL produced interferon gamma (IFN gamma), but not interleukin-2 (IL-2) or IL-4, in response to anti-CD3 mAb or IL-2.
Gerber et al. (1989)IL2lymphocytesThe radiosensitivity of human lymphocytes was investigated by the method of colony formation in the absence of interleukin-2 (IL2) and feeder cells, both of which enhance growth of T-cell colonies.
Roussel et al. (1996)IL-2TILHowever, most TIL populations did not express IFN-gamma, IL-2, and tumour necrosis factor-beta (TNF-beta) at higher levels than healthy normal PBL.
Ruan et al. (1992)IL-2lymphocytesIL-2 was not expressed in lymphocytes of controls and only occasionally in mild or moderate cellular rejection, humoral rejection, and Quilty lesions.
Aoki et al. (1992)IL-2lymphocytesCytokines such as IL-2 or interferon (IFN) are not considered to be involved in the medullasin induction of AK cells for the following reasons: (1) neither IL-2 nor IFN activity were detected in the supernatant of lymphocytes treated with medullasin; (2) the supernatant of lymphocytes treated with medullasin failed to induce AK cells; and (3) the presence of antibodies against IL-2 or IFN did not influence the effect of the protease.
Redelman et al. (1984)cell growth factorlymphocytesAdR blocked neither the production of T cell growth factor (TCGF) by lectin-stimulated lymphocytes nor the expression of TCGF receptors as detected by the anti-Tac monoclonal antibody that recognizes the human TCGF receptor.
Robinson and Morstyn (1987)IL-2-mediatedlymphocyteNK cells appeared to be the IL-2-responsive lytic cell population in these experiments as Leu 11b-depleted lymphocytes expressed little IL-2-mediated augmentation of activity against these target cells, and most of this IL-2-mediated augmentation of activity was located in the large granular lymphocyte-enriched fraction of the lymphocyte population.
Packard (1990)IL-2TILsThe presence of four irradiated cultured human tumor cell lines, three of which were derived from the same melanoma patients as the TILs, were found to stimulate proliferation of human TILs in the absence of IL-2.
Brown et al. (1982)TCGFlymphocytesIn the absence of TCGF, activated owl monkey (8I) and human (RG) lymphocytes displayed a TCGF-sensitive block; addition of TCGF stimulated these cells to enter the S phase after 12 and 16 hr, respectively.
Noma et al. (1985)IL 2lymphocyteFurthermore, these populations produced relatively pure interleukin 2 (IL 2) by stimulation of an autologous mixed lymphocyte reaction without any absorption of IL 2 produced in the same culture.
Teodorczyk-Injeyan et al. (2008)IL-2lymphocytesAs resting lymphocytes do not produce IL-2, sera from normal individuals contain usually very little or no detectable IL-2.
Rabin et al. (1984)IL-2lymphocytesFour to 6 weeks later, the lymphocytes showed increased clumping and cell growth and the ability to grow in the absence of IL-2.
Soulillou et al. (1985)interleukin 2lymphocytesPeripheral blood lymphocytes (PBL) of patients with Hodgkin's disease were studied for their capacity to produce interleukin 2 upon in vitro phytohemaglutinin stimulation in the presence or absence of either interleukin 1 or indomethacin (2 micrograms/ml); eight patients were studied at the discovery of their disease before receiving any therapy (onset HD; OHD).
Kitas et al. (1988)IL-2lymphocytesThese were: (a) a possible lack of the IL-2-producing CD4+2H4+ lymphocytes and (b) the possible inhibitory role of monocytes and neutrophils.
Yoshizawa et al. (1994)IL2lymphocytesPatient's lymphocytes pretreated with 2 to 2000 ng/ml doses of oxatomides for 24 to 48 hours failed to produce Df-induced IL2 responsiveness in a dose-dependent manner.
Ceuppens et al. (1985)IL 2lymphocyteUpon stimulation by OKT3, lymphocyte preparations from OKT3-nonresponders failed to produce interleukin 2 (IL 2) and to display IL 2 receptors.
Linker-Israeli et al. (1985)IL-2lymphocytesThree lines of evidence suggest that the SLE OKT8+ cells actively inhibit the production of IL-2 rather than passively absorb this lymphokine: (a) only 3.2% of SLE lymphocytes expressed IL-2 receptors as detected with anti-Tac; (b) freshly prepared SLE lymphocytes did not absorb IL-2; and (c) cell-free supernatants from SLE OKT8+ cells inhibited IL-2 production, but not IL-2 activity.
Blauvelt et al. (1996)IL-2lymphocytesInterleukin (IL)-15 is a recently described cytokine that shares many functional activities with IL-2; however, unlike IL-2, IL-15 is produced by monocytes/macrophages, and not by lymphocytes.
Ishimitsu and Torisu (1993)IL-2lymphocyteOn the other hand, no ECA was found in the supernatant of normal lymphocyte cultures, nor in IL-2 itself.
Miescher et al. (1988)interleukin-2lymphocytesThese cells were small T11+, T3+ lymphocytes that did not express DR antigens or the receptor for interleukin-2.
Burmester et al. (1984)IL-2lymphocytesThe patient's lymphocytes produced diminished amounts of immune interferon, and there was no detectable interleukin 2 (IL-2) activity after stimulation with phytohemagglutinin (PHA).
Kamio et al. (1990)IL-2lymphocytesRadiolabeled IL-2 binding assay revealed that IM lymphocytes from all patients examined had a considerable number of IL-2 binding sites with an intermediate affinity, although they did not express the IL-2 receptor recognized by anti-Tac antibody (p55).
Wang et al. (1983)interleukin 2lymphocytesBy measuring the presence of a soluble helper mediator (SHF) in MLC supernatants, we found that CsA-treated lymphocytes produced no SHF, possibly interleukin 2 (IL-2).
Lanier and Weiss (1986)interleukin 2lymphocyteBut a T leukaemia cell line, IL-2 (interleukin 2) dependent T-cell clones established from fetal blood and IL-2 dependent cell lines established from immunodeficiency patients with bare lymphocyte syndrome and ectodermal dysplasia syndrome have recently been shown to express CD3, but not Ti (detected due to monoclonal antibody WT31).
Kradin et al. (1989)IL-2PBLLectin stimulation of PBL produced little IL-2 secretion during treatment, while IFN-gamma secretion persisted.
Yoshizawa et al. (1989)IL-2lymphocytesNormal lymphocytes stimulated with Df expressed Tac antigen (low-affinity IL-2 receptor) but, in contrast to the patients' lymphocytes, did not absorb nor respond to IL-2.
Bulgarini et al. (1991)IL-2lymphocytesThus, our studies indicate that IL-6 directly and selectively stimulates the GO----S progression of CD8+ lymphocytes in the presence of mitogen and absence of IL-2: this phenomenon may be of interest for the elucidation of mechanisms activating cytotoxic T lymphocytes.
Vitale et al. (1998)IL-2lymphocytesIn this study we identified a novel 44-kD surface molecule (NKp44) that is absent in freshly isolated peripheral blood lymphocytes but is progressively expressed by all NK cells in vitro after culture in IL-2.
Chang et al. (2008)IL-2lymphocyteIL-2 and IFN-gamma were not detected in any co-cultures suggesting lack of lymphocyte activation.
Chusid et al. (1981)lymphokinelymphocytesHis lymphocytes failed to produce the lymphokine LMIF normally.
Hornicek et al. (1992)IL-2lymphocytesOxidized lymphocytes maintained in the medium containing 0.2 mM Ca2+ failed to proliferate or to produce IL-2, whereas a 1.4 mM Ca2+ concentration was shown to be sufficient to sustain cellular proliferation and IL-2 secretion.
Bertotto et al. (1989)lymphokinelymphocytesUnder certain experimental conditions (anti-CD3 or anti-CD2 antibody stimulation), the patients' lymphocytes expressed low levels of IL-2 surface receptors and failed to produce normal amounts of this lymphokine.
Grove et al. (1992)IL-2lymphocytesHowever, no IL-2 was produced after the exposure of lymphocytes to the combination of cytochalasans and PMA.
Shau et al. (1990)IL-2PBLsIL-2 treatment, the CD56-positive cells in the PBLs were predominantly CD16 positive and CD3 negative.
Fujioka et al. (1994)interleukin-2lymphocytesThese findings suggest that interferon-alpha does not consistently produce a beneficial effect on interleukin-2 expanded tumor-infiltrating lymphocytes in patients with renal cell carcinoma.
Gallo et al. (1991)IL-2lymphocyteFurthermore, the data argue for a predominant activation of an IL-2- and sIL-2R-producing but not IL-4-producing T-helper (Th) lymphocyte subpopulation, Th1/CD4 + CD45R + cells.
Elkins and Cambier (1983)IL 2lymphocyteIt does not itself contain any detectable IL 2 or BCGF or interferon activity, however. 14G3.1F2 activity is probably an important component of the conventional TRF preparations produced by mixed lymphocyte populations, and will be useful in further dissection of the contributions of different soluble T cell products to B cell differentiation.
Crosier (1986)interleukin-2lymphocytesThe T-CLL cells did not suppress the production of polyclonal antibody and did not produce interleukin-2 to levels above normal control lymphocytes.
Berg et al. (1991)interleukin 2lymphocytesThe absence of Leu-8 messenger RNA in intestinal lymphocytes and circulating Leu-8 negative lymphocytes was not caused by recent activation in vivo because these cells did not have detectable interleukin 2 messenger RNA, and intestinal lymphocytes did not express Leu-8 after culture in vitro.
McLeod et al. (1990)Interleukin 2LymphocytesLymphocytes from congenitally infected babies failed to produce either gamma interferon or Interleukin 2 when cultured with TLA.
Eckert et al. (1999)IL-2lymphocytesNo IL-2 was found in the supernatants of untreated and treated lymphocytes from healthy donors.
Combe et al. (1987)interleukin-2lymphocytesThis lymphocytic sub-population produces little interleukin-2, responds weakly to mitogens (PHA, CON A, PWM), and inhibits the response of normal lymphocytes to the same mitogens.
Lomnitzer et al. (1976)lymphokinelymphocytesAlthough the lymphocytes of 12 of these patients produced adequate amounts of LIF, the rest of the group failed to produce lymphokine after PHA activation.
Wang et al. (1994)IL-2lymphocyteWhen we studied the anti-CD4 effects on cytokine production in T cells stimulated in mixed lymphocyte reaction (MLR) or by mitogens, we found that neither IL-2 nor IL-4 production was dramatically influenced by anti-CD4 in CD4,45RO+ cells.
Enokihara et al. (1994)lymphokinelymphocytesWe found that lymphocytes from eosinophilic patients expressed IL-5 mRNA, but lymphocytes from normal volunteers did not express the lymphokine.