Viewing affirmative mentions of gene expression of IL2 (H. sapiens) in NK cells

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Ghoneum et al. (1987)interleukin-2natural killer cellWe conclude that MCA exerts an inhibitory effect on T-cell functional activity such as interleukin-2 and lymphotoxin production which correlate with a suppression of blastogenesis and natural killer cell activity.
Sirota et al. (1995)interleukin-2natural killer cellEffect of human colostrum on interleukin-2 production and natural killer cell activity.
Watson et al. (1991)IL-2NK cellsThe increase in the percentage of cells with markers of NK cells and in expression of IL-2 receptors was dose dependent.
Li and Weir (1990)IL-2natural killer cellTW evidenced little capability of impairing IL-2 receptor expression, or efferent immune mechanisms such as cell-mediated cytotoxicity or natural killer cell-mediated cytotoxicity.
Toossi et al. (1989)interleukin 2large granular lymphocytesPeripheral blood large granular lymphocytes (LGL) expressing Leu 11 (CD16) antigen with potent natural killer cytotoxicity inhibited soluble antigen-induced T-cell production of interleukin 2 (IL-2).
Mitsuyasu (2001)Interleukin-2natural killer cellsInterleukin-2 (IL-2) is a secretory cytokine produced by activated T cells that stimulates T cells, B cells, and natural killer cells to proliferate and release cytokines.
Lister et al. (1995)rhIL-2NK cellsAdoptive transfer of A-NK cells and rhIL-2 during the pancytopenic phase after HDC-PBSCT was feasible and well tolerated, did not adversely affect engraftment, and resulted in amplified natural killer activity in the peripheral blood during the immediate posttransplantation period.
Ishizaka et al. (1992)IL-2large granular lymphocytesCultured cell viability, IL-2 receptor-beta expression on large granular lymphocytes (LGL), the percentage of IL-2 receptor-beta positive LGLs and cell proliferation were not affected by oxygen-limited conditions.
Nagashima et al. (1998)IL-2 transgeneNK cellsStable expression of the IL-2 transgene in NK cells improved their therapeutic potential in tumor-bearing hosts.
Neveu (1992)interleukin-2natural killer cellIn rodents, lesions of right or left neocortex induced opposite effects on various immune parameters including mitogen-induced lymphoproliferation, interleukin-2 production, macrophage activation or natural killer cell activity.
Neville et al. (2000)IL-2NK cellsThus, Oncolipin is receptor-targeted to activated T and NK cells by virtue of its surface expression of IL-2 and has the potential to release IL-2 following deposition within lymphoid organs.
Watanabe et al. (1990)IL-2NK cellThe skin tests and the NK cell activity showed poorer correlations, and no exact correlation was noted between the IL-2 production and the immune response.
Rey et al. (1983)interleukin-2natural killer cellsDiminished interleukin-2 activity production in cancer patients bearing solid tumors and its relationship with natural killer cells.
Sibbitt et al. (1983)IL-2NK cellThis study was designed to determine the relationship between IL-2 production and NK cell activity in SLE.
Voss et al. (1992)interleukin 2natural killer cellsCharacterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R.
Voss et al. (1992)IL-2NK cellsIn a previous study of the IL-2 receptors expressed on NK cells obtained from cancer patients after in vivo IL-2 therapy, we documented a discrepancy between the level of beta chain and the level of intermediate-affinity IL-2 binding sites expressed on the cell surface.
Voltarelli et al. (1990)IL-2NK cellsTreatment with the eight antibody mixture produced more than three log depletion of precursors for IL-2-producing cells (pIL-2) and approximately one log depletion of precursors for NK cells.
Iseki et al. (1987)IL-2null cellThese findings suggest that the T3- fraction (null cell fraction) contains predominantly cells expressing IL-2.R at the resting state.
Trzonkowski et al. (2006)IL2NK cellsThe numbers of Treg cells in peripheral blood, their influence on CD8+ T and NK cells and production of IL2 as well as apoptosis intensity of Treg cells were measured.
Trzonkowski et al. (2006)IL2NK cellsConcluding, we found that Treg accumulated as a result of ageing and/or medical conditions were capable of decreasing cytotoxic activity of CD8+ T and NK cells and production of IL2.
Fehniger et al. (2003)IL-2NK cellsOne subset of human NK cells (CD56(bright)) constitutively expresses the high-affinity interleukin 2 (IL-2) receptor and produces immunoregulatory cytokines.
Zerhouni et al. (1997)IL-2NK cellWe therefore conclude that the alteration of NK cell activity occurs at an advanced stage of HIV infection, that the reduction of cytotoxic activity is partially restored by exogenous IL-2, and that decreased production of IL-2 and increased production of IL-10 may account for part of this reduction in cytotoxicity.
Clark et al. (2000)IL-2natural killer cellsCationic lipid gene transfer of an IL-2 transgene leads to activation of natural killer cells in a SCID mouse human tumor xenograft.
Clark et al. (2000)IL-2NK cellsThese results indicate that local cationic lipid-mediated gene transfer of IL-2 induces activation of intratumoral NK cells and slows tumor growth.
Rey et al. (1984)interleukin 2natural killer cellsTheir relation with interleukin 2 activity production and natural killer cells in cancer patients.
Smyth and Ortaldo (1991)IL-2LGLIn particular, IL-6 did not stimulate detectable LGL IL-2 production or IL-2R modulation, and mAb to the p75 IL-2R had no effect on IL-6 induction of LGL NK activity.
Echevarria et al. (1991)IL2NK cellEnhanced NK cell activity appears to be secondary, at least in part, to increased production of IL2.
Keever et al. (1990)IL2NK cellsIL2 receptor (CD25) expression was low in all cultures but was consistently higher in cultures containing IL1 and IL2, however, CD25 was not coexpressed on NK cells.
Carson et al. (1995)IL-2large granular lymphocytesNatural killer (NK) cells are large granular lymphocytes that constitutively express functional IL-2 receptors.
Zambello et al. (1994)interleukin-2natural killer cellsIndependent expression of p55 and p75 interleukin-2 receptors (IL-2R) during intravenous or subcutaneous administration of recombinant interleukin-2 (rIL-2) by T-lymphocytes and natural killer cells.
Gerosa et al. (1992)interleukin 2NK cellsDifferent sensitivity to interleukin 4 of interleukin 2- and interferon alpha-induced CD69 antigen expression in human resting NK cells and CD3+, CD4-, CD8- lymphocytes.
Nagler et al. (1990)interleukin 2natural killer cellsConstitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo.
Voss et al. (1990)interleukin 2natural killer cellsIncreased expression of the interleukin 2 (IL-2) receptor beta chain (p70) on CD56+ natural killer cells after in vivo IL-2 therapy: p70 expression does not alone predict the level of intermediate affinity IL-2 binding.
Ostensen et al. (1987)IL 2large granular lymphocytesBy flow cytometric analysis, it was found that expression of IL 2 receptors was induced on purified CD16+ large granular lymphocytes by rTNF alpha alone and to an even greater degree by the combination of rTNF alpha and rIL 2.
Hoyt et al. (1988)IL-2natural killer cellsSignificant T-cell changes in patients who developed sepsis include: decreased total T-cells, decreased helper cells, decreased natural killer cells, increased Ia expressing mononuclear cells, increased activated T-cells, (L22) and increased IL-2 expressing cells (TAC).
Downing and Taylor (1987)interleukin-2natural killer cellIn order to determine whether hyperthermia was associated with other immunostimulatory effects, we measured lymphocyte activation, natural killer cell activity, interleukin-2 (IL-2) production and endotoxin-induced tumor necrosis factor (TNF) activity in blood samples obtained from normothermic (37 degrees C) and hyperthermic (39 degrees C) individuals.
Kasahara et al. (1983)interleukin 2large granular lymphocytesHuman large granular lymphocytes (LGL), which are known to be responsible for natural killer (NK) cell activity, also produced a variety of lymphokines including interleukin 2 (IL 2), colony stimulating factor (CSF), and interferon (IFN) in response to phytohemagglutinin (PHA) or concanavalin A (Con A).
Kasahara et al. (1983)IL 2LGLMoreover, IL 2 production by LGL could be further distinguished in that it was not enhanced by the addition of macrophages or macrophage-derived factor, i.e., IL 1, whereas addition of macrophages did potentiate IL 2 production by T lymphocytes.
Kasahara et al. (1983)IL 2LGLFurther analysis of cells in the LGL population using various monoclonal antibodies revealed that removal of cells with OKT11 or AF-10, a monoclonal antibody against human HLA-DR antigen, decreased IL 2 production, whereas removal of OKT8+, OKM1+, Leu-M1+, or Leu-7+ cells led to enhanced IL 2 production.
Kasahara et al. (1983)IL 2LGLAn atypical T cell subset (OKT3-, Leu-1-, OKT11+) rather than the myeloid subset of LGL (Leu-M1+ or OKMI+) was the source of LGL-derived IL 2, whereas the latter subset and/or another subset of OKT8+ cells appear to regulate this IL 2 production.
Kasahara et al. (1983)IL2LGLIn addition to performing NK activity, LGL on a per cell basis seem to be more effective than T lymphocytes in producing lymphokines, namely, IL2, CSF, and IFN.
Nagaraj et al. (2004)IL-2 cytokine genenatural killer cellsIn this regard, adenoviral-mediated expression of IL-2 cytokine gene in several tumor models has been found to induce strong and specific antitumor responses [18] by stimulating immune cells including T and natural killer cells.
Biswas et al. (1997)IL-2NK cellThese observations suggest that in vitro human NK cell augmentation with analogs (1) and (2) reported earlier may be due to enhanced IL-2 production.
Ingram et al. (2009)IL2NK cellAML cells transduced with a lentivirus expressing CD80 (B7.1) and IL2 (LV-CD80/IL2) are capable of stimulating T and NK cell cytotoxicity in vitro.
London et al. (1986)IL 2NK cellsInteraction of IL 2 with the Tac IL 2 receptor expressed on activated NK cells is necessary to maintain continued growth of these cells.
Konstantinidis et al. (2005)IL-2NK cellsGenetic modification of NK cells expressing IL-2 in a localized and controlled manner could be a powerful tool for overcoming these obstacles.
Baxevanis et al. (1993)interleukin-2natural killer cellMononuclear cells isolated from peripheral blood were tested in the following tests: (a) proliferative responses in the autologous and allogeneic mixed lymphocyte reaction (auto- and allo-MLR respectively): (b) natural killer cell activity; (c) production of interleukin-2 during the allo-MLR, and (d) interleukin-1 beta production by lipopolysaccharide-stimulated monocytes.
Chandra (1992)interleukin-2natural killer cellSubjects in the supplement group had higher numbers of certain T-cell subsets and natural killer cells, enhanced proliferation response to mitogen, increased interleukin-2 production, and higher antibody response and natural killer cell activity.
Wanebo et al. (1989)interleukin-2natural killer cellPatients showed the expected depression of lymphocyte proliferation to phytohemagglutinin and had borderline depressed natural killer cell activity and relatively normal interleukin-2 production.
Caligiuri et al. (1990)IL-2NK cellsIn contrast, most NK cells constitutively express the isolated intermediate affinity p75 IL-2 receptor.
Caligiuri et al. (1990)IL-2NK cellsIn addition, a subpopulation of NK cells, distinguished by high density expression of the NKH1 antigen, constitutively express the high affinity IL-2 receptor, in addition to an excess of the isolated intermediate affinity p75 IL-2 receptor.
Caligiuri et al. (1990)IL-2NK cellsThe intermediate affinity p75 IL-2 receptor, as it exists in its isolated form on resting NK cells, does not transduce a growth signal equivalent to that seen in NK cells expressing the high affinity IL-2 receptor, despite doses of IL-2 that are known to fully saturate the isolated p75 chain.
Lu et al. (1992)IL-2NK cells[The production of IL-2, IL-6 in relation to the functional development of NK cells in human fetal spleens].
Lu et al. (1992)IL-2natural killer cellThe production of IL-2, IL-6 by fetal splenic mononuclear cells (FSMC) and relationship between them and the ontogenetic development of natural killer cell function were studied in human fetal spleens.
Lu et al. (1992)IL-2NK cellsLastly, the production of IL-2, IL-6 in relation to the functional development of NK cells during the embryonic development was discussed.
Darko et al. (1988)interleukin-2natural killer cellsPercent of total lymphocytes labeled as all T lymphocytes, all B lymphocytes, and natural killer cells did not differ in the two groups, nor did mitogen-induced interleukin-2 production.
Santos et al. (1996)interleukin 2NK cellThe reason for this is unknown; however, it was not due to an increase in the percentage of NK cells, nor to an increase in interleukin 2 (IL-2) receptor expression, nor to IL-2 production. beta-carotene may be acting directly on one or more of the lytic stages of NK cell cytotoxicity, or on NK cell activity-enhancing cytokines other than IL-2, such as IL-12.
Roberts et al. (1987)IL-2null cellsInterleukin 2 stimulated null cells, retained a Leu-11+, Leu-4- phenotype, and expressed only low levels of receptors for IL-2 and transferrin.
Payvandi et al. (2005)IL-2NK cellsTaken together, our results demonstrate that the IMiDs exert their effects at least in part by activating PKC-theta and acting on AP-1 DNA-binding activity in T cells, resulting in augmented IL-2 synthesis and activation of IL- 2-dependent downstream effectors, such as NK cells.
Meropol et al. (1996)IL-2NK cellsAs predicted by in vitro studies of IL-2 receptor structure-activity relationships, the subset of NK cells that constitutively express high-affinity IL-2 receptors (CD3(-)CD56(bright+)) showed more profound dose-dependent expansion, with increases ranging from 368 to 2763% (P = 0.015).
Mantovani et al. (1987)interleukin 2NK cellsAs far as the interleukin 2 involvement in HD is concerned, our study suggests: an impaired endogenous interleukin 2 production by T lymphocytes, a most probable deficiency of the interleukin 2 receptor (Tac) expression and 3) a decrease of the number and/or of the function of NK cells no longer responsive in vitro to interleukin 2.
Matos et al. (1993)IL-2NK cellsIn the present study we show the c-kit receptor to be uniquely expressed on a subset of resting human NK cells (CD56bright) which constitutively expresses both the high affinity IL-2 receptor (IL-2R) and the intermediate affinity IL-2R.
Beilin et al. (2007)IL-2natural killer cellWe have assessed the effect of preoperative administration of a sub-anaesthetic dose of ketamine on the mitogen response and production of interleukin (IL)-1beta, IL-2, IL-6, and tumour necrosis factor (TNF)-alpha by peripheral blood mononuclear cells (PBMCs), as well as natural killer cell cytotoxicity (NKCC) in patients undergoing abdominal surgery.
Nagler et al. (1990)IL-2NK cellsIn contrast to CD16+ NK cells that express only p75 IL-2 receptors, CD16- NK cells constitutively co-express both p75 and p55 IL-2 receptors in vivo and preferentially respond to low concentrations of IL-2 with increased cytolytic activation and proliferation.
Nagler et al. (1990)IL-2NK cellsCD16+ NK cells expressed only a single intermediate affinity IL-2 receptor of approximately 1.9 nM kD (approximately 9,000 sites per cell).
Vitolo et al. (1993)IL-2NK cellsOnly low proportions of R-NK cells expressed genes for IL-2Rp55 (16%) or cytokines IL-2 (20%), IFN-gamma (18%), TNF-alpha (16%), and TGF-beta (7%).
Perussia et al. (1987)IL-2NK cellsOur data indicate that proliferation of both T and NK cells is dependent upon IL-2 production in the culture, because an anti-IL-2 antiserum completely suppresses proliferation.
Cen et al. (1999)IL-2natural killer cellRESULTS: The natural killer cell activity and IL-2 production in the experimental group were higher than that of the control group.
Melder and Jain (1994)IL-2NK cellsCultures of adherent human NK cells were expanded in interleukin 2 (IL-2) for 14 days, removed from culture and resuspended in medium with IL-2 and selected concentrations of TGA ranging from 0.032 mg/ml to 0.250 mg/ml.
Melder and Jain (1992)IL-2NK cellsReintroduction of IL-2 for 24 h to a culture of NK cells depleted of IL-2 for 48 h did not restore the cells to the pre-depletion level of rigidity.
Heiskala and Timonen (1987)IL-2natural killer cellInterleukin-2 (IL-2), when present during an 18-hr contact of peripheral blood lymphocytes with monolayers, did not affect the inhibition of natural killer cell activity.
Ortaldo et al. (1984)IL 2LGLThe mechanism of IL 2 boosting appears to be a direct interaction with LGL, resulting in the production of IFN gamma.
Murphy et al. (1992)rhIL-2NK cellsThese activated NK cells were then adoptively transferred with the donor BMC and rhIL-2 into lethally irradiated allogeneic hosts.
Umekage et al. (1998)IL-2natural killer cellsEnhancement by stem cell factor of interleukin-2 (IL-2)-induced DNA synthesis in human decidual CD16- CD56bright natural killer cells mediated by increased expression of the IL-2 receptor alpha chain.
Nagashima et al. (1998)interleukin-2natural killer cellStable transduction of the interleukin-2 gene into human natural killer cell lines and their phenotypic and functional characterization in vitro and in vivo.
Teschendorff and Severini (2010)IL2natural killer cellsSimilarly, our findings suggest that increased randomness in the patterns of expression of the IL2 pathway, a well-known tumour suppressor pathway mediating tumour inhibition through formation of natural killer cells [34], is a critical determinant of breast cancer metastasis.
Einspahr et al. (1992)Interleukin-2NK cellsInterleukin-2 signal transduction in human NK cells: multisite phosphorylation and activation of the tyrosine kinase p56lck.
Braun et al. (1987)IL-2natural killer cellIn vitro tests included (a) phytohemagglutinin (PHA) responsiveness in the presence of indomethacin or interleukin-2 (IL-2), (b) natural killer cell (NK) function, and (c) PHA-induced IL-2 synthesis.
Weil-Hillman et al. (1991)IL-2NK cellsThese results, together with preclinical murine studies, suggest that a combined in vivo protocol of anti-CD3 mAb and IL-2, starting first with the anti-CD3 mAb, may cause activation of the T cells in addition to the activation of NK cells and thus warrant clinical testing.
Pedrol et al. (1995)IL-2NK cellsTransferrin and IL-2 receptors, proliferating cells and NK cells were detected in some cases from both diseases.
Nakamura et al. (1989)interleukin 2natural killer cellA large number of interleukin 2 receptors lacking the Tac epitope (IL-2R/p75) were found to be constitutively expressed on the human large granular lymphocyte/natural killer cell line YT, which bears inducible IL-2R/p55 associated with Tac antigen.
Matsuse et al. (1989)interleukin-2natural killer cell[Immunologic evaluation in patients with lung cancer with special regard to peripheral blood natural killer cell activity and interleukin-2 productivity].
Martin et al. (2010)IL-2NK cellsMechanistic studies indicated that the activation of CD56(bright) NK cells was likely IL-2 driven, as low doses of IL-2, but not IL-15, mimicked this activation in vitro.
Metelitsa et al. (2001)IL-2NK cellsHuman NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells.