Viewing affirmative mentions of positive regulation of Trav6-3 (M. musculus) in T cells

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Kunjibettu et al. (2001)TCRT cellsConserved transmembrane tyrosine residues of the TCR beta chain are required for TCR expression and function in primary T cells and hybridomas.
Igari et al. (2007)TCRT-cellTo investigate the relationship between the radiation-induced increase of T-cell receptor (TCR) defective variant fractions and physiological status such as pregnancy, C57BL/ 6N mice were irradiated with 3 Gy of gamma rays at various days of gestation, just before and just after pregnancy.
Rubinstein et al. (2003)TCRT cellsThe transfer of TCR genes to mature T cells to generate tumor-reactive T cells provides a potential mechanism to overcome these limitations.
Shores et al. (1994)TCRT cellThe zeta chain played a role in thymic development by promoting TCR surface expression, but zeta-mediated signals were not essential because TCRs that contained signaling-deficient zeta chains promoted T cell maturation and transduced signals associated with thymic selection.
Dossett et al. (2009)TCRT cellsHowever, by introducing the TCR into a cell with a known endogenous specificity, activation of these T cells by stimulation through the endogenous TCR can be used to increase expression of the introduced TCR, potentially providing a strategy to increase the total number of tumor-reactive T cells in the host and restore more potent antitumor activity.
Coccoris et al. (2005)TCRT cellBecause the T cell receptor is the single specificity-determining molecule in T cell function, adoptive transfer of TCR genes into patient T cells may be used as an alternative approach for the transfer of tumor-specific T cell immunity.
Wasserman and Evavold (2008)TCRT cellsPrevious studies have found that a 95% reduction in TCR expression does not adversely affect response to foreign Ags, indicating that T cells have an excess of TCR for Ag recognition.
Felli et al. (2005)TCRT-cellWe previously showed that overexpression of pT alpha/pre-TCR and constitutive activation of NF-kappa B characterize the T-cell leukemia/lymphoma developing in Notch3-IC transgenic mice.
Tahara et al. (2003)TCRT cellsThese findings suggest that it is possible to reconstitute functional tumor-specific CD8(+) T cells by transfer of TCR alphabeta-chain genes derived from TIL, and that such T cells might be useful as cytotoxic effector cells or as a vehicle for delivering therapeutic agents.
Sleckman et al. (1998)TCRT cellThe generation of a productive "in-frame" T cell receptor beta (TCR beta), immunoglobulin (Ig) heavy (H) or Ig light (L) chain variable region gene can result in the cessation of rearrangement of the alternate allele, a process referred to as allelic exclusion.
Hernández-Munain et al. (1996)TCRT cellDevelopmental activation of VDJ recombination at the T cell receptor (TCR) delta locus is controlled by an intronic transcriptional enhancer (E delta).
Gonzalo et al. (1995)TCRT lymphocytesThe response of T lymphocytes to superantigens requires expression of the appropriate TCR V beta gene products as well as the establishment of cellular interactions mediated by adhesion molecules.
Esch et al. (1990)TCRT cellExperiments using mutated I-Ak molecules indicate that the ability of a mutant Ia species to present Ag is distinct from its ability to stabilize the Ag-recognition complex, suggesting that T cell stimulation depends not only upon stabilization of Ag-TCR-Ia complexes, but also upon distinct Ia-influenced conformational signals.
Leo et al. (1987)TcRT cellsNevertheless, cell surface expression of the TcR complex is required for optimal triggering of T cells via the Ly-6.2C molecule.
Shores et al. (1993)TCRT cellsIndeed, the present results indicate that successful differentiation into single-positive T cells requires surface expression of fully assembled TCR complexes.
Weinhold et al. (2007)TCRT cellsThese results are shown with T cells from dual TCR transgenic mice or T cells that were redirected by TCR gene transfer.
Popmihajlov et al. (2010)TCRT cellWe have previously created a transgenic mouse strain with increased TCR avidity in a diverse T cell population.
Rosenzweig et al. (2008)TCRT cellMETHODS: Using intravital microscopy we examined the ocular inflammatory response after the onset of arthritis in mice that overexpressed the T cell receptor (TCR) specific for a dominant arthritogenic epitope of cartilage proteoglycan [TCR-Tg (transgenic) mice] or BALB/c controls.
Nakamura et al. (2001)TCRT cellsDistinct oligoclonal accumulation of TCR Vbeta1, 10, and 13 T cells was found in both recipient and donor hearts in 3 of 4 mice.
Samelson et al. (1990)TCRT-cellActivation of the T-cell antigen receptor (TCR) results in tyrosine phosphorylation of the TCR zeta chain and other intracellular substrates.
Boulter et al. (2007)TCRT cellSuch peptides are efficient at inducing TCR down-regulation, T cell proliferation and acquisition of effector function (including cytotoxic activity) in response to a range of peptide concentrations.
Bonneville et al. (1990)TCRT cellsAlternatively, the signals that induce TCR-gamma/delta expression in developing T cells may also induce homing properties in such cells, presumably in the form of cell surface receptors.
Kato et al. (2002)TCRT cellTo clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic mutation was evaluated by measuring the T cell receptor (TCR) gene expression in p53(+/+) and p53(-/-) mice.
Huang et al. (2005)TCRT cellsFurthermore, those thymocytes that do generate an alphabeta TCR have a diminished capacity to be positively selected, and TCRalpha(sJ/sJ) mice have significantly reduced numbers of mature alphabeta T cells.
Fujio et al. (2000)TCRT lymphocytesTransfer of the alphabeta TCR genes into T lymphocytes will provide a means to enhance Ag-specific immunity by increasing the frequency of tumor- or pathogen-specific T lymphocytes.
Kündig et al. (1996)TCRT cellsCurrent models suggest that T cells that receive only signal-1 through antigenic stimulation of the T cell receptor (TCR) become anergic, but will mount an immune response when a costimulatory signal-2 is provided.
Levelt et al. (1993)TCRT-cellThymic repertoire selection requires the expression of the alpha beta CD3 T-cell receptor (TCR) together with the coreceptors CD4 and CD8.
Hachimura et al. (2004)TCRT cellsThus, as a consequence of caspase activation, orally tolerant CD4 T cells could not form normal TCR signaling complexes associated with GADS and showed downregulated PLC-gamma1 activation, which resulted in impairment of TCR-induced calcium signaling.
Kuvibidila and Porretta (2002)TCRT lymphocyteThe interaction of CD28 and its ligands (CD80, CD86) on antigen presenting cells and that of TCR/CD3-MHC are required for T lymphocyte activation.
Magnan et al. (2001)TCRT cellAfter stimulation of the T cell receptor (TCR), the tyrosine residues 292 and 315 in interdomain B of the protein tyrosine kinase ZAP-70 become phosphorylated and plausibly function as docking sites for Cbl and Vav1, respectively.
Delon et al. (1998)TCRT cellThe critical involvement of the cytoskeleton in antigen recognition on B cells introduces a checkpoint in T cell activation: the initial TCR engagement triggers a Ca2+ response only after an amplification step corresponding to a cytoskeleton-controlled increase in the number of engaged TCR.
Engels et al. (2005)TCRT lymphocytesTo circumvent this problem, we cloned T cell receptor (TCR) alpha and beta chains from a tumor-infiltrating lymphocyte clone specific for an RCC tumor antigen and transferred the TCR into human T cell lines and primary T lymphocytes.
Weissman et al. (1988)TCRT cellsTCR stimulation by Ag or anti-receptor antibodies in murine T cells results in the activation of two independent protein kinases, protein kinase C (PKC) and a protein tyrosine kinase.
Han et al. (2005)TCRT cellsTCR internalization was slightly increased in HIP-55 knockout T cells.
Leitão et al. (2009)TCRT cellsSurvival of peripheral CD8(+) T cells requires TCR interactions with peptide-MHC complexes (p-MHC).
Haks et al. (2002)TCRT cellThe immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains associated with the T cell receptor (TCR) are crucial for TCR signaling.
Kanagawa et al. (1994)TCRT cellThere are two distinct T cell populations which can be distinguished based on their TCR expression and function in the TCR transgenic mice, one bearing the transgene derived alpha- and beta-chain TCR that is nonreactive to MAIDS superantigen and the other bearing an endogenous alpha- but transgene-derived beta-chain TCR that is reactive to superantigen.
Gomes et al. (2006)TCRT cellThe contribution of cGMP in Th2 signaling was supported by the following results: 1) TCR activation elicited cGMP production, which triggered calcium increase responsible for nuclear factor of activated T cell translocation and Il4 gene expression; 2) guanylate cyclase activation by nitric oxide donors increased intracellular cGMP concentration and induced calcium inflow and IL-4 production; 3) reciprocally, guanylate cyclase inhibition reduced calcium response and Th2 cytokine production associated with TCR activation.
Serreze et al. (2001)TCRT-cellsTo address this issue, we reduced the precursor frequency of autoreactive T-cells in NOD mice through allelic exclusion induced by transgenic expression of an H2-Db class I-restricted T-cell receptor (TCR) specific for a pathologically irrelevant lymphocytic choriomeningitis virus (LCMV) peptide.
Kodaira et al. (1996)TCRT-cellModifications at V-(D)-J junctions increase the diversity of T-cell receptors (TCR).
Lucas et al. (1994)TCRT cellThese data suggest that high TCR expression and cell activation are necessary for positive selection and subsequent T cell maturation.
Yamazaki et al. (1997)TCRT cellsFrom these observations, the decrease in TCR signaling by CD3 zeta deficiency resulted in both the avoidance of negative selection and the acquisition of positive selection of autoreactive T cells in male HYTg/zeta KO mice.
Leduc et al. (2000)TCRT cellT cell differentiation in the mouse thymus is an intricate, highly coordinated process that requires the assembly of TCR complexes from individual components, including those produced by the precisely timed V(D)J recombination of TCR genes.
Leduc et al. (2000)TCRT cellMice carrying a homozygous deletion of the TCR beta transcriptional enhancer (E beta) demonstrate an inhibition of V(D)J recombination at the targeted TCR beta locus and a block in alpha beta T cell differentiation.
Kunugita et al. (2007)TCRT-cellMeasurement of mutant frequency in T-cell receptor (TCR) gene by flow cytometry after X-irradiation on EL-4 mice lymphoma cells.
McCaughtry et al. (2008)TCRT cellWe used the HY(cd4) model, where T cell receptor for antigen (TCR) expression is appropriately timed and a ubiquitous self-antigen drives clonal deletion in male mice.
Tokunaga et al. (2010)TCRT cellsStimulation of TCR induces ATP release from T cells through gap junction hemichannels and maxianion channels, at least in part.
Montaudouin et al. (2010)TCR chainT cellsEndogenous TCR chain expression by the T-cells recovered from the allogeneic hosts could result from the expansion of pre-existing donor T cells or be “de novo” induced upon T cell transfer.
Birkholz et al. (2010)TCRT cellsWe measured antigen presentation with specific autologous CD4(+) T cells, generated by TCR-RNA transfection.
Acosta-Iborra et al. (2009)TCRT cellsHypoxic macrophages generated productive immune synapses with CD8 T cells that were more efficient for activation of TCR/CD3epsilon, CD3zeta and linker for activation of T cell phosphorylation, and T cell cytokine production.
Gruber et al. (2008)TCRT cellsImportantly, however, both atypical PKCzeta and PKCiota were functionally required in TCR/CD28-mediated activation of NF-kappaB downstream of PKCtheta in Jurkat T cells albeit, activation responses of PKCzeta-deficient CD3+ T cells were comparable with wildtype controls.
Gonnella et al. (2008)TcRT cellsIn situ immunohistochemistry showed increased colocalization of cleaved caspase 3 and TcR Vbeta 8.1, 8.2+ CD4+ T cells in TLR-4-/- mice compared to wild type.
Choy et al. (2008)TCRT cellsT-cell-receptor (TCR)-activated CD8 T cells rapidly downregulated CXCR4, which coincided with diminished ability of CXCL12 to induce iNOS in activated T cells. iNOS expression in infiltrating human CD8 T cells was spatially associated with CXCL12 expression both in the humanized mouse model of allograft artery rejection and in clinical specimens of coronary arteries displaying allograft vasculopathy.
Atherly et al. (2006)TCRT cellThese proteins are involved in the regulation of signaling processes downstream of the TCR in CD4(+) T cells, particularly in the phosphorylation of phospholipase C-gamma1 after TCR activation; furthermore, both Itk and Rlk are important in CD4(+) T cell development, differentiation, function, and homeostasis.
Chamoto et al. (2004)TCRT-cellHere, we have developed an efficient protocol for preparing mouse antigen-specific Th1 cells from nonspecifically activated Th cells after retroviral transfer of T-cell receptor (TCR)-alpha and TCR-beta genes.
Yadav et al. (2004)TCRT cellsCD4 T cells showed some hallmarks of hyporesponsiveness because TCR/CD28-mediated stimulation led to defective activation and failure to induce disease in NODscid recipients.
Capone et al. (2003)TCRT lymphocytesDespite the forced expression of the human CD1d-restricted TCR in C alpha(-/-) mice, staining with mCD1d-alpha-GalCer tetramers reveals that the absolute numbers of peripheral CD1d-dependent T lymphocytes increase at most by 2-fold.
Sommers et al. (2002)TCRT cellT cell antigen receptor (TCR)-induced activation of phospholipase C-gamma1 (PLC-gamma1) and of nuclear factor of activated T cells, calcium influx, interleukin-2 production, and cell death were reduced or abrogated in T cells from LAT mutant mice.
Yahata et al. (2002)TCRT cellsFurthermore, these T cells bear polyclonal TCR-alphabeta, and respond not only to mitogenic stimuli, such as PHA and IL-2, but to allogenic human cells.
Exley et al. (2001)TCRT cellsA subset of CD161 (NK1) T cells express an invariant Valpha14Jalpha281 TCR-alpha chain (Valpha(invt) T cells) and produce Th2 and Th1 cytokines rapidly in response to CD1d, but their physiological function(s) remain unclear.
Schaeffer et al. (2001)TCRT cellThe Tec kinases Rlk and Itk are critical for full T cell receptor (TCR)-induced activation of phospholipase C-gamma and mitogen-activated protein kinase.
Newton et al. (2000)TCRT-cellIn rag-1(-/-) thymocytes, which are defective in antigen receptor gene rearrangement, FADD-DN bypassed the requirement for pre-TCR signalling, promoting pro-T-cell survival and differentiation to the more mature pre-T stage.
Liu et al. (2000)TCRT cellsConcurrently, a larger amount of IFN-gamma was produced by the splenic T cells from C57BL/6 mice in response to immobilized anti-TCRalphabeta mAb than by those from BALB/c mice, while the splenic T cells from BALB/c mice produced a higher level of IL-4 upon TCR alphabeta stimulation than did those of C57BL/6 mice.
Viret et al. (2000)TCRT lymphocyteThese observations indicate that the strong influence of productive beta-chain rearrangements on the TCR sequence and specificity of developing thymocytes, which operates through positive selection on self-determinants, applies to both classical and nonclassical alphabeta T cells and therefore represents a general phenomenon in intrathymic alphabeta T lymphocyte development.
Lentz and Manser (2000)TCRT cellsThe T cell compartment can be partially reconstituted in mice with targeted inactivation of the TCR C(beta) and C(delta) genes by injection of mature, syngeneic T cells.
Bertolino et al. (1998)TCRT cellsDying cells acquired a CD8(low) TCR(low) B220+ phenotype similar to the one described for apoptotic intrahepatic T cells, suggesting an alternative model to account for the origin of these cells in the liver.
Tang et al. (1998)TCRT cellEvaluation of the supernatants of the T cell hybridomas for cytokine production in response to the peptides revealed a close correlation between the induction of phosphorylation of TCR-zeta and the amount of cytokine induced.
Lepage et al. (1998)TCRT cellsThe protective IEL appear to be CD8+, TCR-alpha/beta and are at least partially dependent upon the presence of TCR-gamma/delta T cells in the host.
Reid et al. (1997)TCRT-cellWhilst the molecular mechanisms underlying T-cell receptor (TCR)-coupling to PtdCho-PLD activation in these cells have not been fully defined, kinetics studies and experiments using pharmacological inhibitors of protein tyrosine phosphatases (PTPases) and reconstituting CD3-coupled PtdCho-PLD activity in streptolysin-O permeabilized cells, suggest that the TCR/CD3 complex, under optimal conditions of activation, may be predominantly coupled to PtdCho-PLD activation downstream of tyrosine phosphorylation of phospholipase C-gamma (PLC-gamma), phosphatidylinositol (PtdIns)P2 hydrolysis, calcium mobilization and protein kinase C (PKC) activation.
Kawamura et al. (1997)TCRT cellRestricted TCR V alpha repertoire in the T cell response to a tolerogenic determinant of type II collagen.
Liossis et al. (1997)TCRT cellsOverexpression of the heat shock protein 70 enhances the TCR/CD3- and Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells.
Perumal et al. (1997)TCRT cellsThese data point to a specific role for IL-7/IL-7R signaling in regulating the transcriptional activity, possibly mediated by STAT5, of the rearranged TCR-gamma complex during development of gammadelta T cells, and point to mechanistic differences in the regulation of rearrangement of Vgamma4 and Vgamma6 genes vs Vgamma5.
Sundstedt et al. (1996)TCRT-cellInjection of SEA to adult mice activates CD4+ T cells expressing certain T-cell receptor (TCR) variable region beta-chain families and induces strong and rapid production of interleukin 2 (IL-2).
Broussard-Diehl et al. (1996)TCRT cellsMature E beta-myc T cells respond less vigorously than controls to activation through their TCR/CD3 complex, as measured by proliferation and induction of the activation marker CD69.
Liu et al. (1996)TCRT cellCrystallization of a deglycosylated T cell receptor (TCR) complexed with an anti-TCR Fab fragment.
Ofir et al. (1995)TcRT cellsThe expression of the germ-line gene V gamma 1.1-C gamma 4 of the T cell receptor (TcR) gamma chain depends on interleukin (IL)-3 induction in hematopoietic cells, while in T cells, the rearranged gene is expressed constitutively.
Flesch and Kaufmann (1994)TCRT cellsElevated IL-10 production in RAG-1 mutants and TCR beta mutants, but not in TCR delta mutants, is consistent with an inhibition of macrophage IL-10 release by alpha beta T cells.
Hayashi et al. (1994)TCRT cellsTranscript for V beta 8 was predominantly detected in the T cells infiltrating sialadenitis from the onset of the disease, suggesting that CD4+ T cells bearing TCR V beta 8 play an essential role in recognizing unknown autopeptide in the autoimmune sialadenitis of MRL/lpr mice.
Kobayashi et al. (1994)TCRT-cellAdoptive transfer of burn-associated CD8+ CD11b+ TCR gamma/delta + suppressor T (BAST) cells, prepared from TI mice, increased the susceptibility of N mice to infection by HSV, while the susceptibility of N mice, inoculated with the CD8+ T-cell fraction prepared from Z-100-treated TI mice (ZTC), to infection was not changed.
Franco et al. (1994)TCRT-cellRegardless of whether this implies a direct or indirect binding of GTP/GDP to CD3-zeta, these nucleotides and their hydrolysis must play an important role in T-cell activation through the TCR/CD3 complex.
Galandrini et al. (1993)TCRT cellIn conclusion, this study shows that the ligated CD44 molecule provides the necessary stimuli for a variety of T cell-mediated functions triggered via protein tyrosine kinase-dependent signal transduction pathways at least in part similar to those that follow stimulation of the CD3/TCR complex.
Amirayan et al. (1992)TCRT cellsThese results suggest a role for class I molecules in regulation of TCR/CD3- but not surface IgM-mediated cell signaling, which depends on the form of stimulation and the stage of differentiation of T cells.
Tsukada et al. (1992)TCRT cellIn SPL2-1-2, a murine B-committed immature cell line transformed with a temperature-sensitive mutant of Abelson virus, T cell receptor (TCR) gamma gene rearrangements, together with IgH gene rearrangements, were induced during culture at a non-permissive temperature (39 degrees C).
Bean et al. (1992)TCRT cellDeterminations of the phenotype of 10 LAK cell clones showed six with rearrangements for the T cell receptor (TCR) beta chain gene, suggesting a T cell origin, and four with germ line configurations for the TCR beta and delta chain genes, a result consistent with a non-T cell lineage.
Brunaud et al. (1992)TCRT cellA T cell hybridoma denoted D011107 was used as recipient for transfection of cytotoxic KB5C20 TCR alpha/beta heterodimer genes by protoplast fusion or electroporation.
Brunaud et al. (1992)TCRT cellIn the present work, we tested in SCID and Balb/c mice the activity of T hybridoma transfected with T cell receptor (TCR) alpha/beta chain genes.
Gotlieb et al. (1991)TCRT cellHowever, the cells that were generated from precursor thymic cells stimulated with IL-2 represent a completely different T cell subset compared to IL-1-generated cells; these IL-2-stimulated cells express comparable levels of CD3, but also express substantial levels of CD2 and the TCR-gamma/delta, and a subset expresses CD8.
Ohno et al. (1991)TCRT cellsWe have re-explored this issue by using a series of CD2-transfected, TCR/CD3 surface membrane-negative human and mouse T cells.