Viewing affirmative mentions of binding of IL2 (H. sapiens) in lymphocytes

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Wickremasinghe et al. (1987)IL2lymphocyteWe show here that binding of IL2 to its receptors on the lymphocyte surface triggers the generation of cyclic AMP.
Sedman et al. (1990)IL-2lymphocytePrompted by two clinical trials which have suggested distinct but apparently opposite effects of lipid emulsions on the production of and lymphocyte responses to IL-2 we have examined the effects of pharmacological concentrations of three lipid emulsions currently in clinical use on IL-2 related interactions in vitro.
Siekierka and DeGudicibus (1988)IL-2lymphocytesIL-2 radioiodinated by this method binds with high affinity to receptors present on phytohemagglutinin-stimulated peripheral blood lymphocytes and should be useful for the study of receptor structure and function.
Mills et al. (1990)IL2lymphocyteSince IL2 plays a role in lymphocyte proliferation and differentiation, the ability of suramin to inhibit binding of IL2 to its receptor may explain, in part, the in vivo immunosuppressive activities of suramin.
Burrai and Di Lallo (1991)Interleukin2LymphocytesParticular emphasis has been dedicated to Lymphokine Activated Killers in association with Interleukin2 (IL2) and Tumor Infiltrating Lymphocytes, which have shown a very strong and specific anticancer activity.
Randak et al. (1990)IL-2lymphocyteCyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer.
Randak et al. (1990)interleukin 2lymphocyteUsing protein extracts from El4 lymphoma cells we show that the binding of lymphocyte-specific factors interacting with the two so-called purine boxes (Pu-boxes) of the interleukin 2 (IL-2) enhancer are missing in CsA-treated cells.
Sirota et al. (1997)IL-2lymphocytesIt is conceivable that administration of intralipid to preterm infants may interfere with the binding of IL-2 to the specific receptors on their activated lymphocytes, with a possible subsequent suppression of their immune response.
Kay et al. (1990)IL-2lymphocytesInteraction between endogenous opioids and IL-2 on PHA-stimulated human lymphocytes.
McCarthy et al. (1990)IL 2lymphocyteOur results strongly support the concept that polyamines are required for a relatively late event in lymphocyte activation occurring after the interaction of IL 2 and its receptor.
Malaguarnera et al. (2001)IL-2lymphocytesTo date, the association of tumour-infiltrating lymphocytes, IL-2 and IFN alpha provided the best results in terms of survival and toxicity.
Kuo and Robb (1986)Interleukin 2lymphocyteInterleukin 2 (IL 2) modulates the growth and differentiation of a variety of lymphocyte subclasses through its interaction with a specific cell surface receptor.
Papermaster et al. (1983)IL 2PBLIFN gamma production by human PBL thus appears to be regulated by an interaction between IL 2 (from helper cells), suppressor cells (absorption of IL 2), and IFN gamma-producing cells.
Wilkinson and Newman (1994)IL-2lymphocyteThese results suggest that the beta-chain of the IL-2R is required for activation of lymphocyte locomotion by IL-2 and that binding of IL-2 to this chain alone is sufficient for a response.
Thoman and Weigle (1981)IL-2lymphocytesOn the other hand, both young adult T cells and IL-2 can interact with young adult T-depleted splenic lymphocytes to produce a normal, high level anti-SRBC response.
Rudniki et al. (1991)IL-2lymphocytesBinding of exogenous IL-2 to activated lymphocytes from 10 patients was also determined.
Yarbrough et al. (1994)IL-2lymphocytesThe increase in p75 expression in the presence of PM paralleled with an increase in IL-2 binding to these lymphocytes.
Saneto et al. (1987)IL-2lymphocyteThe antibody TAC, which specifically binds the lymphocyte IL-2 receptor, has been shown to also bind oligodendrocyte progenitor cells cultured in a serumless, chemically defined medium.
Liu et al. (1996)IL-2lymphocytesWhereas human IL-2 effectively binds to either human or murine lymphocytes, murine IL-2 binds with markedly higher affinity to murine receptor complexes than to human complexes.
Daefler and Krueger (1989)interleukin 2lymphocytesLack of dynamic lipid changes after binding of interleukin 2 in chronic lymphatic leukemia lymphocytes indicates defective transmembrane signalling.
Daefler and Krueger (1989)Il-2lymphocytesThe role of membrane fluidity in the process of signal transduction after binding of Interleukin-2 (Il-2) to its specific cell-surface receptor was investigated in lymphocytes from normal donors and patients with Chronic Lymphocytic Leukemia (CLL).
Peters and Norback (1990)interleukin-2lymphocytesBinding and internalization of biotinylated interleukin-2 in human lymphocytes.
Saito et al. (1991)IL-2lymphocyteAlthough the H (beta) chain expressed on lymphocytes can bind IL-2 with a Kd value of 1 nM (intermediate affinity), transfected fibroblasts expressing the H chain cannot bind IL-2, suggesting the involvement of other lymphocyte-specific factors for the function of the H chain.
Carson et al. (1994)IL-2lymphocytesScatchard analysis of radiolabeled IL-15 and IL-2 binding to NK-enriched human lymphocytes revealed the presence of high and intermediate affinity receptors for both ligands.
Flad and Ulmer (1981)interleukin 2lymphocyteInteraction of human lymphocyte subpopulations with interleukin 2 (II-2).
Lotze et al. (1985)IL-2lymphocyteOur approach using fresh human tumors as both targets in cytotoxicity assays and stimulators in proliferative assays with other appropriate controls makes possible a careful analysis of the reactivities present following either direct expansion in Interleukin 2 (IL-2) or following mixed lymphocyte tumor interaction and subsequent limiting dilution cloning.
Allegretta et al. (1986)IL-2lymphocyteThe failure of the antibodies to neutralize the biological activity of recombinant interleukin-2 (IL-2) in lymphocyte proliferation assays and to bind to the native lymphokine suggests that they may not affect IL-2-dependent cellular immune functions in vivo.
Saito et al. (1993)IL-2lymphocytesSince lymphocytes devoid of the I chain were not available, we employed functional depletion of the I chain from a mouse T cell line CTLL-2 transfected with cDNA for the human H chain and its defective mutants which can bind IL-2 but cannot transduce a growth signal.
Baroja and Ceuppens (1987)IL-2lymphocyteWe conclude that addition of anti-Tac to lymphocyte cultures enables more exact quantification of in vitro IL-2 production, presumably by blocking IL-2 consumption.
Paiardini et al. (2001)IL-2lymphocytesConversely, treatment of lymphocytes with IL-2 alone restores the phase-specific pattern of expression of cell cycle-dependent proteins and is associated with low levels of apoptosis.
Eizenberg et al. (1995)interleukin-2lymphocyteNorthern blot analysis revealed the presence of several interleukin-2 transcripts of different sizes in the brain, all recognized by lymphocyte-derived interleukin-2 cDNA probes.
Owen-Schaub et al. (1988)IL-2lymphocytesHuman lymphocytes can respond to interleukin 2 (IL-2) under serum-free conditions with generation of major histocompatibility locus-unrestricted oncolytic activity.
Buchli and Ciardelli (1993)IL-2lymphocytesThe biologic activity of this analog is greatly reduced, primarily as a result of decreased affinity to the beta/gamma IL-2 receptor complex; however, it is only weakly antagonistic to the IL-2 response of normal peripheral blood lymphocytes.
Klingemann et al. (1986)IL 2lymphocytesProstaglandins are said to influence T and B cell function by inhibiting the generation of interleukin 2 (IL 2) and the formation of suppressor lymphocytes.
D’Alessandria et al. (2009)IL2lymphocytesThese clinical studies have demonstrated the efficacy of using scintigraphy to detect activated lymphocytes, which correlate with the severity of tissue lymphocytic infiltration and that scintigraphy with radiolabeled IL2 can be used for monitoring the efficacy of specific therapies.
Ito et al. (1984)IL-2PBLIn both groups, pretreatment for 18 hr with IL-2 was able to augment the NK activity of PBL.
Boldt et al. (1988)IL-2lymphocytesAdoptive immunotherapy with interleukin 2 (IL-2) and lymphokine-activated killer (LAK) cells (IL-2/LAK) is a technically demanding cancer therapy dependent upon large scale isolation and culture of lymphocytes.
Iwano et al. (1988)IL-2PBLAlthough in patients with good prognosis the ability of PBL to respond to IL-2 was not changed before and after treatment, in patients with poor prognosis the response was significantly increased after chemotherapy.
Chen et al. (2000)IL2EALThe proliferative response of EAL, cocultured with IL-15, with or without alphaCD3, was partly inhibited by pretreatment with an anti-IL2 receptor beta chain monoclonal antibody (mAb).
Wagner et al. (1998)IL2lymphocyteWhereas the presence of a lymphocyte infiltrate in tissue samples was associated with a TH1 cytokine mRNA profile (TNF-alpha, INF-gamma, IL12p35, IL12p40, IL2Rbeta, and IL2Rgamma), clinically and histologically regressive samples exhibited additionally increased transcript levels for GM-CSF, IL2, and IL15. mRNAs of TH2 cytokines IL4 and IL5 were detected only in a minor portion of progressive melanoma samples and regressive melanoma lesions.
Jordan et al. (2003)interleukin-2lymphocyteWe have established a lymphocyte activation assay that utilizes fluorescein isothiocyanate (FITC)-streptavidin bound to recombinant biotinylated human interleukin-2 (IL-2).
Smith (2006)IL2lymphocytesIn other words, there are a finite number of sites expressed on activated lymphocytes that are capable of binding only IL2, among all of the other cytokines.
Rubin et al. (1987)IL-2lymphocytesThe binding of IL-2 to specific cell-surface receptors (IL-2R) has previously been shown to be essential to the growth and proliferation of activated lymphocytes.
Breite et al. (1990)IL-2lymphocytesFollowing activation with IL-2, both groups of lymphocytes exhibited comparable cytolytic activity against K562 targets.
Wakasugi et al. (1982)IL-2lymphocytesSignificant activity of both interferon (IFN) (both alpha- and gamma-types) and interleukin-2 (IL-2) was detected in the culture supernatants from nonadherent lymphocytes.
Ingram et al. (1987)interleukin 2lymphocytesThe protocol is based on surgical debulking followed by implantation into the tumor bed of autologous lymphocytes that have been stimulated with phytohemagglutinin-P and then cultured in vitro in the presence of interleukin 2.
Szamel et al. (1990)interleukin 2lymphocytesActivation signals in human lymphocytes: interleukin 2 synthesis and expression of high affinity interleukin 2 receptors require differential signalling for the activation of protein kinase C.
Wilkinson and Newman (1994)IL-2lymphocytesChemoattractant activity of IL-2 for human lymphocytes: a requirement for the IL-2 receptor beta-chain.
Conry et al. (1998)IL-2lymphocyteThe antiproliferative effect of BCX-34 was tested in normal human peripheral blood mononuclear cells (PBMCs) induced to proliferate with OKT3, tetanus toxoid, the mixed lymphocyte reaction, or IL-2.
Kondo et al. (1988)IL-2lymphocyteSoluble IL-2R protein thus prepared retained the ability to bind IL-2 specifically and suppressed the in vitro IL-2-mediated immune responses, including proliferation of IL-2-dependent cell line (CTLL-2), induction of secondary cytotoxic T lymphocytes (CTL) and the mixed lymphocyte reaction (MLR), but did not suppress the growth of IL-3-dependent cell line.
Sato et al. (1986)IL-2lymphocytesTwo monoclonal antibodies (designated as KNT-1 and KNT-2) out of six established clones reacted with natural human IL-2 molecule obtained from cultured human peripheral blood lymphocytes (PBL) stimulated with PHA-P and TPA.
Nano et al. (1995)IL-2lymphocytesThe following aspects were examined: the morphological pattern of IL-2 stimulated lymphocytes; the ability of these cells to recognize, bind, attack and destroy tumoral lines; their cytochemical and immunological (CD) feature.
Quan et al. (2008)IL-2lymphocytesFamotidine may increase LAK activity by increasing IL-2 internalization by the IL-2 receptor on lymphocytes.
Heaton et al. (1993)IL-2lymphocyteThese data suggest the interaction of IL-2 and the high-affinity IL-2 receptor on human PBMC or peripheral blood lymphocyte is required for maximal secretion of IL-1 beta, TNF-alpha, TNF-beta, and IFN-gamma.
Kawano et al. (1990)IL2lymphocytes[Anti-CD45R antibody-treated normal lymphocytes respond to interleukin 2 (IL2) after stimulation by allergens].
Mulders et al. (1998)IL-2TILsCombination therapy with interleukin-2 (IL-2) and tumor-infiltrating lymphocytes (TILs) demonstrates significant clinical activity in patients with metastatic renal cell carcinoma (RCC).
Tanaka (1989)IL2LymphocyteLymphocyte proliferation was inhibited by anti-IL2 receptor and anti-IL2 antibodies as well, indicating that zinc augments signal transduction through IL2 receptors through enhancement of the interaction between the IL2 and IL2 receptors.
Owen-Schaub et al. (1988)IL-2lymphocytesChemical crosslinking of 125I-IL-2 to Tac-depleted lymphocytes followed by SDS-PAGE determined that the size of the non-Tac-binding protein was approximately 75 kDa.
Paciucci et al. (1989)interleukin-2lymphocytesTwenty-five patients with disseminated cancer (nine with renal cell carcinoma, five with melanoma, three with Hodgkin's lymphoma and chronic myelocytic leukemia [CML], two with soft tissue sarcoma, one each with large-cell lymphoma, breast cancer, and colon cancer), 13 males and 12 females, aged 25 to 68, were treated with recombinant human interleukin-2 (rIL2) by continuous infusion and adoptive transfer of autologous lymphocytes activated in vitro with IL2.
Mu et al. (1999)IL-2lymphocytesThe percentage of lymphocytes that coexpressed membrane Pgp and cytoplasmic IL-2 accounted for < 10% of the total IL-2 producing lymphocytes.
Stern et al. (1990)interleukin 2lymphocytesA cytokine that can synergize with interleukin 2 to activate cytotoxic lymphocytes was purified to homogeneity.
Iseki et al. (1987)recombinant IL-2lymphocytesThe interaction of recombinant IL-2 with human resting lymphocytes: blocking effects of monoclonal antibodies to IL-2 receptors.
Weil-Hillman et al. (1990)IL-2lymphocytesHowever, this IL-2/p75 interaction induces TAC chain synthesis and formation of high affinity IL-2 receptor required for the proliferation of resting peripheral blood lymphocytes.
Mahvi et al. (1996)IL-2lymphocytesThese results imply that the pulmonary edema associated with IL-2 is not caused by activated lymphocytes.
Saito et al. (1991)IL-2lymphocytesWe found that lysates of transfected Cos7 cells expressing H chains can bind IL-2 when mixed with lysates from lymphocytes that cannot bind IL-2.
Kanra and Vesikari (1975)lymphokinelymphocytesAlthough the nature of cytotoxic activity remains to be characterized, it is suggested that it is associated with a lymphokine released immune-specifically from rubella virus-stimulated lymphocytes.
Lagoo-Deenadayalan et al. (1992)IL-2lymphocytesThese FcR+ cells are also capable of antibody-dependent cytotoxicity (ADCC), which can be detected using fresh human peripheral blood lymphocytes (PBL) directed to murine targets, however, PBL-mediated ADCC to human tumors usually is very low, requiring a stimulation of the PBL, which also can be accomplished with IL-2.
Santoli et al. (1988)IL-2lymphocytesDose-response curves using increasing concentrations of IL-2 and IL-3 and isobologram analysis of these interactions revealed a clear synergy of action between the two growth factors in inducing proliferation of unfractionated PBL, purified T cells, mitogen-activated lymphocytes, and alloantigen-stimulated T cells.
Helfand et al. (1992)hrIL-2PBLIL-2 receptor expression by mitogen-stimulated canine PBL was confirmed by the binding of hrIL-2 with high affinity, and with characteristics comparable to those of the human and murine IL-2 receptor.
Yagita et al. (1989)IL-2TILIn contrast, TIL from the other three of eight melanoma and all three sarcoma contained one-third Tac-positive cells as assessed by flow cytometry analysis, and expressed surface non-Tac (p70-75) and Tac (p55) peptides by [125I]IL-2 cross-linking.
Peters and Norback (1990)IL-2lymphocytesThe binding, internalization, and fate of interleukin-2 (IL-2) were studied in phytohemagglutinin (PHA)-activated human lymphocytes using biotinylated recombinant IL-2 (rIL-2).
Pujol-Borrell et al. (1986)IL-2lymphocytesMonolayer cultures from 25 human pancreatic glands were supplemented with alpha-interferon (IFN), beta-IFN or gamma-IFN, interleukin 2 (IL-2) and supernatants from activated lymphocytes.
Kawahara et al. (1992)IL-2lymphocytesIn vitro immunization was effectively caused by the addition of OK-432 or muramyl peptides, IL-2, and IL-6, to the coculture of A549 cells and lymphocytes.
Lamaze et al. (2001)IL2lymphocytesUltrastructural and biochemical experiments showed that clathrin-independent endocytosis of IL2 receptors exists constitutively in lymphocytes and is coupled to their association with detergent-resistant membrane domains.
Blanchard et al. (1988)IL-2LymphocytesLymphocytes were incubated with recombinant interleukin 2 (IL-2) for 3-4 days and then assessed for tumoricidal activity in a 51chromium-release assay.
Dogan et al. (2006)IL-2lymphocyteslymphocytes expressing IL-2 receptors are found at increased
Garrido et al. (1990)IL-2lymphocytesThe high buoyant density lymphocytes, depleted of NK cells, had no targetable activity, but were able to generate over several days, targetable T cell activity in the presence of a TCR cross-linking signal plus IL-2.
Di Ianni et al. (1996)IL-2lymphocyteTwo lymphocyte activation procedures were employed: a) phytohemagglutinin/interleukin-2 (PHA/IL-2) polyclonal stimulation; b) allogeneic stimulation in a mixed irradiated or non irradiated lymphocyte reaction, both supplemented with IL-2 (MLR/IL-2).