Viewing affirmative mentions of regulation of IL2 (H. sapiens)

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Chouaib and Fradelizi (1982)interleukin-2[Cellular regulation of human interleukin-2 production].
Chouaib and Fradelizi (1982)IL2Previous studies have also suggested that control of IL2 production is similar in the Human.
Chouaib and Fradelizi (1982)IL2A model for the cellular control of human IL2 production is proposed.
Weaver et al. (2007)IL-2 geneTranscription of the IL-2 gene is tightly controlled by the combined actions of multiple transcriptional activators.
Pahlavani and Richardson (1996)interleukin-2The effect of age on the expression of interleukin-2.
Su et al. (1991)interleukin 2[Effect of diethyldithiocarbamate on interleukin 2 production of patients with oral lichen planus and its clinical therapeutic efficacy].
Efrat et al. (1984)IL-2 geneThese findings suggested the involvement of a labile protein repressor in the regulation of human IL-2 gene expression.
Smith and Pruett (1989)IL-2Therefore, the recently reported circadian variations in T helper to T suppressor ratios do not seem to significantly affect mitogen-induced IL-2 production.
Sasagawa et al. (2006)IL-2Modulation of IL-2 production by submaximally stimulated Jurkat cells was determined in response to treatment with extracts prepared from dried aerial parts of Echinacea purpurea.
Cadée et al. (2002)rhIL-2In contrast with non-degradable dex-MA hydrogels, degradable dex-lactate-HEMA gels with comparable network characteristics (degree of methacrylate substitution and initial water content) showed an almost zero-order, degradation controlled release of rhIL-2 in a time period of 5-15 days.
Li and Weir (1990)IL-2This inhibition is likely mediated through a reduction in both IL-2 production and IL-2 responsiveness.
Calder et al. (1987)IL-2Effects of cyclosporin A on expression of IL-2 and IL-2 receptors in normal and multiple sclerosis patients.
Ketzinel and Kaempfer (1999)IL-2Human IL-2 gene expression is regulated by cell-mediated suppression.
Ulmer and Flad (1982)Il-2This population appears to participate in the regulation of Il-2 production.
Carrillo-Vico et al. (2005)IL-2Moreover, we demonstrated that this endogenous melatonin interfered with the exogenous melatonin effect on IL-2 production.
Meuer et al. (1984)IL-2Perhaps more importantly, the findings demonstrate that antigen-induced proliferation is mediated through an autocrine pathway involving endogenous IL-2 production, release, and subsequent binding to IL-2 receptors.
Fernandez et al. (1995)IL-2Does thalidomide affect IL-2 response and production?
Wacholtz et al. (1991)IL2The effect of cyclic AMP-elevating agents on mitogen-stimulated IL2 production was examined.
Efrat and Kaempfer (1984)IL-2The net result is the generation of a relatively short wave of IL-2 mRNA activity, demonstrating the tight control of IL-2 gene expression.
Barcellini et al. (1988)IL-2In vivo immunopotentiating activity of thymopentin in aging humans: modulation of IL-2 receptor expression.
Modiano et al. (1991)IL2The inhibition of PKC affected the expression of IL2 receptors by these cells differently; it had little effect on gene expression or on the membrane-bound form of the receptor, but it decreased soluble receptors in the supernatants by 50-80%.
Arya and Gallo (1985)TCGFNo evidence was obtained suggesting abnormal regulation of the TCGF or of the IFN-gamma gene consequent to HTLV-III infection.
Wiranowska-Stewart and Hadden (1986)interleukin-2Effects of isoprinosine and NPT 15392 on interleukin-2 (IL-2) production.
Dornand et al. (1987)IL 2We have studied the mechanism whereby amiloride inhibits the blastogenesis by measuring their effect on: 1) IL 2 production, 2) acquisition of IL 2 responsiveness and induction of IL 2 receptors, 3) IL 2-induced proliferation.
Gaffen and Liu (2004)IL-2Here we present a broad overview of IL-2 history, functional activities, biological sources, regulation and applications to disease treatment.
Rossi et al. (1988)IL2However, IL2 secretion increased in the BM cells from B-CLL patients after addition of indomethacin or prior irradiation, in a similar way to that observed in PB and BM of normal controls, suggesting an apparent normal control of the IL2 production in BM from B-CLL patients.
Rezai et al. (1990)IL-2Histamine blocks interleukin 2 (IL-2) gene expression and regulates IL-2 receptor expression.
Rezai et al. (1990)IL-2In addition, histamine seems to exert immunomodulating effects on IL-2 receptor expression, particularly in those individuals with AIDS-KS.
Yegane-Sarkandy et al. (2009)IL-2The effect of glutamine, as one of the amino acids most influencing the expression of IL-2 in batch and fed-batch high-cell-density cultures, was studied.
Hopkins and Failla (1999)IL-2 geneSynthesis of this cytokine is regulated by alterations in transcription of the IL-2 gene and the stability of IL-2 mRNA.
Prasad et al. (2002)IL-2We also showed a significant effect of zinc on the gene expression of IL-2 receptors alpha and beta.
Prasad et al. (2002)IL-2Our studies demonstrate, for the first time, the role of zinc in gene expression of IL-2 and its receptors in HUT-78 cells.
Shaw et al. (1988)IL-2 mRNAHuman Jurkat cells show a rapid increase of IL-2 mRNA on induction of IL-2 synthesis, followed by an equally rapid decline 4 to 6 h later.
Krönke et al. (1984)TCGFTo define further both the specificity of CsA and the level at which it interferes with lymphokine gene expression, we have studied its effects on TCGF mRNA accumulation as well as TCGF gene transcription.
Sutton et al. (2004)IL-2There are limited data regarding the effects of pregnancy and HIV infection on IL-2 production in humans.
Sutton et al. (2004)IL-2To investigate the effects of human pregnancy, HIV infection, and HIV therapy on IL-2 production, we evaluated 61 women.
West et al. (1994)interleukin 2Biological response modifiers and chemotherapeutic agents that alter interleukin 2 activities.
Cooley et al. (1989)IL2The only variable significantly affecting IL2 and IFN production in marrow transplant recipients was increasing time post transplant.
Ohmura and Onoue (1990)IL-2 mRNAThese results indicate the presence of a mechanism controlling the stability of IL-2 mRNA that is regulated by PKC.
Povlsen et al. (1989)interleukin-2Cyclosporin A mediated immunosuppression in vitro: effect on high affinity interleukin-2 receptor expression and -turnover.
Arad et al. (1996)interleukin-2Dual control of human interleukin-2 and interferon-gamma gene expression by histamine: activation and suppression.
Mårtensson and Leanderson (1989)interleukin 2Regulation of interleukin 2 gene expression: discrepancy between enhancer activity and endogenous gene expression.
Monti et al. (1993)IL-2The availability of purified anti-IL-2 antibodies, obtained from healthy individuals, able to modulate IL-2 activity, could be important in several therapeutic approaches.
Huchet and Grandjon (1988)IL-2Histamine-induced regulation of IL-2 synthesis in man: characterization of two pathways of inhibition.
Liu et al. (2006)IL-2We aimed to observe the effects of morphine, fentanyl and tramadol on NF-kappa B and IL-2 from both laboratory and clinical perspective.
Yao et al. (2003)IL-2The effect of adenovirus-mediated interleukin-2 (IL-2) gene on rat basal nociceptive response and chronic neuropathic pain was explored.
Kabuki et al. (1990)IL2The effect of Saibokuto on induction of antigen specific IL2 responsiveness was studied.
Kabuki et al. (1990)IL2Effect of Saibokuto on induction of antigen specific IL2 responsiveness was studied.
Kabuki et al. (1990)IL2Effect of Saibokuto on induction of antigen specific IL2 responsiveness was studied.
Ferguson et al. (2001)IL-2 geneWe present a kinetic model for a single round of basal transcription at the IL-2 promoter that provides insight into mechanisms by which the IL-2 gene is transcriptionally regulated.
Muñoz et al. (1985)interleukin 2The expression of interleukin 2 in this plasmid is controlled by both the consensus promoter and a consensus ribosome binding site characteristic of Escherichia coli.
Hashimoto et al. (1993)IL-2To examine the role of cellular interactions involving class I histocompatibility antigens in the response to low concentrations of phytohaemagglutinin, we studied the effect of antibodies to components of these antigens on proliferative responses, interleukin-1 and interleukin-2 production, and IL-2 receptor expression.
Wu and Yang (1991)IL-2Selenium could only enhance IL-2 production by MLA144, whereas in none of these three systems was IL-2 production altered by zinc.
Tadmori et al. (1986)IL 2These findings indicate that signals induced by antibody 9.6 regulate IL 2 production at a pre-translational level, are operative for an extended period of time overlapping with the early phase of IL 2 mRNA accumulation, suppress IL 2 gene expression induced by PHA as well as TPA, and that antibody 9.6 and CsA exert their inhibitory effect by distinct mechanism(s).
Sfikakis et al. (1993)IL-2OBJECTIVE: To further investigate the mechanism of action of gold compounds by studying their effects on interleukin-2 (IL-2) and IL-2 receptor (IL-2R) biosynthesis.
Espinoza-Delgado et al. (1995)IL-2The regulation of the expression of the IL-2 receptor subunits differs in terms of response to extracellular stimuli and intracellular control, suggesting that the response to IL-2 will vary depending on the nature and extent of environmental stimulation.
Fletcher and Goldstein (1987)IL-2A more precise understanding of the mechanism of action IL-2, in particular its role in the induction of the IL-2 receptor, and aspects of the control of IL-2 production was also achieved.
Usui (1990)IL-2In addition, the effect of the patient's serum on the expression of IL-2 receptors and LAK activity were investigated.
Pitzer et al. (1999)IL-2Most importantly for clinical application, IL-2 expression by the transduced melanoma cells could also be regulated in vivo.
Zehavi-Willner and Shalit (1989)IL-2The effect of the two quinolones on IL-2 production was both time and concentration dependent, reaching a 3-5 fold increase at a drug concentration of 50-100 micrograms/ml, following 24 h incubation.
Bunting et al. (2006)interleukin-2Control of interleukin-2 gene transcription: a paradigm for inducible, tissue-specific gene expression.
Bunting et al. (2006)IL-2 geneThe mechanisms that control IL-2 gene transcription have been studied in detail for the past 20 years and our current understanding of the nature of the inducible and tissue-specific controls will be discussed.
Yenicesu et al. (1997)IL-2Effect of short-course high-dose methylprednisolone treatment on serum IL-2 levels in children with myelodysplastic syndromes: a pilot study.
Yenicesu et al. (1997)IL-2In the present study the effect of HDMP treatment on serum levels of interleukin 2 (IL-2) was evaluated in five children with MDS.
Li et al. (1992)interleukin 2Effects of surgical trauma on interleukin 2 production and interleukin 2 receptor expression.
Bailey et al. (1992)IL-2The effect on IL-2 production was most marked in animals weaned for as little as 24-48 h.
Kazakova et al. (1991)interleukin-2[Immunomodulating peptides, regulation of interleukin-2 expression and its possible mechanism].
Ridgway and Borzy (1989)IL-2In addition, of 37 patients examined during clinical remission (both during chemotherapy and after the completion of maintenance chemotherapy), five had IL-2 production values above the control range and four of these five patients subsequently had relapses, compared with only one relapse in the remaining 32 patients with normal or below-normal levels of IL-2 production.
Abraham et al. (1988)interleukin-2In order to examine the mechanism which underlies its suppressive action, the effects of hemorrhagic serum on the production and utilization of interleukin-2 (IL-2) by PBMCs in mitogen-stimulated cultures were investigated.
Kishter et al. (1985)IL-2These results suggest that several immunomodulators may produce their effects by the modulation of IL-2 or other lymphokines.
Abraham and Regan (1985)interleukin 2The effects of hemorrhage and trauma on interleukin 2 production.
Santoli and Zurier (1989)IL-2In this report, we investigate the effects of the immediate (DGLA, precursor to PGE1), arachidonic acid (AA, PGE precursors, dihomogamma linolenic acid (DGLA, precursor to PGE1), arachidonic acid (AA, precursor to PGE2), and eicosapentaenoic acid (EPA, precursor to PGE3) on IL-2 production by PHA-stimulated human PBMC.
Reinherz et al. (1984)IL-2Perhaps more importantly, the findings demonstrate that antigen-induced proliferation is mediated through an autocrine pathway involving endogenous IL-2 production, release, and subsequent binding to IL-2 receptors.
McElhaney et al. (1992)IL2The effect of influenza vaccination on IL2 production in healthy elderly: implications for current vaccination practices.
de Faucal et al. (1984)IL2In 9 cases, the effect of addition of indomethacin (2 micrograms/ml) or of an optimal amount of IL1 on PHA-induced IL2 production was studied.
Dohlsten et al. (1988)interleukin 2Inhibitory effects of histamine on interleukin 2 and gamma interferon production of different human T helper cell subsets.
Umlauf et al. (1993)IL-2The delivery of costimulation and the effects of the anergic state impinge on IL-2 production via different molecular mechanisms.
Flescher et al. (1994)IL-2The most distal step of CD3-mediated signal transduction is dependent upon transcription factors that regulate a set of genes, including IL-2.
Flescher et al. (1994)IL-2 geneIn summary, our data suggest that chronic low-level oxidative stress, via suppression of mitogen-induced transmembrane signaling (protein-tyrosine phosphorylation and calcium mobilization), causes a decrease in the DNA binding activity of transcription factors that regulate the IL-2 gene.
Drexler et al. (1988)IL-2Changes in morphology, Tac (IL-2 receptor) expression, RNA synthesis measured by 3H-uridine uptake, and immunoglobulin production tested by enzyme-linked immunosorbent assay were used as parameters of successful signal transduction.
Kaempfer (1994)interleukin-2Regulation of the human interleukin-2/interleukin-2 receptor system: a role for immunosuppression.
Di Felice et al. (1996)IL-2The immunotherapy with IL-2 can induce objective tumor regressions, but at present there are no data about the influence of a chronic exogenous IL-2 administration on endogenous secretion of IL-2.
Moreau et al. (1986)IL2Evidence that this production is under IL2 control.
Granelli-Piperno et al. (1990)interleukin 2Previous experiments have defined six different sites that may contribute to the transcriptional control of the interleukin 2 (IL-2) promoter, and for each, active nuclear binding factors are induced upon mitogenic stimulation.
Kucharz and Sierakowski (1990)interleukin 2Effect of isoniazid on interleukin 2 production and interleukin 2-receptor expression.
Lardone et al. (2006)IL-2Therefore, we investigated whether endogenous melatonin produced by Jurkat cells was involved in the regulation of IL-2 production.
Bryl et al. (1999)IL-2Our studies show that the therapy with rhEPO affects IL-2 secretion.
Tsang et al. (2000)IL-2 geneThe first approach was to use the new SR-alpha promoter to control IL-2 gene expression.
Aiello et al. (1986)IL-2In addition it was found that the presence of IL-1 constituted a crucial requirement for the induction and the positive modulation of IL-2 receptor expression.
Wang and Liu (2002)interleukin-2OBJECTIVE: To study the effect of Bushen Huayu Composite (BSHY) on interleukin-2 (IL-2) secretion and IL-2 receptor expression in the aged.
Christensen et al. (2006)IL2The SNP (rs2069762) that showed the most consistent results is located in the promoter and has previously been shown to influence the level of IL2 expression.
Murayama et al. (2006)IL2Our observations indicate that Oct-1-binding followed by CpG demethylation are key events in the epigenetic regulation of IL2 expression and may act as a memory of the regulatory event.
Garrity et al. (1994)Interleukin-2Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors.
Garrity et al. (1994)IL-2This raises several questions about the molecular mechanism by which IL-2 expression is regulated.